Peptides

<p>Interferon-beta 1a is a cytokine that is used to treat multiple sclerosis and other diseases. It is the product of human recombinant DNA technology and has been shown to be an effective treatment for MS. Interferon-beta 1a inhibits the growth of neuroblastoma cells by inducing apoptosis, or programmed cell death. The drug also down-regulates the expression of proinflammatory cytokines in sh-sy5y neuroblastoma cells. Interferon-beta 1a has been shown to inhibit the proliferation of CHO (Chinese Hamster Ovarian) cells in vitro and may have therapeutic potential for the treatment of breast cancer, colorectal cancer, and ovarian cancer.</p>

<p>GnGn-bi-Asn-PABA is a peptide that has been shown to activate the nicotinic acetylcholine receptor. It binds to the ligand binding site of the receptor and mimics the natural neurotransmitter acetylcholine, increasing the probability of neurotransmitter release. GnGn-bi-Asn-PABA has also been shown to inhibit calcium ion channels and ligand gated ion channels, which are proteins that regulate the flow of ions in and out of cells. GnGn-bi-Asn-PABA is a research tool used for studying cell biology and pharmacology.</p>

<p>Exendin (5-39) is a synthetic Mexican beaded lizard venom-derived peptide and is available as a 0.5mg vial. This product has has a GLP-1 Receptor antagonist application..</p>

<p>DOTA-tris(Acid)-Amido-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>HP MS Calibrator-8 (25nmol) is a peptide that is used in proteomics research. It contains haptoglobin beta chain, haptoglobin alpha chain, zonulin, tryptic peptide and trypTides. This product can be used to identify the presence of Haptoglobin beta chain in samples. HP MS Calibrator-8 (25nmol) also has the ability to inhibit protein synthesis in human cells.</p>

DBCO-dPEG®4-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DBCO-dPEG®4-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Leptin is a protein hormone that is produced by fat cells. Leptin regulates appetite and energy use, and it has been shown to be involved in the regulation of body weight. Leptin binds to receptors on the surface of cells, which activates signaling pathways inside the cell. This receptor can be activated by other ligands such as ghrelin, adiponectin, and insulin. Leptin also inhibits ion channels in neurons, resulting in an increase in potassium conductance.</p>

<p>MAL-dPEG®8-t-Boc-Hydrazide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®8-t-Boc-Hydrazide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Phth-dPEG®4-Tris(-TFP Ester)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Phth-dPEG®4-Tris(-TFP Ester)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance. It is also known as a vasopressor and as an activator of the renin-angiotensin system. Angiotensin II is synthesized from the precursor protein angiotensinogen, which is cleaved by renin to form angiotensin I. Angiotensin I is then converted to angiotensin II by the enzyme ACE (angiotensin-converting enzyme). Angiotensin II is found in the lungs, kidneys, adrenal glands, brain and blood. The biological effects of angiotensin II are mediated by its receptor on cells which stimulates G proteins to activate phospholipase C activity. This leads to increased levels of inositol triphosphate (IP3) and diacylglycerol (DAG) which cause release of calcium ions from intracellular stores such as the endoplasmic

Bis-MAL-Lysine-dPEG®4-TFP Ester is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. This product has a particle size of 280-320 µm and capacity: 02-03 meq/g.

IL-23 is a cytokine that belongs to the IL-12 family and plays an important role in the regulation of immune responses. It has been shown to activate T cells and promote the differentiation of B cells into immunoglobulin-producing cells. IL-23 is also produced by keratinocytes, epithelial cells, fibroblasts, and other immune cell types. IL-23 is an inhibitor that blocks the activation of specific receptors on cells. The CAS number for IL23 is 78626-61-8. This product can be used as a research tool for studying protein interactions and receptor activity. It can also be used as a reagent for antibody production or as a high purity protein for life science research.

<p>Biotin-dPEG®3-TFPA is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®3-TFPA is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Anti Motilin (Porcine) Serum is a potent inhibitor of motilin, a peptide hormone that stimulates the gastrointestinal tract. The anti motilin serum is useful for pharmacological research as well as in cell biology, where it can be used to inhibit motilin-induced contraction in cultured cells. Anti motilin also serves as an excellent research tool for studying the regulation of other receptors and ion channels. It has been shown to activate these receptors and ion channels.

