Peptides

<p>IL-1 beta is a cytokine, which belongs to the IL-1 family of cytokines. It is a proinflammatory cytokine that induces fever and pain, and stimulates the immune system. IL-1 beta binds to the IL-1 receptor, which is a member of the class 1 cytokine receptor family. The binding activates phospholipase A2 and protein kinase C, which leads to an increase in prostaglandin production by cyclooxygenase 2. IL-1 beta also has been shown to inhibit ion channel activity and calcium uptake in cells.</p>

<p>Bromoacetamido-dPEG®4-Amido-DBCO is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®4-Amido-DBCO is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bis-dPEG®4-Acid is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®4-Acid is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Atosiban is a drug that is used to prevent preterm labor in pregnant women. It works by inhibiting the release of oxytocin from the hypothalamus, which decreases contractions and relaxes the uterus. Atosiban has been shown to be effective in decreasing the incidence of preterm birth in women with bacterial vaginosis who are at high risk for preterm delivery (e.g., those with a history of preterm labor). Clinical trials have shown that it may also be useful as an adjunct therapy in treating women with unexplained infertility and recurrent pregnancy loss. The drug binds to receptors on cells, which inhibits the release of intracellular calcium, thus preventing contraction of uterine muscle cells. This effect can be reversed by administration of estradiol benzoate or other drugs that affect receptor activity. It is not known whether atosiban affects fetal development during pregnancy or if it causes any effects on the mother's heart rate or body mass index after childbirth.</p>

<p>Carboxyfluorescein-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.</p>

<p>Gly-Gly-Tyr-Arg acetate dihydrate is a tetrapeptide and a ligand for the enzyme papain. It binds to the active site of papain and inhibits its proteolytic activity. Gly-Gly-Tyr-Arg acetate dihydrate has been shown to be an inhibitor of trypsin and chymotrypsin, but not other proteases. It has also been shown to inhibit the polymerase chain reaction and RNA synthesis in vitro.</p>

<p>Bromoacetamido-dPEG®23-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®23-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>A TIMP1 Heavy Tryptic Peptide Standard for protein identification and quantitation studies. TIMP1, also known as TIMP metallopeptidase inhibitor 1 is an inhibitor of matrix metalloproteinases, which are enzymes that break down the extracellular matrix. It has also been associated with cell proliferation promotion and may have a role in apoptosis.</p>

<p>Streptavidin-NC is a recombinant protein that is used in immunoassays. It binds to biotin and can be used as an alternative to the antigen-antibody reaction. Streptavidin-NC binds to the biotinylated antigen at the same time as it binds to the specific antibody, forming a sandwich complex. Streptavidin-NC has been shown to be more sensitive than antibodies in cardiac muscle and skeletal muscle immunoassays, with better specificity for cardiac troponin I and T than monoclonal antibodies. The molecular mass of this protein is about 50000 Da, which corresponds to a chain with about 500 amino acids.</p>

<p>MAL-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Gly-Phe is a kinetic glycolytic inhibitor that has antiviral properties. It has been shown to be effective against a number of viruses, including the herpes simplex virus type 1 (HSV-1), influenza virus A/PR/8/34 (PR8), and human immunodeficiency virus type 1 (HIV-1). Gly-Phe inhibits viral growth by blocking the synthesis of nucleic acids in cells infected with these viruses. The antiviral activity of Gly-Phe was demonstrated in animal models and humans, where it acted as an effective treatment for HSV-1 infection. Gly-Phe also has anti-inflammatory properties, which may be due to its ability to inhibit bacterial enzymes in the intestinal tract.</p>

<p>HG1 toxin is a peptide that is found in the venom of the scorpion Heterometrus fulvipes. It is a member of the short-chain scorpion toxins, which are composed of a single chain of amino acids. This protein has been shown to bind to potassium channels and inhibit their function, leading to paralysis of the prey's nervous system. HG1 toxin has been shown to be able to activate or inhibit ion channels and other receptors. It can also bind to ligands such as peptides or antibodies and affect cellular activity. HG1 toxin is produced by recombinant DNA technology and purified by HPLC for use in biochemical research and pharmacological studies.</p>

