Acides aminés (AA)

Impurity Cefoperazone EP Impurity C
Applications N-Methyl-5-tetrazolethiol (Cefoperazone EP Impurity C) is an impurity of Cefoperazone.
References Kitson, T., et al.: Biochem. J., 175, 83 (1978), Elenbaas, R., et al.: Clin. Pharmacol. Ther., 32, 347(1982),

Applications 5-Methyl-3,4-diphenylisoxazole is a reagent for the preparation of valdecoxib and valdecoxib analogues.
References Di Nunno, L., et al.: J. Med. Chem., 47, 4881 (2004); Reddy, A. R., et al.: Synth. Commun., 42, 639 (2012); Huang, Y., et al.: Zhongguo Xiandai Yingyong, 26, 456 (2009)

Applications D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.
References Molinaro, C., et al.: J. Org. Chem., 77, 2299 (2012); Gervais, F.G., et al.: Mol. Pharmacol., 79, 69 (2011); Gallant, M, et al.: Bioorg. Med. Chem. Lett., 21, 288 (2011)

Applications L-Tyrosine-13C9 ,15N is labelled analogue of L-Tyrosine (T899975), one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)

Applications 5-Carboxy-2-methylphenylboronic Acid acts as a reagent in the synthesis of pyrazolopyridinone-based p38 MAP kinase inhibitor
References Milburn, R. R., et al.: Org. Process Res. Dev., 15, 31 (2011); Achmatowicz, M., et al.: J. Org. Chem., 74, 795 (2009)

Applications A labelled product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.
References Wejksza, K., et al.: Pharmacol. Rep., 61, 751 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Di Natale, B., et al.: Toxicol. Sci., 115, 89 (2010),

Applications DL-Proline is the racemic mixture of both L-Proline (P755995) and D-Proline (P755990).
References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);

Applications L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.
References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);

Stability Hygroscopic, Temperature Sensitive
Applications A carnitine ester of unsaturated fatty acid. Used in the studies of fibroblasts in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders.
References Gross R.W., et al.: J. Biol. Chem., 258, 5221 (1983),

Applications 6-Chloro-2-methoxy-7-deazapurine (cas# 90057-08-2) is a compound useful in organic synthesis.

Applications Labelled analogue of L-Phenylalanine, an essential amino acid.
References Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);

Applications L-Arginine-2,3,3,4,4,5,5-d7 HCl (CAS# 204244-77-9) is a useful isotopically labeled research compound. It can be used with Raman scattering for imaging living cells and organisms.
References Min, W., et al., PCT Int. Appl. (2014), WO 2014205074 A2

Applications β-Alanine-13C3,15N is the isotope labeled analogue of β-Alanine (A637320), which is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of Dihydro Uracil (D449990) and Carnosine. β-Alanine is also the rate-limiting precursor of Carnosine, as a result supplementation with β-Alanine increases the concentration of Carnosine in muscles.
References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);

Applications N-Isobutyrylglycine detection is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-Isobutyrylglycine detection is also used in the diagnosis of isobutyryl-CoA dehydrogenase deficiency.
References Costa, C. G. et al.: J. Pharmac. Biomed. Anal., 21, 1215 (2000); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000); Sass, J. et al.: J. Inher. Metab. Dis., 27, 741 (2004);

Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.
References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)

Applications (S)-2-METHYL GLYCIDOL (cas# 86884-90-4) is a useful research chemical.

Impurity Anastrozole 1,3-Dicyanomethyl Impurity
Applications 5-Methyl-1,3-benzenediacetonitrile is an Anastrozole intermediate. Anastrozole 1,3-Dicyanomethyl Impurity. Anastrozole is an aromatase inhibitor and used as an antineoplastic.
References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Applications A serine derivative. Used in the synthesis of constrained amino acid buildings blocks and their incorporation into biologically active peptidomimetics.
References Rew, Y., et al.: J. Med. Chem., 45, 3746 (2002),

Stability Very Hygroscopic
Applications Hydroxyisovaleroyl Carnitine is used as a diagnostic tool to identify the presence of orofacial clefts. Also used in the screening and diagnostics of inborn errors of metabolism.
References Denes, J. et al.: Anal. Chem., 84, 10113 (2012); Budner, M. et al.: Arch. Oral. Biol., 58, 459 (2013);

