Peptides

TIP39 is a peptide inhibitor that is a member of the TIP family. It inhibits the activity of calcineurin, a calcium-dependent phosphatase enzyme, and thereby prevents it from dephosphorylating nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which regulates signaling pathways that control inflammatory responses. TIP39 has been shown to inhibit calcineurin in both human and bovine cell lines. This drug has been used as a research tool to study peptide-receptor interactions and ion channels.

m-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-Amido-dPEG®24-DSPE is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Amino-dPEG®4-(m-dPEG®11)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-(m-dPEG®11)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

IL1-beta is a pro-inflammatory cytokine that belongs to the Interleukin family. It is expressed in response to inflammation, trauma, and infection and can be found in many tissues of the body. IL1-beta has been shown to have a wide variety of effects on the body including regulating cell growth and differentiation. IL1-beta has also been shown to bind with high affinity to specific receptors that are known as type I interleukins. These receptors are able to activate other cells such as T cells and macrophages, which produce more inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ).
IL1-beta Mouse is a mouse monoclonal antibody that binds specifically with IL1-beta. This antibody can be used for immunohistochemistry or Western blotting experiments. It can also be used for blocking studies using an ELISA assay or RIA assay.

Please enquire for more information about Fmoc-Trp-Rink-Amide MBHA Resin including the price, delivery time and more detailed product information at the technical inquiry form on this page

Neuromedin U is a peptide that plays a role in the regulation of cardiovascular function and the modulation of pain. It has been found to activate receptors for calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). Neuromedin U has also been found to be an inhibitor of ligand-induced activation of ion channels, such as those activated by bradykinin or histamine. This protein can be used as a research tool in cell biology, pharmacology, and biochemistry.

AC 253 is an amylin (AMY3) receptor antagonist.

Joining peptide is a peptide that activates the receptor. It consists of two parts: a receptor-binding domain and a cell-penetrating domain. The receptor-binding domain is designed to bind to specific receptors on cells, while the cell-penetrating domain allows the peptide to cross the plasma membrane and penetrate into the cytoplasm. Joining peptide is used as an activator for ion channels and ligands for antibodies or receptors. Joining peptide can be used in research as a tool for investigating protein interactions, pharmacology, and cell biology.

Salusin-beta is a peptide that is used as a research tool for the study of ion channels and protein interactions. Salusin-beta inhibits potassium currents in cells, which may be due to its ability to bind to receptor sites on the cell membrane. It also inhibits the activity of protein kinase C and calcium channels. Salusin-beta has been shown to be an inhibitor of protein interactions, such as those between α-synuclein and synaptotagmin, which are involved in Parkinson's disease.

Neuromedin B is a neuropeptide that is found in the central nervous system and peripheral tissues. It activates ligand-gated ion channels, including nicotinic acetylcholine receptors. Neuromedin B has been shown to inhibit the activity of voltage-gated potassium channels and calcium channels, which are involved in neurotransmission. It also inhibits the activation of phospholipase C, which is involved in cellular signaling pathways. This peptide can be used as a research tool for studying the pharmacology of peptides and as an antibody for immunohistochemistry studies.

TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.
Application: (90 µm)
Substitution Functional Group:-CH2-CH2-SH

Obestatin is a neuropeptide that was first isolated from the mouse and rat hypothalamus. The Obestatin (Mouse, Rat)-EIA Kit is an in-house ELISA assay for the detection of mouse and rat obestatin. This kit can be used to detect obestatin in serum, plasma, or cell culture supernatant samples. It is a useful tool for studying the role of this peptide in various biological processes.

Anti-EGFR (Epidermal Growth Factor Receptor) is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR). The EGFR is a transmembrane tyrosine kinase receptor that plays an important role in cell proliferation, differentiation, and survival. Anti-EGFR can be used as a research tool for studying protein interactions, such as the interaction of peptides with receptors or ligands. It can also be used for pharmacological studies and can be used to isolate proteins from cells. This product is available in high purity, which means it has been purified by chromatography to have less than 0.1% other proteins than the product. This product is also available in a form of an antibody conjugate, which means that it has been linked to an antibody molecule that recognizes the target antigen specifically. Anti-EGFR is available in CAS No., which stands for Chemical Abstracts Service Number.

This product is an antiserum targeting amino acids 34-40 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.

Polystyrene is a thermoplastic polymer that is used in the production of polystyrene resins, which are used as building blocks for peptide synthesis. New England Peptide offers a variety of polystyrene resin products including particle resins and Rapp Polymere resins. The particle size of the resin ranges from 5-100 µm. Polymers can be synthesized using various methods including solid-phase synthesis and solution phase synthesis, which both require polystyrene resins. This product is available with a variety of functionalities, such as amine, hydroxyl and carboxyl groups.

1-Deoxyfructosyl-Gly is a multifunctional inhibitor that has been shown to inhibit the activity of protein interactions, activator, ligand, and receptor. It is a research tool used to investigate the role of ion channels in cell biology. The antibody has high purity and is suitable for use in life science research.

Please enquire for more information about TentaGel® MB RAM, particle size: 200 - 250 µm including the price, delivery time and more detailed product information at the technical inquiry form on this page

Glu17,Gla21,24-Osteocalcin is a peptide that is used as a research tool to study ion channels and receptor interactions. It has been shown to bind to the human insulin receptor and act as an agonist. Glu17,Gla21,24-Osteocalcin also binds to the calcitonin receptor with high affinity. This peptide can be used in pharmacology studies as an inhibitor of insulin-mediated glucose uptake or as an activator of calcium release from intracellular stores.

Big Endothelin-3 (Rat, 1-41 Amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide, that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11 and is available as a 0.1mg vial.

Prosaposin is a human, recombinant secretory protein that is produced by the freeze-drying of a lysosomal extract. It is used to treat cerebrospinal fluid that has been depleted of prosaposin. This protein functions as a linker and interacts with choline, glycosphingolipids, and phospholipids to form the myelin sheath in the central nervous system. Prosaposin can also be reconstituted with deionized water and aliquots containing 1 mg/mL of this protein are available for purchase.