Acides aminés (AA)

Applications Labelled Tiopronin. It is used as antidote against heavy metal poisoning; hepatoprotectant; mucolytic.
References Capasso, F., et al.: Agents Actions, 11, 741 (1981), Amor, B., et al.: Arthritis Rheum., 25, 698 (1982), Ichida, F., et al.: J. Int. Med. Res., 10, 325 (1982),

Applications N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.
References Kwon, Y.E. et al.: Bioorg. Med. Chem., 15, 6596 (2007); Knutsen, L.J.S. et al.: J. Med. Chem., 42, 3463 (1999);

Applications D-Glutamic acid 1-tert-butyl ester is a protected form of D-Glutamic acid (G596965). D-Glutamic acid is an unnatural isomer of L-Glutamic acid (G596960), and is found in bacterial cell wall peptidoglycan of gram-positive and gram-negative bacteria. D-Glutamic acid also occurs as poly-gamma-Glutamic acid, which is a weak immunogen but is capable of acting as a hapten (a small molecule that induces the production of antibodies, as well as binding to them).
References Dougherty, T., et al.: J. Bacteriol., 175, 111 (1993); Goodman, J. & Nitecki, D.: Immunology, 13, 577 (1967); Robinson, T.: Life Sci., 19, 1097 (1976)

Applications Perfluoro-3-methoxypropanoic acid (cas# 377-73-1) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Chloro-2-methoxyphenol is used as a reagent in the synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists which may be used in development of treatment against autoimmue diseases and viral infections. Also used in the synthesis of novel inhibtors of P. falciparum enoyl-ACP-reductase which may be used in treatment of malaria.
References Guerrero, M., et al.: Bioorg. Med. Chem. Lett., 22, 537 (2012); Belluti, F., et al.: J. Med. Chem., 56, 7516 (2013);

Stability Hygroscopic
Applications 2-(N-Methyl-2-pyrrolidinyl)ethyl Chloride is an intermediate used in the synthesis of reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxcity.
References Zhu, S.J., et al.: Bioorg. Med. Chem., 14, 3131 (2006); Tanaka, N., et al.: Chem. Pharma. Bull., 48, 245 (2000);

Applications VINYLTRIS(2-METHOXYETHOXY)SILANE (cas# 1067-53-4) is a useful research chemical.

Applications Myristoyl-L-carnitine Hydrochloride is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.
References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)

Applications 2-Deoxy-2-chloro-D-glucose is a D-Glucose (G595000) derivative used in the synthesis of sugar nucleotides and oligosaccharides.
References Herr, D., et al.: Euro. J. App. Microbiol., 1, 41 (1975);

Stability Hygroscopic
Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyl-7-carboxy-heptyl Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).
References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)

Applications A labelled version of Nateglinide, an amino-acid derivative that stimulates insulin secretion which is used as an antidiabetic.
References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),

Applications Isotope labelled Intermediate for transsulfuration whereby a mammal transfers the sulfur of methionine via homocysteine to cysteine.
References Thompson, J.W., et al.: J. Biol. Chem., 266, 17011 (1991), Yoshida, Y., et al.: Microbiol., 148, 3961 (2002), Jiracek, J., et al.: J. Med. Chem., 49, 3982 (2006),

Applications 1-Boc-4-(6-aminopyridin-3-yl)piperazine is used to prepare pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of cyclin-dependent kinases 4 and 6.
References Toogood, P., et al.: J. Med. Chem., 48, 2388 (2005); Cho, Y., et al.: J. Med. Chem., 53, 7938 (2010)

Applications 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several “inborn errors of metabolism” (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),

Applications 4-METHYL-2-PHENYL-2-PENTENAL (cas# 26643-91-4) is a useful research chemical.

