Peptides

<p>Custom research peptide; min purity 95%.</p>

Portion of Influenza NP

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>m-dPEG®4-Propionaldehyde is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®4-Propionaldehyde is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Phthalimidooxy-dPEG®12-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Phthalimidooxy-dPEG®12-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

A synthetic cone snail toxin sourced from the marine snail, Conus striatus. This product is a tetrodotoxin-resistant Na+ channel blocker with analgesic activity, has disulfide bonds between Cys3-Cys13, Cys4-Cys19, and Cys8-Cys20 and is available as a 0.5mg vial.

Chagas disease is caused by the parasite Trypanosoma cruzi and is transmitted to humans by the bite of an infected triatomine bug. The Chagas multiantigen (CM) is a recombinant protein that contains the entire sequence of the T. cruzi trypomastigote surface glycoprotein gp41, which plays a critical role in parasite invasion of host cells. CM can be used as a research tool for studying receptor-ligand interactions, ion channels, cell biology, and pharmacology. It also has potential use as an inhibitor of the invasion of mammalian cells by T. cruzi trypomastigotes.

<p>ANP (Human, 7-28) is a peptide with inhibitor activity. ANP (Human, 7-28) binds to the receptor for atrial natriuretic peptide and inhibits its interaction with other proteins. It can also activate the receptor by binding to it. ANP (Human, 7-28) contains an N-terminal sequence of amino acids that are not present in the human atrial natriuretic peptide and can be used as a research tool or an antibody against this protein.</p>

<p>CCK-Tetrapeptide (30-33) is a peptide hormone that is structurally related to cholecystokinin. It has been shown to inhibit the activity of adenylate cyclase and phosphodiesterase, which are enzymes that are involved in cellular signaling. CCK-Tetrapeptide (30-33) has significant interactions with other drugs and can cause symptoms such as nausea, vomiting, diarrhea, or headache.</p>

Amino acids 1-34 of the Pararthyroid Hormone (PTH) containing a tyrosine residue and disulfide bonds between Cys3-Cys14. This product is of Bovine source and available as a 0.5mg vial. Parathyroid hormone (PTH) is a peptide hormone that regulates calcium and phosphate homeostasis. PTH stimulates the production of active vitamin D, which increases calcium absorption from the gut and promotes reabsorption of calcium in the kidney. The inhibitory effect of PTH on renal phosphate excretion causes hyperphosphatemia and hypocalcemia. PTH also stimulates osteoblasts to produce more bone matrix, resulting in increased bone mineralization and density. It is used as a research tool to study protein interactions, activation, ligand binding, receptor regulation and ion channels. It has been shown to have effects on some cell types such as T-cells, B-cells, neutrophils and mast cells. In addition to its effects on bone metabolism, PTH also has many other functions including vasoconstriction, inhibition of food intake and stimulation of glucose production by the liver.

<p>DNP-dPEG®12-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DNP-dPEG®12-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Glucagon is a peptide hormone that is produced by alpha cells in the pancreas. It has many effects, including increasing blood sugar levels and causing the release of fatty acids from fat cells. Glucagon also stimulates the liver to release glucose into the bloodstream. Glucagon binds to specific receptors on the membrane of cells, which then causes adenylate cyclase activity and increased production of cyclic AMP (cAMP). This hormone is used in cancer treatment because it can stimulate cell growth, inhibit apoptosis, and cause cancerous tumors to shrink.</p>

<p>Interferon-beta 1a is a cytokine that is used to treat multiple sclerosis and other diseases. It is the product of human recombinant DNA technology and has been shown to be an effective treatment for MS. Interferon-beta 1a inhibits the growth of neuroblastoma cells by inducing apoptosis, or programmed cell death. The drug also down-regulates the expression of proinflammatory cytokines in sh-sy5y neuroblastoma cells. Interferon-beta 1a has been shown to inhibit the proliferation of CHO (Chinese Hamster Ovarian) cells in vitro and may have therapeutic potential for the treatment of breast cancer, colorectal cancer, and ovarian cancer.</p>