H2N-PEG-O-C3H6-COOH hydrochloride is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. H2N-PEG-O-C3H6-COOH hydrochloride is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Anti Basic-FGF, human serum is a peptide that is used as a research tool for studying the activation of protein kinase C. It can be used as an activator or inhibitor, depending on its concentration. Anti Basic-FGF, human serum has been shown to inhibit cell proliferation and migration in vitro. This peptide also binds to the receptor for Basic Fibroblast Growth Factor (bFGF) and interacts with the ligand binding site of the receptor. Anti Basic-FGF, human serum can be used to study protein interactions and signaling pathways involved in cancer cell growth.<br>Anti Basic-FGF, human serum is a highly purified recombinant peptide with an amino acid sequence identical to that of bovine Basic Fibroblast Growth Factor (bFGF). It has been shown to inhibit bovine FGF2 binding to bFGF receptors and reduce cellular proliferation in vitro. This peptide also inhibits angiogenesis induced by bFGF in</p>

The CYP2D6 MS Calibrator is a peptide that is used for calibrating the mass spectrometer. It is a tryptic peptide and contains an internal standard, which can be used to calculate the concentration of the peptide. The peptides are synthesized using recombinant DNA technology and purified by HPLC.

<p>Amino-dPEG®11-ONH-t-boc is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®11-ONH-t-boc is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Angiotensin II is a peptide that is involved in the regulation of blood pressure and fluid balance. Angiotensin II has been shown to be an activator of angiotensin-converting enzyme (ACE), which converts angiotensin I into angiotensin II. ACE is inhibited by the drug captopril, which reduces the conversion of angiotensin I to angiotensin II. Angiotensin II has also been shown to activate potassium channels, including voltage-gated potassium channels, and inhibit calcium channels. It has been found to bind to the receptor AT1 and trigger a number of responses, including vasoconstriction and increased heart rate. The ligand for this receptor is angiotensin II. The pharmacology of Angiotensin II includes its ability to act as an inhibitor on protein interactions with various proteins or enzymes, such as alpha-1 antitrypsin or beta-2 adrenergic receptors.</p>

Anti Urocortin (Rat) Serum is a protein that can be used as a research tool in pharmacology, cell biology, and other life science fields. Anti Urocortin (Rat) Serum is an inhibitor of the urocortin receptor.

<p>Methoxytrityl-S-dPEG®4-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Methoxytrityl-S-dPEG®4-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Adrenomedullin 2, a peptide hormone product with a disulfide bond between Cys10-Cys15. Adrenomedullin 2 can be applied as a potent cardiovascular and renal regulator as well as a suppressor for food intake and gastric emptying. This product is available as a 0.1mg vial.</p>

<p>Mouse GIP (Active) ELISA (1ea) is a Mouse GIP (Active) ELISA Kit that can be used to measure the levels of active Mouse GIP in serum, plasma or other biological fluids. The assay employs a monoclonal antibody specific for mouse GIP. This antibody captures Mouse GIP from test samples, and a biotinylated polyclonal antibody specific for mouse GIP is then used to measure the captured Mouse GIP by means of a colorimetric reaction. The amount of Mouse GIP in the test sample is inversely proportional to the intensity of the color developed.</p>

<p>Hyaluronidase is a glycosaminoglycan that is synthesized by the cells of the synovial membrane, and is used in the treatment of osteoarthritis. It has been shown to be potent inducers of apoptosis in cancer cell lines, with a high percentage of caspase-3 activation. Hyaluronidase also inhibits angiogenesis and induces cell death through an unknown mechanism. This enzyme functions as an extracellular matrix-degrading enzyme and has been shown to have anti-inflammatory properties.</p>

<p>HGF is a cytokine that is thought to play an important role in the development of cancer. HGF stimulates the proliferation, differentiation, and survival of cells and acts as a chemoattractant for cells. It is also known to inhibit apoptosis and promote angiogenesis. HGF has been found in many human tissues, including liver, lung, kidney, heart, muscle, pancreas and brain. HGF is a member of the platelet-derived growth factor family and can be used as a marker for certain types of cancer.</p>

