APIs pour la recherche et les impuretés

<p>Quinidine is a drug that has been used in the treatment of cardiac arrhythmias and as an antiarrhythmic. It is an uncharged compound that can cross cell membranes by passive diffusion. Quinidine binds to the sodium ion channel, which is the pore through which sodium ions enter the cell, and causes it to close, thereby preventing them from entering the cell. This leads to decreased conductance of nerve impulses and a decrease in membrane potential. The effectiveness of quinidine is dependent on its concentration and on the duration of exposure to this drug.</p>

<p>Cis-phenothrin is a carbamate insecticide that is used in agriculture, public health, and veterinary medicine. It has been shown to have a high degree of toxicity to mosquitoes and other pests. Cis-phenothrin acts as an acetylcholinesterase inhibitor, preventing the breakdown of acetylcholine by enzymes in the central nervous system. This allows acetylcholine levels to build up and produce toxic effects on insects such as paralysis or death. Cis-phenothrin has also been shown to be toxic to bacteria in vitro studies. It inhibits bacterial growth by binding to fatty acids and fatty acid synthases, which are essential for bacterial cell wall integrity. The inhibition of this enzyme leads to increased membrane permeability and cell lysis.</p>

<p>Metabolite of montelukast</p>

<p>Please enquire for more information about Nonanal-d18 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CPI 0610 is a medicinal compound that acts as a potent inhibitor of protein phosphorylation. It has been shown to inhibit the cell cycle and promote apoptosis in Chinese hamster ovary cells. CPI 0610 is an effective inhibitor of kinase activity in cancer cells, leading to decreased tumor growth and increased survival rates. In preclinical studies, CPI 0610 has demonstrated efficacy against a wide range of cancers, including breast, prostate, and lung cancer. This inhibitor has also been shown to be effective in human cancer cell lines, making it a promising candidate for future cancer therapies.</p>

<p>Please enquire for more information about 8-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-octen-4-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>RS 67506 hydrochloride is a biochemical that is used in experimental and descriptor studies. The ketone group has been found to be an important part of the molecular structure. RS 67506 hydrochloride has been shown to have a number of biological properties, including inhibition of the synthesis of neurotransmitters such as dopamine, serotonin and norepinephrine; it also has anti-nervous system activity. This chemical was also found to inhibit the synthesis of prostaglandin E2 in human neutrophils. It is hypothesized that RS 67506 hydrochloride may inhibit phospholipase A2, which would prevent the release of arachidonic acid from phospholipids into the cell membrane and block the production of eicosanoids.</p>

<p>Enniatin B2 is a natural cyclic hexadepsipeptide that has been isolated from Chinese medicinal herbs. It is an analog of enniatin, which is known to be a potent inhibitor of protein kinase C. Enniatin B2 has been shown to induce apoptosis in cancer cells and inhibit tumor growth in human cell lines. It exerts its anticancer effects by disrupting the cell cycle and inhibiting the activity of various protein kinases involved in cell signaling pathways. Enniatin B2 also exhibits inhibitory effects on urease, which makes it a potential therapeutic agent for urinary tract infections caused by urease-producing bacteria. Its unique characteristics make it a promising candidate for further research into its potential as an anticancer and antimicrobial agent.</p>

<p>Ys-035 hydrochloride is a drug product that is custom synthesized and has no CAS number. It has a high purity and analytical results, as well as metabolism studies. This chemical is natural and the drug development stage is Pharmacopoeia or Metabolite. Synthetic and impurity standards are available for research and development, HPLC standard.</p>

<p>Please enquire for more information about (3,5-Dimethyl-2-hexeno)-4-hydroxyphenone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>5-[(Hydroxyacetyl)amino]-N,N'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide is a drug product that was synthesized for research purposes. It is an analytical standard for HPLC and has not been approved for clinical use. 5-[(Hydroxylacetyl)amino]-N,N'-bis [2-hydroxy-1-(hydroxymethyl)ethyl]-2,4,6-triiodo-1,3-benzenedicarboxamide is a compound with natural origin and has been classified as an API impurity. This synthetic drug product is custom synthesized to meet the requirements of pharmacopoeia standards.</p>

<p>Ciprofibrate methyl ester is an analytical standard that can be used for the detection of impurities in drug products. It is a metabolite of Ciprofibrate and is used as a reference material for HPLC. The impurity standards are available in high purity or with different levels of purity, depending on the application. In addition, it can be custom synthesized to meet specific needs. This product has been tested according to the requirements of the USP-NF and has been found to meet these requirements.</p>

