Acides aminés (AA)

Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),

Applications (3R)-Tetrahydrofuran-3-yl 4-Methylbenzenesulfonate is derived from (R)-(-)-3-Hydroxytetrahydrofuran (H957760), which is a versatile chemical reactant used in the synthesis of pharmaceutical agents.
References Hrapchak, M., et al.: J. Labelled. Comp. Radiopharm., 57, 687 (2014);

Applications Labelled analogue of L-Phenylalanine, an essential amino acid.
References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);

Applications Cucumopine is used in biological studies to evaluate Agrobacterium rhizogenes cucumopine strain T-DNA ORF8 and its effects on transgenic tobacco root cultures.
References Bonfill, M., et al.: Curr. Top. Plant Biol., 3, 223 (2002);

Applications N-Acetyl-L-cystine is an antioxidant, used in the treatment of influenza A virus pandemic (1). N-Acetyl-L-cystine promotes fertilization by reducing disulfide bonds in zona pellucida of mouse (2).Releases N-Acetyl-L-cysteine, which is an antidote for paracetamol poisoning.
References (1) Zhang, R., et al.: (2014) Int. Immunopharmacol. 22: 1-8 (2) Takeo, T., et al.: Biol Reprod. (2015) 92: 1-7

Applications 1-(2-Chloroethoxy)-2-methoxy benzene, is an impurity of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure.
References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990); Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996);

Applications A labelled product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.
References Wejksza, K., et al.: Pharmacol. Rep., 61, 751 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Di Natale, B., et al.: Toxicol. Sci., 115, 89 (2010),

Applications L-Tyrosine-13C9 ,15N is labelled analogue of L-Tyrosine (T899975), one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)

Applications Isotope labelled 2-Chloro-2-methylpropane is a starting molecule to carry out nucleophilic substitution reactions.
References Eyet, N., et al.: J. Phy. Chem. A., 117, 1136 (2013); Eyet, N., et al.: J. Am. Mass. Spec., 18, 1046 (2007);

Applications 6-Methylmercaptopurine Riboside (cas# 342-69-8) is a compound useful in organic synthesis.

Stability Hygroscopic
Applications Used in peptide N-terminal amino acid determination.
References Prota, G., et al.: Biochimie, 53, 51 (1971),

Applications A metabolite of S-propylcysteine.
References Jones, A.R., et al.: Xenobiotica, 10, 827 (1980), 25) Ramu, K., et al.: Chem. Res. Toxicol., 8, 515 (1995), Krause, R., et al.: Drug Metab. Dispos., 25, 1013 (1997), Powley, M., et al.: Chem. Res. Toxicol., 16, 1448 (2003),

Stability Hygroscopic
Applications Trigonelline-d3 HCl is deuterium labelled Trigonelline HCl. Trigonelline HCl has utility in developing site-specific system that delivers drugs to the brain. It has also been suggested as a potential anti-Alzheimer disease agent.
References Bodor, N., et al.: J. Med. Chem 26, 313 (1983); Makowska, J., et al.: J. Chromatogr. B 968, 101 (2014)

Applications This item is a cis trans mixture.

Applications 2-Methoxy-3-methylaniline is an important building block.

Applications This compound contains up to 25% of the two other regioisiomers.

Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.

Stability Moisture Sensitive
Applications A biologically active, cell permeable, but nonphysiologic ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A and activates MAP Kinase2.
References Inoue, T., et al.: J. Biol. Chem., 284, 9566 (2009), Kang, J., et al.: Bioorg. Med. Chem., 17, 1498 (2009), Rath, G., et al.: Int. J. Biochem. Cell Biol., 41, 1165 (2009),

Stability Hygroscopic
Applications D-Histidine, Hydrochloride Monohydrate was a useful reagent for the preparation of diastereomeric histidine-containing dipeptides to analyze lipophilicity and ionization constants.
References Vistoli, G., et al.: Chirality, 24, 566 (2012)

Stability Light Sensitive
Applications 6-Methoxy-2-naphthol is a reactant in the development of sirtuin inhibitors from pyrazolone and isoxazol-5-one cambinol analogs.
References Mahajan, S.S., et. al.: J. Med. Chem., 57, 3283 (2014)

Applications It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.
References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),

Stability Hygroscopic
Applications L-3-(4-Hydroxy-3-methoxy-d3-phenyl)alanine (CAS# 586954-09-8) is a useful isotopically labeled research compound.