<p>FRETS-25Pro (1 umol) is a peptide that belongs to the group of activator. It has been shown to inhibit ion channels and protein interactions, as well as receptor and ligand. FRETS-25Pro (1 umol) has high purity, which will be useful in research tools such as antibody or cell biology.</p>

<p>Stanniocalcin-1 is a protein that belongs to the stanniocalcin family of proteins. It is expressed by a variety of tissues and has been shown to have chemotactic, pleiotropic, and adipogenic effects. Stanniocalcin-1 also regulates luteinization and homologous differentiation in cells. The recombinant form of this protein has been shown to stimulate the growth of cells in culture with high levels of expression. Additives such as deionized water and chromatographic techniques can be used to purify this protein.</p>

<p>IL 17 Mouse is a recombinant mouse monoclonal antibody that binds to the IL-17 receptor. It has been shown to activate the signal transduction pathway by binding to the IL-17 receptor and inducing activation of nuclear factor kappa B (NF-κB) and other signal transducers. This antibody is used as a research tool in cell biology, pharmacology, and immunology. IL 17 Mouse is a high purity product with an amino acid sequence identical to that of human IL-17 receptor, with no detectable contaminants.<br>!--</p>

Anti-GIP (Rat) Serum is a recombinant, affinity-purified antibody that recognizes the peptide sequence of rat GIP. Anti-GIP (Rat) Serum is an important research tool used in the study of protein interactions, activation, ligand binding, and receptor activation. It can also be used to inhibit GIP activity by blocking the binding site on the receptor. Anti-GIP (Rat) Serum is available in high purity and at competitive pricing.

<p>BNP Human, His is a recombinant peptide which inhibits the activity of the beta-adrenergic receptors. It is a research tool that can be used to study protein interactions and receptor activation. BNP Human, His has been shown to inhibit the activity of ion channels in cells. This peptide also activates G-protein coupled receptors and is used as a reagent for antibody production.</p>

<p>Matrix Metalloproteinase-13 is a metalloproteinase with a broad substrate specificity. It is used as a prognostic factor for cancer patients, and is also used to diagnose and monitor inflammatory bowel disease. In addition, it has been shown to have chemiluminescence activity in the presence of hydrogen peroxide. The MMP-13 protein can be detected using Western blotting with monoclonal antibodies against the human MMP-13 protein. This recombinant human Matrix Metalloproteinase-13 (rMMP-13) can be used as an antigen for immunoassays such as ELISA and RIA.</p>

<p>TIP39 is a peptide inhibitor that is a member of the TIP family. It inhibits the activity of calcineurin, a calcium-dependent phosphatase enzyme, and thereby prevents it from dephosphorylating nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which regulates signaling pathways that control inflammatory responses. TIP39 has been shown to inhibit calcineurin in both human and bovine cell lines. This drug has been used as a research tool to study peptide-receptor interactions and ion channels.</p>

G-CSF is a glycoprotein that belongs to the cytokine family and is used as a medication. It stimulates the production of neutrophils, which are important in defending the body against infections. G-CSF also has a role in stimulating stem cell production and can be used to treat cancer patients undergoing chemotherapy. G-CSF binds to receptors on the surface of cells, activating intracellular signaling pathways. The binding of G-CSF to its receptor activates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 causes release of calcium from intracellular stores, leading to an increase in cytosolic free calcium concentration. DAG activates protein kinase C (PKC)

<p>Leptin ELISA Kit is a sandwich ELISA for the quantitative measurement of mouse leptin in rat serum. Leptin is a 16-kDa peptide hormone that regulates energy balance and body weight. It is produced by adipose tissue, and circulates in the blood as a protein complex with high-density lipoprotein (HDL). The assay employs monoclonal antibodies (MAbs) to measure mouse leptin in rat serum. The Mabs are specific for the mouse leptin sequence, which allows them to selectively bind to the mouse leptin in rat serum. Quantitative measurements of mouse leptin can be made using standard colorimetric procedures.</p>

<p>FGF-19 is a protein that has been shown to be an activator of the FGF receptor. It also has been shown to act as a ligand for the FGF receptor, which is a cell surface-bound protein. This protein is involved in the regulation of ion channels and other cellular processes that are important for growth and development. Recent studies have demonstrated that FGF-19 can inhibit the binding of peptides to antibodies, which may have an effect on pharmacology and immunology.</p>

Prolactin is a protein that is secreted by the anterior pituitary gland. It has many functions, including the stimulation of milk production and the regulation of other hormones. Prolactin Human contains purified human prolactin in a lyophilized powder form. It can be reconstituted with sterile water for injection or bacteriostatic water for injection for use in research or therapeutic applications.

