Peptides

<p>MOCA is a small peptide with anti-inflammatory properties that binds to the receptor IL-1R. It has been shown to inhibit sodium currents in neurons by binding to the Na+ channel and preventing the influx of sodium ions, which leads to an inhibition of action potentials. MOCA has also been shown to bind with high affinity to the IL-1R and blocks its activity. This inhibition of IL-1R leads to decreased production of proinflammatory cytokines.<br>MOCA has not been shown to have any affinity for other receptors or ligands.</p>

<p>A potent vasoconstrictor (Source rat, 110-123) containing disulfide bonds between Cys8-Cys13 and available as a 0.5mg vial.  <br>Urotensin II is a peptide involved in biological systems such as the nervous, endocrine, cardiovascular and renal and in rats it is primarily found in brainstem and spinal cord motor neurons. Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function.<br>Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.<br>UT-II has been shown to have a wide range of physiological effects in rats, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin.<br>In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.</p>

<p>IGF1 is a protein hormone that stimulates growth and development. It binds to the IGF-1 receptor and activates it. IGF1 is used in research as an activator, ligand, or receptor for cell biology studies. IGF1 can be used in antibody production, ion channels, and peptide synthesis. It has been shown to inhibit the binding of other proteins to DNA and RNA. IGF1 is also used in pharmacology and life science research for its protein interactions and pharmacological effects.</p>

<p>A soluble transferrin receptor (sTfR) light tryptic peptide standard for protein identification and quantitation studies. sTfR is a cleaved extracellular segments of the transferrin receptor 1 and it can be used to measure the status of iron in the blood and thus help in studies into anemia, where iron is deficient.</p>

<p>Please enquire for more information about Fmoc Gly TentaGel® S RAM resin (particle size: 90 µm capacity: 0.2 - 0.25 mmol/g) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>C-Peptide II (Mouse)-EIA Kit is a Mouse C-Peptide II (C-PEPTIDE) ELISA Kit. This kit is designed to measure the level of C-peptide in mouse serum by using a sandwich enzyme immunoassay. The assays are carried out in microtiter plates coated with monoclonal antibodies specific for mouse C-peptide. After incubation, unbound material is removed and the wells are washed. The amount of bound mouse C-peptide is then determined by adding an enzyme conjugate that reacts with the mouse C-peptide and measuring the degree of color development with a spectrophotometer.</p>

<p>Anti Bombesin Serum is a research tool that can be used to study the interactions of proteins with receptors and ion channels. Anti Bombesin Serum may also be used to study the inhibition of peptide receptor activity, for example, by bombesin or other ligands. This product is made from high-quality antibodies that have been selected for their ability to bind bombesin.</p>

<p>Suc-Ala-Leu-Pro-Phe-pNA is a synthetic peptide that can bind to the beta 2 adrenergic receptor. It is an activator of the receptor and it can be used as a research tool to study protein interactions. This peptide is a potent inhibitor of the receptor. Suc-Ala-Leu-Pro-Phe-pNA binds to the beta 2 adrenergic receptor by preventing the binding of other ligands and thus reducing its activity. The peptide has been shown to bind with high affinity, but low potency, in vitro.<br>Suc-Ala-Leu-Pro-Phe pNA is not toxic as it does not lead to cell death.</p>

<p>Alpha-1-Acid Glycoprotein light tryptic peptide standard for protein identification and quantitation. Alpha-1-Acid Glycoprotein is an acute phase protein whose concentration in serum increases during, infection, inflammation and tissue injury.</p>

