Peptides
Sous-catégories appartenant à la catégorie "Peptides"
29793 produits trouvés pour "Peptides"
CMV IE-1 (213-225)
CMV pp65 (415-429) (HLA-B7) is a CEF (cytomegalovirus, Epstein-Barr virus, and influenza virus) control peptide that is derived from the Cytomegalovirus (CMV). CMV is capable of infecting a wide range of human cell types, where the body's primary immune response to CMV is innate, and relies on inflammatory cytokines and costimulatory molecules in order to control the spread of the virus. CMV pp65 (415-429) (HLA-B7) is defined as a CEF control peptide due to its antigenic properties. Clinically, these peptides are suitable epitopes for CD8+ T cells and can be used to stimulate the release of IFNg. HLA-B7 refers to the cell HLA type that this peptide acts on.Masse moléculaire :1,516.8 g/molAzido-dPEG®4-NHS ester
CAS :Azido-dPEG®4-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Formule :C15H24N4O8Degré de pureté :Min. 95%Masse moléculaire :388.37 g/molTemporin L
Temporin L is a highly potent anti-microbial peptide (AMP) active against both Gram-positive and Gram-negative bacteria. Temporins are a large family of short, linear, AMPs produced in the skin of frogs belonging to Rana species, but are also found in wasp venom. Temporin L was originally isolated from the frog Rana temporaria and has the highest anti-microbial potency among tested temporins, especially against Gram-negative bacteria.Temporin L increases bacterial inner membrane permeability in a dose-dependent manner without destroying cell integrity. At low peptide concentrations, the inner membrane becomes permeable to small molecules but this does not kill the bacteria. At high concentrations, larger molecules, but not DNA, leak out, resulting in cell death. Temporin L has a different mode of action to many AMPs as it does not lyse the cells but instead forms ghost-like bacteria shells.Couleur et forme :PowderMasse moléculaire :1,639 g/molH-EIPISINYR^-OH
Peptide H-EIPISINYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.(Asn670,Sta671,Va672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
CAS :Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormule :C73H118N16O27Masse moléculaire :1,651.83 g/molH-FSGEYIPTV^-OH
Peptide H-FSGEYIPTV^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CMVpp65 - 134 (PAAQPKRRRHRQDAL)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,800.1 g/molH-SILKV-NH2
Peptide H-SILKV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
5-FAM-Fz7-21
Fz7-21 is a potent and selective peptide antagonist of Frizzled 7 (FZD 7) receptor which selectively binds to FZD7 cysteine rich domain (CRD) subclass at the cysteine rich region proximal to the lipid-binding groove. Binding alters the conformation of the CRD and the architecture of its lipid-binding groove and impairs Wnt/β-catenin signalling. Peptide Fz7-21 also shows cross-species binding to both the human and mouse FZD7 CRD.The FZD7 receptor is enriched in intestinal stem cells which express the LGR5 receptor and plays a critical role in the cells self-renewal. FZD7 is essential for maintaining human embryonic stem cells in their undifferentiated state and is therefore an attractive pharmacological target for diseases associated with stem cell dysfunction and cancer biology.FZD7 is also upregulated in subsets of colon, pancreatic and gastric tumours, therefore Fz7-21 serves as a pharmacological probe to explore further the function of FZD7 in stem cell and cancer biology.Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Masse moléculaire :2,110.8 g/molC-terminal Sortagging-[Cys(AF680)] amide