<p>Carboxyl-dPEG®4-(m-dPEG®8)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Carboxyl-dPEG®4-(m-dPEG®8)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>it is a non-glycosylated polypeptide chain containing 350 amino acids (31-359 a.a) with a molecular mass of 38.6kDa.  It is fused to a 21 amino acid His-tag at N-terminus.</p>

<p>Ac-Abu-D-Tyr-Leu-Gln-VS is a synthetic peptide that can be used as a research tool, an activator, or an inhibitor. It is a high purity product that has been extensively tested for its use in ion channels and receptor pharmacology.</p>

<p>Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.<br>Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.</p>

<p>Anti GRF/GH-RH (Rat) Serum is a research tool that is used to detect the presence of GH and GRF receptors. This antibody can be used for the study of GH and GRF receptor interactions and their roles in cell biology. Anti GRF/GH-RH (Rat) Serum can also be used as an inhibitor to block protein interactions.</p>

<p>This is a Biologically Active Peptides, Short=PN-II, Proteomics, Amyloid Precursor Protein, New England Peptide calibrated to 25nmol. This peptide has been shown to be a major component of amyloid plaques in Alzheimer's Disease. It is one of the most abundant proteins in the brain and is found in association with beta-amyloid protein (A4). The precursor protein for APP is encoded by the gene on chromosome 21. APP and its products are involved in many cellular processes such as signal transduction, cell proliferation, apoptosis and inflammation. APP can be cleaved by Beta-secretase or Gamma secretase to release A4 and N-APP.</p>

<p>SMRT peptide (amino acids 1414-1430 corresponding to the SMRT BCL6 binding domain.</p>

<p>Alyerserin-1b is a C-terminally α-amidated 23 residue Cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-1 peptides have limited structural similarity to the ascaphins from the skins of frogs of the Leiopelmatidae family. Alyteserin-1 peptides are selective at inhibiting growth activity of Gram-negative bacteria-such as Escherichia coli and show weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards these peptides compared to conventional antibiotics.</p>

<p>The RGD peptide is an adhesive peptide present in extracellular matrix proteins allowing them to attach to a range of biological materials. It is labelled with Alexa Fluor 647.</p>

<p>Collagens are the most abundant family of extra cellular matrix (ECM) proteins, accounting for two-thirds of the dry mass of adult articular cartilage. Several subtypes have been identified including types II, IX, X, XI, VI, XII, and XIV collagen, however 80 to 90% of the collagen in the body consists of types I, II, and III. Collagen is a long thin protein which consists of three coiled subunits: two α1(I) chains and one α2(I). Type 1 collagen forms part of the major structure of the bone, and mutations in the α1(I) or α2(I) genes lead to-osteogenesis imperfecta, or brittle-bone disease.Collagen is cleaved by mammalian tolloid (mTld) and its splice variant- bone morphogenetic protein 1 (BMP1), a metalloprotease and member of the peptidase M12A family enzymes.This peptide contains a FRET (fluorescence or F&amp;ouml-rster resonance energy transfer) pair. N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag which excites at 495 nm and emits at 517 nm, and a 5-Carboxytetramethylrhodamine-(5-TAMRA), present on the side chain of a C-terminal lysine which has been added to the peptide. 5-TAMRA is a widely used fluorescent dye which excites at 546 nm and emits at 579 nm. In the intact peptide TAMRA quenches the fluorescence of 5-FAM, however upon cleavage of the peptide by a protease such as BMP1, the fluorescence of 5-FAM is recovered and can be monitored.</p>