<p>Diornithine is a medicinal compound that has been identified as an analog of ornithine, a non-essential amino acid found in human urine. This compound is an inhibitor of the enzyme ornithine decarboxylase (ODC), which plays a critical role in the regulation of cell growth and proliferation. Diornithine has been shown to induce apoptosis (programmed cell death) in cancer cells by inhibiting ODC activity and disrupting the cell cycle. In addition, Diornithine has been found to be effective against various types of human cancers, making it a promising anticancer agent. This compound has also been studied for its potential use as a protein kinase inhibitor, which could have therapeutic applications in the treatment of other diseases.</p>

<p>N-Piperacillinyl ampicillin is a drug product that is used for research and development. It is an impurity standard for the preparation of analytical reference standards for the determination of Metabolism studies in Natural API, Custom synthesis, Impurity standard, Synthetic drugs. N-Piperacillinyl ampicillin has been shown to inhibit bacterial growth by binding to the 50S ribosomal subunit. It is also used as a pharmacopoeia HPLC standard and a high purity pharmaceutical product in niche markets.</p>

<p>4’-Hydroxy rac-kavain-d3 is a metabolite of the natural product kavain. It can be used as an analytical reference standard for HPLC to quantify the amount of kavain in samples. The metabolite is often found as an impurity in synthetic preparations of kavain. 4’-Hydroxy rac-kavain-d3 can also be used as a research and development (R&amp;D) or drug development (DD) standard for measuring the metabolism of kavain in humans or animals. This compound is not included in any pharmacopoeia, but it is an API impurity that should be monitored during synthesis and purification to ensure high purity standards are met.</p>

<p>Bosentan impurity C is a stable crystalline compound that is soluble in organic solvents. It has been identified as an impurity of the drug bosentan, and has been found to be present in the drug at concentrations of up to 0.2%. Bosentan impurity C can be prepared by crystallization from an alkaline solution and can also be obtained as a salt form. The salt form is a dimer that consists of two bosentan molecules linked together by one oxygen atom. Bosentan impurity C is stable under normal conditions and does not undergo any changes when exposed to light or heat. This compound has shown no significant adverse effects on humans who have taken it, with no adverse effects on the kidney, liver, or lungs reported.</p>

<p>(2R)-2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile hydrochloride (ZD4054) is a drug that has been shown to be sensitive to the efflux pump in Escherichia coli. It is also able to inhibit multidrug resistance in nematodes and cross-resistance in humans. ZD4054 inhibits multidrug resistance by inhibiting the efflux of drugs from cells. This prevents the development of resistance to antibiotics and other drugs. The mechanism of action for this drug is unknown, but it may affect chloride channels that are found on the cell membrane. ZD4054 has also been shown to be effective against C.elegans and Drosophila melanogaster, two species commonly used for research purposes.</p>

<p>Eplivanserin is a potent tumor inhibitor that belongs to the class of indirubin kinase inhibitors. It has shown great promise as an anticancer agent due to its ability to induce apoptosis in cancer cells and inhibit their growth cycle. Eplivanserin has been found to be effective against a variety of cancers, including breast, lung, and prostate cancer. This medicinal compound is derived from Chinese herbs and has been extensively studied for its potential in cancer treatment. In addition, eplivanserin has been found in urine samples from humans, indicating that it may have potential as a diagnostic tool for cancer detection. Its protein targets are still being investigated, but it is believed that eplivanserin works by inhibiting key enzymes involved in cell signaling pathways that promote cancer cell growth and survival.</p>

<p>4-Chloro-4-methyl-5-methylene-1,3-dioxolan-2-one is a synthetic metabolite that is used as an impurity standard for the drug product 4-[4-(4,5-dichloro-1H,3H)-imidazolinyl]-N-[(dimethylamino)sulfonyl]benzamide. It is also used in analytical methods such as HPLC to measure the concentration of 4-[4-(4,5-dichloro-1H,3H)-imidazolinyl]-N-[(dimethylamino)sulfonyl]benzamide in a sample. This compound is also used in metabolism studies to study how it is broken down by the body.</p>

<p>Melatonin methoxy-d3 is a synthetic melatonin metabolite that is used as an impurity standard in the manufacture of drug products. It is also used as a research and development intermediate, a custom synthesis, or a raw material in the production of other drugs. Melatonin methoxy-d3 has CAS Number 60418-64-6 and its chemical name is 3-[2-(Methoxymethyl)benzofuran-5-yl]oxyindole. Melatonin methoxy-d3 is a synthetic drug product with high purity and pharmacopoeia grade. It has been shown to be effective in metabolism studies and to have niche applications for analytical work.</p>

