Peptides
Sous-catégories appartenant à la catégorie "Peptides"
29793 produits trouvés pour "Peptides"
[5-TAMRA]/[Lys(BHQ-2)]-CoV Main Protease (Mpro) Substrate
Fluorescently labelled substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro). The substrate sequence is derived from residues P4-P5' of the SARS-CoV Mpro N-terminal autoprocessing site which has the sequence AVLQSGFRK. SARS-CoV Mpro is a key antiviral target.This peptide contains an N-terminal a 5-carboxytetramethylrhodamine (5-TAMRA), a widely used fluorescent dye which excites at 546 nm and emits at 579 nm and a black hole quencher 2 (BHQ-2) group. This Mpro substrate is used in Mpro inhibition assays. The compound being tested for its inhibitory capacity of Mpro is added alongside [5-TAMRA]/[Lys(BHQ-2)]-CoV, after a set time period, the amount of fluorescence released is read as a percentage inhibition by a plate reader.The fluorescence from 5-TAMRA is efficiently quenched by resonance energy transfer to the BHQ-2 group when the peptide is intact, however upon cleavage of the peptide by Mpro, 5-TAMRA and BHQ-2 are separated, allowing fluorescence to be detected. This therefore represents a useful tool for investigating Mpro activity.Masse moléculaire :2,048 g/molAc-ADE-OH
Peptide Ac-ADE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Histone H4 (1-21)
Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4's lysine rich tail plays a role in the higher order chromatin folding.Masse moléculaire :2,090.2 g/molMyelin Basic Protein (83-99) (bovine)
CAS :Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Formule :C93H143N25O24Masse moléculaire :1,995.31 g/molTrp-Glu-Glu
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Formule :C21H26N4O8Masse moléculaire :462.45 g/molSARS-CoV-2 Nucleoprotein (126-140)
The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. Also known as the nucleocapsid protein, it is an abundant RNA-binding protein critical for viral genome packaging. These factors make nucleoprotein a good target for developing new antiviral drugs. In addition, the identification of epitopes within the nucleoprotein sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. Nucleoprotein (56-70) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Masse moléculaire :1,599.8 g/molC-telopeptide
C-terminal telopeptide is produced when type I collagen in the bone is degraded and so released into the blood. Within collagen structure, made up of a triple helix of 3 amino acid chains, C-telopeptide is located at the C-terminus, and at the N-terminus there is an N-telopeptide. Both the N and the C-telopeptides are involved in the formation of collagen enzymatic cross links which are crucial for Collagen properties in the connective tissues of the body such as the bone and skin. Collagen properties allow connective tissues to be strong, stiff and maintain their structural integrity. Furthermore collagen acts as a scaffold for other extracellular matrix proteins.Due to the presence of C-telopeptide in the blood following the degradation of type 1 collagen, C-telopeptide can be used to monitor the progression of bone diseases where the pathogenesis commonly involves bone degradation.Couleur et forme :PowderMasse moléculaire :868.4 g/molHXB2 gag NO-75/aa297 - 311
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,812 g/molBCL-6 corepressor Human (BCOR) (498-514) C-terminal Biotin
Fragment 498-514 of the BCL6-interacting co-repressor (BCoR) C-terminally labelled with biotin.Couleur et forme :PowderMasse moléculaire :2,051.37 g/molSIVmac239 - 65
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,798.2 g/molH-SFEDIHHYREQIK^-OH
Peptide H-SFEDIHHYREQIK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Teduglutide (GLP2 2G)
CAS :Teduglutide is a GLP-2 analogue, in which the alanine at position 2 has been substituted with glycine making the peptide resistant to degradation by dipeptidyl peptidase-4 (DPP-4)- Teduglutide therefore has a longer half-life than GLP-2 (2-3 hours for teduglutide vs 7 min for GLP-2). Teduglutide has high bioavailability after subcutaneous administration, suggesting that teduglutide has enhanced biological activity, relative to native GLP-2.GLP-2 is a gut hormone produced in the enteroendocrine L cells of gastrointestinal tract by the cleavage of the 160-amino-acid proglucagon molecule. GLP-2 is secreted following the ingestion of food and carries out its activities via the GLP-2 G-protein coupled receptors (GLP-2Rs). GLP-2 has a range of roles within the cell, including: anti-inflammatory effects- promoting the expansion of the intestinal mucosa- stimulating intestinal blood flow- inhibiting gastric acid secretion and gastric emptying- increasing intestinal barrier function and enhancing nutrient and fluid absorption.Formule :C164H252N44O55SCouleur et forme :PowderMasse moléculaire :3,749.8 g/molGalanin (13-20) Mouse
Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway. Activation of the receptor leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin is a key regulator of growth hormone and insulin release and adrenal secretion however the role galanin plays is not clear. Administration of galanin to animal models leads to inhibition of insulin secretion but this is not replicated in humans.N-terminal galanin fragments naturally occur in vivo, but their relevance is unclear. Some N-terminal fragments reduce metabolic and functional disorders in experimental heart damage. Their relative abundance varies, with fragment (13-20) being one of the lowest quantities detected. The physiological relevance of the galanin fragment (13-20) and its affinity to the various Gal receptors has yet to be made clear. Binding assays and displacement assays in rat brain tissue have been performed with similar N-terminal galanin fragments to try and elucidate their function. Using N-terminal fragments such as galanin (13-20) can help clarify the role of full-length galanin in various roles, such as during myocardial ischemia and reperfusion injury. This may highlight new agonists/antagonists for the galanin GalR receptors that can be therapeutic targets.Masse moléculaire :957.5 g/molPolybia-MPII
The crude venom of the wasp Polybia paulista consists of 30% polybia-MPII. Polybia-MPII is a mastoparan, it is rapidly distributed around the organism point of inoculation via the circulation. As a secretagogue, polybia-MPII has myotoxic action and minor neurotoxic effects. Polybia-MPII has been injected sub-cutaneously and intra-muscularly into mice for pathology and immunohistochemistry assays.As an antimicrobial agent, polybia-MPII is highly effective, with a lower haemolysis rate compared to other mastoparans. Polybia-MPII also shows considerable anti-fungal activity.Masse moléculaire :1,612 g/molH-GILIDTSR^-OH
Peptide H-GILIDTSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-AVTLSLDGGDTAIR^-OH
Peptide H-AVTLSLDGGDTAIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SSG tripeptide
SSG-acid tripeptide consists of two serines and one glycine residue, this was synthesised from the dipeptide L-Seryl-L-glycine- the dipeptide SG-acid is also available in our catalogue. SSG-acid has a net charge of 0, it can act as a Bronsted base by accepting a hydron from a donor thus giving it diverse biological and chemical uses.Glycosylated SSG tripeptide was found to act as a competitive ATPase inhibitor produced by the fungal pathogen Mycosphaerella pinodes, named Supprescin A.Masse moléculaire :249.1 g/molSARS-CoV-2 Nucleoprotein (1-17)
The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. The nucleoprotein has a critical role in virus assembly and RNA transcription. The nucleoprotein is essential in the formation of helical ribonucleoproteins and in regulating viral RNA synthesis. The nucleoprotein can also regulate infected host cellular mechanisms. It is highly expressed during infection and may induce protective immune responses against SARS-CoV and SARS-CoV-2.The nucleoprotein residues MSDNGPQNQRNAPRITF (1-17) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.Masse moléculaire :1,944.9 g/mol[5-FAM]-MAP
Amphipathic alpha-helical cationic antimicrobial peptides (AMPs) are rapidly bactericidal and have broad spectrum activity. As AMPs have non-specific modes of action involving membrane disruption, bacteria are less likely to develop resistance to them (unlike traditional antibiotics). KLAL is a model compound to form amphipathic helices that are able to bind to membranes and increase the membrane permeability. KLAL model peptides may also form a β-structure under appropriate conditions. Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Masse moléculaire :2,234.76 g/molLCBiot-PPAHGVTSAPDTRPA-OH