Applications DL-Proline-2,5,5-d3 (CAS# 784086-28-8) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications 2S,2’S,5S)-5-Hydroxy Lysinonorleucine is one of the stereoisomers of 5-Hydroxylysinonorleucine, reduced collagen cross links.
References Astbury, C., et al.: Br. J. Rheumatol., 33, 11 (1994), Watts, N., et al.: Clin. Chem., 45, 1359 (1999), Banse, X., et al.: Bone, 31, 70 (2002),

M02961 - H-Phe-OH

Applications Important compounds in coffee aroma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications L-Threonic acid calcium salt is the salt of L-Threonic acid, a naturally occurring compound that can be found in the leaves of Pelargonium crispum. L-Threonic acid is also the degradation product of Dehydroascorbate (DHA), a metabolite of Vitamin C (A786990).
References Helsper, J. & Loewus, F.: Plant Phys., 69, 1365 (1982); Koch, C. & Biaglow, J.: J. Cell. Phys., 94, 299 (1978); Nielsen J., et al.: J. Agr. Food Chem., 49, 2998 (2001)

Applications Felypressin(Octapressin) is a vasopressin 1 agonist and a peptide containing eight amino acids including cystine. Felypressin is used as a vasoconstrictor.
References Boissonnas, G., et al.: Helv. Chim. Acta, 43, 190 (1960), Farkas, D., et al.: Curr. Drug Metab., 6, 111 (2005), Elferink, M., et al.: Toxicol. Appl. Pharmacol., 229, 300 (2008),

Applications 8-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione is an intermediate used to prepare selective inhibitors of dipeptidyl peptidase 4 (DPP4) for potential use in the treatment of type 2 diabetes.
References Sutton, J., et al.: Bioorg. Med. Chem. Lett., 22, 1464 (2012); Lai, Z., et al.: Eur. J. Med. Chem., 83, 547 (2014)

Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.
References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)

Stability Volatile
Applications 2-Chloro-2-Methylpentane (cas# 4325-48-8) is a useful research chemical.

Applications 3,5-Dichloro-4-methylaniline

Applications The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
References Berna, M., et al.: Anal. Chem., 79, 4199 (2007), Pritt, M., et al.: Toxicol. Sci., 103, 382 (2008), Tonomura, Y., et al.: Toxicology, 266, 48 (2009),

Applications Zinc Glycinate is used in the preparation of hydroxy acid complexes used in skin antiaging, acne and skin whitening formulations.

Applications 6-Methylquinoline, is a building block used for the synthesis of various pharmaceutical compounds, and biologically active compounds. It can be used for the preparation of pyranobenzopyrone compounds, having anti-norovirus activity.
References Pokhrel, L., et al.: bioorg. Med. Chem. Lett., 22, 3480 (2012);

Applications 4-Chloro-3-methylaniline (cas# 7149-75-9) is a compound useful in organic synthesis.

Applications 3-Methyl-1,3,5-pentanetriol is used in the synthesis of Mevalonolactone (M339040), in the synthesis of vitamins and isoprenoids such as steroids.
References Yamashita, H. et al.: Frag. J., 28, 62 (2000); Huang, F. et al.: J. Am. Chem. Soc., 97, 4144 (1975);

Applications N-Carbamyl-L-glutamic Acid has been shown to have protective effects against ammonia intoxication and is used in the treatment of acute hyperammonemia.
References Paik, W.K. et al.: Life Sci., 15, 1189 (1974); O'Connor, J.E. et al.: Eur. J. Pediat., 148, 540 (1989); Lee, J.H. et al.: Biochem. Biophys. Res. Chem., 248, 391 (1998);

Applications p-Methoxytoluene is a building block that has been used as a reactant for the preparation of electrophilic fluorinating agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Baudoux, J., Cahard, D.: Org. Reactions, 69, 347 (2007)

Applications 1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Also used as a reagent in the synthesis of Metolachlor (M338700); a selective pre-emergence herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Titchenell, P.M., et al.: Bioorg. Med. Chem. Lett., 23, 3034 (2013); Zhang, H.: Nongyao Kexue Yu Guanli, 32, 26 (2011)

Applications Epsilon-n-methyl-l-lysine Hydrochloride

Applications 5-Bromo-4-methyl-1,3-thiazol-2-amine is used in the synthesis of poly(4-(p-alkoxystyryl)thiazole)s for solar cells.
References Jaeger, Jakob. et al., MACROMOL. CHEM. PHYS.219,(2018)

Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.