<p>Insl3 is a protein that is localized in the ovary and human chorionic gonadotropin. It is also found in human serum. In animals, Insl3 causes fertility. In humans, it stimulates the development of the gubernaculum, which attaches to the testes. The expression of Insl3 increases during puberty and continues to be expressed throughout adulthood. Insl3 is translated from mRNA as a precursor protein with an N-terminal signal peptide sequence that directs its secretion from the cell into the extracellular space. The Insl3 precursor protein has two C-terminal domains: an internal domain and a carboxy-terminal domain. These domains are translated from separate initiation codons on one mRNA molecule. The internal domain contains sequences for translation initiation, ribosome binding sites, and translational stop codons; these sequences are not present in the carboxy-terminal domain. Insl3 can be detected by using an</p>

<p>FRETS-25Tyr (1 umol) (1umol) is a peptide that is used as a research tool for the study of protein interactions, receptor function, ion channels and ligand binding. FRETS-25Tyr (1 umol) (1umol) is an activator of protein kinase C and has been shown to inhibit ion channels. This peptide is also used in the study of cell biology, with an antibody that detects it. FRETS-25Tyr (1 umol) (1umol) has high purity and CAS No. 6058-57-2.</p>

<p>Bromoacetamido-dPEG®24-Amido-DBCO is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®24-Amido-DBCO is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>β-Defensin-2 is a protein that belongs to the class of defensins. It has been shown to have antimicrobial activity against a wide range of microorganisms and to be an activator of ion channels. β-Defensin-2 is also a ligand for the GPR18 receptor, which may be involved in the regulation of pain perception. β-Defensin-2 is purified from human leukocytes and has a purity of &gt;98%.</p>

<p>NPY is a peptide that is released by neurons and acts as an activator. It is also found in the central nervous system and regulates appetite, as well as other autonomic, behavioral, and endocrine functions. NPY has been shown to be an inhibitor of ion channels in the central nervous system. NPY has been shown to bind to receptors on the surface of cells, which are ligands for NPY. This binding activates or inhibits the receptor's signaling pathway. The CAS number for NPY is 1139-14-1 and it has a molecular weight of 9.6 kDa.END&gt;</p>

<p>[D-Ala2,Met5]-Enkephalinamide is a peptide that belongs to the group of opioid peptides. It acts as an agonist and binds to the µ-opioid receptor. This receptor is involved in transmitting signals from outside the cell to inside the cell by regulating ion channels and controlling protein interactions. The binding of [D-Ala2,Met5]-Enkephalinamide to this receptor results in an inhibitory effect on neurotransmitter release, leading to a decrease of pain sensation. It has also been shown that [D-Ala2,Met5]-Enkephalinamide can act as an antagonist at other opioid receptors, such as the κ-opioid receptor.</p>

<p>Orexin-A is a peptide that has been shown to activate orexin receptors, which are ligand-gated ion channels. It is used as a research tool in cell biology and pharmacology. Orexin-A, also known as hypocretin-1, is an endogenous neuropeptide that regulates arousal and wakefulness. The activation of the orexin receptor by Orexin-A leads to the opening of voltage-gated Ca2+ channels, resulting in Ca2+ influx into the cell and increased neurotransmitter release. Orexin-A binds to both orexin receptor subtypes (orexins 1 and 2) with similar affinity but with different binding modes. This antibody can be used for western blotting or immunohistochemistry studies in order to detect the presence of Orexin-A in cells or tissues.</p>

<p>Cytochrome P450 3A4 is an enzyme that is involved in the metabolism of a wide range of compounds, including drugs and other xenobiotics. CYP3A4 can metabolize a drug from one chemical to another by adding or removing a functional group. CYP3A4 also has monooxygenase activity, meaning it can convert one compound into another using oxygen as a reactant. CYP3A4 is responsible for the metabolism of many drugs and is commonly found in humans, mice, rats, dogs and cattle.</p>

<p>Mu-conotoxin GIIIB is a peptide that acts as an inhibitor of the nicotinic acetylcholine receptor. This toxin blocks the activation of the receptor, which leads to paralysis and death. Mu-conotoxin GIIIB is a highly purified peptide that has been shown to be a useful research tool for studying ion channels and their interactions with other proteins. The protein has also been used as an effective drug in treating myasthenia gravis and neuromuscular disorders.</p>