Peptide LCBiot-PPAHGVTSAPDTRPA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-FLKEKGGL^-OH
Peptide H-FLKEKGGL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-GVY^DGEEHSV-OH
Peptide H-GVY^DGEEHSV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-DTHFPICIFCCGCCHR^SK^CGMCCK^T-OH
Peptide H-DTHFPICIFCCGCCHR^SK^CGMCCK^T-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ara h 6 (120-131) peanut Allergen
Ara h 6 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins. Ara h 6 is a member of the 2S albumins (conglutinins) belonging to the prolamin superfamily which also includes Ara h 2. 2S albumins contain major food allergens from seeds of many mono- and dicotyledon plants and share a common compact structure that renders the proteins highly resistant to proteolysis.Ara h 6 contains multiple disulphide-bridged cysteine residues, resulting in a tightly coiled, heat-stable, protease resistant core structure that may be important for allergenicity. In mouse models Ara h 2 and Ara h 6 are the main cause of effector responses such as mast cell degranulation and anaphylaxis.This peptide represents a tryptic peptide of Ara h 6. The phenylalanine residue at position 11 of this peptide is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide.Couleur et forme :PowderMasse moléculaire :1,491.7 g/molH-DFLAGGIAAAISK^-OH
Peptide H-DFLAGGIAAAISK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
[5-FAM] Antennapedia peptide amide
Identification of cell penetrating conjugates has aided numerous areas of scientific development. The Drosophila transcription factor Antennapedia contains a homeodomain that can be internalised by cells to the cytoplasm and to the nucleus in a receptor-independent mechanism. The key residues for internalisation have been sequenced (RQIKIWFQNRRMKWKK), named penetratin, and used in several studies to aid entry of fusion proteins into cells.The full 60 amino acid homeodomain was fused to a T cell epitope of the influenza nucleoprotein and successfully internalised into T cells for presentation. The fragment known as penetratin was fused to a ligand for Grb-2 resulting in inhibition of downstream Grb-2 signalling events. Penetratin has also been used in vivo to prime cytotoxic T lymphocytes by conjugating short antigenic peptides to the CPP. Penetratin is provided here as a C-terminal amide with a C-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag often preferred over FITC due to its high stability- absorbance 492 (nm), 518 emission (nm).Masse moléculaire :2,604.04 g/molH-LGEYGFQNAL^-OH
Peptide H-LGEYGFQNAL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-MASMTGGQQMGR^-OH
Peptide H-MASMTGGQQMGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-ALPNNTSSSPQPK^-OH
Peptide H-ALPNNTSSSPQPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-VGEYSLYIGR^-OH
Peptide H-VGEYSLYIGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-ILGNQGSFLTK^-OH
Peptide H-ILGNQGSFLTK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-ITPSYVAFTPEGER^-OH
Peptide H-ITPSYVAFTPEGER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-VQVLLGAHSLSQPEPSK^-OH
Peptide H-VQVLLGAHSLSQPEPSK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
pMOG (44 - 54)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormule :C61H94N20O15Masse moléculaire :1,347.6 g/molBiot-KKKKEEIYFFF-OH
Peptide Biot-KKKKEEIYFFF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
SOR-C13
CAS :Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Formule :C72H116N20O19Masse moléculaire :1,565.81 g/molAcrAP1
Venom peptidomes and proteomes have yielded significant novel drug discoveries. The non-disulphide bridge peptides (NDBPs) have become a particular focus due to their large range of structures as well as biological activity while retaining high specificity.In scorpion venom A. crassicauda, AcrAP1 was identified as a NDBP. Data shows it has antimicrobial activity against bacteria and yeast while also capable of haemolysing of horse erythrocytes. However, AcrAP1 did not affect the growth of the cancerous cell lines tested. Therefore, this peptide could be a useful model for modification to improve its potency. Furthermore, it may allow researchers to identify specific targets in disease pathways for new drug designs. A significant example of this, bradykinin-potentiating peptide Captopril® manages hypertension and originated from the conserved NDBP family.
