Peptides

<p>FRET-25Asp is a peptide that can be used in research as an activator, antibody, and inhibitor. It is used as a tool to study protein interactions with the cell membrane and ion channels. FRET-25Asp has also been shown to inhibit the activity of some receptors and ligands.</p>

<p>An aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition.  The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents.</p>

<p>Neurokinin A is a peptide that is derived from the precursor protein, preprotachykinin A, and has been found to be an endogenous ligand for the NK-1 receptor. It is involved in a wide range of physiological processes such as neurotransmission and regulation of blood pressure. Neurokinin A has been shown to inhibit adenylate cyclase activity in guanethidine-sensitive tissues and ionophores-resistant cells. The effects of Neurokinin A are not due to its ability to bind to the NK-1 receptor but rather through other mechanisms. The amino acid sequence of this peptide was first determined by cloning methods in 1984 and it has since been used extensively as a tool for studying the function of this receptor. Neurokinin A also inhibits cell proliferation in glioma cells and has been shown to have an inhibitory effect on Ca2+ concentration during electrical nerve stimulation.</p>

D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin is a peptide that is an antagonist of bradykinin. It has been shown to bind to bradykinin receptors and inhibit the effects of bradykinin in both the vascular system and central nervous system. D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin may be used to treat diseases such as asthma or chronic obstructive pulmonary disease (COPD).

Fibroblast growth factor 8 (FGF8) is a cytokine that belongs to the family of fibroblast growth factors. It is a protein that is secreted by cells in the family of organs, including liver, kidney, lung, and heart. FGF8 has been shown to promote cell growth and organogenesis. In addition, FGF8 has been shown to stimulate tumor growth in animal models and humans. The function of FGF8 is mediated through binding to its receptor FGFR-2 on the cell surface. This receptor activates signaling pathways inside the cell by interacting with other proteins such as PI3K or Ras.

m-dPEG®24-DSPE is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-DSPE is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>Originally identified in Heloderma horridum horridum (Mexican beaded lizard), exendin-3 is in the glucagon family. Exendin 3 stimulates vasoactive intestinal peptide (VIP) receptors in high concentrations. This leads to increased cAMP levels and amylase secretion in the pancreas. However, low exendin-3 exposure only increases cAMP levels. In applications, exendin-3 was found to induce hypotension by relaxation of cardiac, smooth muscle. Using a tag, exendin-3 is being investigated as a stable agonist for GLP1R to detect insulinomas, a pancreatic B cell-derived cancer with high GLP1R expression. Exendin 3 has also been used on mouse models to assess its effect on glucose-stimulated insulin secretion in glucagon receptor knockout (Gcgr-/-) backgrounds. Understanding the interplay between exendin 3 and metabolism could provide new insights into the obesity crisis.</p>

Anti Motilin (Dog) Serum is a fractionated serum that is a potent inhibitor of motilin. It inhibits motilin-induced contractions in the small intestine and colon. The Anti Motilin (Dog) Serum is supplied as a lyophilized powder containing purified fractions of dog serum, which are produced by fractionation on an ion-exchange column. The product contains high purity antibody and peptides with no detectable endotoxin or other microbial contaminants. The Anti Motilin (Dog) Serum is supplied in a volume of 5 mL and has a CAS number of 46887-37-2.

The RLN1 gene encodes a protein that is involved in the regulation of cell growth, differentiation, and apoptosis. It interacts with a number of proteins involved in cancer, tumour progression and metastasis. The function of RLN1 is to interact with other proteins, such as p53 and BRCA2, and regulate their activity. The frequency of this gene has been analysed in healthy controls versus patients with cancer. A number of different tissues have been analysed for this gene including testicular tissue from healthy controls versus patients with testicular cancer. There are also data on the expression levels in normal tissue and cancerous tissue from the same individual. This gene has also been shown to be homologous to other genes that are involved in DNA repair and apoptosis.

<p>m-dPEG®2-Tosylate is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®2-Tosylate is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

Fibronectin is a soluble protein that belongs to the group of linker proteins. It is found in blood plasma and extracellular fluids, where it helps to maintain the integrity of the blood vessel walls. Fibronectin also provides a scaffold for cell migration, which is especially important during wound healing. Fibronectin has been found to interact with thrombotic factors and help organize clot formation. Fibronectin also binds to collagen, which forms an insoluble network within the extracellular matrix. This insoluble network serves as a framework for cells to grow and migrate within tissues.