<p>Lys(1-Deoxyfructosyl) is a research tool used in cell biology and pharmacology. It interacts with many receptor types, such as ion channels, ligands, and antibodies. Lys(1-Deoxyfructosyl) binds to receptors and activates them. This leads to changes in the cells that are observed under a microscope. Lys(1-Deoxyfructosyl) has also been shown to inhibit protein interactions in living cells.</p>

<p>CRF is a human antibody that is used as a research tool. It has reactivity with cells that are activated by CRF, and binds to the receptor on these cells. CRF is also known as a ligand, which can bind to the receptor and trigger changes in the cell, such as ion channels or protein interactions. CRF is an activator of G-protein coupled receptors.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of F2RL2 antibody, catalog no. 70R-9968</p>

<p>Apelin-36 is a peptide hormone that is derived from a larger precursor protein. It is a member of the apelin peptide family, which is involved in regulating cardiovascular and metabolic functions.<br>Apelin-36 binds to a G protein-coupled receptor called APJ (apelin receptor), which is widely expressed in various tissues. The interaction between apelin-36 and APJ receptor leads to a range of physiological effects, such as cardiac contractility stimulation and blood pressure suppression as well as lowering body weight and improving glucose homeostasis.<br>Research has shown that apelin-36 may have therapeutic potential in the treatment of cardiovascular diseases, such as hypertension and heart failure, as well as metabolic disorders, such as obesity and diabetes. Apelin-36 has also been implicated in other physiological processes, including inflammation, angiogenesis, and cancer progression. This product is available as a 0.1 mg vial.</p>

<p>PLGF-2 is a cytokine that is secreted by activated platelets. It has been shown to inhibit the proliferation of various human cancer cells, including breast and prostate cancer cells. PLGF-2 is also a potent stimulator of endothelial cell growth and angiogenesis.</p>

<p>This product is an antiserum targeting amino acids 34-40 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.</p>

<p>Anti-EGFR (Epidermal Growth Factor Receptor) is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR). The EGFR is a transmembrane tyrosine kinase receptor that plays an important role in cell proliferation, differentiation, and survival. Anti-EGFR can be used as a research tool for studying protein interactions, such as the interaction of peptides with receptors or ligands. It can also be used for pharmacological studies and can be used to isolate proteins from cells. This product is available in high purity, which means it has been purified by chromatography to have less than 0.1% other proteins than the product. This product is also available in a form of an antibody conjugate, which means that it has been linked to an antibody molecule that recognizes the target antigen specifically. Anti-EGFR is available in CAS No., which stands for Chemical Abstracts Service Number.</p>

<p>This Scyllatoxin product is a synthetic scorpion (Leiurus quinquestriatus hebraeus) toxin with disulfide bonds between Cys3-Cys21, Cys8-Cys26, and Cys12-Cys28. It can be used as a small conductance Ca2+-activated K+ channel blocker and may assist in pharmacology receptor studies. This product is available as a 0.1mg vial.</p>

<p>Magainin 1 is a research tool that belongs to the class of activators. It binds to receptor and ligand, which are proteins in cells. Magainin 1 is used as a tool in cell biology to study protein interactions and pharmacology, as well as for the study of ion channels. It has high purity and can be used with other reagents, such as antibodies or peptides, in research.</p>

<p>The enzyme is a glycohydrolase that catalyzes the hydrolysis of gamma-glutamyl peptide bonds. It is a member of the family of enzymes that catalyze the hydrolysis of peptide bonds in proteins, polypeptides, and oligopeptides. The enzyme has been purified from Escherichia coli and characterized by chromatographic techniques and molecular mass determination. The gene encoding this protein has been cloned into prokaryotic expression vectors or eukaryotic expression vectors for use in protein studies or other investigations.</p>