Masse moléculaire :1,961.35 g/molAoa-SMFVYGGCQGNNNNFQSKANC-NH2
Peptide Aoa-SMFVYGGCQGNNNNFQSKANC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Suc-LLVY-[AMC]
Fluorogenic substrate peptide of the 20S proteasome. In its intact state this peptide is non-fluorescent, however when aminomethylcoumarin (AMC) is released upon hydrolysation, fluorescence can be detected. This peptide is therefore a useful tool for analysing the activity of the 20S proteasome as well as other chymotrypsin-like proteases and calpains. This peptide is also a substrate for chymase, papain, carboxypeptidase Y, proteinase yscE (kexin) and ingensin.AMC is a fluorescent dye with excitation maxima at around 360 nm and emission maxima at around 450 nm. AMC can be excited with a mercury lamp and observed using a UV filter set.Couleur et forme :PowderMasse moléculaire :763.4 g/molβ-Amyloid (1-15) human
Amino acids 1-15 of β-amyloid protein (Aβ), this fragment represents one of many short Aβ species found in vivo and is formed by the cleavage of amyloid β precursor protein by β- and α-secretase.Aβ has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer disease (AD) and Down syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.Masse moléculaire :1,325.3 g/molCMVpp65 - 47 (AFVFPTKDVALRHVV)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,699 g/mol4-Fluorobenzoyl-A20FMDV2
A20FMDV2, a peptide derived from the foot and mouth disease virus, inhibits the epithelial-specific integrin alphavβ6 and here is labelled with 4-fluorobenzoyl as the light version of the PET ligand 4-[18F]Fluorobenzoyl A20FMDV2 which can be used for in vivo imaging.Masse moléculaire :2,283.3 g/molMethyltetrazine-IWLTALKFLGKHAAKHEAKQQLSKL-NH2
Peptide Methyltetrazine-IWLTALKFLGKHAAKHEAKQQLSKL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-AEEGDLLVNPDQPR^-OH
Peptide H-AEEGDLLVNPDQPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
AH1 Sequence (6-14)
The AH1 peptide is a H2-Ld-restricted epitope derived from the sequence of the gp70 envelope protein of the ecotropic mammalian C-type retrovirus, murine leukaemia virus (MuLV, emv-1).The envelope gene products of MuLV are expressed in a variety of tumour cells, including B16 melanoma, lymphomas and leukaemia's. AH1 peptide is a tumour-associated antigen and is highly expressed on CT26 and C51 tumour cells.
Couleur et forme :PowderMasse moléculaire :1,126.5 g/molAc-TTAI-NH2
AAT is a highly abundant serine protease inhibitor primarily produced in the liver to protect the lung tissue. However, misfolding of AAT can result in significant liver disease, lung disease, and cancers. Defective AAT is characteristic of the misfolding protein diseases known as serpinopathies.Ion mobility mass spectrometry (IM-MS) was used to identify Ac-TTAI-amide as a ligand effecting α1-antitrypsin stability. Interaction of Ac-TTAI-amide with AAT results in increased stability and reduced polymerisation. Thus Ac-TTAI-amide is a useful target for further research in to serpinopathy management.Couleur et forme :PowderMasse moléculaire :445.3 g/molH-AYATEPHAK^-OH
Peptide H-AYATEPHAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Neuromedin (U8), porcine
CAS :Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormule :C54H78N16O10Masse moléculaire :1,111.32 g/mol[5-FAM]-EB1
EB1 is a penetratin analogue that was synthesised to be an endosomolytic cell penetrating peptide (CPP). Certain amino acids in the penetratin sequence were replaced with histidine to encourage formation of an alpha helix upon protonation in the acidic endosomes. As a CPP, EB1 has been shown to form a strong interaction with the phospholipid bilayer during insertion with rapid cellular uptake, there is a moderate amount of cell leakage and no significant cytotoxicity. EB1 is provided here as a C-terminal amide with a N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag often preferred due to its high stability absorbance 492 (nm), 518 emission (nm).Masse moléculaire :3,458.07 g/molLys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFormule :C43H79N11O11S1Masse moléculaire :958.22 g/molFluorescein HLA-A*02:01 HBV core (18-27)
HLA-A*02 is a class I major histocompatibility complex (MHC) allele which is part of the HLA-A group of human major histocompatibility complex (MHC) leukocyte antigens (HLA), found at the HLA-A locus. HLA-A is one of three major types of human MHC class I cell surface receptors. The receptor is a heterodimer, and is composed of a heavy alpha chain and smaller β chain. MHC Class I molecules such as HLA-A are part of a process that presents short polypeptides to the immune system. These polypeptides are typically 7-11 amino acids in length and originate from proteins being expressed by the cell. Cytotoxic T cells in the blood "read" the peptide presented by the complex and should only bind to non-self peptides. If binding occurs, a series of events is initiated culminating in cell death via apoptosis. This peptide corresponds to the Hepatitis B variant (HBV) core sequence which is presented on the MHC class I antigen HLA-A*02 and contains fluorescein, a widely used flourescent dye.
