Composés et métabolites pharmaceutiques et vétérinaires

<p>11-epi-Chaetomugilin I, from Chaetomium globosum, has cytotoxic effects against P388, HL-60, L1210 leukemia, and KB carcinoma cells.</p>

<p>Fumiquinazoline D, from A. fumigatus, inhibits Gram-positive/negative bacteria (MIC 8-16 μg/ml) and F. solani, C. albicans (MIC 32, 64 μg/ml).</p>

<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>

<p>Tajixanthone is the fungus metabolite from Aspergillus variecolor [1] .</p>

<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>

<p>Leucine dehydrogenase from Bacillus spheroides oxidizes/reduces branched-chain amino acids and their keto analogs.</p>

<p>γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite with a structure resembling GABA (γ-aminobutyric acid).</p>

<p>Butyrolactone II is a useful organic compound for research related to life sciences. The catalog number is T124034 and the CAS number is 87414-44-6.</p>

<p>Pristanic acid, found in blood, aids in studying Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome.</p>

<p>Adenylosuccinic acid, orally active, is a purine ribonucleotide involved in nucleotide metabolism, may aid in DMD studies.</p>

<p>Mesembrenone is a selective the serotonin transporter (SERT) inhibitor. Mesembrenone is the main alkaloid of Sceletium tortuosum.</p>

<p>Hepaxanthin is a carotenoid.</p>

<p>L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults.</p>

<p>5-(3'-Hydroxyphenyl)-γ-valerolactone, a metabolite resulting from the transformation of polyphenols such as (+)-catechin and (−)-epicatechin by gut microbiota,</p>

<p>N-acetyl Leukotriene E4 is an endogenous metabolite of Leukotriene E4, less active than Leukotriene E4, causing constriction of the airways.</p>

<p>γ-Glu-Phe (γ-Glutamylphenylalanine) is a γ-3 glutamyl dipeptide found in sourdough.it is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae</p>

<p>Endogenous metabolite in urine, 1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, linked to obesity research.</p>

<p>Myristoyl coenzyme A lithium, a compound marked by lithium in its myristoylated form, plays a crucial role in the biochemical mechanism of myristoylation, essential for both viral functionalities and tumor growth in colon epithelial cells. This process is predominantly governed by N-myristoyltransferase (NMT), which exhibits increased activity in colon epithelial tumors compared to normal cells. The activity of NMT is significantly influenced by the reduction of coenzyme A (CoA), a vital regulator that enhances NMT's ability to induce myristoylation, unlike its oxidized form which impedes this process. Consequently, Myristoyl coenzyme A serves as an inhibitor to the demyristoylation activity, showcasing its potential as an anticancer and antiviral agent.</p>

<p>1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol is an intrinsic metabolite and a component of the cell membrane [1].</p>

<p>NahK phosphorylates GlcNAc/GalNAc at C1 using ATP to form GlcNAc-1P/GalNAc-1P.</p>