<p>Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin (Ig) protein superfamily and is expressed exclusively in the central nervous system (CNS) on the surface of myelin sheaths and oligodendrocyte processes. MOG is expressed at the onset of myelination, and therefore is a potential marker for oligodendrocyte maturation.MOG contains an extracellular domain, a transmembrane domain, a cytoplasmic loop, a membrane-associated region and a cytoplasmic tail. MOG may function as a cell surface receptor or cell adhesion molecule. -Fifteen different alternatively spliced isoforms have been detected in humans. These are present either on the cell surface, the endoplasmic reticulum in the endocytic system, or in secreted form.The secreted form of MOG may trigger autoimmunity if released into the cerebrospinal fluid and periphery. MOG is thought to be a key target for autoantibodies and cell-mediated immune responses in inflammatory demyelinating diseases such as multiple sclerosis (MS) and is therefore widely studied in this field.Fragment (35-51) of the human MOG can be rapidly degraded by the serine protease CatG. Conversion of arginine 46 to citrulline in this peptide reduces the sensitivity of the citrullinated MOG 35-51 peptide to degradation. This peptide has an uncharged C-terminal amide.</p>

<p>Histone H3 peptide with a C-terminal GGC linker labelled with fluorescein.</p>

<p>Substance P (SP) is a peptide that is highly conserved across the animal kingdom and is involved in a number of inflammatory and growth promoting processes. SP has a net positive charge at physiological pH, it is an amphiphilic peptide with positively charged residues at the N-terminus and hydrophobic residues at the C-terminus, this controls how it interacts with cell membranes. SP is stable in plasma (several hours) but has a short half-life in tissues (seconds/minutes).SP is encoded by the TAC1 gene and is a member of the tachykinin peptide hormone family. SP is expressed by many cell types including: neurons, astrocytes, microglia, epithelial cells, endothelial cells, immune cells such as T cells and macrophages- dendritic cells and eosinophils and some stem cells and progenitor cells. The huge variety of cell types expressing SP suggest it is involved in a wide variety of physiological and pathophysiological functions.SP mediates its functions by interacting with members of the neurokinin (NK) family of G protein-coupled receptors with high selectivity. Among these, SP binds to NK1R with the highest affinity, this receptor is expressed in a wide range of tissue types.Biotin (B7) has been added to the N-terminus.</p>

<p>ALPHA FACTOR SIGNALING PEPTIDE</p>

<p>MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.</p>

<p>Galanin is a peptide that is involved in the regulation of many physiological processes, including the regulation of food intake, water balance, and pain perception. The rat galanin antiserum reacts with both human and rat galanin. Galanin is a member of the family of G protein-coupled receptors (GPCRs).</p>

<p>Sar1,Ala8]-Angiotensin II is a peptide that has been shown to bind to the angiotensin receptor and activate it. This peptide is a research tool for studying ion channels, ligand-receptor interactions, and protein interactions. The peptide can be used to study the pharmacology of the angiotensin receptor, as well as its role in cell biology and other biological processes. Sar1,Ala8]-Angiotensin II binds to the angiotensin receptor with high affinity, making it an excellent candidate for use in antibody production against this receptor.</p>

<p>Anti G-Protein: Galpha olf (23-38), humanSerum is a research tool that is used to study protein interactions. It can be used for the investigation of ion channels, cell biology, and pharmacology. The antibody reacts with the specific antigen for which it was raised. The antibody may be used in immunohistochemistry on tissue sections or in ELISA as a detection tool.</p>

<p>Cancer antigen 125 (CA 125) heavy tryptic peptide standard for proteomics studies. CA 125 is an antigenic tumor marker which can be used to diagnose epithelial ovarian cancers. It is expressed by epithelial ovarian neoplasms and cells lining the fallopian tubes, endometrium, pericardium, peritoneum and pleura.</p>

<p>Substance P (4-11) is a peptide that is a member of the tachykinin family. This protein is released by neurons and acts as a neurotransmitter in the brain, where it binds to neurokinin receptors. The structure of Substance P (4-11) has been determined using high-resolution nuclear magnetic resonance spectroscopy and X-ray crystallography. It contains four tryptophans, seven prolines, and nine amino acids in total. Substance P (4-11) has been shown to bind to neurokinin receptors, which are ligand-gated ion channels found on the surface of cells. Binding of this protein leads to an increase in cell permeability through ion channels and causes an increase in intracellular calcium levels.</p>