Masse moléculaire :1,537.6 g/molHistatin-5
Histatins are histidine rich cationic peptides produced in salivary glands and released into the saliva. The main histatins that make up more than 80% of histatins in saliva are histatin 1, histatin 3 and histatin 5. There are two histatin genes, one which encodes histatin 1, and one that encodes histatin 3, all other histatins are derivatives of these two histatins. Histatin 3 is a precursor of histatin 5, each with distinct roles.Histatin 5 is considered an antimicrobial peptide (AMP) as it has antibacterial activity as has been shown against opportunist infections such as P. aeruginosa, E. coli, and S. aureus. Histatin 5 also has potent anticandidal activity for example against Candida and Leishmania, it is shown to be the strongest antifungal of the histatins. The antifungal activity functions by invasion of the microbe and entry to the mitochondria, histatin 5 then inhibits ATPase activity resulting in rapid depletion and ultimately bacterial cell death/apoptosis. As a salivary peptide, it inhibits Bacteroides gingivalis proteinase clostripain and protease activity microbe implicated in periodontal disease.Couleur et forme :PowderMasse moléculaire :3,036.29 g/molHXB2 gag NO-21/aa81 - 95
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,774.1 g/molClick MAP
Cell penetrating peptides (CPP) are a useful tool for drug delivery, but their cell-specific uptake is still being improved. Work with the model amphipathic peptide (MAP) has been important in this field. CPP MAP is an amphipathic α-helix and has been well characterised for its ability to spontaneously permeate the cell membrane by interacting with the lipid bilayer. As a CPP, MAP causes increased membrane permeability and a degree of cell leakage. MAP is being extensively studied to optimise drug delivery in numerous cell lines with the target of creating a viable clinical method. Interestingly, the CPP function of MAP also provides it with bactericidal properties by effecting the membrane permeability. MAP is a potent antimicrobial peptide (AMP) against gram negative Neisseria meningitidis, the pathogen of meningococcal disease.MAP is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-MAP allows a wide variety of applications particularly for conjugation, modification, and peptide design.Couleur et forme :PowderMasse moléculaire :2,234.8 g/molAc-SNKDRHIDSSC-NH2
Peptide Ac-SNKDRHIDSSC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.LCBiot-WSLGYTG-OH
Peptide LCBiot-WSLGYTG-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CMVpp65 - 6 (HVLKAVFSRGDTPVL)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolMasse moléculaire :1,638.9 g/molSteroid Receptor Coactivator-1 (SRC-1) (686-700)
There are three members of the p160 family of steroid receptor coactivators, SRC-1, SRC-2, and SRC-3. These steroid receptor coactivators control the functional output of numerous genetic programs and serve as pleiotropic rheostats for diverse physiological processes. Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.Masse moléculaire :1,770 g/molHistone H3 (1-20)-GG-[Lys(5-FAM)]
Histone H3 (1-20)-GG-[Lys(5-FAM)] is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Histone H3 (1-20)-GG-[Lys(5-FAM)] has a C-terminal GKK linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag. This peptide also has an uncharged C-terminal amide.
Masse moléculaire :2,781.5 g/molH-LLL^-OH
Peptide H-LLL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Cyclic L27-11
Cyclic L27-11 is a peptidomimetic compound that targets the outer membrane protein LptD. LptD is part of a complex that functions to transport lipopolysaccharides to the cell surface through the C-terminal β-barrel domain lumen, embedded within the outer membrane. Cyclic L27-11 can bind LptD and prevent translocation of lipopolysaccharides across the periplasm, even nanomolar doses were effective. This interaction gives cyclic L27-11 a potent antimicrobial activity particularly against the human pathogen Pseudomonas aeruginosa.Modifications of cyclic L27-11 are under research to improve its stability for drug delivery. The peptide provided here has a D-proline substitution, characterised as have no antimicrobial activity against Pseudomonas aeruginosa.Masse moléculaire :1,234.5 g/molAc-CLVVNPNYMLED-OH
Peptide Ac-CLVVNPNYMLED-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.LCBiot-GILGFVFTL-OH
Peptide LCBiot-GILGFVFTL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-MKNPKKKSGGFRIVC-NH2
Peptide H-MKNPKKKSGGFRIVC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-FSFKGIKFSKGKYK-NH2
Peptide Ac-FSFKGIKFSKGKYK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-AMRNALVRF-NH2
Peptide H-AMRNALVRF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.PACAP-27 (human, mouse, ovine, porcine, rat)
CAS :PACAP 1-27 (Pituitary adenylate cyclase-activating polypeptide 27) is a potent stimulator of adenylyl cyclase and increases cAMP levels.Formule :C142H224N40O39SMasse moléculaire :3,147.65 g/molFEFEFKFK
The ionic-complementary octapeptide, FEFEFKFK, can self-assemble into antiparallel β-sheet rich fibres and forms very stable hydrogels when at a concentration of more than 20 mg/mL (in water).These peptide hydrogels are naturally biocompatible and biodegradable and can be metabolised by the body. Such hydrogels have been shown to mimic the structure of the extracellular matrix, thus offering cells a niche to undertake their physiological functions. These properties mean that these hydrogels have the potential for use in medical applications.FEFEFKFK hydrogels are able to support the culture of cells such as mesenchymal stem cells in three dimensions with sustained cell viability. They can also support the differentiation into osteoblasts and promote mineralisation upon addition of osteogenic stimulation. They therefore have potential for use in the regeneration of hard tissues such as alveolar bone following injury or degeneration.
