Peptides

MOCA is a small peptide with anti-inflammatory properties that binds to the receptor IL-1R. It has been shown to inhibit sodium currents in neurons by binding to the Na+ channel and preventing the influx of sodium ions, which leads to an inhibition of action potentials. MOCA has also been shown to bind with high affinity to the IL-1R and blocks its activity. This inhibition of IL-1R leads to decreased production of proinflammatory cytokines.
MOCA has not been shown to have any affinity for other receptors or ligands.

A potent vasoconstrictor (Source rat, 110-123) containing disulfide bonds between Cys8-Cys13 and available as a 0.5mg vial.  
Urotensin II is a peptide involved in biological systems such as the nervous, endocrine, cardiovascular and renal and in rats it is primarily found in brainstem and spinal cord motor neurons. Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function.
Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.
UT-II has been shown to have a wide range of physiological effects in rats, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin.
In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.

Tyr-3/Trp- 5 Monooxygenase Activation Protein Zeta (TAZ) is an enzyme that is involved in the regulation of cellular proliferation, differentiation and apoptosis. This protein contains a domain with high similarity to the Tyr-3/Trp-5 monooxygenase activation domain and has been shown to be an activator of this enzyme. TAZ also interacts with ion channels and has been shown to inhibit their function. TAZ is a recombinant human protein produced in E. coli cells and purified by a proprietary process that yields a high purity product.

Sourced from the marine snail, conus striatus, this synthetic cone snail toxin is a nicotinic acetylcholine receptor blocker. This product has disulfide bonds between Cys2-Cys7 and Cys3-Cys7.

TentaGel® XV RAM is a particle-based reagent for peptide synthesis. It contains the building blocks for peptides and has been designed to be used in conjunction with a TentaGel® XV reactor. This product is designed to increase the yield of peptides via the use of a patented process that eliminates the need for purification and can reduce reaction time by up to 50%.

H-Gln-2-ClTrt-Resin is a resin that consists of polystyrene crosslinked with divinylbenzene. It is used in peptide synthesis to provide amino acids and building blocks for the synthesis of peptides and proteins. This resin can be used as a component in the production of amines, alcohols, thiols, and other organic compounds. The crosslinking agent in this resin is divinylbenzene (DVB).

APETx2 is a drug that inhibits the activity of apetx2, a protein which is involved in the regulation of ion channels and endothelin-A receptors. APETx2 has been shown to inhibit the activity of channels involved in pain perception and may have therapeutic potential as a pressor agent. This drug has also been shown to have anti-inflammatory properties, which are likely due to its inhibition of EGF receptor activity. The mechanism of action for this drug remains unclear, but it may work by blocking the channel or receptor for EGF.

MiniAP-4 peptide is a short nontoxic derivative of apamin (a neurotoxin from bee venom) used as a blood-brain barrier (BBB) shuttle peptide.

A synthetic peptide for use as a blocking control in assays to test for specificity of MPEG1 antibody, catalog no. 70R-3787

Portion of EBV RTA

Tyrosinase protein:
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is a human tyrosinase-derived (369-377) peptide by posttranslational conversion of the sequence YMNGTMSQV. Tyrosinase is an oxidase membrane-bound protein. Tyrosinase play a key role in the melanin synthesis pathway. Tyrosinase is presented on the surface of HLA-A*02:01 melanomas and also expressed in melanocytes. Tyrosinase has been still suggested to be a tumor antigen and might be implicated in improvement of immunotherapeutic strategies such as for efficient anticancer vaccine development.
Applications of Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV):
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is used to stimulate specific cytotoxic T lymphocytes (CTL) in PBMCs and then to analyze CTL response especially the cytokine production by ELISPOT assay. Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is also involved in experimental therapies of metastatic melanoma by allogeneic hematopoietic stem cell transplantation. In fact, cytotoxic T cells were generated from peripherical blood mononuclear cells (PBMCs) of HLA-A*02:01 healthy donors after being stimulated by injection of Asp371 antigen (2). This strategy raises issues which concern the graft versus tumor (GvT) effect and graft versus host disease (GvHD).

CRF is a human antibody that is used as a research tool. It has reactivity with cells that are activated by CRF, and binds to the receptor on these cells. CRF is also known as a ligand, which can bind to the receptor and trigger changes in the cell, such as ion channels or protein interactions. CRF is an activator of G-protein coupled receptors.

Noggin Mouse is a protein that is secreted by the mouse brain. It is a member of the transforming growth factor-beta superfamily and is involved in development, cell differentiation, and immune regulation. Noggin Mouse has been shown to inhibit cytokine production by E. coli and other bacterial strains. Noggin Mouse also inhibits the release of proinflammatory cytokines from macrophages and synoviocytes.

Bis-dPEG®17-PFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®17-PFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

KLPGF peptide is a sequence from egg white albumen. This peptide have recently shown interest for Alzheimer’s disease.

A synthetic peptide for use as a blocking control in assays to test for specificity of USP13 antibody, catalog no. 70R-9735

A synthetic peptide for use as a blocking control in assays to test for specificity of KRT16 antibody, catalog no. 70R-2870

Please enquire for more information about Calcitonin, rat including the price, delivery time and more detailed product information at the technical inquiry form on this page

A synthetic peptide for use as a blocking control in assays to test for specificity of KRT13 antibody, catalog no. 70R-2265

Bz-Ala-OMe is a reactive mercuric chloride that undergoes hydrolysis to form reactive mercuric acetate. It has been shown that the activation energy of the reaction is high and the reaction can be initiated by soybean trypsin. The reactive site of Bz-Ala-OMe is composed of chloride atoms and sephadex g-100. This compound reacts with serine proteases, such as trypsin or chymotrypsin, to form an amide intermediate. This intermediate reacts with n-acetyl-l-tyrosine to produce a chloromethyl ketone which then undergoes a nucleophilic attack by histidine to produce histamine in the presence of H2O2 or O2. Histamine binds to H1 receptors in the body, leading to an inflammatory response.

ANP (Rat, 3-28) is a peptide that is a potent inhibitor of protein interactions. This peptide binds to the ligand-binding domain of the receptor and blocks the binding of the ligand. ANP (Rat, 3-28) also has high purity and can be used as a research tool or an antibody in life science studies.

Blocker of voltage-gated sodium channels and T-type Cav

Gastrin-related peptide is a peptide that is involved in the regulation of the growth of cells. It has been shown to promote cancer cell growth, and may be involved in other cancers such as prostate cancer and neurological disorders. Gastrin related peptide is not active against normal cells, which makes it a potential therapeutic target for cancer treatment.

Peptide YY (PYY) is a peptide hormone that inhibits gastric emptying and increases intestinal transit time. This peptide can be given as an intubation, perfusion, or intravenous infusion to increase the absorption of nutrients. It also has the potential to reduce body weight in obese people. PYY is a potent activator of protein synthesis and it has been shown to stimulate lipolysis in adipocytes. PYY is found in the ileum and colon, where it may have its effects on appetite suppression and regulation of gastrointestinal motility.

A synthetic peptide for use as a blocking control in assays to test for specificity of CLDN11 antibody, catalog no. 70R-6144

A synthetic peptide for use as a blocking control in assays to test for specificity of TUBB2A antibody, catalog no. 70R-2910

A synthetic peptide for use as a blocking control in assays to test for specificity of FLYWCH1 antibody, catalog no. 70R-10075