Stability Hygroscopic
Applications Labelled N-Acetyl-S-(carbamoylethyl)-L-cysteine (A171870). N-Acetyl-S-(carbamoylethyl)-L-cysteine is the urinary metabolite of Acrylamide (AA). Acrylamide is formed during the heating of food and is classified as a genotoxic carcinogen.
References Besaratinia, A., et al.: Mutat. Res., 80, 31 (2005), Bjellaas, T., et al.: Xenobiotica, 35, 1003 (2005), Bjellaas, T., et al.: Food Chem. Toxicol., 45, 1020 (2007), Bjellaas, T., et al.: Toxicol. Sci., 98, 110 (2007),

Stability Unstable in Aqueous Solution
Applications 2-METHYL-1,4-BUTANEDIOL (cas# 2938-98-9) is a useful research chemical.

Stability Light Sensitive
Applications 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. It was also used to synthesize diarylpyrazoles as possible cyclooxygenase 2 ((COX-2)) inhibitors.
References Iwakawa, T., et al.: Chem. Pharm. Bull., 48, 160 (2000); Penning, T., et al.: J. Med. Chem., 40, 1347 (1997)

Applications 5-Benzyloxy-6-methoxyindole (cas# 4790-04-9) is a compound useful in organic synthesis.
References McBride, C., et al.: Bioorg. Med. Chem. Lett., 16, 3789 (2006), Frost, J., et al.: J. Med. Chem., 51, 1904 (2008),

Applications A labelled derivative of Dibarbituric acid.
References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),

Applications A precursor to 3-Methyl-2-butenyl-1-thiol which is very unstable. We will provide a detailed procedure for the preparation of the thiol from the thiolacetate with spectral data upon request.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Labelled 1-Methyl-2-pyrrolidinone (M326120). It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.
References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),

Applications Used in the synthesis of DMPO-type spin traps.
References Konaka, R., et al.: Free Radical Res., 23, 15 (1995),

Stability Hygroscopic
Applications 3-Indolepropionic-d2 acid is deuterium labelled 3-Indolepropionic acid (I627170). 3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.
References Hwang, I., et al.: J. Neurosci. Res., 87, 2126 (2009); Karbownik, M., et al.: J. Cell. Biochem., 95, 131 (2005)

Applications Piperazine derivative used as reference material for forensic laboratories.
References Brady, J., et al.: Drug Dev. Res., 20, 231 (1990), Winter, J., et al.: J. Pharmacol. Exp. Ther., 262, 682 (1992), Ator, N., et al.: Eur. J. Pharmacol., 241, 237 (1993), Forster, E., et al.: Eur. J. Pharmacol., 281, 81 (1995),

Applications H-ALA-ALA-ALA-ALA-ALA-OH (cas# 10183-34-3) is a useful research chemical.

Applications 3-Fluoro-4-methoxycarbonylphenylboronic acid, pinacol ester is a useful intermediate for organic synthesis and other chemical transformations.
References Zhao, F., et al.: Eur. J. Med. Chem., 134, 147 (2017); Zhao, F., et al.: Bioorg. Med. Chem., 24, 4281 (2016)

Applications L-Cystine Bis(T-butyl Ester) Dihydrochloride is used as a reagent in the synthesis of chelate oxorhenium to create new integrin antagonists.
References Le Gal, J., et al.: J. Inorg. Biochem., 105, 880 (2011);

Applications N-(1H-pyrrol-2-ylcarbonyl)-Glycine has been used as a diagnostic marker of hyperprolinemia type II.
References Walker, V., et al.: Clinica Chimica Acta, 405, 153 (2009).