<p>1-Hydroxycarvedilol is a drug product that is used as a standard in HPLC. It is a natural metabolite of carvedilol and has been found to be involved in the metabolism of carvedilol. The purity of 1-hydroxycarvedilol is &gt;98%. This product is also an impurity standard for analytical purposes and an API impurity. It can also be used in metabolism studies and has CAS No. 146574-41-6.</p>

<p>N-Methyl-y-[3-(trifluoromethyl)-phenoxy]benzenepropanamine hydrochloride is a synthetic drug product that has been shown to be metabolized in humans. It is an impurity standard for HPLC and analytical methods. This compound is used as a research chemical in the development of drugs, and is also used as a pharmacopoeia reference standard.</p>

<p>Please enquire for more information about N,N-Didesmethyl N-tert-butoxycarbonyl diltiazem including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Labetalol EP impurity D is a metabolite of labetalol that is used as an impurity standard for HPLC. This impurity has been identified in the drug product and also in the drug development process. Labetalol EP impurity D is one of many metabolites that can be formed by cytochrome P450 enzymes. Labetalol EP impurity D is a natural metabolite of labetalol, which can be found in the urine of humans and other mammals. It is also present in various plants and fungi, including mushrooms, lichens, yeast, and barley. Synthetic labetalol EP impurity D can also be produced by various chemical reactions.</p>

<p>Tazarotene is a synthetic retinoid that is used in the treatment of psoriasis and acne vulgaris. Tazarotene sulfoxide is the active metabolite of tazarotene. It has been shown to have an acidic pH, and it can be photolysed by exposure to light. Tazarotene sulfoxide has been shown to be reproducible and reliable for analytical purposes and can be used as an additive for medicines.</p>

<p>2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid is a synthetic compound that is being researched as a potential drug product. It is an impurity standard for HPLC and has been used in the past to develop drugs. The chemical structure of this compound closely resembles that of the natural metabolite 4,5-dimethoxybenzoic acid, which is found in plants such as thyme. 2-(3-(1-Benzylpiperidin-4-yl)-2-oxopropyl)-4,5-dimethoxybenzoic acid has shown to inhibit human cytochrome P450 enzymes, which may lead to serious side effects when taken orally.</p>

<p>Albendazole is a sulfoxide anthelmintic drug that is used to treat worm infections in livestock and pets. Albendazole inhibits the synthesis of the parasitic cell membrane, which disrupts the integrity of the cell and leads to death. The analytical method for measuring albendazole includes extraction with hexane followed by analysis using gas chromatography. In humans, albendazole may be used to treat cancer, especially when it occurs in cavities or fatty tissues. It can also be used as a treatment for certain types of parasitic infections, such as toxoplasmosis, amebiasis, and cysticercosis. Albendazole is absorbed well after oral administration and plasma concentrations are proportional to dosage levels. The most common side effects are nausea and headache.</p>

<p>3'-[3-(3-Azido-2,3-dideoxy-b-D-erythro-pentofuranosyl)-3,6-dihydro-5-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-3'-deoxythymidine is an analytical standard used in the R&amp;D and drug development of 3'-azido derivatives of thymidine. It is a synthetic intermediate that has been shown to be a potent inhibitor of human immunodeficiency virus type 1 (HIV) replication and to inhibit intracellular HIV type 2 (HIV2) production in cultured cells. 3'-[3-(3-Azido-2,3,-dideoxy--b erythro--pentofuranosyl)-3,6--dihydro--5--methyl--2,6--dioxo--1(2H)--pyrimidinyl]-</p>

<p>Please enquire for more information about Diphenyl sulfone-3,3'-disulfonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Remdesivir impurity 5 is a metabolite that is generated in the body following metabolism and excretion of remdesivir. It has been shown to be present in urine, plasma, and cerebrospinal fluid following administration of remdesivir. Remdesivir impurity 5 binds to the active site of HIV reverse transcriptase with a Kd value of 0.5 nM. The chemical name for this compound is (5R)-3-[[3-[(2S,4R)-2-amino-4-(2-methylpropyl)piperidin-1-yl]-1H-indol-6-yl]carbonyl]benzoic acid methyl ester.</p>

<p>Sinalexin is an anticancer drug that targets human protein kinases. It is an analog of saxagliptin and has been shown to inhibit the growth of tumor cells in vitro. Sinalexin works by inhibiting the activity of protein kinases, which are enzymes that play a critical role in cell division and proliferation. In addition to its anticancer properties, Sinalexin has also been shown to induce apoptosis in cancer cells. This drug is excreted primarily in urine and has potential as a novel class of kinase inhibitors for the treatment of various types of cancer.</p>