<p>DOTA-tris(Acid)-Amido-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance. It is also known as a vasopressor and as an activator of the renin-angiotensin system. Angiotensin II is synthesized from the precursor protein angiotensinogen, which is cleaved by renin to form angiotensin I. Angiotensin I is then converted to angiotensin II by the enzyme ACE (angiotensin-converting enzyme). Angiotensin II is found in the lungs, kidneys, adrenal glands, brain and blood. The biological effects of angiotensin II are mediated by its receptor on cells which stimulates G proteins to activate phospholipase C activity. This leads to increased levels of inositol triphosphate (IP3) and diacylglycerol (DAG) which cause release of calcium ions from intracellular stores such as the endoplasmic

H2N-PEG-O-C3H6-COOH hydrochloride is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. H2N-PEG-O-C3H6-COOH hydrochloride is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Angiotensin II is a peptide that is involved in the regulation of blood pressure and fluid balance. Angiotensin II has been shown to be an activator of angiotensin-converting enzyme (ACE), which converts angiotensin I into angiotensin II. ACE is inhibited by the drug captopril, which reduces the conversion of angiotensin I to angiotensin II. Angiotensin II has also been shown to activate potassium channels, including voltage-gated potassium channels, and inhibit calcium channels. It has been found to bind to the receptor AT1 and trigger a number of responses, including vasoconstriction and increased heart rate. The ligand for this receptor is angiotensin II. The pharmacology of Angiotensin II includes its ability to act as an inhibitor on protein interactions with various proteins or enzymes, such as alpha-1 antitrypsin or beta-2 adrenergic receptors.</p>

<p>Hyaluronidase is a glycosaminoglycan that is synthesized by the cells of the synovial membrane, and is used in the treatment of osteoarthritis. It has been shown to be potent inducers of apoptosis in cancer cell lines, with a high percentage of caspase-3 activation. Hyaluronidase also inhibits angiogenesis and induces cell death through an unknown mechanism. This enzyme functions as an extracellular matrix-degrading enzyme and has been shown to have anti-inflammatory properties.</p>

<p>Stanniocalcin-1 is a protein that belongs to the stanniocalcin family of proteins. It is expressed by a variety of tissues and has been shown to have chemotactic, pleiotropic, and adipogenic effects. Stanniocalcin-1 also regulates luteinization and homologous differentiation in cells. The recombinant form of this protein has been shown to stimulate the growth of cells in culture with high levels of expression. Additives such as deionized water and chromatographic techniques can be used to purify this protein.</p>

<p>IL 17 Mouse is a recombinant mouse monoclonal antibody that binds to the IL-17 receptor. It has been shown to activate the signal transduction pathway by binding to the IL-17 receptor and inducing activation of nuclear factor kappa B (NF-κB) and other signal transducers. This antibody is used as a research tool in cell biology, pharmacology, and immunology. IL 17 Mouse is a high purity product with an amino acid sequence identical to that of human IL-17 receptor, with no detectable contaminants.<br>!--</p>

<p>FGF-19 is a protein that has been shown to be an activator of the FGF receptor. It also has been shown to act as a ligand for the FGF receptor, which is a cell surface-bound protein. This protein is involved in the regulation of ion channels and other cellular processes that are important for growth and development. Recent studies have demonstrated that FGF-19 can inhibit the binding of peptides to antibodies, which may have an effect on pharmacology and immunology.</p>

<p>Secretogranin III, human, recombinant is a research peptide that is produced using Escherichia Coli. This protein is involved in various physiological processes and has been widely studied in the field of neuroscience. Secretogranin III plays a crucial role in the regulated secretion of hormones and neuropeptides. It is also involved in the formation and trafficking of secretory granules within cells. The recombinant form of Secretogranin III offers researchers a valuable tool for studying its functions and mechanisms in different biological systems.</p>

Anti Urocortin (3-40) Serum is a peptide that can be used as a research tool to activate ion channels and ligand receptors. This product is a high purity, lyophilized serum that can be reconstituted with water. Anti Urocortin (3-40) Serum has been shown to inhibit protein interactions in the cell biology and pharmacology fields. The CAS number for this product is 103425-75-4.

