Composés et métabolites pharmaceutiques et vétérinaires

22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcohol metabolite that exhibits both anti-progestational and anti-glucocorticoid activities. This compound contains an alkyne group and is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Furthermore, 22-Hydroxy Mifepristone demonstrates a relative binding affinity of 48% to the human glucocorticoid receptor.

Zaragozic acid C is an effective inhibitor of squalene synthase.

Tauro-ω-muricholic acid sodium (TωMCA sodium) is an analogue of tauro-α-muricholic acid, a bile acid of hepatic origin.

9(Z),12(E)-Octadecadienoic Acid (C18:2(9E,12Z); C18:2 n-6), an isomer of linoleic acid, is a type of ω-6 polyunsaturated fatty acid containing a trans double bond at the C9 position. It is identified as a minor component in milk fat and partially hydrogenated vegetable oils. The concentration of 9(Z),12(E)-Octadecadienoic Acid in rabbit meat increases following supplementation with heated sunflower seed oil, α-tocopherol acetate, and zinc.

GNTI TFA is a selective kappa opioid receptor antagonist.

Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.

<p>Toladryl is a derivative of Diphenhydramine that can cross the blood-brain barrier and exhibits oral activity, with antihistamine and anticholinergic properties. Its anticholinergic effects are approximately a tenth of those seen with Diphenhydramine, yet it offers 2-4 times the protection against lethal doses of histamine in guinea pigs. The side effects of Toladryl are fewer and milder compared to Diphenhydramine; however, at higher doses, it may cause symptoms such as insomnia, agitation, and disorientation related to the central nervous system. Toladryl is utilized in the research of allergic diseases.</p>

Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.

RS 61756-007 is a selective thromboxane receptor (TP) agonist.

CS-003 HCl is a TNRA - triple neurokinin receptor antagonist.

δ-CEHC, a δ-tocopherol metabolite, exhibits antioxidant activity [1].

Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.

13,14-EDT is an oxylipin and a metabolite of adrenic acid, produced via the cytochrome P450 (CYP) pathway.

<p>7-Hydroxychlorpromazine, an active metabolite of Chlorpromazine, can reversibly counteract the suppression of regionally dense dopaminergic neurons induced by Amphetamine.</p>

Methyl dotriacontanoate (C32:0 FAME; Lacceric acid methyl ester) is a naturally occurring fatty acid methyl ester found in the cuticular wax of P. abies needles. It is also present in sediment samples from the Suwannee River in Florida and Lake Kivu in the East African Rift.

NADH-IN-2 (compound 8) is a Type II NADH dehydrogenase inhibitor.

<p>Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.</p>

8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.

<p>Homodestcardin: cyclic depsipeptide from T. roseum with immunosuppressant properties; inhibits mouse T cell proliferation.</p>

<p>Urobilin hydrochloride, a metabolic byproduct of Hemoglobin, is excreted through urine and feces in various mammals. It also serves as an indicator of human waste contamination.</p>

1-Phenylethanamine, a potential central nervous system stimulant related to β-phenylethylamine (β-phenylethylamine), exhibits diminished glycogenolysis activity in the brain due to its benzene ring being replaced by an indole group. This reduction in activity makes it useful for investigating how the chemical structure of phenylethylamine derivatives influences their effects on the central nervous system. Additionally, 1-Phenylethanamine is also utilized in the synthesis of the tyrosine kinase (tyrosine kinase) inhibitor CLM3.

D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.

JX237 is an SLC6A19 inhibitor, a transporter protein that neutralizes amino acid uptake by the liver, and can be used in the study of cardiovascular disease.

8-Dehydrocholesterol is a compound whose elevated concentration is a diagnostic biochemical hallmark of classical Smith-Lemli-Opitz syndrome.

<p>3-Hydroxy-4-aminopyridine is a natural product for research related to life sciences. The catalog number is T66009 and the CAS number is 52334-53-9.</p>

Dichloroiodomethane is a natural compound found in human beings[1].

L-Cysteine S-sulfate sodium salt sesquihydrate is a useful organic compound for research related to life sciences. The catalog number is T64782 and the CAS number is 150465-29-5.

N1,N8-Diacetylspermidine hydrochloride is a polyamine found in human urine.

1-Arachidoyl-sn-glycero-3-phosphocholine is a lysophospholipid (LyP).

<p>3-Deoxy-galactosone, a 1,2-dicarbonyl compound, originates from the degradation of galactose. It forms in food during Maillard and caramelization reactions.</p>

<p>1-(2,3-Dichlorphenyl)-piperazine (DCPP) is a potent DHCR7 inhibitor. DHCR7 is the last enzyme in cholesterol biosynthesis.</p>

<p>O-Allylvanillin, an O-allylchalcone derivative, exhibits anti-cancer properties by inhibiting the growth of THP-1, HL60, Hep-G2, and MCF-7 cells with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively [1].</p>

<p>2-(Methoxycarbonyl)benzoic acid is a natural product for research related to life sciences. The catalog number is T67426 and the CAS number is 4376-18-5.</p>

GDP-D-mannose disodium is a natural product for research related to life sciences and the catalog number is T65209.

<p>L-Glyceric acid sodium, a urinary metabolite, is predominantly found in individuals with the rare inherited metabolic disorder L-glyceric aciduria. This compound is a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and distinguishing it from primary hyperoxaluria type 1 (PH1) based on its excretion pattern.</p>

2-Methylcitric acid trisodium (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle, which accumulates in methylmalonic and propionic acidemias.

<p>Neuraminic acid: acidic amino sugar, 9 carbon chain, from pyruvic acid + D-mannosamine, in active mucoproteins.</p>

(±)-α-Tocopherol nicotinate is a useful organic compound for research related to life sciences. The catalog number is T64563 and the CAS number is 51898-34-1.

4-Nitrophenyl N-acetyl-β-D-galactosaminide is a useful organic compound for research related to life sciences. The catalog number is T67691 and the CAS number is 14948-96-0.

(S)-3-Hydroxyisobutyric acid is an important interorgan metabolite.

<p>Beta-Cortol is a metabolite of androgen present in adults.</p>

MRS2802 is a P2Y14 receptor agonist, its EC50 value for P2Y14 receptor is 63 nM.

3,5-Dibromotyrosine is a useful organic compound for research related to life sciences. The catalog number is T65914 and the CAS number is 300-38-9.

Vitamin D3 octanoate, an ester derived from vitamin D3, is commonly known as cholecalciferol. Cholecalciferol is a naturally occurring form of vitamin D with notable properties such as inducing cell differentiation and impeding cancer cell proliferation.

Creatinine-D3 is a deuterium-labeled Creatinine which is a break-down product of creatine phosphate in muscle.

Lichenase, an enzyme, breaks down β-glucans in grains into GOS, aiding polysaccharide degradation in cell walls.

<p>4-Hydroxybenzyl cyanide (4-Hydroxyphenylacetonitrile) shows strong antioxidative activity.</p>