Anti CGRP (Rat) Serum is a research tool used to study the function of calcitonin gene-related peptide (CGRP) in cell biology. It is an antibody that binds to the CGRP receptor and blocks the activation of ion channels, which are important for pain perception. This serum can be used as a blocking agent in experiments to study the effects of CGRP on cells.

<p>Secretogranin III, human, recombinant is a research peptide that is produced using Escherichia Coli. This protein is involved in various physiological processes and has been widely studied in the field of neuroscience. Secretogranin III plays a crucial role in the regulated secretion of hormones and neuropeptides. It is also involved in the formation and trafficking of secretory granules within cells. The recombinant form of Secretogranin III offers researchers a valuable tool for studying its functions and mechanisms in different biological systems.</p>

Leptin is a peptide hormone that is produced by adipocytes and regulates appetite. Leptin binds to the leptin receptor, which is found in many tissues including the hypothalamus. The receptor activates an intracellular second messenger system that includes the protein kinase JAK2, leading to the activation of STAT3 transcription factor. Leptin has been shown to inhibit ion channels and activate or block receptors, depending on the type of cell it binds with.

<p>Phosphoramidon is a peptide that is used as a research tool. It has been shown to activate the protein kinase C, which plays a role in the regulation of ion channels and other cellular functions. Phosphoramidon binds to the receptor site of protein A and inhibits the binding of phosphorylated erythropoietin (EPO) to its receptor. EPO is an important hormone for red blood cell production.</p>

<p>Biotin-dPEG®12-DBCO is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Biotin-dPEG®12-DBCO is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

DOTA-tris(Acid)-Amido-dPEG®11-Bromoacetamide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®11-Bromoacetamide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>GLP-2 is a gut peptide that belongs to the glucagon-like peptide family. It is produced by K cells in the ileum and colon, and also by L cells in the stomach. GLP-2 is composed of 31 amino acids, has a molecular weight of 3,000 daltons, and has an amino acid sequence that is highly conserved among species. The EIA kit for human GLP-2 (GLP-2 Human) is designed to detect the presence of GLP-2 in samples from human serum or plasma.</p>

<p>Antithrombin III light tryptic peptide standard for protein identification and quantitation studies. Antithrombin III is a glycoprotein found in blood plasma and is involved in the regulation of the coagulation process.</p>

Anti Urocortin (3-40) Serum is a peptide that can be used as a research tool to activate ion channels and ligand receptors. This product is a high purity, lyophilized serum that can be reconstituted with water. Anti Urocortin (3-40) Serum has been shown to inhibit protein interactions in the cell biology and pharmacology fields. The CAS number for this product is 103425-75-4.

<p>IL 4R is a receptor for Interleukin-4. It is a member of the type II cytokine receptor family and has been shown to be an inhibitor of cell proliferation. IL 4R also interacts with the protein tyrosine phosphatase SHP2, which plays a role in signaling pathways. IL 4R binds to specific Ligands, such as IL-4 and IL-13, that are found in the extracellular matrix and on the surface of cells. These interactions activate the receptor and lead to intracellular signaling cascades. The protein's activation can be inhibited by small molecules like peptides or antibodies that bind to its extracellular domain.</p>

<p>MAL-dPEG®24-Amido-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-Amido-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amino-dPEG®4-(m-dPEG®11)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-(m-dPEG®11)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

TentaGel is a synthetic resin that has been designed to bind to the surface of particles. It has the ability to form a continuous matrix around the particle and has shown potential for use in drug delivery, biotechnology, and nanotechnology. TentaGel can be used as building blocks by adding monomers or polymers which will then be embedded within the gel. This allows for more control over the properties of the final product.