This C-terminal Sortagging peptide acts as an (oligo)glycine nucleophile in the final steps of a sortagging protein labelling reaction. This reaction results in the [Cys(AF680)]- fluorescent moiety being attached to the C-terminus of the target protein or peptide.A substrate peptide containing the LPXTG motif is recognised and cleaved by the enzyme Sortase A (SrtA) from Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA serves as a nucleophile to cleave the peptide bond between threonine and glycine of the substrate peptide. Cleavage results in the formation of a thioacyl intermediate between the substrate peptide and SrtA. This intermediate is then resolved by the N-terminus of this (oligo)glycine nucleophile peptide, resulting in the creation of a new peptide bond that links the substrate peptide to this peptide and its fluorescent dye. This method of protein labelling is known as sortagging.C-Terminal Sortagging-[Cys(AF680)] peptide contains the AF680 fluorescent dye- AF680 is a bright green dye with excitation at 633 nm, well suited for flow cytometry and imagery. AF680 is particularly photostable, allowing better detection of low abundance conjugates. C-Terminal Sortagging-[Cys(AF680)] amide is provided here. However, the acid version is also available in our catalogue.Masse moléculaire :1,240.3 g/molH-Ala-Arg-AMC hydrochloride
CAS :H-Ala-Arg-AMC hydrochloride is a reagent that can be used in the synthesis of various complex compounds. This reagent is a useful scaffold for high quality research chemicals. It is also a versatile building block, which can be used as an intermediate or a building block. H-Ala-Arg-AMC hydrochloride is easily soluble in organic solvents and has a CAS number of 83363-71-7.Formule :C19H26N6O4·HClDegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :438.91 g/molα-CGRP (mouse, rat)
CAS :Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion. It also has a function in temperature homeostasis, increases heart rate, and can play a role in the release of the pituitary hormone.Formule :C162H262N50O52S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :3,806.25 g/molAc-SLGRKIQI-NH2
Peptide Ac-SLGRKIQI-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-PQGR^IVGGK-OH
Peptide H-PQGR^IVGGK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Suc-KGFLGK-NH2
Peptide Suc-KGFLGK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-VQSLQDEVAFLR^-OH
Peptide H-VQSLQDEVAFLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-TSDLIVLGLPWK^-OH
Peptide H-TSDLIVLGLPWK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-GTFAQLSELHCDK^-OH
Peptide H-GTFAQLSELHCDK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ara h 2 (147-155) peanut Allergen
Ara h 2 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins.Ara h 2 is a member of the 2S albumins (conglutinins) belonging to the prolamin superfamily which also includes Ara h 6. 2S albumins contain major food allergens from seeds of many mono- and dicotyledon plants and share a common compact structure that renders the proteins highly resistant to proteolysis.In mouse models Ara h 2 and Ara h 6 are the main cause of effector responses such as mast cell degranulation and anaphylaxis. Ara h 2 has a high predictive value for diagnosis of clinical peanut allergy and is also more potent than Ara h 1 or Ara h 3 in histamine release assays and skin prick tests.This peptide represents a tryptic peptide of Ara h 2.Couleur et forme :PowderMasse moléculaire :1,027.5 g/molHistone H4 (1-23)
Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are fundamental in compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4's lysine rich tail plays a role in the higher order chromatin folding.Couleur et forme :PowderMasse moléculaire :2,400.5 g/molGrowth hormone releasing protein-2
CAS :Please enquire for more information about Growth hormone releasing protein-2 including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormule :C45H55N9O6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :817.98 g/molH-FSVVYAK^-OH
Peptide H-FSVVYAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Biotin-β Amyloid (1-42) Human
Amyloid β-protein (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.This peptide contains a covalently attached N-Terminal biotin tag for convenient detection and purification.Degré de pureté :Min. 95%Couleur et forme :PowderMyr-KFARLWTEIPTAIT-OH
Peptide Myr-KFARLWTEIPTAIT-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
HIV p17 Gag (77-85)