<p>TentaGel H RAM is a building block for peptide synthesis and a resin for peptide synthesis. It is made of 3-hydroxypropyl methacrylate (HPM) and bis-acrylamide (BAM) in a ratio of 1:1. TentaGel H RAM is used as an alternative to polystyrene, which has been used as the base resin for peptide synthesis.</p>

<p>FRETS-25Trp is a peptide that is used as a research tool for the study of protein interactions. It is an activator of ion channels and has been shown to bind to the receptor site of protein. FRETS-25Trp has also been shown to inhibit the interaction between ligands and receptors, which may be due to its ability to mimic the natural ligand or compete with it for binding sites. FRETS-25Trp is synthesized by solid phase peptide synthesis on a resin, which provides high purity and yields of up to 1 umol per reaction.<br>FRETS-25Trp (1 umol) (1umol) is CAS No. 120106-03-5 and Reagent No. F2204.</p>

<p>IL-12 is a proinflammatory cytokine that is produced by activated T cells and natural killer (NK) cells. IL-12 activates macrophages, which then produce tumor necrosis factor alpha (TNFα), inducible nitric oxide synthase (iNOS), and other inflammatory mediators. IL-12 has also been shown to increase the expression of major histocompatibility complex class II molecules on antigen presenting cells, which may be important for activating CD4+ T helper cells. IL-12 is a receptor activator that binds to its receptor with high affinity and specificity. It has been found to inhibit voltage-gated ion channels, ligand binding, and antibody binding in vitro.</p>

<p>Chikungunya E2 Recombinant is a peptide that activates the ion channels. It is derived from the Chikungunya virus, and has been shown to inhibit the binding of ligands to their receptors. The recombinant protein can be used as a research tool in cell biology and pharmacology. Chikungunya E2 Recombinant also binds to antibodies and can be used in immunohistochemistry, Western blotting, and ELISA.</p>

<p>MAL-dPEG®4-(m-dPEG®4)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®4-(m-dPEG®4)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Amyloid β (42- 1) SCR is a peptide that inhibits the interaction of amyloid β with its receptor, which may be useful for research purposes. Amyloid β (42- 1) SCR is an inhibitor that prevents the binding of amyloid β to its receptors. This peptide is a high purity product and has been shown to be effective in inhibiting the interaction between amyloid beta and its receptor.</p>

<p>Glu17,Gla21,24-Osteocalcin is a peptide that is used as a research tool to study ion channels and receptor interactions. It has been shown to bind to the human insulin receptor and act as an agonist. Glu17,Gla21,24-Osteocalcin also binds to the calcitonin receptor with high affinity. This peptide can be used in pharmacology studies as an inhibitor of insulin-mediated glucose uptake or as an activator of calcium release from intracellular stores.</p>

<p>IL-7 is a colony-stimulating factor that is expressed in the stromal cells of human cells. IL-7 has been shown to have modulatory effects on neutrophils and myeloid cells, which are important for immune responses. IL-7 stimulates phagocytosis and the production of reactive oxygen species by neutrophils and myeloids. IL-7 also has autocrine and paracrine effects on lymphoblasts and amplifies their proliferation. This protein may be used as a tumor marker for some malignant tumors because it can be detected in autocrine loops and in the circulation of patients with cancer.</p>

<p>BMP 7 is a cytokine that belongs to the transforming growth factor beta (TGF-β) superfamily. It is produced by many cell types, including E. coli, in response to TGF-β and IL-1. BMP 7 has been shown to be involved in the regulation of cell proliferation and differentiation. BMP 7 has also been shown to be a potent inducer of cytokines such as IL-8, IL-6, IL-1β, and TNF-α from human mononuclear cells.</p>