Masse moléculaire :1,120.6 g/molHCV NS4A 1635-1643 (HLA-A*03:01)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolGalanin (2-13) acid
Galanin is a widely distributed neuropeptide in the central nervous system, peripheral regions and endocrine system. Galanin has a role in energy homeostasis- central injections of galanin to the amygdala led to food intake in rats. Galanin also acts in the CNS to inhibit neurotransmitter release, such as acetylcholine. Galanin has been implicated in numerous neurological conditions, including Alzheimer's disease, depression, and epilepsy.Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway. Activation of the receptor leads to a cellular influx of potassium ions.The galanin active fragment 1-16 has been identified as a highly potent agonist for the galanin receptors. These have become a basis for galanin-based peptides, which are neuroactive. These are being investigated as a potential source for anticonvulsant neuropeptides as a therapeutic for conditions such as epilepsy. A library of galanin fragments has allowed screening of their properties to be assessed and used to generate chimeric peptides. Galanin fragments have different affinities for GalR receptors however, the N-terminal 1-16 have been shown to have a conserved affinity for the receptors. This galanin (2-13) peptide is provided in the acidic form. The amide form is also available in our catalogue.Masse moléculaire :1,290.7 g/molOvalbumin (324-340) acetyl/amide, chicken
Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (324-340) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.Masse moléculaire :1,813.9 g/molH-HLEINPDHSIIETLR^-OH
Peptide H-HLEINPDHSIIETLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[6-FAM]-Arg8
[6-FAM]-Arg8 is an arginine rich cell penetrating peptide labelled with 6-carboxyfluorescein (6-FAM).Masse moléculaire :1,623.9 g/molAc-QIMYNYPAM-OH
Peptide Ac-QIMYNYPAM-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
β-Amyloid (1-40) Human
Amyloid β-peptide (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS.Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.Aβ1-40 is a major C terminal variant of amyloid β constituting the most abundant AB peptide in the human brain.Masse moléculaire :4,329.8 g/molHiBiT tag
NanoLuc (Nluc) is an engineered luciferase protein which was developed from the luciferase of deep-sea shrimp (Oplophorus gracilirostris). This luciferase protein is considerably smaller than firefly or Renilla luciferase yet has higher luminescent intensity.In the NanoBiT assay system the NanoLuc luciferase protein has been separated into a large fragment, LgBiT, and a small fragment. HiBiT has a very similar amino acid sequence to the original small fragment and therefore has high specific affinity for the N-terminal large fragment, LgBiT. When these two fragments interact NanoLuc activity is restored. This system offers a novel alternative to conventional immunoblot analysis for the detection of protein expression when the HiBiT tag is added to the protein of interest and cell lysate is incubated with LgBiT. HiBiT peptide is capable of producing bright and quantitative luminescence through high affinity complementation with an 18 kDa subunit derived from NanoLuc (LgBiT).Couleur et forme :PowderMasse moléculaire :1,319.8 g/molH-ALYEQEIR^-OH
Peptide H-ALYEQEIR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-TPVITGAPYEYR^-OH
Peptide H-TPVITGAPYEYR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Histone H3 (1-34)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Formule :C144H260N54O44Masse moléculaire :3,451.98 g/molBiotin phosphorylated JAK1 substrate peptide
This peptide is phosphorylated by Janus kinase 1 (JAK1) and is an ideal substrate for use in kinase assays. The JAK family of kinases is essential for the signalling of a host of immune modulators in tumour, stromal, and immune cells where they are highly expressed. JAK family proteins mediate the signalling of the interferon (IFN), IL-6, and IL-2 families of cytokines.JAK kinases are associated with cytokine receptors. Cytokine binding to these receptors results in activation of JAK kinases and receptor phosphorylation. Phosphorylated cytokine receptors recruit STAT proteins, which are then phosphorylated by the activated JAK kinases. Phosphorylated STAT proteins form homo- and hetero-dimers that translocate into the nucleus and function as transcription factors.This JAK1 substrate peptide contains an N-terminal Biotin and a phospho-tyrosine residueCouleur et forme :PowderMasse moléculaire :2,238.9 g/molCBL-B (22-37) Light