<p>IL 4R is a receptor for Interleukin-4. It is a member of the type II cytokine receptor family and has been shown to be an inhibitor of cell proliferation. IL 4R also interacts with the protein tyrosine phosphatase SHP2, which plays a role in signaling pathways. IL 4R binds to specific Ligands, such as IL-4 and IL-13, that are found in the extracellular matrix and on the surface of cells. These interactions activate the receptor and lead to intracellular signaling cascades. The protein's activation can be inhibited by small molecules like peptides or antibodies that bind to its extracellular domain.</p>

Amino-dPEG®24-Amido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®24-Amido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>G CSF Mouse is a recombinant protein that is an inhibitor of the G-CSF receptor. It has been shown to inhibit the activity of ion channels in cells. G CSF Mouse is a research tool that can be used to study the biology of proteins and peptides. This product can also be used for antibody production and as a reagent for cell biology and pharmacology experiments.</p>

<p>Human s-IgA (Saliva) ELISA (1ea) is a human IgA immunoglobulin that is found in saliva. It is used to detect the presence of antibodies against specific substances such as drugs, food, and other allergens.</p>

<p>IL-9 is a cytokine that is involved in the regulation of immune system. IL-9 signaling is essential for the induction of B cell responses and mast cell activation, and IL-9 is also expressed in epithelial cells. The IL-9 Mouse (CAS No. 207870-05-2) antibody reacts with IL-9 protein, which has a molecular weight of 18 kDa. This antibody detects an epitope corresponding to amino acids 1 to 13 of human Interleukin 9 (IL-9).</p>

<p>Bis-dPEG®9-NHS Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®9-NHS Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>monoFITC INSL3 is a fluorescent peptide that can be used as a research tool. It is an activator of the Ligand-Receptor interaction and has been shown to inhibit Ion channels. The high purity of this product is suitable for use in Cell Biology, Antibodies, and Protein interactions. This ligand has also been shown to bind to Receptors and is used in Pharmacology and Peptides. monoFITC INSL3 has been shown to have anti-inflammatory properties in the body, which may be due to its inhibition of Prostaglandin synthesis.</p>

<p>Mono-fluoro-4-carboxylic acid, N-(3,6-dioxo-1,2,3,6-tetrahydro-7H-purin-9yl) ester (FITC RLN1) is a fluorescent ligand for the receptor. It binds to the receptor and activates it by increasing the frequency of opening of ion channels on the cell membrane. This ligand can be used as a pharmacological tool in research into ion channels and ligands.</p>

<p>monoFITC INSL6 is a Research Tool that is an activator of the Insulin-like peptide 6 receptor (INSL6). It is a ligand that binds to the Insulin-like peptide 6 receptor and activates it. MonoFITC INSL6 can be used in research on Cell Biology, Antibodies and Ion channels. This product has high purity, with a CAS number, and is a Protein Interactions inhibitor. MonoFITC INSL6 can be used in Pharmacology or Peptides, as well as Life Science.</p>

<p>Anti Pro-LH-RH (1-26) is a peptide that binds to the LH/hCG receptor of human cells and inhibits the binding of hCG and LH. This peptide is a cell biology research tool that can be used in antibody production and as an inhibitor in receptor binding studies. Anti Pro-LH-RH (1-26) has been shown to bind to the LH/hCG receptor of human cells and inhibit the binding of hCG and LH, which are necessary for sperm maturation. It also has been shown to inhibit ion channels, such as calcium channels. The high purity of this product makes it ideal for use in antibody production and receptor binding studies.</p>

<p>BMP 2 is a member of the TGF-β superfamily and is a potent activator of bone morphogenetic protein receptors. It is a ligand for type I and II receptor complexes. BMPs play a crucial role in embryonic development, tissue repair, and maintenance of cartilage. BMP 2 has been shown to inhibit ion channels such as calcium-activated potassium channels. It also inhibits protein synthesis by inhibiting the activation of transcription factors like CREB, c-Jun N-terminal kinase (JNK), and p38 mitogen activated protein kinase (MAPK). BMP 2 also binds to antibodies that are specific for phosphorylated receptor tyrosine residues, which can be used as research tools in immunohistochemistry experiments or other applications.</p>