<p>Please enquire for more information about MPS-Acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Phth-dPEG®12-Tris (-TFP Ester)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Phth-dPEG®12-Tris (-TFP Ester)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

IL-1α is a cytokine that belongs to the group of proinflammatory cytokines. It plays a role in the immune response and inflammatory reactions by inducing the synthesis of other cytokines, such as IL-6, IL-8, and TNF-α. IL-1α binds to its receptor on a cell surface and activates an intracellular signalling cascade. The binding of IL-1α to its receptor induces conformational changes in the receptor, which leads to activation of phospholipase C (PLC) and production of IP3. This process results in increased levels of calcium ions inside the cell and activation of protein kinases such as PKC, MAPKs and JNKs. This results in increased activity of enzymes such as cyclooxygenase and lipoxygenase, which are responsible for inflammatory responses.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Portion of Influenza NP

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Protease-activated receptor 1 (PAR-1) selective activating peptide, 95%, TFA salt

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>Custom research peptide; min purity 95%.</p>

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

Custom research peptide; min purity 95%.

<p>ANP (Human, 7-28) is a peptide with inhibitor activity. ANP (Human, 7-28) binds to the receptor for atrial natriuretic peptide and inhibits its interaction with other proteins. It can also activate the receptor by binding to it. ANP (Human, 7-28) contains an N-terminal sequence of amino acids that are not present in the human atrial natriuretic peptide and can be used as a research tool or an antibody against this protein.</p>

Anti ACTH (21-39) (Rat) Serum is a research tool that can be used to activate, bind, or inhibit the receptor. This product is a monoclonal antibody against the ACTH (21-39) peptide. It binds to the ACTH receptor and blocks calcium channels in cells. Anti ACTH (21-39) (Rat) Serum is suitable for use in cell biology, pharmacology, and peptide research.

dPEG®24-SATA (S-Acetyl-dPEG®24-NHS Ester) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. dPEG®24-SATA (S-Acetyl-dPEG®24-NHS Ester) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

DNP-dPEG®12-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DNP-dPEG®12-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Glucagon is a peptide hormone that is produced by alpha cells in the pancreas. It has many effects, including increasing blood sugar levels and causing the release of fatty acids from fat cells. Glucagon also stimulates the liver to release glucose into the bloodstream. Glucagon binds to specific receptors on the membrane of cells, which then causes adenylate cyclase activity and increased production of cyclic AMP (cAMP). This hormone is used in cancer treatment because it can stimulate cell growth, inhibit apoptosis, and cause cancerous tumors to shrink.

Chlorotrityl Polystyrene Macrobeads are anti-cancer agents that can be used for the treatment of a variety of cancers. These macroparticles are composed of a chlorotrityl resin and polystyrene beads. They form a spherical particle with an average diameter of 100 microns, which can be used to encapsulate chemotherapeutic drugs. The chlorotrityl resin is made up of alcohols, amino acids, amines, and cyclic peptides that are soluble in water and have antibacterial and antifungal activities. The macroparticles also contain cyclic molecules with anti-viral activity and anti-cancer properties.

Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance. It is also known as a vasopressor and as an activator of the renin-angiotensin system. Angiotensin II is synthesized from the precursor protein angiotensinogen, which is cleaved by renin to form angiotensin I. Angiotensin I is then converted to angiotensin II by the enzyme ACE (angiotensin-converting enzyme). Angiotensin II is found in the lungs, kidneys, adrenal glands, brain and blood. The biological effects of angiotensin II are mediated by its receptor on cells which stimulates G proteins to activate phospholipase C activity. This leads to increased levels of inositol triphosphate (IP3) and diacylglycerol (DAG) which cause release of calcium ions from intracellular stores such as the endoplasmic

IL-23 is a cytokine that belongs to the IL-12 family and plays an important role in the regulation of immune responses. It has been shown to activate T cells and promote the differentiation of B cells into immunoglobulin-producing cells. IL-23 is also produced by keratinocytes, epithelial cells, fibroblasts, and other immune cell types. IL-23 is an inhibitor that blocks the activation of specific receptors on cells. The CAS number for IL23 is 78626-61-8. This product can be used as a research tool for studying protein interactions and receptor activity. It can also be used as a reagent for antibody production or as a high purity protein for life science research.