Applications L-2-Aminobutyric Acid-d6 is the isotope labelled analog of L-2-Aminobutyric Acid (A602930); a receptor antagonist.
References Porter, D.J.T., et al.: Biochem. Pharmacol., 50, 1475 (1995)

Stability Hygroscopic
Applications Lauryl Betaine is an amphoteric surfactant derived from N-dodecyl-N,N-dialkanol amine with protein denaturing potency. Lauryl Betaine is mainly used in shampoo, personal hygiene products and oil field chemicals.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kimura, Y. et al.: J. SCCJ, 29, 106 (1995); Qin, C. et al.: GUang. Huag., 34, 30 (2006); Peng, Z. et al.: Riy. HUax. Gong., 37, 135 (2007);

Applications A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);

Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

M02961 - H-Phe-OH

Stability Very Hygroscopic
Applications A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells.
References Vallence, P., et al.: Lancet, 339, 572 (1992),

Applications 3-Methyl-3-buten-1-ol is used in the synthesis of antiproliferative, antiandrogenic and cytotoxic caffeic acid derivatives.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sanderson, J. T. et al.: Bioorg. Med. Chem., 21, 7182 (2013);

Applications Isotope labelled Intermediate for transsulfuration whereby a mammal transfers the sulfur of methionine via homocysteine to cysteine.
References Thompson, J.W., et al.: J. Biol. Chem., 266, 17011 (1991), Yoshida, Y., et al.: Microbiol., 148, 3961 (2002), Jiracek, J., et al.: J. Med. Chem., 49, 3982 (2006),

Applications N-[(Benzyloxy)carbonyl]glycylglycine is a reagent in the synthesis of Glycylglycyl-L-tyrosine (G718500), which is a fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.
References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),

Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.

Applications Dimethyl L-Aspartate Hydrochloride was used in the synthesis of enzyme and pH dual responsive L-amino acid based biodegradable polymer nanocarrier that can be used for multidrug delivery to cancer cells.
References Saxena, S., et al.: J. Polym. Sci. Pol. Chem., 54, 3279 (2016);

Applications Labelled DL-Pipecolinic Acid (P479762). Pipecolic acid is involved in synaptic transmission in the central nervous system.
References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),

Applications 2-Methylpentane is used as a raw material/intermediate in organic synthesis, rubber solvent, and vegetable oil extraction solvent.
References Choi, D., et al.: Adv. Funct. Mater. 25, 920 (2015)

Applications N-Acetyl-L-phenylalanine is an protected analogue of L-Phenylalanine (P319415), an essential amino acid produced for medical, feed, and nutritional applications such as in the preparation of Aspartame.
References Sriram, S., et al.: J. Med. Chem., 56, 2540 (2013); Parker, B.M., et al.: J. Biotech., 155, 396 (2011);

Applications S-Phenylmercapturic Acid-d5 is the labelled analogue of S-Phenylmercapturic Acid (P335600), an important metabolite of Benzene.
References Qu, Q., et al.: Am. J. Ind. Med., 37, 522 (2000); Ghittori, S., et al.: Int. Arch. Occup. Environ. Health, 67, 195 (1995);

Applications The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
References Berna, M., et al.: Anal. Chem., 79, 4199 (2007), Pritt, M., et al.: Toxicol. Sci., 103, 382 (2008), Tonomura, Y., et al.: Toxicology, 266, 48 (2009),

Applications 2-Methylresorcinol (cas# 608-25-3) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Used in peptide synthesis.
References Flohr, S., et al.: Chem. Eur. J., 5, 669 (1999), Kadereit, D., et al.: ChemBioChem., 1, 144 (2000), Volkert, M., et al.: Biol. Chem., 382, 1133 (2001),

Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.

Applications 6-Methylmercaptopurine Riboside (cas# 342-69-8) is a compound useful in organic synthesis.

Applications 3-Methylbutyric-2,2-d2 Acid (CAS# 95927-02-9) is a useful isotopically labeled research compound.