<p>β-Defensin-4 is a human defensin that belongs to the class of β-defensins. It has been found in a wide range of tissues, such as the skin and respiratory tract. <br>β-Defensin-4 is a small, cationic peptide with an amphipathic structure. It binds to cell membranes and forms ion channels that allow ions to flow into the cell. The channel formed by β-defensin-4 is selective for monovalent cations such as Na+, K+, and Ca2+. β-Defensin-4 has been shown to be an activator of G protein coupled receptors and may play a role in inflammatory responses.</p>

<p>CBZ-amido-dPEG®24-amido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CBZ-amido-dPEG®24-amido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Vasopressin is a peptide hormone that is synthesized from the amino acid arginine and stored in vesicles. It is released into the bloodstream by the hypothalamus, where it acts as an antidiuretic and also stimulates vasoconstriction and contraction of smooth muscle. Vasopressin has been shown to inhibit the binding of ligands to their receptors, which may be due to its ability to activate these receptors. This protein has been used as a research tool for studying receptor-ligand interactions, cell biology, and pharmacology. It can also be used as a reagent for Western blotting or immunohistochemistry.</p>

<p>Noggin is a protein that is involved in the regulation of neuronal growth and development. It acts as a morphogen, binding to a receptor on the surface of cells and initiating signaling cascades that lead to changes in gene expression. Noggin binds to Retinoid-X-receptor (RXR) and the Ligand-binding domain of Notch1. These interactions may be important for the regulation of CNS cells, such as neurons and glial cells. The protein has been shown to have a role in synaptic plasticity, axonal guidance, and synaptogenesis. Noggin has also been shown to be an inhibitor of cell proliferation and an activator of cell differentiation.</p>

<p>FGF4 is a protein that is encoded by the FGF4 gene. It belongs to the fibroblast growth factor family and is a potent activator of the receptor tyrosine kinase FGFR1. FGF4 activates cell proliferation and migration, as well as inducing angiogenesis. FGF4 has been shown to inhibit potassium channels in some types of cells, leading to increased neuronal activity in rats.<br>FGF4 also binds to insulin-like growth factor receptor 1 (IGF1R) and IGF2R. It has been shown to regulate the activation of these receptors, which are known for their roles in cell proliferation, differentiation, survival, and metabolism.</p>

<p>Fmoc-N-Amido-dPEG®36-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Fmoc-N-Amido-dPEG®36-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>IGHG1 MS Calibrator-7 is a 25nmol peptide that is derived from the C region of Ig gamma-1 chain. It is a tryptic peptide that corresponds to the sequence of IGHG1. The molecular weight of this peptide is 584.6Da and its theoretical pI is 9.26. This calibrator can be used in various proteomics applications, including proteomics tools such as TrypTides and Proteomics Tools from New England Peptide Company.</p>

<p>SPDP-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>CPN-116 is an ion channel ligand that binds to the voltage-gated sodium channels of excitable cells. It is used for research purposes in pharmacology and cell biology. CPN-116 has been shown to activate the TRPM8 receptor, which is a ligand-gated cation channel expressed in cold sensing neurons. The purified peptide is supplied as a lyophilized powder containing at least 98% CPN-116 by weight.</p>

<p>Vasoactive Intestinal Peptide (VIP) Antiserum is a research tool that can be used to investigate the function of VIP in different cell types. VIP Antiserum is also an inhibitor of Protein interactions and may have applications in pharmacology.</p>

<p>BMP 2 is a member of the TGF-β superfamily and is a potent activator of bone morphogenetic protein receptors. It is a ligand for type I and II receptor complexes. BMPs play a crucial role in embryonic development, tissue repair, and maintenance of cartilage. BMP 2 has been shown to inhibit ion channels such as calcium-activated potassium channels. It also inhibits protein synthesis by inhibiting the activation of transcription factors like CREB, c-Jun N-terminal kinase (JNK), and p38 mitogen activated protein kinase (MAPK). BMP 2 also binds to antibodies that are specific for phosphorylated receptor tyrosine residues, which can be used as research tools in immunohistochemistry experiments or other applications.</p>