H2N-PEG-O-C3H6-COOH hydrochloride is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. H2N-PEG-O-C3H6-COOH hydrochloride is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Angiotensin II is a peptide that is involved in the regulation of blood pressure and fluid balance. Angiotensin II has been shown to be an activator of angiotensin-converting enzyme (ACE), which converts angiotensin I into angiotensin II. ACE is inhibited by the drug captopril, which reduces the conversion of angiotensin I to angiotensin II. Angiotensin II has also been shown to activate potassium channels, including voltage-gated potassium channels, and inhibit calcium channels. It has been found to bind to the receptor AT1 and trigger a number of responses, including vasoconstriction and increased heart rate. The ligand for this receptor is angiotensin II. The pharmacology of Angiotensin II includes its ability to act as an inhibitor on protein interactions with various proteins or enzymes, such as alpha-1 antitrypsin or beta-2 adrenergic receptors.

<p>BNP Human, His is a recombinant peptide which inhibits the activity of the beta-adrenergic receptors. It is a research tool that can be used to study protein interactions and receptor activation. BNP Human, His has been shown to inhibit the activity of ion channels in cells. This peptide also activates G-protein coupled receptors and is used as a reagent for antibody production.</p>

<p>TIP39 is a peptide inhibitor that is a member of the TIP family. It inhibits the activity of calcineurin, a calcium-dependent phosphatase enzyme, and thereby prevents it from dephosphorylating nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which regulates signaling pathways that control inflammatory responses. TIP39 has been shown to inhibit calcineurin in both human and bovine cell lines. This drug has been used as a research tool to study peptide-receptor interactions and ion channels.</p>

G-CSF is a glycoprotein that belongs to the cytokine family and is used as a medication. It stimulates the production of neutrophils, which are important in defending the body against infections. G-CSF also has a role in stimulating stem cell production and can be used to treat cancer patients undergoing chemotherapy. G-CSF binds to receptors on the surface of cells, activating intracellular signaling pathways. The binding of G-CSF to its receptor activates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 causes release of calcium from intracellular stores, leading to an increase in cytosolic free calcium concentration. DAG activates protein kinase C (PKC)

MAL-dPEG®24-Amido-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-Amido-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

<p>CIF1 is a protein that in humans is encoded by the CIF1 gene. It belongs to the family of ion channels and ligand-gated ion channels. The channel is activated by acetylcholine, a neurotransmitter, and mediates fast synaptic transmission at neuromuscular junctions. CIF1 has been shown to bind to the nicotinic acetylcholine receptor (nAChR) subunit alpha-4/beta-2. This binding leads to inhibition of nAChR function, which may be useful for treatments of conditions such as Parkinson's disease or Alzheimer's disease.</p>

TGF b 1 is a member of the transforming growth factor family and is a potent inhibitor of cell proliferation. Recombinant human TGF b 1 has been shown to inhibit the proliferation of various cell types in culture, including fibroblasts, endothelial cells, and smooth muscle cells. It also inhibits tumor growth in vivo. The binding site for TGF b 1 on target cells has been localized to the extracellular domain of type II receptor kinase, which is composed of three immunoglobulin-like domains. This protein can be used as an antibody or ligand to study protein interactions.

Des-Arg9-Bradykinin is a peptide that is structurally related to bradykinin. It is synthesized by removing the first two amino acids from the N terminus of bradykinin and replacing them with an acetyl group. It has been shown to have potent activity against inflammatory cells in vitro, including mast cell degranulation and histamine release. Des-Arg9-Bradykinin also inhibits the production of nitric oxide, which may be responsible for its anti-inflammatory effects.