Anti Pancreatic Polypeptide (18-36), humanSerum is a recombinant protein that belongs to the group of peptides. It is an activator of ion channels, which are proteins that regulate the flow of ions across cell membranes. This product is used as a research tool in pharmacology and cell biology. Anti Pancreatic Polypeptide (18-36), humanSerum has been shown to inhibit the activity of ion channels by binding to their ligands, thereby preventing activation. The purified recombinant protein has no detectable endotoxin levels and is suitable for use in research applications.

<p>IL1-beta is a pro-inflammatory cytokine that belongs to the Interleukin family. It is expressed in response to inflammation, trauma, and infection and can be found in many tissues of the body. IL1-beta has been shown to have a wide variety of effects on the body including regulating cell growth and differentiation. IL1-beta has also been shown to bind with high affinity to specific receptors that are known as type I interleukins. These receptors are able to activate other cells such as T cells and macrophages, which produce more inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ).<br>IL1-beta Mouse is a mouse monoclonal antibody that binds specifically with IL1-beta. This antibody can be used for immunohistochemistry or Western blotting experiments. It can also be used for blocking studies using an ELISA assay or RIA assay.</p>

<p>CIF1 is a protein that in humans is encoded by the CIF1 gene. It belongs to the family of ion channels and ligand-gated ion channels. The channel is activated by acetylcholine, a neurotransmitter, and mediates fast synaptic transmission at neuromuscular junctions. CIF1 has been shown to bind to the nicotinic acetylcholine receptor (nAChR) subunit alpha-4/beta-2. This binding leads to inhibition of nAChR function, which may be useful for treatments of conditions such as Parkinson's disease or Alzheimer's disease.</p>

Amino-dPEG®24-Amido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®24-Amido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Methoxytrityl-S-dPEG®8 Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Methoxytrityl-S-dPEG®8 Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Heat Shock Protein-90 alpha (HSP-90α) is a molecular chaperone protein that is involved in the folding and stabilization of proteins. HSP-90α is a member of the HSP family, which are known to be involved in many processes such as apoptosis, cell cycle regulation, DNA repair, and intracellular signaling. HSP-90α has been shown to inhibit the replication of viruses such as HIV by binding to viral proteins and preventing their assembly into virus particles. This protein also has antiviral effects on other viruses such as influenza and herpes simplex virus type 1.</p>

<p>Insulin Chicago is a recombinant human insulin produced in E. coli. It is an insulin analog that has improved pharmacokinetic properties and a more rapid onset of action after subcutaneous injection, with a duration of activity approximately twice as long as regular insulin. Insulin Chicago has been shown to be effective in reducing the incidence of hypoglycemia in type 1 diabetes mellitus patients, especially when used in combination with sulfonylureas or metformin. This product can also be used as a research tool for the study of protein interactions, peptides, and antibodies. Insulin Chicago has high purity and is supplied in vials containing 100 units/mL or 500 units/mL.</p>

<p>TGF b 1 is a member of the transforming growth factor family and is a potent inhibitor of cell proliferation. Recombinant human TGF b 1 has been shown to inhibit the proliferation of various cell types in culture, including fibroblasts, endothelial cells, and smooth muscle cells. It also inhibits tumor growth in vivo. The binding site for TGF b 1 on target cells has been localized to the extracellular domain of type II receptor kinase, which is composed of three immunoglobulin-like domains. This protein can be used as an antibody or ligand to study protein interactions.</p>

Des-Arg9-Bradykinin is a peptide that is structurally related to bradykinin. It is synthesized by removing the first two amino acids from the N terminus of bradykinin and replacing them with an acetyl group. It has been shown to have potent activity against inflammatory cells in vitro, including mast cell degranulation and histamine release. Des-Arg9-Bradykinin also inhibits the production of nitric oxide, which may be responsible for its anti-inflammatory effects.