<p>A gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol). The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>TentaGel; HL (High Load) (mean particle size 75 µm: capacity 04-06 meq/g)<br>Substitution Functional Group: -O-CH2-CH2-BrTentaGel</p>

<p>DOTA-tris(Acid)-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Azido-dPEG®4-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®4-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Glicentin is a rat-specific serum protein that is the major component of the alpha-2 macroglobulin (A2M) in the rat. Glicentin binds to various peptides, including beta-endorphin, vasopressin, angiotensin II, and oxytocin. This kit contains 1 vial of antibody against glicentin. The antibody has been purified by immunoaffinity chromatography on a column of immobilized peptide-glicentin complex. This kit can be used for detection of glicentin in rats.</p>

<p>Amyloid β (1-40) is a peptide that belongs to the group of amyloid proteins. It has been shown to decrease the activity of ion channels and receptors, as well as inhibit ligand binding to these receptors. Amyloid β (1-40) has also been shown to interact with other proteins by binding to them and inhibiting their function. Amyloid β (1-40) is used in research for pharmacology, cell biology, and neuroscience studies. It is purified from natural sources or synthesized in a laboratory, which yields high purity. The CAS number for this product is 43981-14-2.</p>

<p>DNP-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ is a synthetic peptide that belongs to the group of Ligands. It interacts with receptors, ion channels, and other proteins. DNP-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ can be used as a research tool in pharmacology, protein interactions, cell biology, and antibody production. This compound is also an activator or inhibitor depending on the type of receptor it binds to.</p>

<p>FRETS-25Val is a research tool that is used to activate, inhibit, or modulate the function of ion channels. FRETS-25Val is an agonist of G protein-coupled receptors (GPCRs) and ligands for receptor tyrosine kinases (RTKs). It has been shown to bind to Ligand Binding Domains (LBDs) on cell surface receptors. FRETS-25Val binds to antibody Fc regions and also inhibits the binding of peptides to proteins by competing with them for binding sites.</p>

<p>Noggin is a protein that is involved in the regulation of neuronal growth and development. It acts as a morphogen, binding to a receptor on the surface of cells and initiating signaling cascades that lead to changes in gene expression. Noggin binds to Retinoid-X-receptor (RXR) and the Ligand-binding domain of Notch1. These interactions may be important for the regulation of CNS cells, such as neurons and glial cells. The protein has been shown to have a role in synaptic plasticity, axonal guidance, and synaptogenesis. Noggin has also been shown to be an inhibitor of cell proliferation and an activator of cell differentiation.</p>

<p>Mannose-binding lectin 2 (MBL2) is a protein that is encoded by the MBL2 gene. It is an activator of the lectin complement pathway, which plays an important role in innate immunity. MBL2 binds to mannose-rich oligosaccharides and activates the lectin complement pathway. This protein also interacts with ion channels, cell surface receptors and other proteins. The recombinant human MBL2 has been expressed in E. coli. The purified protein is supplied at &gt;95% purity and has a CAS number of 80613-62-8.</p>

<p>Anti EGF (Rat) Serum is a research tool that can be used for the detection of protein-protein interactions and receptor-ligand interactions. This serum has a high purity and can be used in cell biology, pharmacology, and life science. Anti EGF (Rat) Serum is an inhibitor that binds to EGFR. It blocks the activation of EGFR by blocking ligand binding to EGFR or by preventing GPCR from activating downstream signaling pathways.</p>

<p>Obestatin is a neuropeptide that was first isolated from the mouse and rat hypothalamus. The Obestatin (Mouse, Rat)-EIA Kit is an in-house ELISA assay for the detection of mouse and rat obestatin. This kit can be used to detect obestatin in serum, plasma, or cell culture supernatant samples. It is a useful tool for studying the role of this peptide in various biological processes.</p>

<p>IGHG1 MS Calibrator-7 is a 25nmol peptide that is derived from the C region of Ig gamma-1 chain. It is a tryptic peptide that corresponds to the sequence of IGHG1. The molecular weight of this peptide is 584.6Da and its theoretical pI is 9.26. This calibrator can be used in various proteomics applications, including proteomics tools such as TrypTides and Proteomics Tools from New England Peptide Company.</p>