Applications β-Hydroxyisobutanol is used as a reagent in the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals as inhibitors of HCV protein NS4B and of hepatitis C viral replication and their lack of cytotoxicity in human cells.
References Tai, V.W.-F., et al.: Bioorg. Med. Chem. Lett., 24, 2288 (2014);

Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.

Applications D-Serine Methyl Ester Hydrochloride (cas# 5874-57-7) is a compound useful in organic synthesis.

Applications Important compounds in coffee aroma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications N-Methyldiethanolamine-13C,d3 Hydrochloride is isotopically labelled salt form of N-Methyldiethanolamine (M301625), which is used as a reagent in the synthesis of broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. It is also used as a reagent in the synthesis of dihydroxy quaternary ammonium salts with long chain alkyl bromides that can exhibit antibacterial and antifungal activity.
References Pascual, A., et al.: Biomacromolecules, 16, 1169 (2015); Liu, W., et al.: Chem. Biol. Drug Des., 85, 91 (2015);

Applications DL-Proline-2,5,5-d3 (CAS# 784086-28-8) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.
References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)

Applications 3-Methyl Salicylic Acid is a toxic compound, it’s toxicity is similar to salicylic acid. Reagent used in manufacturing and preparation of dyes.
References Egorova, T. V., et al.: Tekstil'naya Promyshlennost , 3, 48 (1987); Keshavarz, M. H., et al.: J. Hazard. Mater., 237, 79 (2012)

Applications (2-methylphenoxy)acetic acid (cas# 1878-49-5) is a useful research chemical.

Applications Labelled analogue of an essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.
References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);

Applications 5-Amino-6-methylbenzimidazolone

Applications m-Tyramine Hydrochloride affects the firing pattern of Heobania vermiculata. Potential organ or tumor imaging agent.
References Avoli, M., et al.: Comp. Biochem. Physiol. C: Pharmacol., 59C, 173-175 (1978); Counsell, R. E., et al.: J. Med. Chem., 16, 684-687 (1973);

Applications 8-Bromo-3,9-dihydro-3-methyl-1H-purine-2,6-dione, is a substituted derivative of Xanthine (X499950), found in animal organs, yeast, potatoes, coffee beans, tea. It can also be used for the synthesis of Linagliptin (L465900), which is a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.
References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011); Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011); Mtthias E., et. al: J. Med. Chem., 50, 6450 (2007);

Stability Hygroscopic
Applications L-Saccharopine is a product of breakdown of essential amino acid Lysine (L468895). Saccharopine is also part of the α-aminoadipate pathway of fungal lysine biosynthesis.
References Higashino, K., et al.: Biochem. Biophys. Res. Commun., 20, 285 (1965); Johansson, E., et al.: Structure, 8, 1037 (2000)

M03060 - H-Leu-OH

Applications 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several “inborn errors of metabolism” (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),

Applications 2-Ethyl-4-methyl-1-pentanol is a volatile chemical that can be used to diagnose ratoon stunting disease in Sugar cane.
References Berna, A. Z., et al.: Pro. of the Conf. of the Austr. Soc. of Sugar Cane Tech., 37th, 150-157 (2015)

Applications Protected L-Tyrosine (T899975), an amino acid, used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine.
References Rasmussen D.D. et al.: J. Clin. Endocrinol. Metab., 57, 760 (1983); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977)

Applications 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer.
References Surh, Y., et al.: Mutat. Res., 480, 243 (2001), Balkwill, F., et al.: Lancet, 357, 539 (2001), Kawanishi, S., et al.: Biol. Chem., 387, 365 (2006), Hoki, Y., et al.: Cancer Sci., 98, 163 (2007),

Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.

Stability Hygroscopic
Applications (S)-(+)-2-Methylbutyric Acid is a chiral starting reagent used in various synthetic preparations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Neves, F., et al.: Beilstein. J. Org. Chem., 7, 1504 (2011); King, A.M., et al.: J. Medn. Chem., 54, 6432 (2011); Ferrarni, A., et al.: Chirality., 26, 9 (2011);

Applications Used for the synthesis of Bortezomib from L-phenylalanine via dipeptidyl boronic acid ester intermediates.
References Zhu, Y., et al.: J. Med. Chem., 52, 4192 (2009),