<p>CPN-116 is an ion channel ligand that binds to the voltage-gated sodium channels of excitable cells. It is used for research purposes in pharmacology and cell biology. CPN-116 has been shown to activate the TRPM8 receptor, which is a ligand-gated cation channel expressed in cold sensing neurons. The purified peptide is supplied as a lyophilized powder containing at least 98% CPN-116 by weight.</p>

<p>SPDP-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>IGHG1 MS Calibrator-7 is a 25nmol peptide that is derived from the C region of Ig gamma-1 chain. It is a tryptic peptide that corresponds to the sequence of IGHG1. The molecular weight of this peptide is 584.6Da and its theoretical pI is 9.26. This calibrator can be used in various proteomics applications, including proteomics tools such as TrypTides and Proteomics Tools from New England Peptide Company.</p>

<p>Insulin I is a mouse insulin. Insulin I is an ion channel activator, which means that it can open and close ion channels in the cell membrane to regulate the flow of ions into and out of cells. Insulin I is a receptor ligand, which means that it binds to a receptor on the surface of cells to activate or inhibit their function. Insulin I is used as a research tool for pharmacology and cell biology, as well as for the study of protein interactions. It has been shown to have high purity. Insulin I has also been shown to be an inhibitor of cellular growth, but not always an apoptosis inducer.</p>

<p>Anti EGF (Rat) Serum is a research tool that can be used for the detection of protein-protein interactions and receptor-ligand interactions. This serum has a high purity and can be used in cell biology, pharmacology, and life science. Anti EGF (Rat) Serum is an inhibitor that binds to EGFR. It blocks the activation of EGFR by blocking ligand binding to EGFR or by preventing GPCR from activating downstream signaling pathways.</p>

<p>Mannose-binding lectin 2 (MBL2) is a protein that is encoded by the MBL2 gene. It is an activator of the lectin complement pathway, which plays an important role in innate immunity. MBL2 binds to mannose-rich oligosaccharides and activates the lectin complement pathway. This protein also interacts with ion channels, cell surface receptors and other proteins. The recombinant human MBL2 has been expressed in E. coli. The purified protein is supplied at &gt;95% purity and has a CAS number of 80613-62-8.</p>

<p>Noggin is a protein that is involved in the regulation of neuronal growth and development. It acts as a morphogen, binding to a receptor on the surface of cells and initiating signaling cascades that lead to changes in gene expression. Noggin binds to Retinoid-X-receptor (RXR) and the Ligand-binding domain of Notch1. These interactions may be important for the regulation of CNS cells, such as neurons and glial cells. The protein has been shown to have a role in synaptic plasticity, axonal guidance, and synaptogenesis. Noggin has also been shown to be an inhibitor of cell proliferation and an activator of cell differentiation.</p>

<p>FRETS-25Val is a research tool that is used to activate, inhibit, or modulate the function of ion channels. FRETS-25Val is an agonist of G protein-coupled receptors (GPCRs) and ligands for receptor tyrosine kinases (RTKs). It has been shown to bind to Ligand Binding Domains (LBDs) on cell surface receptors. FRETS-25Val binds to antibody Fc regions and also inhibits the binding of peptides to proteins by competing with them for binding sites.</p>

Bromoacetamido-dPEG®3-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®3-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Amyloid β (1-40) is a peptide that belongs to the group of amyloid proteins. It has been shown to decrease the activity of ion channels and receptors, as well as inhibit ligand binding to these receptors. Amyloid β (1-40) has also been shown to interact with other proteins by binding to them and inhibiting their function. Amyloid β (1-40) is used in research for pharmacology, cell biology, and neuroscience studies. It is purified from natural sources or synthesized in a laboratory, which yields high purity. The CAS number for this product is 43981-14-2.</p>