Applications Intermediate in the preparation of Epinephrine metabolites
References Mizuta, H., et al.: Bioorg. Med. Chem., 10, 675 (2002),

Applications Methyl 4-Methyl-3-hydroxybenzoate is used in the preparation of potent antimalarial agents. Also used in the preparation of aromatic inhibtors of anthranilate synthase.
References Fattorusso, C. et al.: J. Med. Chem., 51, 1333 (2008); Payne, R. et al.: Org. biomol. Chem., 3, 3629 (2005);

Applications Intermediate for the preparation of Glimepiride.

Applications 2-Methylpropylamine is used in the synthesis of arylsulfonamide inhibitors that act upon afflictions of osteoarthritis. In addition, it is used in the synthesis of novel reservatrol amide derivatives that act as anti-tumor agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yao, Ri-Sheng. et al.: Eur. J. Med. Chem. Lett., 62, 222 (2013); Nuti, E. et al.: Eur. j. Med. Chem., 62, 379 (2013)

Applications An endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. It is a neurotransmitter in the central nervous system and also implicated in a variety of physiological processes such as regulating water balance by antidiuretic action. It is a peptidic V1a receptor agonist that produces vasoconstriction via V1aR-mediated vascular smooth muscle cell contraction and is being used to increase blood pressure in septic shock, a form of vasodilatory hypotension.
References Perucca, J. et al.: J. AM. Soc. Nephrol., 19, 1721 (2008); Toba, K. et al.: Prog. Brain Res., 119, 337 (1998); Berrada, K. et al.: J. Biol. Chem., 275, 27229 (2000);

Applications 4'-Methylacetanilide (cas# 103-89-9) is a compound useful in organic synthesis.

Applications 4,4'-Methylene-d2-dianiline (CAS# 215590-72-0) is a useful isotopically labeled research compound.

Applications 4-Methylfluorene is a polycyclic aromatic hydrocarbon that has been found to be emitted by wastewater treatment facilities.
References Zhang, W., et. al.: Sci. Total Environ., 432m 396 (2012)

Applications L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound.
References Olivella, M. et al.: Bioorg. Med. Chem., 20, 6109 (2012);

Applications A labelled trans-4-Hydroxy-L-proline. A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);

Applications This compound contains up to 25% of the two other regioisiomers.

Applications 3,3’-Methylimino-di-propionitrile (cas# 1555-58-4) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications (2E)-3-Methyl-1,3-benzothiazol-2(3H)-one Hydrazone Hydrochloride is used in method for synthesizing Methylbenzothiazolinone Hydrazone Hydrochloride Hydrate.
References Chen, W., et al.: Faming Zhuanli Shenqing, (2020);

Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),

Applications (3R)-Tetrahydrofuran-3-yl 4-Methylbenzenesulfonate is derived from (R)-(-)-3-Hydroxytetrahydrofuran (H957760), which is a versatile chemical reactant used in the synthesis of pharmaceutical agents.
References Hrapchak, M., et al.: J. Labelled. Comp. Radiopharm., 57, 687 (2014);

Applications 3-Methyl-3-buten-1-ol is used in the synthesis of antiproliferative, antiandrogenic and cytotoxic caffeic acid derivatives.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sanderson, J. T. et al.: Bioorg. Med. Chem., 21, 7182 (2013);

Applications L-Aspartic Acid is a non-essential amino acid found in food sources. L-Aspartic Acid is one of the 20 proteinogenic amino acids; the building blocks of proteins. Its conjugate base L-aspartate is an excitatory neurotransmitter in the central nervous system.
References Ager, D.J. et al.: J. Mol. Catal. Enzym., 11, 199 (2001); Velisek, J. et al.: Cze. J. Food. Sci., 24, 1 (2006); Nagahama, M. et al.: Cell Tiss. Res., 318, 483 (2004);

Impurity Imatinib EP Impurity G
Applications 1-Methylpiperazine (Imatinib EP Impurity G) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug. It is a COVID19-related research product.
References Mallevais, M.L. et al.: Biochimie, 66, 477 (1984);