The HIV gag gene encodes p17 and p24. P17 Gag is a matrix protein that is vital to HIV life cycle, it targets viral RNA to the nucleus and Gag polyproteins to the cell membrane- p17 Gag accumulates in the extracellular space of tissue while interacting with receptors on various cell types to deregulate cell function.During HIV infection the cytotoxic T lymphocyte (CTL) response is key to attenuating viral replication. CTL recognition epitope of p17 Gag is identified as residues 77-85 to activate the immune response. HIV p17 Gag CTL epitope has been used in IgG titres and has been suggested as a suitable prognostic tool for onset of AIDS. A high affinity of IgG for p17 Gag was correlated to patients remaining in an asymptomatic state. p17 Gag epitope has been shown to induce a strong CTL response in the majority of chronically infected HIV patients. This makes the p17 Gag epitope a target for molecular therapy for HIV treatment and potentially a vaccine development.Couleur et forme :PowderMasse moléculaire :980.5 g/molH-NVPLPVIAELPPK^-OH
Peptide H-NVPLPVIAELPPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Albumin (mouse, rat)
Albumin is a family of globular, water soluble, un-glycosylated proteins commonly found in blood plasma. Albumins generally act as transport proteins that bind to various ligands to transport them around.The most common member of this family is serum albumin. Serum albumin is produced by the liver and is the most abundant plasma protein, it provides oncotic pressure, transports bilirubin, steroids, fatty acids, thyroid hormones and other hormones, and serves as an extracellular antioxidant agent.Too much or too little circulating serum albumin may be harmful. Perturbations in serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). Increase in serum albumin concentration might protect against early glycemic deterioration and progression to type 2 diabetes even in subjects without MetS. Albumin in the urine usually denotes the presence of kidney disease.Masse moléculaire :1,055.7 g/molH-VPFLVAETPR^-OH
Peptide H-VPFLVAETPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ILSPFLP^LL-OH
Peptide H-ILSPFLP^LL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Z-Ile-Ser-OH
CAS :Z-Ile-Ser-OH is a fine chemical that belongs to the group of useful scaffolds and versatile building blocks. It is a useful intermediate in research and as a reaction component in speciality chemicals. Z-Ile-Ser-OH has been shown to be an excellent reagent for complex compounds. This compound is used as a building block for pharmaceuticals, agrochemicals, and other chemicals. Z-Ile-Ser-OH has high quality and can be used as a research chemical or as an intermediate for other chemical syntheses.Formule :C17H24N2O6Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :352.38 g/molUrumin
Urumin is a veridical host defence peptide against influenza A virus.The peptide specifically targets the evolutionarily conserved H1 hemagglutinin stalk region of H1-containing influenza A viruses.Urumin has been used against drug-resistant influenza A viruses that are resistant against oseltamivir, zanamivir and peramivir. While its mechanism of action is not fully understood, urumin seems to inhibit viral growth by physically destroying influenza A virions, and is able to protect naive mice from doses of influenza A infection as high as 2 times the LD50. Because of its specific targeting of the hemagglutinin stalk region of the influenza A virus, the mechanism of action of urumin is similar to that of antibodies induced in the body by universal influenza vaccines.Masse moléculaire :2,959.4 g/mol1,2-Dimyristoyl-rac-glycerol
CAS :1,2-Dimyristoyl-rac-glycerol (1,2-DMG) is a monomolecular fatty acid that has been found to inhibit the replication of herpes simplex virus. It binds to the surface glycoprotein and inhibits the release of diacylglycerol from the lipid membrane. 1,2-DMG also inhibits the activity of acyl chain enzymes, which are necessary for the synthesis of fatty acids in trypanosomes. This inhibition prevents the growth and proliferation of lung fibroblasts and may be beneficial in treating cancer. The ionisation mass spectrum shows that 1,2-DMG has a molecular weight of 270 Da. The binding affinity between 1,2-DMG and water is 9 x 10 M at room temperature.Formule :C31H60O5Degré de pureté :Min. 90%Couleur et forme :White PowderMasse moléculaire :512.81 g/molHLA-A*02:01 HBV core (18-27)