<p>IL 10 rat (IL-10) is a cytokine that belongs to the family of IL-10 cytokines. IL-10 binds to the IL-10 receptor and inhibits the release of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6. This cytokine has been shown to inhibit the production of reactive oxygen species by macrophages and neutrophils. The physiological role of this cytokine is not yet fully understood, but it is believed to be important for immune regulation in response to bacterial infections.</p>

<p>AC 253 is an amylin (AMY3) receptor antagonist.</p>

<p>Insulin II is a peptide hormone that is secreted by the pancreas in response to elevated blood glucose levels. The insulin II receptor is a G protein-coupled receptor that binds insulin II and mediates its effects. Insulin II has been shown to inhibit ion channels, such as potassium channels, and activate other proteins, such as phospholipase C. Insulin II is used as a research tool for investigating protein interactions, receptor pharmacology, and ligand binding.</p>

<p>Bromoacetamido-dPEG®11-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®11-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>m-dPEG®12-Amido-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Amido-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.<br>Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.</p>

<p>Des-Arg9-Bradykinin is a peptide that is structurally related to bradykinin. It is synthesized by removing the first two amino acids from the N terminus of bradykinin and replacing them with an acetyl group. It has been shown to have potent activity against inflammatory cells in vitro, including mast cell degranulation and histamine release. Des-Arg9-Bradykinin also inhibits the production of nitric oxide, which may be responsible for its anti-inflammatory effects.</p>

<p>TGF b 1 is a member of the transforming growth factor family and is a potent inhibitor of cell proliferation. Recombinant human TGF b 1 has been shown to inhibit the proliferation of various cell types in culture, including fibroblasts, endothelial cells, and smooth muscle cells. It also inhibits tumor growth in vivo. The binding site for TGF b 1 on target cells has been localized to the extracellular domain of type II receptor kinase, which is composed of three immunoglobulin-like domains. This protein can be used as an antibody or ligand to study protein interactions.</p>

<p>IL1-beta is a pro-inflammatory cytokine that belongs to the Interleukin family. It is expressed in response to inflammation, trauma, and infection and can be found in many tissues of the body. IL1-beta has been shown to have a wide variety of effects on the body including regulating cell growth and differentiation. IL1-beta has also been shown to bind with high affinity to specific receptors that are known as type I interleukins. These receptors are able to activate other cells such as T cells and macrophages, which produce more inflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ).<br>IL1-beta Mouse is a mouse monoclonal antibody that binds specifically with IL1-beta. This antibody can be used for immunohistochemistry or Western blotting experiments. It can also be used for blocking studies using an ELISA assay or RIA assay.</p>

<p>Anti Pancreatic Polypeptide (18-36), humanSerum is a recombinant protein that belongs to the group of peptides. It is an activator of ion channels, which are proteins that regulate the flow of ions across cell membranes. This product is used as a research tool in pharmacology and cell biology. Anti Pancreatic Polypeptide (18-36), humanSerum has been shown to inhibit the activity of ion channels by binding to their ligands, thereby preventing activation. The purified recombinant protein has no detectable endotoxin levels and is suitable for use in research applications.</p>

<p>MAL-dPEG®24-Amido-dPEG®24-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-Amido-dPEG®24-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Secretogranin III, human, recombinant is a research peptide that is produced using Escherichia Coli. This protein is involved in various physiological processes and has been widely studied in the field of neuroscience. Secretogranin III plays a crucial role in the regulated secretion of hormones and neuropeptides. It is also involved in the formation and trafficking of secretory granules within cells. The recombinant form of Secretogranin III offers researchers a valuable tool for studying its functions and mechanisms in different biological systems.</p>