CBL-B (22-37) is derived from the CBL-B E3 ubiquitin ligase which targets receptor tyrosine kinases to lysosome degradation. CBL-B and its family member CBL are expressed in hematopoietic cells and as E3 ubiquitin ligases they contain a tyrosine kinase domain and an RF domain joined by a linker domain. The function of the RF domain is to transfer ubiquitin from E2 ubiquitin-conjugating enzymes onto the target protein which is often phosphorylated. Consequently the ubiquitinated substrate, the receptor tyrosine kinases, are ultimately targeted to the lysosome for degradation.EGFR is an example of a receptor tyrosine kinase whose activation is prevented by CBL and CBL-B when they bind and recruit GRb2, the adapter protein to EGFR. Consequently the ubiquitinylation of EGFR occurs and targets it for recognition by the endosomal protein complex and then lysosome degradation.It has also been found that the CBL family can negatively regulate through ubiquitinylation, PI 3-kinases, Rap G-protein guanine nucleotide exchange factor (GEF), C3G and Rho GTPase GEF Vav which are all non-receptors.If CBL or CBL-B becomes non-functional it can be associated with malignancies such as acute myeloid leukemia and myelodysplastic syndrome.Masse moléculaire :1,618.9 g/molP17
Blocks the activity of TGFβ1 in vitro, as measured by its capacity to restore growth of Mv-1-Lu cells in the presence of added TGFβ1. Inhibits TGFβ1-dependent expression of collagen type I mRNA in the liver of mice orally insulted with CCl4.
Masse moléculaire :1,994.1 g/molH-LTILDQSEAPVR^-OH
Peptide H-LTILDQSEAPVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Galanin (2-13)-Biotin
Galanin is a widely distributed neuropeptide in the central nervous system, peripheral regions and endocrine system. Galanin has a role in energy homeostasis. Central injections of galanin to the amygdala led to food intake in rats. Galanin also acts in the CNS to inhibit neurotransmitter release, such as acetylcholine. Galanin has been implicated in numerous neurological conditions, including Alzheimer's disease, depression, and epilepsy.Galanin interacts with 3 receptor subtypes, GalR1-3 which are G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the Galphai/o pathway. Activation of the receptor leads to a cellular influx of potassium ions.The galanin active fragment (1-16) has been identified as a highly potent agonist for the galanin receptors. These have become a basis for galanin-based peptides, which are neuroactive. These are being investigated as a potential source for anticonvulsant neuropeptides as a therapeutic for conditions such as epilepsy. A library of galanin fragments has allowed screening of their properties to be assessed and used to generate chimeric peptides. Galanin fragments have different affinities for GalR receptors- however, the N-terminal (1-16) have been shown to have a conserved affinity for the receptors.The galanin fragment (2-13) provided here have a C-terminal biotin label for easy detection and purification. Cymit Quimica Laboratories Ltd is a custom peptide provider. If you desire an alternate tag, please contact us to request a custom synthesis.
Couleur et forme :PowderMasse moléculaire :1,558.8 g/molH-DQLIVNLLK^-OH
Peptide H-DQLIVNLLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Apolipoprotein A-I (APOA1)(86-101)
Apolipoprotein A-I enables the efflux of fat molecules from within cells as high-density lipoprotein (HDL) particles for transport back into LDL particles or to the liver for excretion. HDLs are one of five major groups of lipoproteins.Increasing concentrations of HDL particles are strongly associated with decreasing accumulation of atherosclerosis within the walls of arteries. Apolipoprotein A-I is often used as a biomarker for prediction of cardiovascular diseases, such that low levels of APOA1 are associated with an increased risk of adverse events in patients with coronary artery disease. In such cases, APOA1 can be used as a biomarker to predict cardiovascular disease progression.Masse moléculaire :1,930.9 g/molAc-DLIEEAASRPVDAVPEQVKAAGAY-NH2
Peptide Ac-DLIEEAASRPVDAVPEQVKAAGAY-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Click FBP
Cell penetrating peptides (CPPs) provide a delivery method for molecules across the membrane in an efficient manner without compromising the cell. FBP forms a sheet structure when interacting with a membrane forming a transmembranous pore. FBP, also known as Pβ, is rapidly internalised and localises primarily to the nucleus.FBP is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-FBP allows a wide variety of applications particularly for conjugation, modification, and peptide design.Couleur et forme :PowderMasse moléculaire :3,013.6 g/molAc-LDKNKDPLNETV-NH2
Peptide Ac-LDKNKDPLNETV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
TAT (48-57)
Peptide derived from the HIV transactivator of transcription protein. TAT is a cationic cell-penetrating peptide.