Applications (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent.
References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);

Applications 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid is used in the synthesis of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase. Also used in the synthesis of 4-carboxamide derivatives acting as antifungal agents.
References Cheng, G. et al.: Bioorg. Med. Chem. Lett., 23, 2035 (2013); Wu, Z. et al.: Molecules, 17, 14205 (2012);

Applications 7-Methoxy-1-naphthaleneacetamide, can be used for the synthesis of the analogs of Melatonin (M215000), containing naphthalene moiety instead of indole nucleus, having high affinity for the melatonin receptor. Agomelatine Impurity 6
References Tang, J. D., et al.: Org. Prep. Proc. Int., 41, 164 (2009); Sndrieux Y. J., et al.: J. Med. Chem., 35, 1484 (1992);

Applications 4-Hydroxy-4-methylhepta-1,6-diene is a compound useful in organic synthesis.
References Ji, X., et al.: Xiangliao Xiangjing Huazhuangpin, 4, 6 (2011)

Applications 3-[(4-Methylphenyl)amino]phenol, is the reagent that can be used in the preparation of Phentolamine Hydrochloride (P302550), an adrenergic blocking agent, and an antihypertensive
References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949), Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970), Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976)

Applications 6-Methylpurine (cas# 2004-03-7) is a compound useful in organic synthesis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.

Applications 3-Acetyl-2-methylquinoxaline is an intermediate in the synthesis of Desoxyquinocetone which is a metabolite of the veterinay drug Quinocetone.
References Li, Y. et al.: J. AOAC Int., 91, 1494 (2008); Liu, Z.-Y. et al.: Anal. Bioanal. Chem., 396, 1259 (1271);

Applications DL-glutamine

Applications Norvaline, a hydrogen analogs of an amino acid, was found to be racemates from the Murchison meteorite show. Norvaline was used in chiral separation by electrokinetic chromatography.
References Cronin, J., et al.: Science, 275, 951 (1997); Pizzarello, S., et al.: Geochim. Cosmochim. Acta., 64, 329 (2000); Gerabe, S., et al.: J. Chromatogr., 480, 403 (1989);

Applications Dl-lysine monohydrate

Applications L-Valine (1-13c, 99%) (cas# 81201-85-6) is a useful research chemical.

Applications rel-(4R,5R)-5-(4-Chlorophenyl)-4-methyl-2-thiazolidinone is a useful building block and has been used in the synthesis of hexythiazox (H298500).
References Lou, J.; et al.: Nongyao, 47, 328 (2008).

Applications 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.
References Allen, C., et al.: Org. Synth., 3, 418 (1955); Esposito, L., et al.: Kirk-Othmer Encyclopedia of Chemical Technology, 4th edition, 24, 812 (1997)

Applications Ethametsulfuron-methyl Sodium Salt, a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.
References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)

Applications 2-Methylpropylamine is used in the synthesis of arylsulfonamide inhibitors that act upon afflictions of osteoarthritis. In addition, it is used in the synthesis of novel reservatrol amide derivatives that act as anti-tumor agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yao, Ri-Sheng. et al.: Eur. J. Med. Chem. Lett., 62, 222 (2013); Nuti, E. et al.: Eur. j. Med. Chem., 62, 379 (2013)

Applications 4,4-methylenebis(N,N-diethylaniline) (cas# 135-91-1) is a useful research chemical.

Applications Used in the synthesis of DMPO-type spin traps.
References Konaka, R., et al.: Free Radical Res., 23, 15 (1995),

Applications (3-Glycidoxypropyl)triethoxysilane is used in the fabric industry to treat and modify fabrics.
References Schramm, Christian, et al.: Coloration Tech., 133(3), 234-242 (2017);Grancaric, Ana Marija, et al.: Pro. in Org. Coatings, 103, 174-181 (2017); Yeo, Jun-Seok, et al.: J. of Ind. and Eng. Chem., 45, 301-306 (2017)

Impurity Ranitidine EP Impurity H
Applications N-Methylnitroacetamide (Ranitidine EP Impurity H) is a degradation product of Ranitidine (R120000).
References Sharma, N. et al.: Sci. Pharmac., 79, 309 (2011); Haywood, P.A. et al.: J. Chem. Soc., 5, 951 (1987);

Applications D,L-o-Tyrosine is a metabolite of Phenylalanine (P319415). A precursor in the formation of catecholamines. Used as biomarkers of protein oxidative damage in β-thalassemia.
References Tsugita, A., et al.: Eur. J. Biochem., 124, 585 (1982), Nielsen, F., et al.: Clin. Chem., 43, 1209 (1997), Mates, J., et al.: Clin. Biochem., 32, 595 (1999),

Applications 3-Methyl-1,3-butanediol is a useful compound in carbon oxygen coupling reactions.