HLA-A*02 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA). HLA-A is a human MHC class I cell surface receptor and is involved in presenting short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood "read" the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis. This peptide corresponds to the Hepatitis B variant (HBV) core sequence which is presented on the MHC class I antigen HLA-A*02.Masse moléculaire :1,154.6 g/molAc-CMKKDDQIAAAMVLRGMAKDGQFALK-NH2
Peptide Ac-CMKKDDQIAAAMVLRGMAKDGQFALK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.h-Chemerin-9 (149-157)
A Chemerin-9 peptide derived from chemerin, a protein that is involved in a variety of functions such as autocrine, angiogenic, reproductive and chemotactic processes. Chemerin-9 binds to the chemerin receptor 23 (G-protein coupled receptor) and causes the receptors internalisation.Masse moléculaire :1,063.5 g/molH-EIYKRWII^-OH
Peptide H-EIYKRWII^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LEGPGEQETK^-OH
Peptide H-LEGPGEQETK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-KMLEILFEL^-OH
Peptide H-KMLEILFEL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ITVVDALHEIPVK^-OH
Peptide H-ITVVDALHEIPVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SETD8 Peptide
Setd8 is a member of the SET domain containing family of proteins and is the sole methyltransferase that catalyses monomethylation of lysine 20 on histone H4 (H4K20me1). This histone modification is involved in regulating DNA replication, chromosome condensation and gene expression.Setd8 is widely expressed and in addition to modifying histone H4, it can modify non-histone proteins, including p53. Setd8 has been shown to play a role in maintaining skin differentiation and is dysregulated in multiple cancer types.Masse moléculaire :1,076.7 g/molDRB1*01:01 gag DYVDRFYKTLRAE
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolH-AVCVLK^-OH
Peptide H-AVCVLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Acetyl-Histone H4 (1-21)
Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4 lysine rich tail plays a role in the higher order chromatin folding.Acetyl-Histone H4 (1-21)-has an uncharged C-terminal amide and is protected from N-terminal modifications by a covalently bonded acetyl group.Masse moléculaire :2,131.3 g/molPAR-4 Agonist (Mouse)
CAS :Thrombin is the main effector of the coagulation cascade- it is a serine protease. Thrombin binds to active protease activated receptor (PAR) which belongs to a subfamily of G-protein coupled receptors (GPCR). Thrombin activation of mouse PAR-4 reveals an amino terminus sequence of GYPGKF. This is the natural ligand for PAR-4. GYPGKF binds internally to the receptor and leads to signalling activation. Identification of GYPGKF as a PAR-4 agonist has allowed better understand of the function of PAR. Addition of GYPGKF to PAR-4 expressing cell lines achieved 55% of the maximal response of thrombin. GYPGKF can provide understanding of PAR-4 and a template for more potent agonists.
Formule :C33H46N8O7Couleur et forme :PowderMasse moléculaire :666.3 g/molSpexin
Spexin is a neuropeptide that is conserved amongst humans and rodents. Spexin activates galanin2/3 receptors, inducing a different active conformation of GalR2 to galanin. The broad distribution of spexin suggests multiple physiological roles including as a regulating factor in obesity and energy metabolism. Spexin is ubiquitously expressed in human tissue, however, a correlation has been found with obesity and age. Obese patients had significantly lower levels of circulating spexin than those with a healthy weight range. The significance of this suggests spexin regulates appetite, feeding behaviour, and energy expenditure. Spexin also specifically inhibits the uptake of long-chain fatty acids by adipocytes.Spexin is a central modulator of cardiovascular and renal function and can elicit central nervous system behavioural responses. As spexin levels decrease with age there is research to understand if it plays a role in age-related pathophysiology of cardiometabolic conditions. Spexin is also being considered an early biomarker for cardiovascular disease due to the magnitude with which it decreases as the pathophysiology progresses.Masse moléculaire :1,618.8 g/molHXB2 gag NO-93
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,698 g/molFibrinopeptide