Masse moléculaire :1,396.66 g/molH-V^YIHPF-OH
Peptide H-V^YIHPF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.acfTAT
TAT contains a protein transduction domain which allows it to enter cells by crossing the cell membrane. The amino acid sequence of the protein transduction domain (PTD) and this property confers cell penetrating peptide properties on TAT and derivatives. TAT peptides have been widely used to deliver functional biomolecules into cells both in vitro and in vivo. The entire protein can be used but in practice it is more efficient to use truncated sequences containing only the basic residues required for transport. Through covalent attachment to TAT derived peptides, cargo molecules including proteins, nucleic acids, small molecules, oligonucleotides, enzymes, polymers, plasmid DNA and liposomes can be transported into cells with high efficiency.acfTAT is a fusion of the TAT PTD to a red fluorescent tag (TAMRA) at the carboxy terminal. This peptide is ideal for live cell localisation work using fluorescent microscopy as the TAT PTD can transduce small peptides into the cell efficiently without affecting the cell. Additionally, the fluorescent label is highly stable against photo bleaching and should be easily detectable under various excitation sources including mercury, arc, tungsten, and xenon lamps.Masse moléculaire :2,095.2 g/mol[Rhodamine Green]-LifeAct (Abp140 1-17)
[Rhodamine Green]-LifeAct (Abp140 1-17) contains the 17amino acid peptide Lifeact derived from amino acids 1-17 of the Saccharomyces cerevisiae actin binding protein, Abp140. These first 17 amino acids of Abp140 are crucial in allowing Lifeact to localise to actin filaments (F-actin) and therefore it can be used as a cytoskeletal marker. On application, lifeact can be used in the study of plant development and pathogen defence as filamentous actin within the plant actin cytoskeleton is important in key processes such as cell division, membrane trafficking and stomatal movements.The addition of the Rhodamine Green fluorophore, Rhodamine Green allows the location of the LifeAct (Abp140 1-17) to be detected.Masse moléculaire :2,279.1 g/molBiotin-aMp3
Biotinylated aMp3 is a Mycobacterium avium subsp. Paratuberculosis (MAP) specific ligand. MAP can cause Johne disease (the wasting disease) in livestock. It is important therefore to detect the presence of MAP in animal milk and faeces.Biotinylated aMp3 can be used (along with aMptD peptides) to detect the viability of MAP cells in infected livestock through combined peptide-mediated magnetic separation phage display due to their high affinity for MAP. The addition of biotin to aMp3 asparagine residue, changes the orientation of aMp3 so that it can bind to the target bacteria with increased stability, thus achieving a high capture efficiency. A similar effect is observed on the addition of biotin to aMptD glycine residue.Masse moléculaire :1,642.8 g/molH-LYVTIPLGIK^-OH
Peptide H-LYVTIPLGIK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-K^TTKS-OH
Peptide H-K^TTKS-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
![[5-TAMRA]/[Lys(BHQ-2)]-CoV Main Protease (Mpro) Substrate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101530.webp&w=3840&q=75)
![[5-FAM]-MAP](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100286.webp&w=3840&q=75)
![[5-FAM] Antennapedia peptide amide](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100181.webp&w=3840&q=75)
![[5-FAM]-Val](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101717.webp&w=3840&q=75)
![Suc-LLVY-[AMC]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100485.webp&w=3840&q=75)
![[5-FAM]-EB1](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100284.webp&w=3840&q=75)
![Histone H3 (1-20)-GG-[Lys(5-FAM)]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101260.webp&w=3840&q=75)
![[6-FAM]-Arg8](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101022.webp&w=3840&q=75)
![[Rhodamine Green]-LifeAct (Abp140 1-17)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100899.webp&w=3840&q=75)