<p>The enzyme is a glycohydrolase that catalyzes the hydrolysis of gamma-glutamyl peptide bonds. It is a member of the family of enzymes that catalyze the hydrolysis of peptide bonds in proteins, polypeptides, and oligopeptides. The enzyme has been purified from Escherichia coli and characterized by chromatographic techniques and molecular mass determination. The gene encoding this protein has been cloned into prokaryotic expression vectors or eukaryotic expression vectors for use in protein studies or other investigations.</p>

<p>Fmoc-N-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Fmoc-N-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Magainin 1 is a research tool that belongs to the class of activators. It binds to receptor and ligand, which are proteins in cells. Magainin 1 is used as a tool in cell biology to study protein interactions and pharmacology, as well as for the study of ion channels. It has high purity and can be used with other reagents, such as antibodies or peptides, in research.</p>

<p>Anti Somatostatin (Human, Rat) Serum is a research tool that can be used to activate or suppress the function of cells by binding to their receptors. This antibody binds to somatostatin receptors and blocks their ability to bind to the ligand. It is also used for the detection of ion channels in cell biology. Antibody against somatostatin can be used as an inhibitor in pharmacological studies.</p>

<p>This product is an antiserum targeting amino acids 34-40 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.</p>

<p>Polystyrene is a thermoplastic polymer that is used in the production of polystyrene resins, which are used as building blocks for peptide synthesis. New England Peptide offers a variety of polystyrene resin products including particle resins and Rapp Polymere resins. The particle size of the resin ranges from 5-100 µm. Polymers can be synthesized using various methods including solid-phase synthesis and solution phase synthesis, which both require polystyrene resins. This product is available with a variety of functionalities, such as amine, hydroxyl and carboxyl groups.</p>

<p>Procalcitonin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids. Molecular weight is 12.8 kDa.amino acid sequence: APFRSALESS PADPATLSED EARLLLAALV QDYVQMKASE LEQEQEREGS SLDSPRSKRC GNLSTCMLGT YTQDFNKFHT FPQTAIGVGA PGKKRDMSSD LERDHRPHVS MPQNAN</p>

<p>Apelin-36 is a peptide hormone that is derived from a larger precursor protein. It is a member of the apelin peptide family, which is involved in regulating cardiovascular and metabolic functions.<br>Apelin-36 binds to a G protein-coupled receptor called APJ (apelin receptor), which is widely expressed in various tissues. The interaction between apelin-36 and APJ receptor leads to a range of physiological effects, such as cardiac contractility stimulation and blood pressure suppression as well as lowering body weight and improving glucose homeostasis.<br>Research has shown that apelin-36 may have therapeutic potential in the treatment of cardiovascular diseases, such as hypertension and heart failure, as well as metabolic disorders, such as obesity and diabetes. Apelin-36 has also been implicated in other physiological processes, including inflammation, angiogenesis, and cancer progression. This product is available as a 0.1 mg vial.</p>

<p>A gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>TentaGel; HL (High Load) (mean particle size 75 µm: capacity 04-06 meq/g)<br>Substitution Functional Group: -O-CH2-CH2-BrTentaGel</p>

<p>BMP 7 is a cytokine that belongs to the transforming growth factor beta (TGF-β) superfamily. It is produced by many cell types, including E. coli, in response to TGF-β and IL-1. BMP 7 has been shown to be involved in the regulation of cell proliferation and differentiation. BMP 7 has also been shown to be a potent inducer of cytokines such as IL-8, IL-6, IL-1β, and TNF-α from human mononuclear cells.</p>

<p>Z-Leu-Leu-H aldehyde is a water soluble and non-toxic chemical compound that belongs to the class of heterocycles. It inhibits ion channels by binding to their receptor and also has a high affinity for ligand binding sites. Z-Leu-Leu-H aldehyde is used as a research tool in pharmacology, cell biology, and antibody production. It can be used to activate or inhibit the function of proteins in cells by acting as an agonist or antagonist, respectively. This chemical is also an inhibitor with high purity, which is suitable for use in protein crystallization experiments.</p>

