Peptides

Ac-Ala-Ser-Thr-Asp-AMC is a versatile building block that can be used as an intermediate in organic synthesis, a reagent, or a speciality chemical. It is also a useful scaffold for drug discovery and development. Ac-Ala-Ser-Thr-Asp-AMC has been shown to be an effective inhibitor of phosphodiesterase 3 (PDE3) and cyclic nucleotide phosphodiesterases (PDEs).

<p>Lys-Arg-OH acetate salt (LRA) is a protein transport peptide that is found in the neurosecretory system and has been used as a growth factor for the production of human insulin. LRA stimulates the release of pepsinogen, which breaks down food proteins into polypeptides and amino acids. It also has proteolytic activity, which helps break down proteins into peptides. LRA shares structural similarities with other peptide hormones such as vasopressin and oxytocin, but it differs by having an amide instead of an ester linkage between the lysine and arginine residues.</p>

<p>Neuropeptide W-23 (human) is an antibody that recognizes the neuropeptide receptor, specifically the Neuropeptide Y receptor 1. The antibody binds to the Npy1 receptor and inhibits its activity. Neuropeptide W-23 (human) can be used as a research tool in cell biology and pharmacology studies.</p>

<p>Please enquire for more information about Prostaglandin A1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cyclo[Arg-Gly-Asp-D-Phe-Lys(Cys)] is a RGD peptide for radiolabeling and imaging. It contains the Arg-Gly-Asp (RGD) sequence which is a highly conserved integrin recognition sequence within fibronectin.<br>One letter code: c[RGDfK(C)]</p>

This resin is for use in combinatorial chemistry. TentaGel is a gelatinous resin and an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. Particle size 130 µm; capacity: 0.2-0.35 meq/g Substitution Functional Group: -O-CH2-CH2-NH2

Please enquire for more information about Cys-Ala-Thr-Lys-Val-Asn(NGA2)-Phe-Thr-Glu-Ala-Gln-Lys-Ala-Ala-Leu-Asp-Val including the price, delivery time and more detailed product information at the technical inquiry form on this page

Somatostatin-28 is the 28 amino acid isoform of somatostatin and has similar activity to the 14 amino acid isoform. While the 14 amino acid form mainly acts in the brain, somatostatin-28 mainly operates in the gastrointestinal tract. Somatostatin is a peptide hormone that is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. It has been found to inhibit pituitary growth hormone release as well as endocrine, pancreatic and GI secretions. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.

Modified HIV TAT Sequence 49-57 for Click Chemistry. Product available as a trifluoroacetate salt

Human Hepcidin peptide hormone product also know as LEAP-1 (liver-expressed antimicrobial peptide), where the disulfides are formed by random oxidation. Hepcidin is a peptide hormone that is synthesized in the liver and is an important regulator of iron homeostasis. Through binding to ferroportin Hepcidin prevents the exportation of iron thus reducing the amount of circulating iron. Furthermore through inflammatory cytokine induction Hepcidin leads to the internalization and degradation of ferroportin thus further reducing the amount of iron in circulation. This in turn make conditions unfavourable to invading pathogens. This demonstrates Hepcidin's ability as an anti-microbial peptide. This antimicrobial behaviour can be used in research into the elimination of pathogens but also in combatting diseases where iron dysregulation is prevalant.Disulfide bonds between C7-C23; C10-C13; C11-C19; C14-C22

Fmoc4-Lys2-Lys-ß-Ala-Wang resin is a resin that is used as an activator for the synthesis of peptides. It has been used in research to study the interactions between proteins, as well as other cell biology and pharmacology studies. The resin is also used to prepare antibodies with high purity. Fmoc4-Lys2-Lys-ß-Ala-Wang resin can be used to purify ligands and receptors, including those that are difficult to purify by conventional methods.

Please enquire for more information about Head activator (7-11) acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>CRF (human, rat) acetate is a synthetic chemical that has been shown to produce long-term changes in the brain. It is chemically similar to CRF, which is an endogenous hormone produced by the hypothalamus. This drug is used for the treatment of cerebral edema and intracranial hypertension caused by various conditions, such as cancer. The effects of CRF (human, rat) acetate on humans are not well understood as this drug has only been tested in women who have undergone surgery to remove their ovaries. These women had increased levels of corticotropin-releasing hormone (CRH), which could be due to CRF (human, rat) acetate or its metabolites. There is also some evidence that it may cause corrosion in long-term use.</p>

Fmoc-Cys((S)-2,3-di(palmitoyloxy)-propyl)-OH is a reagent used in the synthesis of complex compounds. It is also a useful scaffold for the synthesis of speciality chemicals and versatile building blocks. This compound is an intermediate that can be used in the preparation of fine chemicals and pharmaceuticals. Fmoc-Cys((S)-2,3-di(palmitoyloxy)-propyl)-OH has a CAS number of 139573-78-7 and can be purchased as a high quality chemical.