<p>Leptin ELISA Kit is a sandwich ELISA for the quantitative measurement of mouse leptin in rat serum. Leptin is a 16-kDa peptide hormone that regulates energy balance and body weight. It is produced by adipose tissue, and circulates in the blood as a protein complex with high-density lipoprotein (HDL). The assay employs monoclonal antibodies (MAbs) to measure mouse leptin in rat serum. The Mabs are specific for the mouse leptin sequence, which allows them to selectively bind to the mouse leptin in rat serum. Quantitative measurements of mouse leptin can be made using standard colorimetric procedures.</p>

<p>IL 17 Mouse is a recombinant mouse monoclonal antibody that binds to the IL-17 receptor. It has been shown to activate the signal transduction pathway by binding to the IL-17 receptor and inducing activation of nuclear factor kappa B (NF-κB) and other signal transducers. This antibody is used as a research tool in cell biology, pharmacology, and immunology. IL 17 Mouse is a high purity product with an amino acid sequence identical to that of human IL-17 receptor, with no detectable contaminants.<br>!--</p>

<p>Stanniocalcin-1 is a protein that belongs to the stanniocalcin family of proteins. It is expressed by a variety of tissues and has been shown to have chemotactic, pleiotropic, and adipogenic effects. Stanniocalcin-1 also regulates luteinization and homologous differentiation in cells. The recombinant form of this protein has been shown to stimulate the growth of cells in culture with high levels of expression. Additives such as deionized water and chromatographic techniques can be used to purify this protein.</p>

<p>Hyaluronidase is a glycosaminoglycan that is synthesized by the cells of the synovial membrane, and is used in the treatment of osteoarthritis. It has been shown to be potent inducers of apoptosis in cancer cell lines, with a high percentage of caspase-3 activation. Hyaluronidase also inhibits angiogenesis and induces cell death through an unknown mechanism. This enzyme functions as an extracellular matrix-degrading enzyme and has been shown to have anti-inflammatory properties.</p>

<p>Amino-dPEG®11-ONH-t-boc is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®11-ONH-t-boc is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>Leptin is a protein hormone that is produced by fat cells. Leptin regulates appetite and energy use, and it has been shown to be involved in the regulation of body weight. Leptin binds to receptors on the surface of cells, which activates signaling pathways inside the cell. This receptor can be activated by other ligands such as ghrelin, adiponectin, and insulin. Leptin also inhibits ion channels in neurons, resulting in an increase in potassium conductance.</p>

<p>Exendin (5-39) is a synthetic Mexican beaded lizard venom-derived peptide and is available as a 0.5mg vial. This product has has a GLP-1 Receptor antagonist application..</p>

<p>SPDP-dPEG®8-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. SPDP-dPEG®8-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.</p>

<p>HBB MS Calibrator is a research tool that is used to calibrate mass spectrometry. It is an activator of Ligand and Receptor, which are proteins that play a role in cell biology. HBB MS Calibrator binds to ion channels and inhibits the opening of these channels. This leads to a decrease in the flow of ions through the channel, which can affect a number of cellular processes. HBB MS Calibrator also has pharmacological properties that are used for drug discovery and peptide production.</p>

<p>TentaGel® S AC Resin is a building block that is used as a synthetic tool to make peptides. TentaGel® S AC Resin is composed of styrene, acrylates, and divinylbenzene, which are all monomers. TentaGel® S AC Resin is used for the synthesis of peptides to be used in various experiments such as proteomics and cell biology.</p>

<p>RLN2 is an oncogene that encodes a protein with a sequence of amino acids similar to the anti-cancer drug docetaxel. It is expressed in resistant prostate cancer cells and has been shown to modulate cytogenetics, haematology, and tissue microarrays. The RLN2 gene is also expressed in ligaments and may be associated with chemoresistance.</p>