<p>IL-9 is a cytokine that is involved in the regulation of immune system. IL-9 signaling is essential for the induction of B cell responses and mast cell activation, and IL-9 is also expressed in epithelial cells. The IL-9 Mouse (CAS No. 207870-05-2) antibody reacts with IL-9 protein, which has a molecular weight of 18 kDa. This antibody detects an epitope corresponding to amino acids 1 to 13 of human Interleukin 9 (IL-9).</p>

<p>Bromoacetamido-dPEG®11-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®11-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Anti GLP-1 (7-36)-NH₂, human serum is a recombinant protein that inhibits the activity of the glucagon-like peptide-1 receptor. It is used as a research tool to study the role of GLP-1 and its receptor in regulating blood glucose levels. Anti GLP-1 (7-36)-NH₂, human serum can be used as a ligand for the isolation of the GLP-1 receptor from cells. The anti GLP-1 (7-36)-NH₂, human serum is also used to study ion channels and antibody binding.</p>

monoFITC INSL3 is a fluorescent peptide that can be used as a research tool. It is an activator of the Ligand-Receptor interaction and has been shown to inhibit Ion channels. The high purity of this product is suitable for use in Cell Biology, Antibodies, and Protein interactions. This ligand has also been shown to bind to Receptors and is used in Pharmacology and Peptides. monoFITC INSL3 has been shown to have anti-inflammatory properties in the body, which may be due to its inhibition of Prostaglandin synthesis.

<p>Salusin-beta is a peptide that is used as a research tool for the study of ion channels and protein interactions. Salusin-beta inhibits potassium currents in cells, which may be due to its ability to bind to receptor sites on the cell membrane. It also inhibits the activity of protein kinase C and calcium channels. Salusin-beta has been shown to be an inhibitor of protein interactions, such as those between α-synuclein and synaptotagmin, which are involved in Parkinson's disease.</p>

BMP 2 is a member of the TGF-β superfamily and is a potent activator of bone morphogenetic protein receptors. It is a ligand for type I and II receptor complexes. BMPs play a crucial role in embryonic development, tissue repair, and maintenance of cartilage. BMP 2 has been shown to inhibit ion channels such as calcium-activated potassium channels. It also inhibits protein synthesis by inhibiting the activation of transcription factors like CREB, c-Jun N-terminal kinase (JNK), and p38 mitogen activated protein kinase (MAPK). BMP 2 also binds to antibodies that are specific for phosphorylated receptor tyrosine residues, which can be used as research tools in immunohistochemistry experiments or other applications.

<p>Glutathione S-transferase recombinant is a research tool that can be used in the study of protein interactions. This enzyme is an activator, ligand and receptor that is involved in cell biology, immunology, and pharmacology. Glutathione S-transferase recombinant has been shown to have a role in the metabolism of xenobiotics and endogenous compounds. The glutathione S-transferases are a family of enzymes with broad substrate specificity that catalyze the conjugation of glutathione (GSH) with small electrophilic substrates such as drugs, environmental toxins, and electrophiles generated during oxidative stress.</p>

C-Peptide I (Mouse)-EIA Kit is a mouse monoclonal antibody specific to the C-terminus of human proinsulin. It is used in ELISA as a sandwich reagent.

<p>Leptin (Mouse)-ELISA Kit is a ready-to-use assay kit for the quantitative determination of mouse leptin in serum, plasma, and cell culture supernatants. The assay is based on a sandwich ELISA using monoclonal antibodies to mouse leptin. This kit provides a simple and accurate method for the detection of mouse leptin in biological samples.</p>

<p>IGHG1 MS Calibrator-7 is a 25nmol peptide that is derived from the C region of Ig gamma-1 chain. It is a tryptic peptide that corresponds to the sequence of IGHG1. The molecular weight of this peptide is 584.6Da and its theoretical pI is 9.26. This calibrator can be used in various proteomics applications, including proteomics tools such as TrypTides and Proteomics Tools from New England Peptide Company.</p>

<p>Vasopressin is a peptide hormone that is synthesized from the amino acid arginine and stored in vesicles. It is released into the bloodstream by the hypothalamus, where it acts as an antidiuretic and also stimulates vasoconstriction and contraction of smooth muscle. Vasopressin has been shown to inhibit the binding of ligands to their receptors, which may be due to its ability to activate these receptors. This protein has been used as a research tool for studying receptor-ligand interactions, cell biology, and pharmacology. It can also be used as a reagent for Western blotting or immunohistochemistry.</p>

CBZ-amido-dPEG®24-amido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CBZ-amido-dPEG®24-amido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.