<p>2-Methoxy-5-sulfamoylbenzamide is a white crystalline solid that is soluble in water. This compound has been shown to be an antiemetic agent, and also possesses antidopaminergic properties. It is used as an antiemetic, but has not been studied extensively for this indication. 2-Methoxy-5-sulfamoylbenzamide has also been shown to be effective in the treatment of Parkinsonism.</p>

<p>4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol hydrochloride is a drug product that is custom synthesized for research and development purposes. It has been shown to be an active metabolite of diazepam with a half life of 3 hours and low toxicity. 4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol hydrochloride is used as an analytical standard in the pharmaceutical industry. This compound has been studied in metabolism studies and pharmacopoeia. It has also been shown to have antiinflammatory properties.</p>

<p>Please enquire for more information about 6β-Hydroxy 21-acetyloxy budesonide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>3,4-Dimethoxyphenyl isopropyl ketone (DMPK) is a calcium antagonist that has been shown to be hypotensive in rats. It is also used as a pharmacological agent to study muscle physiology and biotransformations. DMPK has been shown to have microbial uptake and chronotropic properties, which may explain its use in the treatment of bacterial infections. DMPK binds to sulfoxides and chiral compounds, blocking their activity by inhibiting the enzyme systems involved in oxidation reactions. The drug is an analog of benzyl alcohol, with which it shares similar pharmacological profile.</p>

<p>Defluoropitavastatin calcium salt is a synthetic, high purity, pharmacopoeia drug product. It is a metabolite of pitavastatin and has been shown to have similar pharmacological activity. Defluoropitavastatin calcium salt has a niche in the analytical industry due to its high purity and stability. It has been used as an impurity standard for HPLC analysis. Defluoropitavastatin calcium salt is not found in nature and can be synthesized with the help of our Custom Synthesis service.</p>

<p>Please enquire for more information about (Nitrosoimino)bisacetic acid diethyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Desmethyl dehydro lercanidipine is a metabolite of lercanidipine, an antihypertensive agent. Lercanidipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into cardiac muscle cells and vascular smooth muscle cells. The desmethyl form of lercanidipine has been shown to have anti-inflammatory effects in rats with experimental arthritis. It has also been shown to inhibit the production of inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.</p>

<p>Oxybutynin EP impurity B is a metabolite of oxybutynin and is a natural product. It is used as an analytical reference substance, to develop new drugs, and in pharmacopoeia in order to measure the purity of oxybutynin. The compound is synthesized by chemical synthesis and can be used as a standard for HPLC analysis.</p>

<p>Palbociclib Impurity F is a high purity synthetic intermediate for the production of Palbociclib. It is made by reacting 4-chloro-3-[4-(4-methylpiperidinium)butyl]benzoic acid with 3,5-dichloro-2-hydroxybenzaldehyde in the presence of triethylamine and 2,6-diisopropylaniline. This product has been shown to be metabolized through an oxidation process to form metabolites that are structurally similar to those found in urine. The chemical structure of this impurity can be found in CAS No. 851067-56-6.</p>

<p>1-[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone is a drug product that is used as an HPLC standard. It is a natural metabolite of the drug product 1-[4-(4-Amino-6,7-dimethoxyquinazolinyl)-1piperazinyl]-5hydroxypentane. The synthesis of this compound has been reported in the literature.<br>The impurity content of this compound meets the pharmacopoeia requirements for an analytical reference standard for API impurities.</p>

<p>N,N-Dimethylsulfonyl dofetilide is a research and development impurity with no known drug product. It is synthesized in a high-purity form for use as an analytical standard. N,N-Dimethylsulfonyl dofetilide is not found in any pharmacopoeia. This compound has been used in metabolite studies and HPLC standards.</p>

<p>Please enquire for more information about Mezlocillin impurity III including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3,5-Diiodo-4’-o-methyl thyroacetic acid ethyl ester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-Phenyl-1,2,3,4-tetrahydro-isoquinoline is a synthetic compound which has been used as a lead compound for the development of drugs with dopamine β-hydroxylase inhibitory activity. In vitro studies have shown that 1-phenyl-1,2,3,4-tetrahydro-isoquinoline inhibits human serum dopamine β-hydroxylase and can be used to study the possible role of this enzyme in Parkinson's disease. This drug is racemized in the body and has been found to be effective against Parkinson's disease in rats. It is also an enantiomer that has industrial applications for the production of polyurethane foam insulation coatings.</p>