<p>Frets-25Glu is a peptide inhibitor of the alpha subunit of the voltage-gated potassium channel. It is a high purity, water-soluble, stable peptide that can be used as a research tool to study the function of ion channels and receptors. Frets-25Glu has been shown to inhibit potassium channel currents in rat dorsal root ganglion neurons and rat dorsal spinal cord neurons. It also binds to the alpha subunit of voltage-gated potassium channels in rat brain tissue.</p>

<p>α-defensin-6 is a human protein that belongs to the α-defensin family. It has been shown to have antibacterial activity against Gram-positive bacteria and is thought to be involved in the innate immune response. α-Defensin-6 has been shown to inhibit ion channels, receptor activation, and cell biology.<br>This product is available as a 0.1mg vial and contains disulfide bonds between Cys4-Cyc31, Cys6-Cys20 and Cys10-Cys30. It can be used as an antimicrobial peptide in Paneth cells.</p>

<p>Amino acids 1-34 of the Pararthyroid Hormone (PTH) containing a tyrosine residue and disulfide bonds between Cys3-Cys14. This product is of Bovine source and available as a 0.5mg vial. Parathyroid hormone (PTH) is a peptide hormone that regulates calcium and phosphate homeostasis. PTH stimulates the production of active vitamin D, which increases calcium absorption from the gut and promotes reabsorption of calcium in the kidney. The inhibitory effect of PTH on renal phosphate excretion causes hyperphosphatemia and hypocalcemia. PTH also stimulates osteoblasts to produce more bone matrix, resulting in increased bone mineralization and density. It is used as a research tool to study protein interactions, activation, ligand binding, receptor regulation and ion channels. It has been shown to have effects on some cell types such as T-cells, B-cells, neutrophils and mast cells. In addition to its effects on bone metabolism, PTH also has many other functions including vasoconstriction, inhibition of food intake and stimulation of glucose production by the liver.</p>

<p>CCK-Tetrapeptide (30-33) is a peptide hormone that is structurally related to cholecystokinin. It has been shown to inhibit the activity of adenylate cyclase and phosphodiesterase, which are enzymes that are involved in cellular signaling. CCK-Tetrapeptide (30-33) has significant interactions with other drugs and can cause symptoms such as nausea, vomiting, diarrhea, or headache.</p>

<p>ANP (Human, 7-28) is a peptide with inhibitor activity. ANP (Human, 7-28) binds to the receptor for atrial natriuretic peptide and inhibits its interaction with other proteins. It can also activate the receptor by binding to it. ANP (Human, 7-28) contains an N-terminal sequence of amino acids that are not present in the human atrial natriuretic peptide and can be used as a research tool or an antibody against this protein.</p>

<p>Chagas disease is caused by the parasite Trypanosoma cruzi and is transmitted to humans by the bite of an infected triatomine bug. The Chagas multiantigen (CM) is a recombinant protein that contains the entire sequence of the T. cruzi trypomastigote surface glycoprotein gp41, which plays a critical role in parasite invasion of host cells. CM can be used as a research tool for studying receptor-ligand interactions, ion channels, cell biology, and pharmacology. It also has potential use as an inhibitor of the invasion of mammalian cells by T. cruzi trypomastigotes.</p>

<p>A synthetic cone snail toxin sourced from the marine snail, Conus striatus. This product is a tetrodotoxin-resistant Na+ channel blocker with analgesic activity, has disulfide bonds between Cys3-Cys13, Cys4-Cys19, and Cys8-Cys20 and is available as a 0.5mg vial.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>MBP(1-11) corresponds to amino acids 1 to 11 of the human myelin basic protein (MBP).</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Portion of Influenza M</p>

<p>Custom research peptide; min purity 95%.</p>

<p>A biotinylated, synthetic spider toxin, which can be used as a reagent for a localization study of the omega-Agatoxin IVA binding site. This product has disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34 and is available as a trifluoroacetate salt and as a 0.1mg vial.</p>

<p>Custom research peptide; min purity 95%.</p>

<p>Custom research peptide; min purity 95%.</p>