<p>Leptin (Mouse)-ELISA Kit is a ready-to-use assay kit for the quantitative determination of mouse leptin in serum, plasma, and cell culture supernatants. The assay is based on a sandwich ELISA using monoclonal antibodies to mouse leptin. This kit provides a simple and accurate method for the detection of mouse leptin in biological samples.</p>

<p>Triosephosphate isomerase 1 (TPI1) is a cytosolic enzyme that catalyzes the conversion of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate to erythrose-4-phosphate and phosphoenolpyruvate. TPI1 has been shown to be an important regulator of glycolysis and gluconeogenesis, as well as in the maintenance of cellular redox state. This protein can act as both an inhibitor and activator depending on its interaction with other proteins. TPI1 has been implicated in the development of cancer, diabetes, Alzheimer's disease, Parkinson's disease, and atherosclerosis. TPI1 is also a research tool for studies into ion channels, receptor binding, and antibodies.</p>

<p>DBCO-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DBCO-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bromoacetamido-dPEG®11-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®11-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Hirudin is a protein that has been isolated from the salivary gland of the medicinal leech. It is used to treat thrombosis, or blood clots, and works by neutralizing the activity of thrombin. Hirudin is an enzyme that contains a peptide sequence that binds to thrombin and prevents it from activating other factors in the blood clotting process. The recombinant form of hirudin is produced in Escherichia coli and can be purified using chromatographic techniques. This form of hirudin has increased biological activity than native hirudin due to its higher stability and solubility.</p>

<p>Des-Arg9-Bradykinin is a peptide that is structurally related to bradykinin. It is synthesized by removing the first two amino acids from the N terminus of bradykinin and replacing them with an acetyl group. It has been shown to have potent activity against inflammatory cells in vitro, including mast cell degranulation and histamine release. Des-Arg9-Bradykinin also inhibits the production of nitric oxide, which may be responsible for its anti-inflammatory effects.</p>

<p>TGF b 1 is a member of the transforming growth factor family and is a potent inhibitor of cell proliferation. Recombinant human TGF b 1 has been shown to inhibit the proliferation of various cell types in culture, including fibroblasts, endothelial cells, and smooth muscle cells. It also inhibits tumor growth in vivo. The binding site for TGF b 1 on target cells has been localized to the extracellular domain of type II receptor kinase, which is composed of three immunoglobulin-like domains. This protein can be used as an antibody or ligand to study protein interactions.</p>

<p>TentaGel is a synthetic resin that has been designed to bind to the surface of particles. It has the ability to form a continuous matrix around the particle and has shown potential for use in drug delivery, biotechnology, and nanotechnology. TentaGel can be used as building blocks by adding monomers or polymers which will then be embedded within the gel. This allows for more control over the properties of the final product.</p>

<p>G-CSF is a glycoprotein that belongs to the cytokine family and is used as a medication. It stimulates the production of neutrophils, which are important in defending the body against infections. G-CSF also has a role in stimulating stem cell production and can be used to treat cancer patients undergoing chemotherapy. G-CSF binds to receptors on the surface of cells, activating intracellular signaling pathways. The binding of G-CSF to its receptor activates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 causes release of calcium from intracellular stores, leading to an increase in cytosolic free calcium concentration. DAG activates protein kinase C (PKC)</p>

<p>TIP39 is a peptide inhibitor that is a member of the TIP family. It inhibits the activity of calcineurin, a calcium-dependent phosphatase enzyme, and thereby prevents it from dephosphorylating nuclear factor of activated T cells cytoplasmic 1 (NFATc1), which regulates signaling pathways that control inflammatory responses. TIP39 has been shown to inhibit calcineurin in both human and bovine cell lines. This drug has been used as a research tool to study peptide-receptor interactions and ion channels.</p>