<p>(S)-(-)-1,1,2-Triphenyl-1,2-ethanediol is a chiral compound that is used in the synthesis of pharmaceuticals. The allylation of (S)-(-)-1,1,2-triphenyl-1,2-ethanediol with benzaldehyde gives (R)-(+)-benzaldehyde diethyl acetal. This reaction is conducted in an acidic solution and uses hydrogen bonding as a driving force for the reaction. It also has been shown to be useful in preparative chemistry because it can be used as a ligand for magnesium ions. The kinetic form of (S)-(-)-1,1,2-triphenyl-1,2-ethanediol is an acid at pH 7.0 and has a melting point of -41 °C. The neutral form of this compound has a melting point of 53 °C and exhibits hydrogen bonding properties. Acetonitrile is the</p>

<p>6-Bromo-1-hydroxypyrene is a natural metabolite of the aromatic hydrocarbon benzo[a]pyrene. It has been used as an analytical standard for HPLC and GC analyses, and as a research and development (R&amp;D) drug product in pharmacopoeia. 6-Bromo-1-hydroxypyrene has been shown to have anti-inflammatory activities in mouse skin. It also inhibits liver microsomal cytochrome P450 enzymes, suggesting that it may be useful in the treatment of disorders such as Alzheimer's disease.</p>

<p>Urea nitrate is an analog of urea that has been shown to have potent anticancer activity. It acts as a kinase inhibitor, specifically targeting the chitin kinase pathway, which is involved in cell growth and apoptosis. Urea nitrate has been tested in Chinese hamster ovary cells and has demonstrated significant tumor inhibition. It has also been shown to be effective against various types of cancer cells, including those resistant to other inhibitors such as heparin. Urea nitrate can be found in urine and is a potential candidate for the development of new cancer therapies. However, caution should be taken when handling urea nitrate as it can form explosive mixtures with potassium and other oxidizing agents.</p>

<p>Phenylacetyl CoA is a precursor in the synthesis of phenylalanine. It is synthesized from acetoacetate and acetyl-CoA by the enzyme phenylacetate synthase, using S-adenosylmethionine as a cofactor. Phenylacetyl CoA is used in vitro to measure the activity of enzymes that are involved in the synthesis of phenylalanine, such as sephadex g-100 and sodium citrate. Phenylacetyl CoA can also be used to measure the activity of enzymes involved in transcriptional regulation, such as wild-type strain.</p>

<p>(±)-Voriconazole is an analog of voriconazole, which is a potent inhibitor of kinases that play a role in cancer cell growth and apoptosis. It has been shown to be effective against tumors in human and Chinese hamster cells. (±)-Voriconazole also inhibits angiotensin-converting enzyme (ACE), which may play a role in its anticancer activity. This drug has been found to have a low potential for toxicity and is well-tolerated by patients. It is excreted primarily through the urine and has been shown to be effective as an inhibitor of multiple kinases involved in cancer progression.</p>

<p>Sacubitril impurity 3 is a custom synthesis that is available in high purity. It has been used as an impurity standard for the drug sacubitril, which is being developed to treat heart failure. Sacubitril is metabolized by cytochrome P450 enzymes and can be detected using HPLC analysis. Sacubitril impurity 3 has been shown to be a metabolite of sacubitril in human liver microsomes and has also been found in rat urine following oral administration.</p>

<p>3' - Destrifluoromethyl 2' - trifluoromethyl cinacalcet is a metabolite of cinacalcet, which is a drug used for the treatment of secondary hyperparathyroidism. It is an impurity in the drug product and can be identified by HPLC.</p>

<p>15-HETE is a protein that has been found to be associated with cancer. It can be detected in urine and has been shown to have inhibitors that promote apoptosis, which is the natural process of programmed cell death. This inhibitor analog has been studied for its potential as an anticancer agent and has shown promise in inhibiting kinase activity, which is essential for tumor growth and replication. 15-HETE has also been used in Chinese medicinal practices for its potential anticancer properties. Further research is needed to fully understand the mechanisms by which 15-HETE works and how it can be used to combat cancer in humans.</p>

<p>Daidzein 4’-β-D-glucuronide is a bioactive metabolite of daidzein, a type of isoflavonoid. Daidzein 4’-β-D-glucuronide has been shown to have estrogenic activity and is thought to be the major contributor to the biological effects of soy. Daidzein 4’-β-D-glucuronide has been found in the blood samples of healthy individuals, as well as people with estrogen deficiency or taking estrogen supplements. This compound is converted into other forms by the action of enzymes such as glucuronidases and sulfatases. It also undergoes oxidation by cytochrome P450 enzymes and conjugation with glucuronic acid. The pharmacokinetics of this compound are not well understood, but it is thought that its bioavailability may be low due to its hydrophilic properties.</p>

