Peptides

MAL-dPEG®12-Tris(-dPEG®11-amido-MAL)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®12-Tris(-dPEG®11-amido-MAL)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Anti-TGF-Beta1 is a recombinant monoclonal antibody that binds to the TGF-beta1 protein and blocks its function. It is a research tool for studying the effects of TGF-beta1 on cells, tissues, and organs in the body. Anti-TGF-Beta1 can be used as a control for blocking TGF-beta1 in various experiments, as well as for studying the effects of TGF-beta1 receptor activation. This antibody can also be used to detect TGF-beta1 in various samples by immunohistochemistry or immunocytochemistry.
The target is human serum proteins which react with this antibody and are detected at dilutions of 1:1000 or greater.

Azido-dPEG®8-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, Aazido-dPEG®8-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

IL-15 is a cytokine that belongs to the IL-2 family and is produced by activated T cells. IL-15 binds with high affinity to the IL-15 receptor, which then signals through the JAK/STAT pathway. IL-15 has been shown to activate NK cells and stimulate their production of IFNγ. In addition, IL-15 has been shown to cause activation of certain B cells, which leads to increased antibody production. This cytokine also stimulates proliferation of CD4+ and CD8+ T cells and induces differentiation into Th1 or cytotoxic T cell subsets.

Anti G-Protein: Galpha olf (23-38), humanSerum is a research tool that is used to study protein interactions. It can be used for the investigation of ion channels, cell biology, and pharmacology. The antibody reacts with the specific antigen for which it was raised. The antibody may be used in immunohistochemistry on tissue sections or in ELISA as a detection tool.

MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

1-Deoxyfructosyl-Val-His-[D7]Leu-Thr-Pro-Glu is a research tool that belongs to the group of activators. It activates receptors and ion channels. This product has been shown to inhibit cell proliferation, peptide binding and protein interactions. 1-Deoxyfructosyl-Val-His-[D7]Leu-Thr-Pro-Glu is a high purity and potent inhibitor of protein interactions with pharmacological applications.

Histone protein H3 is a core component of the nucleosome, functioning in DNA compaction and availability to transcription machinery. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, &amp-ldquo-histone tail&amp-rdquo- which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. There is a wealth of data recording these modifications but understanding their significance is not as clear. The first 20 residues (1-20) of H3 N terminal domain are provided here. This sequence has already been used to investigate H3 phosphorylation and methylation events in the cell cycle.A glycine linker is C-terminally attached as a highly flexibly linker to allow the best pharmacokinetic profiling of the fused domain such as expression, localisation, or activity data. Provision of this H3 sequence with a glycine linker may allow further understanding of histone regulation.

Alyerserin-1b is a C-terminally α-amidated 23 residue Cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-1 peptides have limited structural similarity to the ascaphins from the skins of frogs of the Leiopelmatidae family. Alyteserin-1 peptides are selective at inhibiting growth activity of Gram-negative bacteria-such as Escherichia coli and show weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards these peptides compared to conventional antibiotics.

This is a Biologically Active Peptides, Short=PN-II, Proteomics, Amyloid Precursor Protein, New England Peptide calibrated to 25nmol. This peptide has been shown to be a major component of amyloid plaques in Alzheimer's Disease. It is one of the most abundant proteins in the brain and is found in association with beta-amyloid protein (A4). The precursor protein for APP is encoded by the gene on chromosome 21. APP and its products are involved in many cellular processes such as signal transduction, cell proliferation, apoptosis and inflammation. APP can be cleaved by Beta-secretase or Gamma secretase to release A4 and N-APP.

Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.
Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.

Maleimide-activated BSA (BSA-M) is a maleimide-activated form of Bovine Serum Albumin (BSA). It is a peptide that can be used for immunization, as well as in biochemistry experiments. BSA-M has been shown to stimulate antibody production and can be used in the development of new vaccines.

DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Atosiban is a drug that is used to prevent preterm labor in pregnant women. It works by inhibiting the release of oxytocin from the hypothalamus, which decreases contractions and relaxes the uterus. Atosiban has been shown to be effective in decreasing the incidence of preterm birth in women with bacterial vaginosis who are at high risk for preterm delivery (e.g., those with a history of preterm labor). Clinical trials have shown that it may also be useful as an adjunct therapy in treating women with unexplained infertility and recurrent pregnancy loss. The drug binds to receptors on cells, which inhibits the release of intracellular calcium, thus preventing contraction of uterine muscle cells. This effect can be reversed by administration of estradiol benzoate or other drugs that affect receptor activity. It is not known whether atosiban affects fetal development during pregnancy or if it causes any effects on the mother's heart rate or body mass index after childbirth.

IL-1 beta is a cytokine, which belongs to the IL-1 family of cytokines. It is a proinflammatory cytokine that induces fever and pain, and stimulates the immune system. IL-1 beta binds to the IL-1 receptor, which is a member of the class 1 cytokine receptor family. The binding activates phospholipase A2 and protein kinase C, which leads to an increase in prostaglandin production by cyclooxygenase 2. IL-1 beta also has been shown to inhibit ion channel activity and calcium uptake in cells.

Antithrombin III heavy tryptic peptide standard for protein identification and quantitation studies. Antithrombin III is a glycoprotein found in blood plasma and is involved in the regulation of the coagulation process.

Bekm 1 is a peptide that binds to the nicotinic acetylcholine receptor and activates it. This receptor is found on the post-synaptic membrane of neurons, which are responsible for transmitting messages from one nerve cell to another. Bekm 1 is an agonist at this receptor, which means that it binds to the receptor and triggers a response. The activation of these receptors has been shown to inhibit neuronal activity.

A synthetic peptide for use as a blocking control in assays to test for specificity of ABCB6 antibody, catalog no. 70R-4529

A synthetic peptide for use as a blocking control in assays to test for specificity of C2orf55 antibody, catalog no. 70R-4287

A synthetic peptide for use as a blocking control in assays to test for specificity of MSI2 antibody, catalog no. 70R-1394

A synthetic peptide for use as a blocking control in assays to test for specificity of LYVE1 antibody, catalog no. 70R-6181

A synthetic peptide for use as a blocking control in assays to test for specificity of OPTC antibody, catalog no. 70R-5283

A synthetic peptide for use as a blocking control in assays to test for specificity of PNPLA5 antibody, catalog no. 70R-2827

A synthetic peptide for use as a blocking control in assays to test for specificity of MAFK antibody, catalog no. 20R-1260

A synthetic peptide for use as a blocking control in assays to test for specificity of TMEM138 antibody, catalog no. 70R-6431

A synthetic peptide for use as a blocking control in assays to test for specificity of RORA antibody, catalog no. 70R-1921

A synthetic peptide for use as a blocking control in assays to test for specificity of STOML2 antibody, catalog no. 70R-10371

A synthetic peptide for use as a blocking control in assays to test for specificity of DDX6 antibody, catalog no. 70R-1400