<p>Please enquire for more information about Fmoc-Trp-Rink-Amide MBHA Resin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>G CSF Mouse is a recombinant protein that is an inhibitor of the G-CSF receptor. It has been shown to inhibit the activity of ion channels in cells. G CSF Mouse is a research tool that can be used to study the biology of proteins and peptides. This product can also be used for antibody production and as a reagent for cell biology and pharmacology experiments.</p>

<p>Human s-IgA (Saliva) ELISA (1ea) is a human IgA immunoglobulin that is found in saliva. It is used to detect the presence of antibodies against specific substances such as drugs, food, and other allergens.</p>

<p>Neuromedin U is a peptide that plays a role in the regulation of cardiovascular function and the modulation of pain. It has been found to activate receptors for calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). Neuromedin U has also been found to be an inhibitor of ligand-induced activation of ion channels, such as those activated by bradykinin or histamine. This protein can be used as a research tool in cell biology, pharmacology, and biochemistry.</p>

<p>Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.<br>Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.</p>

<p>m-dPEG®12-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

A cell-penetrating peptide toxin whose sequence is derived from wasp venom and a potent activator of heterotrimeric G proteins. One letter code: INLKALAALAKKIL-NH2

<p>IL-9 is a cytokine that is involved in the regulation of immune system. IL-9 signaling is essential for the induction of B cell responses and mast cell activation, and IL-9 is also expressed in epithelial cells. The IL-9 Mouse (CAS No. 207870-05-2) antibody reacts with IL-9 protein, which has a molecular weight of 18 kDa. This antibody detects an epitope corresponding to amino acids 1 to 13 of human Interleukin 9 (IL-9).</p>

<p>Hirudin is a protein that has been isolated from the salivary gland of the medicinal leech. It is used to treat thrombosis, or blood clots, and works by neutralizing the activity of thrombin. Hirudin is an enzyme that contains a peptide sequence that binds to thrombin and prevents it from activating other factors in the blood clotting process. The recombinant form of hirudin is produced in Escherichia coli and can be purified using chromatographic techniques. This form of hirudin has increased biological activity than native hirudin due to its higher stability and solubility.</p>

<p>Bis-dPEG®9-NHS Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®9-NHS Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Bromoacetamido-dPEG®11-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®11-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>TFF3 is a human protein that is encoded by the TFF3 gene. The TFF3 protein binds to the TGF-β1 receptor and activates it, which causes downstream signaling in cells. It is also a ligand for the activator protein 2 (AP-2) transcription factor, which regulates cell proliferation and differentiation. TFF3 has been shown to inhibit ion channels and may play a role in regulating cellular functions such as metabolism, growth, or apoptosis.</p>

<p>This is a vivitide catalogue product. Please send your vivitide product enquiry to sales@vivitide.com for an up-to-date price and availability.</p>

Big ET-1 is a peptide hormone that is a potent activator of the endothelin receptors. It has been shown to be involved in the regulation of blood pressure and intracellular ion concentrations. Big ET-1 (Porcine, 22-39) Antiserum can be used in immunohistochemical studies, Western blotting and ELISA. This product is suitable for use in research on the role of endothelin in cell biology, pharmacology, and molecular biology. The antiserum recognizes Big ET-1 with high specificity and affinity.

<p>Anti GLP-1 (7-36)-NH₂, human serum is a recombinant protein that inhibits the activity of the glucagon-like peptide-1 receptor. It is used as a research tool to study the role of GLP-1 and its receptor in regulating blood glucose levels. Anti GLP-1 (7-36)-NH₂, human serum can be used as a ligand for the isolation of the GLP-1 receptor from cells. The anti GLP-1 (7-36)-NH₂, human serum is also used to study ion channels and antibody binding.</p>

<p>Phthalimidooxy-dPEG®4-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Phthalimidooxy-dPEG®4-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Insulin II is a peptide hormone that is secreted by the pancreas in response to elevated blood glucose levels. The insulin II receptor is a G protein-coupled receptor that binds insulin II and mediates its effects. Insulin II has been shown to inhibit ion channels, such as potassium channels, and activate other proteins, such as phospholipase C. Insulin II is used as a research tool for investigating protein interactions, receptor pharmacology, and ligand binding.</p>

<p>monoFITC INSL3 is a fluorescent peptide that can be used as a research tool. It is an activator of the Ligand-Receptor interaction and has been shown to inhibit Ion channels. The high purity of this product is suitable for use in Cell Biology, Antibodies, and Protein interactions. This ligand has also been shown to bind to Receptors and is used in Pharmacology and Peptides. monoFITC INSL3 has been shown to have anti-inflammatory properties in the body, which may be due to its inhibition of Prostaglandin synthesis.</p>