<p>[Ser(PO3H2)65]-Ubiquitin is a peptide that binds to the ubiquitin receptor, which is a protein that regulates the degradation of proteins. It has been shown to be an activator of ion channels and ligands for antibodies. This product is used as a research tool in Cell Biology and other life sciences. [Ser(PO3H2)65]-Ubiquitin may also be used as an inhibitor in pharmacology. This peptide has high purity and is CAS No. 544-81-4.</p>

<p>The MAPK1, ERK2, PRKM1, PRKM2 MS Calibrator (25nmol) is a kit that contains the peptide sequences of three MAP kinases: MAPK1, ERK2 and PRKM2. The kit is used in the study of protein kinases and can be used as a calibration standard for Western blotting. It contains the tryptic peptides of MAP kinases and their corresponding molecular weight markers.</p>

<p>FRETS-25His is a synthetic peptide that can be used as a research tool for studying receptor-ligand interactions. FRETS-25His binds to the extracellular loop of the alpha subunit of the nicotinic acetylcholine receptor and inhibits its activity. This peptide is useful for pharmacology studies, such as those investigating the effect of various drugs on the human body. FRETS-25His is synthesized with high purity and has a CAS number: 90415-01-3. FRETS-25His can be used in cell biology studies to study protein interactions, such as those between ion channels and ligands.</p>

<p>Big Endothelin-3 (Rat, 1-41 Amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide, that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11 and is available as a 0.1mg vial.</p>

<p>Prosaposin is a human, recombinant secretory protein that is produced by the freeze-drying of a lysosomal extract. It is used to treat cerebrospinal fluid that has been depleted of prosaposin. This protein functions as a linker and interacts with choline, glycosphingolipids, and phospholipids to form the myelin sheath in the central nervous system. Prosaposin can also be reconstituted with deionized water and aliquots containing 1 mg/mL of this protein are available for purchase.</p>

<p>PSA (53-92) is a peptide with the sequence of Gly-Gly-Ala-Pro-Lys. It is an activator of ion channels and can be used as a research tool in pharmacology, cell biology, and biochemistry. PSA (53-92) has been shown to be an inhibitor of the ligand binding domain of the human erythrocyte receptor for pyruvate dehydrogenase complex. The antibody that recognizes PSA (53-92) is also available.</p>

<p>Porcine follicle stimulating hormone (FSH) is a peptide hormone that belongs to the group of gonadotropin hormones. It is produced in the anterior pituitary gland and stimulates ovarian activity, as well as follicular growth in females. FSH has been shown to stimulate cell factor, an enzyme involved in erythropoiesis, through a dinucleotide phosphate-dependent polymerase chain reaction. FSH also has been shown to increase estradiol benzoate levels and disulfide bond formation. Porcine FSH can be used for in vitro fertilization by stimulating the growth of human egg cells in culture with human serum or sephadex g-100.</p>

<p>Endokinin C is a peptide that is an inhibitor of protein interactions. It has a CAS number of 52783-30-4. Endokinin C has been shown to have the ability to inhibit the activity of ion channels, such as potassium channels, sodium channels, and calcium channels. This peptide also activates ligands and receptors in the body, including epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGF1R), and nerve growth factor receptor (NGFR). Endokinin C is purified from human urine. It has high purity with a protein content of less than 5%.</p>

<p>Centromere protein B (CENP-B) is a protein that belongs to the histone H3 family. It is one of the proteins involved in regulating chromosome segregation during mitosis and meiosis. CENP-B has been shown to be involved in the activation of kinetochores, which are structures on the surface of chromosomes that attach to microtubules and help with mitotic chromosome movement. Centromere protein B can also be used as a ligand or receptor, or a tool for cell biology, immunology, and pharmacology research.</p>

<p>Anti VIP (Human, Porcine) Serum is a research tool for the study of protein interactions. It inhibits the binding of VIP to its receptor. Anti VIP (Human, Porcine) Serum is an inhibitor and activator of ion channels. It has been shown to bind to a wide variety of receptors and ligands, including those involved in cell biology and pharmacology. This product is highly purified and can be used in life science research as well as antibody production.</p>