<p>JNJ-55308942 is a human Chinese nalbuphine analog that has been found to have anticancer properties. It works by inhibiting kinases, which are enzymes that play a crucial role in cancer cell growth and survival. JNJ-55308942 induces apoptosis, or programmed cell death, in tumor cells, making it a promising candidate for the treatment of various types of cancer. This inhibitor has shown to be effective against gastrin-induced proliferation of cancer cells and can be detected in urine after administration. With its potent anticancer activity, JNJ-55308942 holds great potential as a therapeutic agent for cancer treatment.</p>

<p>3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one is a drug product that can be used as an analytical reference standard. It is a synthetic compound that is not found in nature and has CAS number 1199589-74-6. This compound has been synthesized by custom synthesis and it is an impurity standard for HPLC analysis. 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3 -yl)-1 -piperidinyl]ethyl]-6,7,8,9 -tetrahydro - 2 methyl - 4H - pyrido[1,2 -a]p</p>

<p>Ssr 180711 hydrochloride is a synthetic compound with a molecular weight of 557.5. It has been used as an analytical reference standard in the development of drugs and as a natural product in research and development. Ssr 180711 hydrochloride is metabolized to form its active form, Ssr 180711, which is an antibiotic that kills bacteria by inhibiting protein synthesis and DNA replication. This drug also inhibits the growth of Mycobacterium tuberculosis, Mycobacterium avium complex, and Staphylococcus aureus. The purity of this product is 99.0% pure (HPLC).</p>

<p>Please enquire for more information about Etifoxine-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Bendamustine deschloro dimer impurity is a Chinese medicinal compound that acts as an inhibitor of kinases, which are enzymes that play a crucial role in the regulation of cell growth and division. It has been shown to induce apoptosis, or programmed cell death, in tumor cells and has anticancer properties. Bendamustine deschloro dimer impurity works by inhibiting the activity of protein kinases, which are involved in signaling pathways that control cell proliferation and survival. This compound has been identified as an analog of other kinase inhibitors and can be detected in urine samples from human patients receiving cancer treatment with bendamustine. In preclinical studies, it has demonstrated potent anti-tumor effects against various types of cancer cells.</p>

<p>Ethyl 3,6-dioxocyclohexa-1,4-diene-1-sulfonate is an analog that has shown potential as an anticancer agent. It works by inhibiting kinases that are involved in cancer cell growth and proliferation. Studies have shown that this compound induces apoptosis in human tumor cells, making it a promising candidate for cancer treatment. Ethyl 3,6-dioxocyclohexa-1,4-diene-1-sulfonate has also been found to be a potent inhibitor of protein kinase D (PKD), which plays a key role in cancer cell survival and proliferation. This compound has been compared to the well-known kinase inhibitor saxagliptin and found to be more effective at inhibiting PKD activity. Additionally, Chinese hamster ovary cells treated with Ethyl 3,6-dioxocyclohexa-1,4-diene-1-sulfonate showed reduced levels of urinary ex</p>

<p>3-Ethyl-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one is a research and development impurity standard. It is used as a pharmacopoeia and drug product impurity in the manufacture of pharmaceuticals. 3-Ethyl-2-methyl-6,7,8,9-tetrahydro-4H pyrido[1,2 a]pyrimidin 4 one is used in synthetic organic chemistry for the production of drugs. This compound is also used for metabolism studies such as HPLC standards.</p>

<p>PSI 352707 Ammonium Salt is a drug product that has been custom synthesized and is high purity with CAS No. 1233335-78-8. It has analytical and metagenomic studies, as well as pharmacopoeia and metabolite standards. This drug product is used for drug development and research &amp; development purposes as an impurity standard for HPLC.</p>

<p>SMS2-IN-1 is a nuclear ginseng propionate monoester inhibitor that has shown promising antiviral properties. It has been found to inhibit the activity of galacturonic acid, which is crucial for viral replication. Additionally, SMS2-IN-1 has been studied in molecular docking experiments and has shown potential as an inhibitor of tenofovir disoproxil fumarate, a widely used antiviral drug. This compound also exhibits cytotoxic effects on certain cells and has been explored for its potential in recombination studies. It is important to note that SMS2-IN-1 may contain impurities, including the compound ivermectin.</p>

<p>Nicergoline EP Impurity B is a metabolite of nicergoline, a drug product. It has been synthesized for use as an impurity standard for analytical and pharmacopoeia purposes. Nicergoline EP Impurity B is not found in nature and has been shown to be metabolically stable in vitro. It can be used as a reference substance for the determination of nicergoline concentrations in human plasma samples.</p>

<p>nicotinic acetylcholine receptor antagonist</p>

<p>(S)-4-(2-Methylpropyl)-2-pyrrolidinone is a lactam that has been synthesized in the laboratory. It is an organic solvent that is used in the synthesis of other compounds. The compound has a potential for producing impurities, such as isopropyl and phosphite, during synthesis. (S)-4-(2-Methylpropyl)-2-pyrrolidinone can be synthesized by reacting 2-methylpropionic acid with one equivalent of methylamine. This reaction takes place in an organic solvent and requires kinetic control to avoid side reactions.</p>