Fibrinogen is a large plasma glycoprotein with a complex structure, and one of the most abundant proteins in blood. Fibrinogen is important in fibrin clot formation, haemostasis, and inflammatory responses. Increased plasma fibrinogen indicates a proinflammatory state and is a risk factor for vascular inflammatory diseases including hypertension and atherosclerosis. Fibrinogen cleavage products act as inflammatory activators in the pathophysiology of allergic asthma.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to fibrinogen and catalyses cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB). Fibrinopeptide B is protected from modifications such as carbamylation by pyroglutamination of the N-terminal amino acid.Couleur et forme :PowderMasse moléculaire :1,551.7 g/molSakamototide
Sakamototide is phosphorylated by members of the 5'-adenosine monophosphate-activated protein kinase (AMPK) family of kinases as is therefore ideal for use in kinase assays to test the activity of AMPK family members. The AMPK family includes- salt inducible kinases (SIKs), NUAK's, sucrose non-fermenting (Snf1)-related kinase (SNRK), microtubule affinity regulating kinases (MARKs) and brain specific kinase/BR serine/threonine kinase (BRSK). The kinase activity of AMPK and AMPK-related kinases, is dependent on its phosphorylation at Thr175 by the upstream kinase LKB1 (also known as STK11).Couleur et forme :PowderMasse moléculaire :1,738.9 g/molH-GLEVTAYSPLGSSDR^-OH
Peptide H-GLEVTAYSPLGSSDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Exendin 4 (4-39)
This is a truncated exendin-4 peptide, the original peptide was identified in Gila monster lizard (Heloderma suspectum). Exendin-4 is an incretin mimetic, an analog of glucagon-like-peptide-1 (GLP-1), it stimulates insulin secretion and modulates gastric emptying to slow the entry of ingested sugars into the bloodstream. Exendin-4 is resistant to cleavage by plasma DPP-IV unlike GLP-1. This gives it a longer half-life and duration of action than GLP-1, as well as greater potency in vivo. Exendin-4 increases insulin sensitivity and improves glucose tolerance and is currently used for the treatment of Type 2 diabetes mellitus in its synthetic form Exenatide.Exendin-4 also promotes the production and proliferation of β-cells leading to regeneration of the pancreas. It is a ligand to the exendin receptor and increases pancreatic acinar cell cAMP levels. However, the GLP-1 analog was found to have a toxic effect by inducing hypotension due to relaxation of the cardiac smooth muscle.Couleur et forme :PowderMasse moléculaire :3,860.9 g/molPlasmodium falciparum CSP 334-342 (HLA-A*02:01)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolH-SLDLDSIIAEVK^-OH
Peptide H-SLDLDSIIAEVK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-YSPITNF-NH2
Peptide H-YSPITNF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[FITC]-Ahx-(KKEEE)3K carrier peptide
The [FITC]-Ahx-(KKEEE)3K carrier peptide contains the fluorescent label fluorescein isothiocyanate (FITC), where the isothiocyanate can generate a stable thiourea linkage through reacting with the amine group present on protein molecules. The Ahx group (1,6-aminohexanoic acid) is used as a spacer to N-terminally link the FITC to the (KKEEE)3K carrier peptide. The (KKEEE)3K peptide sequence has shown significant specific renal targeting, thus giving it kidney-specific drug carrier properties. In particular its ability to target drugs to the proximal tubule cells of the kidney suggests potential to aid in the treatment of renal diseases.
Masse moléculaire :2,578.83 g/molHistone H3 (20-39)-Biotin
Histone H3 (20-39)-Biotin is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Another modification process histones can undergo is biotinylation where the covalent attachment of a biotin molecule is catalysed by the enzyme Biotinidase. This cleaves biocytin to generate a biotinyl-thiester intermediate. The biotinyl can then be transferred onto the histone lysine ɛ-amino group which is covalently attached to Histone 3. Overall the biotinylation sites identified in histone 3 are: K4, K9 and K18. The presence of biotinylated histones have been detected in human cells such as lymphocytes and lymphomas.