<p>Fmoc-Asn[per-O-Boc-(Fucα1-6GlcNAcß)] is a glycopeptide that is synthesized with an N-linked glycosylation. This product is a disaccharide that contains two hydroxy groups and one hydroxy group. The peptide bond has been shown to be stable in both acidic and basic conditions. It can be used for peptide synthesis and has an affinity for the sugar moieties of proteins.</p>

<p>GDNF is a growth factor that was originally identified in the rat brain as a trophic factor for dopaminergic neurons. It has been found to be involved in the regulation of mood and to have acute-phase effects in animals. GDNF is also an antigen that stimulates antibody production and is used as a diagnostic marker for certain diseases. GDNF is a neurotrophic factor that affects neural progenitor cells, promoting their survival and differentiation into neurons. It has been found to have neurotrophic effects on striatal dopaminergic neurons, which may be responsible for its antidepressant effect. GDNF is a member of the family of neurotrophins, which includes nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). The gene encoding GDNF contains two exons separated by an intron and encodes a protein with 209 amino acids.</p>

<p>Anti PTHrP (15-34)-NH₂, humanSerum is a peptide that specifically binds to the receptor of parathyroid hormone related protein (PTHrP). It inhibits the activity of this receptor by binding to it and preventing PTHrP from binding. This peptide is used as a research tool to study the effects of PTHrP on cells in culture.</p>

<p>TTR MS Calibrator is a research tool that is used to calibrate the mass spectrometer for TTR peptide analysis. It has an excellent purity and is provided as a lyophilized powder. This calibrator contains high-quality TTR peptides with a low level of impurities. The product can be used for pharmacological or proteomic studies, as well as other research applications.</p>

<p>This HER-2 Light Tryptic Peptide standard can be applied to protein identification and quantitation studies. HER-2 is the human epidermal growth factor receptor 2, which has tyrosine kinase activity and is involved the control of epithelial cell growth and differentiation. The overexpression of HER2 has been implicated with adenocarcinomas such as cervix, lung, ovary and breast.</p>

<p>Adrenomedullin (ADM) is a peptide hormone that is a potent activator of the human endothelium. ADM has been shown to be an inhibitor of ion channels, which are pores in cell membranes through which ions can flow. It also interacts with many other proteins, including receptors and ligands. ADM has been shown to have pharmacological properties such as vasoconstriction and anti-inflammatory effects.</p>

<p>Rituximab is a chimeric monoclonal antibody used in the treatment of some cancers like CD20 non-Hodgkin's lymphoma and a few autoimmune conditions such as rheumatoid arthritis. However, antibody treatment can lead to generation of neutralising antibodies thus curtailing the efficacy of the therapy. CD 4+ T cells are critical to initiate antibody response so identification of epitopes within molecules using T cell assays can be a vital tool for understanding the immune response and thereby prevent induction of neutralising antibodies. Within rituximab, the variable region of the light chain (41-55) was found to have strong affinity for leukocytes in a specific binding assay, the epitope was also correlated to patients who developed neutralising antibodies. This T cell epitope within rituximab in further immune studies could help design or selection of antibodies without T cell epitopes present for low immunogenicity.</p>

<p>Alyerserin-2b is a C-terminally α-amidated 17 residue cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-2a, 2b and -2c show some sequence identity with bombinin H6, a peptide from the skins Bombinatoridae family of frogs.Alyteserin-2b is most potent against the Gram-positive bacteria-Staphylococcus aureus and has weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards them compared to conventional antibiotics. Alyteserin-2b has a low probability of adopting a helical conformation unlike related Alyteserin-2 peptides.</p>

<p>Interactions between ECM proteins and growth factors were only thought to concentrate growth factors and to enhance their multimerisation for signalling. However, recent studies indicate that binding of growth factors to ECM proteins may enhance interactions between multi-domain ECM proteins, such as fibronectin (FN), with cell surface receptors, mostly integrins. The discovery of P12 amide revealed that a small peptide can mimic the role of FN with PDGF-BB, suggesting that some ECM-growth factor interactions may be less complex. P12 amide can not only bind to PDGF-BB, but also promote cell survival and improve rat skin burns in a dose dependent manner.P12 amide may have a clinical potential, especially in the reduction of cell death after tissue damage.</p>