<p>Cis-Tadalafil is a potent inhibitor of phosphodiesterase 5, which is used to treat erectile dysfunction (ED) and primary pulmonary hypertension (PPH). It works by increasing blood flow to the penis, allowing men with ED to achieve and maintain an erection. Cis-Tadalafil is also used to treat symptoms of prostatic hyperplasia (enlarged prostate) in men. This drug has been shown to be effective in treating PPH by reducing pulmonary arterial pressure and improving exercise capacity. Cis-Tadalafil belongs to the carboline class of drugs and is a phosphodiesterase 5 inhibitor that selectively inhibits cGMP-specific phosphodiesterase type 5 (PDE5). This drug has been shown to be highly effective in treating both ED and PPH with minimal side effects.</p>

<p>Applications epi-Glycochenodeoxycholic Acid Sodium Salt-d7 is a labelled epimer analogue of Glycochenodeoxycholic Acid Sodium Salt (G641255), which is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.<br>References Ollila, F., et al.: Langmuir, 17, 7107 (2001); Uekama, K., et al.: Chem. Pharm. Bull., 52, 900 (2004); Tongiani, S., et al.: J. Pharm. Sci., 94, 2380 (2005);<br></p>

<p>Applications 3,5-Diiodo-4’-O-methyl Thyroacetic Acid Ethyl Ester is a derivative of 3,5-Diiodo Thyroacetic Acid (D455140), the acetic acid analog of Thyroxine (T425601). It is a reactant in the preparation of bifunctional thyrointegrin inhibitors, thyroxine (T425601) and triiodothyronine (T795380).<br>References Bridoux, A. et al.: J. Enz. Inh. Med. Chem., 26, 871 (2011); Wilkinson, J.: Biochem. J., 63, 601 (1956); Wilkinson, J.: Chem. Ind., 1352 (1955)<br></p>

<p>Please enquire for more information about Apixaban Impurity 6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Rocuronium Bromide EP Impurity F Bromide is an impurity found in Rocuronium Bromide EP. It is a natural component of the drug product, which is a synthetic drug. The metabolite of this impurity is also found in the natural product, although at much lower concentrations. This impurity has been shown to be present as an analytical impurity in the API and custom synthesis process. This impurity standard has been synthesized synthetically for use in drug development and research and development, as well as for use in HPLC standards.</p>

<p>Please enquire for more information about (4-Chlorophenyl)diphenylmethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Atorvastatin is a drug product with an impurity of atorvastatin cyclic sodium salt (isopropyl). The synthesis of this compound can be found in the natural and synthetic routes. Impurity standard is used to identify impurities in drugs and is necessary for pharmacopoeia, research and development, and analytical work. This compound has been shown to have high purity, analytical, metabolism studies, natural, drug development, and pharmacopoeia. CAS No. 1316291-19-6 is the impurity standard for this compound.</p>

<p>Amiodarone impurity E is a nucleophilic compound that is synthesized by the acylation of a diazonium salt with an amine. It has been shown to be active against staphylococci, but not against subtilis. The reaction may be catalyzed by acid or chloride. Amiodarone impurity E is also demethylated and dehydrated to form the final product, amiodarone.</p>

<p>(3R,4S)-Tofacitinib is a synthetic compound that is being researched for the treatment of rheumatoid arthritis. It is a potent inhibitor of Janus Kinase 3 (JAK3) and Janus Kinase 1 (JAK1), which are important enzymes in cytokine signaling pathways that play a role in inflammation. (3R,4S)-Tofacitinib is metabolized to an impurity standard for the drug product. The metabolite has not been characterized and its concentration cannot be determined from analytical data.</p>

<p>Cinacalcet Impurity B HCl is an analytical standard that can be used in HPLC as a reference compound. It is also a metabolite of Cinacalcet and has been shown to have affinity for calcium channels. This impurity is found in Cinacalcet at a concentration of less than 1%.</p>

<p>2-(2-Amino-5-bromobenzoyl)pyridine (2ABBP) is a chemical compound with the molecular formula C10H7BrN3. It is a glucuronide conjugate of 2-amino-5-bromobenzoic acid and has been used as an immunological reagent in the form of a monoclonal antibody. 2ABBP binds to dryopteris, which is a plant species that contains polyphenols called pteridines. 2ABBP has been shown to have anti-inflammatory properties in rat liver microsomes and cell culture experiments. The mechanism of action may involve inhibition of cyclooxygenase enzymes, which are involved in prostaglandin synthesis. 2ABBP also binds to human serum albumin and chaperones, proteins that bind other proteins or small molecules. The biological activity of 2ABBP may be due to its ability to form coval</p>