Couleur et forme :PowderMasse moléculaire :2,256.3 g/molAoa-LALLAK-NH2
Peptide Aoa-LALLAK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-AKFVAAWTL-NH2
Peptide Ac-AKFVAAWTL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.EBV BZLF1 (190-197) (HLA-B8)
Portion of EBV BZLF-1Couleur et forme :PowderMasse moléculaire :1,002.6 g/molLCBiot-GHSFADPASNLGLEDIIRKALMGSF-OH
Peptide LCBiot-GHSFADPASNLGLEDIIRKALMGSF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
MP196
MP196, a RW-rich peptide, displays antibacterial properties through preventing bacterial cell wall synthesis and cellular respiration. Due to it lacking hemolytic and cytotoxic qualities, MP196 can be used to synthesis antibiotics and aid in the global problem of antibiotic resistance.Couleur et forme :PowderMasse moléculaire :1,043.6 g/molH-IFLTEQP^LEGLEK^-OH
Peptide H-IFLTEQP^LEGLEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
SIVmac239 - 77
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Masse moléculaire :1,734 g/molAc-CRVSSEPPASIRPKTDDTSS-NH2
Peptide Ac-CRVSSEPPASIRPKTDDTSS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-EIAEAYLGK^-OH
Peptide H-EIAEAYLGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-FVNEEALR^-OH
Peptide H-FVNEEALR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-YYGYTGAFR^-OH
Peptide H-YYGYTGAFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Ac-ADE-OH
Peptide Ac-ADE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Myelin Basic Protein (83-99) (bovine)
CAS :Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Formule :C93H143N25O24Masse moléculaire :1,995.31 g/molH-DIYSTDYYR^-OH
Peptide H-DIYSTDYYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
HXB2 gag NO-75/aa297 - 311
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,812 g/molH-LADFADALEHPLR^-OH
Peptide H-LADFADALEHPLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SIVmac239 - 65
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,798.2 g/molH-SFEDIHHYREQIK^-OH
Peptide H-SFEDIHHYREQIK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-VTGEVLDILTR^-OH
Peptide H-VTGEVLDILTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ASMTNMEL^M-OH
Peptide H-ASMTNMEL^M-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Neuromedin U 25
Neuromedin U (NmU) is a neuropeptide expressed in various organs including the brain, gut, bone marrow and lungs. NmU has a wide range of roles in physiology including: decreasing appetite and body weight and increasing gross locomotor activity, heat production, oxygen consumption, uterine smooth muscle contraction, body temperature, and bone mass. It is also involved in regulating circadian rhythm, stress response and blood flow and ion transport in the gut. NmU can also stimulate cytokine production and promote mast cell-mediated inflammation and is important during the early proliferative stages of erythroid development. NmU has been shown to be a c-Myb target gene and NmU in turn activates protein kinase C-βII, a factor associated with hematopoietic differentiation-proliferation.Two related G protein-coupled receptors have been identified as NmU receptors: NMU-R1: expressed in various tissues, including the small intestine and lung, and NMU-R2: predominantly expressed in the hypothalamus and the small intestine. Activation of these receptors via NmU binding mobilises intracellular Ca2+ stores and downstream signalling.Masse moléculaire :3,078.5 g/molH-ALVDQVIGSR^-OH
Peptide H-ALVDQVIGSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LTIGEGQQHHLGGA^K^QA^GDV-OH
Peptide H-LTIGEGQQHHLGGA^K^QA^GDV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-GEAGPQGPR^-OH
Peptide H-GEAGPQGPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-SHGQDYLVGNK^-OH
Peptide H-SHGQDYLVGNK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LGEYGFQNAL^-OH
Peptide H-LGEYGFQNAL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-MASMTGGQQMGR^-OH
Peptide H-MASMTGGQQMGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Macropin 1
Macropin-1 (MAC-1) is an anti-microbial peptide (AMP) isolated from venom of the solitary bee Macropis fulvipes (Hymenoptera: Melittidae). MAC-1 has activity against both Gram-positive and Gram-negative bacteria, including drug-resistant strains. MAC-1 can inhibit biofilm formation in Staphylococcus aureus and Pseudomonas aeruginosa and also exhibits anti-fungal activity. MAC-1 has little to no haemolytic activity against human cells at microbiologically effective concentrations.Macropin acts by first binding to negatively charged bacterial membrane components- such as peptidoglycan (PTG) or lipopolysaccharide (LPS). Macropin then kills the bacteria by disrupting the outer bacterial membrane and depolarising the cytoplasmic membrane to cause cell penetration.Masse moléculaire :1,416.86 g/molH-ALPNNTSSSPQPK^-OH
Peptide H-ALPNNTSSSPQPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CMVpp65 - 58 (ESFCEDVPSGKLFMH)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,726 g/molH-FSPDDSAGASA^LLR-OH