<p>DBCO-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DBCO-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>AC 253 is an amylin (AMY3) receptor antagonist.</p>

<p>IL 10 rat (IL-10) is a cytokine that belongs to the family of IL-10 cytokines. IL-10 binds to the IL-10 receptor and inhibits the release of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6. This cytokine has been shown to inhibit the production of reactive oxygen species by macrophages and neutrophils. The physiological role of this cytokine is not yet fully understood, but it is believed to be important for immune regulation in response to bacterial infections.</p>

<p>Rat GIP (Total) ELISA is a sandwich enzyme-linked immunosorbent assay for the quantitative determination of rat GIP in serum. The assay utilizes monoclonal antibodies that are specific to rat GIP and an enzyme-labeled anti-rat GIP antibody. The antibody is then incubated with a sample and the amount of labeled antibody bound to the antigen is determined.</p>

<p>Triosephosphate isomerase 1 (TPI1) is a cytosolic enzyme that catalyzes the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate to erythrose-4-phosphate and phosphoenolpyruvate. TPI1 has been shown to be an important regulator of glycolysis and gluconeogenesis, as well as in the maintenance of cellular redox state. This protein can act as both an inhibitor and activator depending on its interaction with other proteins. TPI1 has been implicated in the development of cancer, diabetes, Alzheimer's disease, Parkinson's disease, and atherosclerosis. TPI1 is also a research tool for studies into ion channels, receptor binding, and antibodies.</p>

<p>Mono-fluoro-4-carboxylic acid, N-(3,6-dioxo-1,2,3,6-tetrahydro-7H-purin-9yl) ester (FITC RLN1) is a fluorescent ligand for the receptor. It binds to the receptor and activates it by increasing the frequency of opening of ion channels on the cell membrane. This ligand can be used as a pharmacological tool in research into ion channels and ligands.</p>

<p>Joining peptide is a peptide that activates the receptor. It consists of two parts: a receptor-binding domain and a cell-penetrating domain. The receptor-binding domain is designed to bind to specific receptors on cells, while the cell-penetrating domain allows the peptide to cross the plasma membrane and penetrate into the cytoplasm. Joining peptide is used as an activator for ion channels and ligands for antibodies or receptors. Joining peptide can be used in research as a tool for investigating protein interactions, pharmacology, and cell biology.</p>

<p>TRAIL is a peptide that belongs to the group of cytokines. It activates the receptor-mediated apoptosis pathway in cells that have been stimulated by tumor necrosis factor-α (TNF-α) and other pro-inflammatory cytokines. TRAIL has also been shown to inhibit protein interactions, such as those between the TNF receptors and their ligands or receptors, like CD4. TRAIL also binds to the Fas receptor and its ligand, FasL, which leads to activation of caspases in a similar manner as FADD binding. The recombinant human TRAIL is a research tool for studying cell biology and pharmacology.</p>

<p>Anti Galanin (15-29) (Rat) Serum is a recombinant protein that is used as a research tool and has been shown to inhibit the activity of ion channels. It has been used to study the interactions between proteins, peptides, and receptors. This product has not been evaluated by the FDA for use in humans.</p>

<p>monoFITC INSL6 is a Research Tool that is an activator of the Insulin-like peptide 6 receptor (INSL6). It is a ligand that binds to the Insulin-like peptide 6 receptor and activates it. MonoFITC INSL6 can be used in research on Cell Biology, Antibodies and Ion channels. This product has high purity, with a CAS number, and is a Protein Interactions inhibitor. MonoFITC INSL6 can be used in Pharmacology or Peptides, as well as Life Science.</p>

CNP-22 is a peptide that is an inhibitor of the protein interactions between the potassium channel Kv1.3 and its natural ligand, CNP-23, which is a member of the guanylate cyclase family of proteins. It has been shown to activate the potassium channel Kv1.2 in rat neurons, leading to increased neuronal excitability. CNP-22 has been used as a research tool for studying ion channels and receptors. The purified antibody can be used as an immunogen in preparing polyclonal or monoclonal antibodies against CNP-22.