<p>2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine is a cytosine analog that is used as an industrial chemical. It is prepared by the reaction of 5'-deoxycytidine with acetic anhydride in the presence of sodium bicarbonate, followed by a purification procedure. 2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine reacts with toluene and trifluoromethanesulfonic acid to form 2',3'-di-O-acetyl 5'-deoxyfluorocytidine. This compound can be converted to 5'-deoxyfluorocytosine by heating in the presence of sodium tetrachloride. The yield for this process is high.</p>

<p>Vildagliptin Related Compound 2 is a synthetic compound that has been shown to be an inhibitor of DPP-4. It is a white solid that can be synthesized by condensation of vildagliptin with chloroacetyl chloride in the presence of an alkali. The compound was found to have impurities, including 1-(2-chlorophenyl)ethanol and 3-chlorobenzaldehyde.</p>

<p>Sacubitril Impurity 2 is a drug product that is an analytical impurity in Sacubitril. This impurity can be found in Sacubitril as a result of natural processes or as an API impurity during the synthesis process. Sacubitril Impurity 2 has been shown to have activity in Metabolism studies, Natural, and Custom synthesis. It has been shown to be a Synthetic impurity standard and HPLC standard. Sacubitril Impurity 2 is used for research and development purposes for the drug development industry, specifically for the niche market. It is also used as an analytical standard for pharmacopoeia methods.</p>

<p>Dicyclopropylamine hydrochloride is a tyrosine kinase inhibitor that blocks the activity of jak2. It is an innovative molecule with the potential to be used in cancer treatment. Dicyclopropylamine hydrochloride has been shown to inhibit activation of tyrosine kinases, which are involved in cell signaling and proliferation. Dicyclopropylamine hydrochloride also has anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis. This drug is not expected to have any toxicity or side effects because it can be easily metabolized by the liver.br&gt;br&gt; Dicyclopropylamine hydrochloride is a white solid with a melting point of 175°C. It has no detectable odor, and it is soluble in water and ethanol. The impurities found in this compound include myristic acid and amines, which can cause inflammatory diseases.br&gt;br&gt; D</p>

<p>Please enquire for more information about P,P′-[1-Hydroxy-3-(pentylamino)propylidene]bis[phosphonic acid] including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Terbinafine is a drug used in the treatment of onychomycosis, tinea versicolor and dandruff. It belongs to the group of medicines known as antifungals and inhibits the growth of fungi by inhibiting their ability to make proteins. Terbinafine dihydrochloride is a form of terbinafine that is more soluble in water than terbinafine hydrochloride and can be used as a lubricant. Terbinafine hydrochloride is an industrial product that is used as a disintegrant in tablets and capsules.</p>

<p>The objective of this project is to design a microcontroller-based system that can monitor and diagnose the level of damage in a composite material. The system will consist of an array of sensors, actuators, and microcontrollers that are connected by a wireless network. The sensors will measure the levels of damage at each point within the composite material. The actuators will provide feedback to the sensors, adjusting their frequency and amplitude based on the level of damage detected. Microcontrollers will be responsible for analyzing data from the sensors and diagnosing any faults in the system. A miniaturized dry skin patch could be used as an alternative to traditional wet skin tests for monitoring skin health.</p>

<p>Atorvastatin lactam phenanthrene calcium salt impurity is a high purity, custom synthesis drug product. It is a metabolite of atorvastatin and was identified using metabolism studies in rat and human liver microsomes. This impurity has been shown to be an analytical standard for HPLC. Atorvastatin lactam phenanthrene calcium salt impurity is used in niche research and development, as well as the development of drugs that are pharmacopoeia grade.</p>

<p>Ezetimibe ketone is a lipid-lowering agent that inhibits cholesterol absorption through the inhibition of Niemann-Pick C1-like 1 (NPC1L1). Ezetimibe ketone is used to reduce the levels of low-density lipoprotein cholesterol (LDL-C) in patients with primary hypercholesterolemia, sitosterolemia, and familial combined hyperlipidemia. Ezetimibe ketone has been shown to be bioequivalent to ezetimibe, which is an oral drug that inhibits cholesterol absorption by blocking NPC1L1. The drug binds to the NPC1L1 receptor in the brush border membrane of enterocytes and prevents cholesterol uptake. Ezetimibe ketone has a high solubility in organic solvents such as dichloromethane or chloroform. It also has a high melting point, which makes it suitable for use on chromatographic columns.</p>