Peptide H-FSPDDSAGASA^LLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Histone H3 (1-20)-GG-[Cys(AZ647)]
Histone H3 (1 - 20) is derived from Histone 3 (H3), which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Like the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing many lysine and arginine residues, they have a positive net charge which interacts electrostatically with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone-modifying enzymes which target histone proteins. Both processes alter the positioning of the nucleosome, allowing the DNA to be either available or inaccessible to the transcription machinery.Histone tails can undergo multiple modifications, including acetylation, methylation, ubiquitylation and sumoylation. The purpose of the modifications is believed to alter chromatin function/structure. Histone H3 (1 - 20), with no modifications, is a valuable peptide in the study of epigenetics. It can aid in understanding interaction with histone effectors and the histone tail using crystallisation and pull-down assays on affinity matrices. Histone H3 (1 - 20) is labelled with the Aurora Fluor 647 fluorescent tag.Masse moléculaire :3,378.6 g/molH-IANVFTNAFR^-OH
Peptide H-IANVFTNAFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-CGVNNSNEDFREENLKTAN-NH2
Peptide Ac-CGVNNSNEDFREENLKTAN-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Thr-Phe-Leu-Leu-Arg-NH2
CAS :H-Thr-Phe-Leu-Leu-Arg-NH2 is a peptide that has been shown to reduce the severity of lung inflammation and injury in rats with pulmonary hypertension. It also prevents the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα) and interleukin 6 (IL6). This peptide also induces an antibody response against collagen gel, which is used to treat fibrotic diseases and wounds. The peptide binds to the soybean trypsin inhibitor, preventing it from inhibiting protease enzymes, thereby allowing for protein synthesis. H-Thr-Phe-Leu-Leu-Arg-NH2 has been shown to have antiapoptotic effects by restoring mitochondrial membrane potential in cancer cells. This peptide can be used as a therapeutic agent for various diseases including primary pulmonary hypertension, cancer tissues, and mitochondrial disorders.Formule :C31H53N9O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :647.81 g/molH-IAVSYQTK^-OH
Peptide H-IAVSYQTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-Glu(Val-OH)-OH
CAS :H-Glu(Val-OH)-OH is a synthetic form of l-glutamic acid. It increases the activity of glutamyl synthetase, which is an enzyme that regulates the synthesis of glutathione. H-Glu(Val-OH)-OH has been shown to have anticarcinogenic effects in animal studies. This compound also inhibits the synthesis of alpha-tocopherol, which is a molecule that protects against oxidative stress and is essential for maintaining cell membranes. H-Glu(Val-OH)-OH may be useful as a dietary supplement for individuals with low body mass index (BMI) or cancer patients undergoing chemotherapy. H-Glu(Val-OH)-OH may be used to treat obesity by increasing energy expenditure and decreasing appetite, although it does not affect glucose levels in mice. The mechanism by which this compound affects obesity is yet unknown, but it may be due to its ability to activate proinflammatory cytokines such as TNFα
Formule :C10H18N2O5Degré de pureté :Min. 98 Area-%Couleur et forme :White Off-White PowderMasse moléculaire :246.26 g/molH-RPPGF^-OH
Peptide H-RPPGF^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.PAR-3 Agonist (Human)
Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. These PAR-activating proteases therefore represent PAR agonists. This PAR-3 agonist peptide represents the sequence of the 'tethered ligand' and is therefore capable of activating the receptor independently of N-terminal proteolysis.PAR-3 is required for intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells and PAR-3 cooperates with PAR-1 to mediate the effect of thrombin on cytokine production and vascular cell adhesion molecule (VCAM- 1) expression.Masse moléculaire :646.4 g/molH-Gly-Ala-AMC monohydrochloride
CAS :H-Gly-Ala-AMC monohydrochloride is a chemical that is used as a reaction component or reagent in pharmaceutical and research laboratories. It has been shown to be a useful scaffold for the synthesis of complex compounds. This compound is also used as an intermediate in the synthesis of other fine chemicals. H-Gly-Ala-AMC monohydrochloride can be used as a building block for the production of versatile building blocks, which are useful for making speciality chemicals.Formule :C15H17N3O4·HClDegré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :339.77 g/mol[5-FAM]-Tyr-Ahx-Ser-Asp-Lys-Pro-acid
[5-FAM]-Tyr-Ahx-SDKP-acid
Couleur et forme :PowderMasse moléculaire :1,079.4 g/mol
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