<p>m-dPEG®12-DSPE is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-DSPE is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Cbz-N-Amido-dPEG®8-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Cbz-N-Amido-dPEG®8-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Anti Pro-LH-RH (1-26) is a peptide that binds to the LH/hCG receptor of human cells and inhibits the binding of hCG and LH. This peptide is a cell biology research tool that can be used in antibody production and as an inhibitor in receptor binding studies. Anti Pro-LH-RH (1-26) has been shown to bind to the LH/hCG receptor of human cells and inhibit the binding of hCG and LH, which are necessary for sperm maturation. It also has been shown to inhibit ion channels, such as calcium channels. The high purity of this product makes it ideal for use in antibody production and receptor binding studies.</p>

<p>CD3 γ is a receptor protein that belongs to the immunoglobulin superfamily. It is involved in signal transduction and provides co-stimulation for T cells. CD3 γ is found on the surface of T cells, where it can bind to other proteins, including CD2, CD28, and members of the B7 family. The antibody against CD3 γ can be used as a research tool to study protein interactions, such as ligand-receptor binding or protein-protein interactions.</p>

<p>Salusin-beta is a peptide that is used as a research tool for the study of ion channels and protein interactions. Salusin-beta inhibits potassium currents in cells, which may be due to its ability to bind to receptor sites on the cell membrane. It also inhibits the activity of protein kinase C and calcium channels. Salusin-beta has been shown to be an inhibitor of protein interactions, such as those between α-synuclein and synaptotagmin, which are involved in Parkinson's disease.</p>

IL-12 is a heterodimeric cytokine that can be produced by T cells and natural killer cells. IL-12 is composed of two subunits, p35 and p40. It has been shown to induce the production of Interferon-gamma (IFN-γ) and other cytokines in response to infection with intracellular bacteria, such as Mycobacterium tuberculosis and M. avium complex. IL 12 Mouse is an antibody against the protein IL 12 that blocks its interaction with cell surface receptors on T cells, thus preventing the activation of these cells.

<p>Neuromedin B is a neuropeptide that is found in the central nervous system and peripheral tissues. It activates ligand-gated ion channels, including nicotinic acetylcholine receptors. Neuromedin B has been shown to inhibit the activity of voltage-gated potassium channels and calcium channels, which are involved in neurotransmission. It also inhibits the activation of phospholipase C, which is involved in cellular signaling pathways. This peptide can be used as a research tool for studying the pharmacology of peptides and as an antibody for immunohistochemistry studies.</p>

BMP 2 is a member of the TGF-β superfamily and is a potent activator of bone morphogenetic protein receptors. It is a ligand for type I and II receptor complexes. BMPs play a crucial role in embryonic development, tissue repair, and maintenance of cartilage. BMP 2 has been shown to inhibit ion channels such as calcium-activated potassium channels. It also inhibits protein synthesis by inhibiting the activation of transcription factors like CREB, c-Jun N-terminal kinase (JNK), and p38 mitogen activated protein kinase (MAPK). BMP 2 also binds to antibodies that are specific for phosphorylated receptor tyrosine residues, which can be used as research tools in immunohistochemistry experiments or other applications.

Polystyrene is a resin used in peptide synthesis. Polystyrene AM is a particle size of 250-315 µm. It is a building block for the synthesis of peptides. The polystyrene polymer has a high affinity for the amino acid side chains, which makes it an excellent choice for building blocks in peptide synthesis.

<p>Glutathione S-transferase recombinant is a research tool that can be used in the study of protein interactions. This enzyme is an activator, ligand and receptor that is involved in cell biology, immunology, and pharmacology. Glutathione S-transferase recombinant has been shown to have a role in the metabolism of xenobiotics and endogenous compounds. The glutathione S-transferases are a family of enzymes with broad substrate specificity that catalyze the conjugation of glutathione (GSH) with small electrophilic substrates such as drugs, environmental toxins, and electrophiles generated during oxidative stress.</p>

<p>Vasoactive Intestinal Peptide (VIP) Antiserum is a research tool that can be used to investigate the function of VIP in different cell types. VIP Antiserum is also an inhibitor of Protein interactions and may have applications in pharmacology.</p>

<p>TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.<br>Application: (90 µm)<br>Substitution Functional Group:-CH2-CH2-SH</p>