Applications N-Methyl-N-nitroso-ethenamine is used as research reagent for base induced fragmentation to give aldehydes or ketones and smaller alkylnitrosamine
References Leoppky, R.N., et al.: J Org. Chem, 23, 135(1982)

066621 - 5-Amino-4-oxopentanoic acid hydrochloride

Applications 4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). 4-Chloromethyl-5-methyl-1,3-dioxol-2-one is also used in the preparation of prodrugs of ampicillin.
References Ikeda, S. et al.: Chem. Pharmac. Bull., 32, 4316 (1984); Wu, T. Yaox. Xueb., 41, 537 (2006);

Applications 4-Methyl-6-(methylamino)-1,3,5-triazin-2(1H)-one is a heterocyclic Triazine based building block useful in organic synthesis. It is related to 2-Amino-4-methoxy-6-methyl-1,3,5-triazine (A616880), which is used to synthesize pesticides.
References Klein, J., et al.: J. AOAC Intrnational, 86, 1015 (2003); Pang, G., et al.: J. Chromat. A, 1125, 1 (2006);

Applications (4-Methylphenyl)-2-pyridinylmethanone is a useful reactant in organic synthesis.
References Hu, Zhiyuan, et al.: Org. & Biomol. Chem., 16(31), 5653-5660 (2018);Liao, Yang, et al.: J. of Organometallic Chem., 881, 1-12 (2019)

Impurity Rifaximin EP Impurity A
Applications 2-Amino-4-methylpyridine (Rifaximin EP Impurity A) is an impurity of Rifaximin.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 4-Methylheptane (cas# 589-53-7) is a useful research chemical.

Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.
References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)

M03060 - H-Leu-OH

Applications VINYLTRIS(2-METHOXYETHOXY)SILANE (cas# 1067-53-4) is a useful research chemical.

Applications 2-Hydroxy-3-methylbutyric Acid is a α-hydroxylated butyric acid derivative used as a marker in chemical diagnosis of organic aciduria and other inborn errors. 2-Hydroxy-3-methylbutyric Acid is also used as a metabolomic biomarkers in preeclampsia.
References Nakagawa, K. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 878, 942 (2010); Kenny, L.C. et al.: Reprod. Sci., 15, 591 (2008); Garcia, A. et al.: Clin. Chem., 44, 1905 (1999);

Applications A red azoic dye. Dyes and metabolites, Environmental Testing
References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),

Applications 9-(N-Methylaminomethyl)anthracene is a reactant that has been used in the synthesis of anthracene-oxyquinoline dyad as a fluorescent indicator for Hg(II).
References Praveen, L., et. al.: Tetrahedron Lett., 53, 3951 (2012)

Impurity Azathioprine EP Impurity C
Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.

Applications 3-Methyl-2-hexanamine HCl Salt is more stable and easier to purify compared to the free base.

Applications 2,2-Dimethoxy-N-methylethanamine is an impurity formed in the synthetic process of Methimazole (M260300), a thiourea antithyroid agent that prevents iodine organification,
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sitar, D.S., et al.: J. Pharmacol. Exp. Ther., 184, 432 (1973), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 8, 351 (1979), Cooper, D.S., et al.: N. Engl. J. Med., 311, 1353 (1984), Atterwill, C.K., et al.: Food Chem. Toxicol., 29, 355 (1991),

Applications 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine is an intermediate used to prepare nonracemic γ-bicyclic heteroarylpiperazine- and heteroarylpiperidine-substituted prolinylthiazolidines as selective and orally active dipeptidylpeptidase 4 inhibitors for use as antidiabetic agents.
References Yoshida, T., et al.: Bioorg. Med. Chem., 20, 5705 (2012)

Applications An intermediate used in the synthesis of Pregabalin (P704800) and related compounds.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Posadas, I., et al.: Br. J. Pharmacol., 142, 331 (2004),

Applications Labelled 4-Methylimidazole (M312990). 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results from the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nishie, K. et al.: Toxicol. Appl. Pharmacol., 14, 301 (1969): Cunha, S.C. et al.: J. Food Comp. Anal., 24, 609 (2011); Chan, P.C. et al.: Arch. Toxicol., 82, 55 (2008);

Applications 5-Methoxy-2-methylaniline (cas# 50868-72-9) is a useful research chemical.