<p>Hyaluronidase is a glycosaminoglycan that is synthesized by the cells of the synovial membrane, and is used in the treatment of osteoarthritis. It has been shown to be potent inducers of apoptosis in cancer cell lines, with a high percentage of caspase-3 activation. Hyaluronidase also inhibits angiogenesis and induces cell death through an unknown mechanism. This enzyme functions as an extracellular matrix-degrading enzyme and has been shown to have anti-inflammatory properties.</p>

<p>Anti Urocortin (Rat) Serum is a protein that can be used as a research tool in pharmacology, cell biology, and other life science fields. Anti Urocortin (Rat) Serum is an inhibitor of the urocortin receptor.</p>

<p>Anti Motilin (Porcine) Serum is a potent inhibitor of motilin, a peptide hormone that stimulates the gastrointestinal tract. The anti motilin serum is useful for pharmacological research as well as in cell biology, where it can be used to inhibit motilin-induced contraction in cultured cells. Anti motilin also serves as an excellent research tool for studying the regulation of other receptors and ion channels. It has been shown to activate these receptors and ion channels.</p>

<p>TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>This product has a particle size of 280-320 µm and capacity: 02-03 meq/g.</p>

<p>GnGn-bi-Asn-PABA is a peptide that has been shown to activate the nicotinic acetylcholine receptor. It binds to the ligand binding site of the receptor and mimics the natural neurotransmitter acetylcholine, increasing the probability of neurotransmitter release. GnGn-bi-Asn-PABA has also been shown to inhibit calcium ion channels and ligand gated ion channels, which are proteins that regulate the flow of ions in and out of cells. GnGn-bi-Asn-PABA is a research tool used for studying cell biology and pharmacology.</p>

<p>Chlorotrityl Polystyrene Macrobeads are anti-cancer agents that can be used for the treatment of a variety of cancers. These macroparticles are composed of a chlorotrityl resin and polystyrene beads. They form a spherical particle with an average diameter of 100 microns, which can be used to encapsulate chemotherapeutic drugs. The chlorotrityl resin is made up of alcohols, amino acids, amines, and cyclic peptides that are soluble in water and have antibacterial and antifungal activities. The macroparticles also contain cyclic molecules with anti-viral activity and anti-cancer properties.</p>

<p>Arphamenine B is a potent, selective, and reversible inhibitor of the protein tyrosine phosphatase 1B (PTP1B). Arphamenine B binds to PTP1B with high affinity and specificity. It is a useful tool for studying protein-protein interactions and protein function. Arphamenine B can also be used as an activator or ligand for receptors, especially G-protein coupled receptors. This peptide has been shown to inhibit ion channels such as calcium channels, potassium channels, and sodium channels.</p>

<p>Azido-dPEG®24-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®24-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Azido-dPEG®24-TFP ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®24-TFP ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Midkine (114-122) is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PAPOLG antibody, catalog no. 70R-4710</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CDCA5 antibody, catalog no. 70R-2883</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of HS2ST1 antibody, catalog no. 70R-5276</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of KIAA0317 antibody, catalog no. 70R-6288</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of SLC7A2 antibody, catalog no. 70R-6789</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of DAZAP1 antibody, catalog no. 70R-4724</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PTP4A3 antibody, catalog no. 70R-8789</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of Dhrs3 antibody, catalog no. 70R-8654</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of OR1J1 antibody, catalog no. 70R-9852</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of Scfd2 antibody, catalog no. 70R-9215</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of C18orf10 antibody, catalog no. 70R-3403</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of CEACAM16 antibody, catalog no. 70R-6445</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of LAMB3 antibody, catalog no. 70R-6075</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of NUDT9 antibody, catalog no. 70R-5105</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TXNDC13 antibody, catalog no. 70R-7432</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of GSTA3 antibody, catalog no. 70R-2939</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PARD6B antibody, catalog no. 70R-2394</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of KIAA1189 antibody, catalog no. 70R-4446</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of FJX1 antibody, catalog no. 70R-6368</p>