<p>Fmoc-Cys((R)-2,3-di(palmitoyloxy)-propyl)-OH is a versatile building block that is useful for the synthesis of complex compounds. This compound has been shown to be a useful intermediate in the synthesis of pharmaceuticals, organic dyes and research chemicals. Fmoc-Cys((R)-2,3-di(palmitoyloxy)-propyl)-OH is a fine chemical that is used as a reagent in organic synthesis. It has CAS No. 139573-77-6 and can be used as a speciality chemical or reaction component.</p>

<p>The Aβ E22delta mutant (Osaka mutation) is more resistant to degradation by two major Aβ-degrading enzymes, neprilysin and insulin-degrading enzyme.  It also shows unusual aggregation properties with enhanced oligomerization but no fibrilization.</p>

Fmoc-Thr(tBu)-Thr(Psi(Me, Me)pro)-OH is a versatile building block that can be used as a starting material for the synthesis of a wide range of compounds. It is often used as an intermediate in organic chemistry reactions and can be converted to a variety of other compounds with different functional groups. This compound has been shown to be useful in the production of pharmaceuticals and research chemicals. Fmoc-Thr(tBu)-Thr(Psi(Me, Me)pro)-OH is also important for generating high-quality chemical products, such as speciality chemicals and reagents that are difficult to synthesize. The CAS number for this compound is 1676104-73-6.

<p>H-Trp-Phe-OH is a chromatographic, ligand, and mass spectrometric compound that has a red shift in its fluorescence spectrum. It has been shown to have anti-cancer properties by blocking the cell cycle at the G2/M phase. The red shift of the fluorescence spectrum is due to the presence of two isomeric forms that have different optical properties. H-Trp-Phe-OH has been analysed for its effects on cancer cells and was found to inhibit growth and induce apoptosis in mononuclear leukemia cells.</p>

Alpha-2-Gliadin (57-89) is a peptide with an antigenic function. It is part of a larger protein that can be found in wheat and other cereal grains, such as barley and rye. Alpha-2-Gliadin (57-89) has been shown to be biologically active in celiac disease patients.

Hepcidin, also known as LEAP-1 (liver-expressed antimicrobial peptide) or Hepcidin-25 is a hormone of 25 amino acids. Hepcidin is a cationic, cysteine-rich and tightly folded peptide stabilized by 4 disulfide bonds that plays a major role in innate immunity and iron homeostasis. Hepcidin inhibits iron transport by binding to the iron export channel ferroportin which is located on the basolateral surface of gut enterocytes and the plasma membrane of reticuloendothelial cells (macrophages). Hepcidin breaks down the transporter protein in the lysosome. Inhibiting ferroportin prevents iron exportation and iron is retained in cells. Hepcidin is regulated by iron through a complex of integral hemochromatosis proteins, like HFE, HJV and transferrin receptor 2. Hepcidin is also characterized by is antimicrobial activity in several vertebrate species, exerting its antimicrobial effect against both Gram-positive and Gram-negative bacteria as well as yeast, with for example an IC50 value against Saccharomyces cerevisae of 18 µM.

<p>H-Tyr-Tyr-Tyr-OH is a synthetic compound that has been used to study the mechanism of lactoperoxidase. Lactoperoxidase is an enzyme that catalyzes the oxidation of thiocyanate to form hypothiocyanite, hydrogen peroxide, and a hydroxy group. The hydroxy group is formed by the reaction of two molecules of hydrogen peroxide with a molecule of thiocyanate. This reaction produces an oxygen atom, which then reacts with water to produce an acid. H-Tyr-Tyr-Tyr-OH has been shown to be a substrate for lactoperoxidase in horse serum and bovine serum. It has also been found to react with oxygen at neutral pH levels, forming a product that absorbs ultraviolet light at 280 nm.</p>

Amyloid β-Protein (1-42) is a fragment of the amyloid beta protein that is thought to be a major contributor to the development of Alzheimer's disease. Amyloid β-Protein (1-42) has been shown to have neuroprotective effects, as it reduces cell death in the brain and preserves memory. It binds to the β-catenin protein in neurons and protects against oxidative stress by reducing production of reactive oxygen species. This molecule also reduces microglia activation and tnf-α levels, which may reduce inflammation. Amyloid β-Protein (1-42) is found in plants such as pueraria lobata, and has been used for centuries in traditional Chinese medicine for its anti-inflammatory properties.

<p>Peptide Lauric Acid-NPSSLFRYLPSD-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Fmoc-Glu(OtBu)-Rink-Amide MBHA Resin is a high purity, ion channel ligand that is used in research as a pharmacological tool. It is an activator of Kv1.3 channels and inhibits the function of Kv1.2 channels. This product can be used for the study of protein interactions and receptor pharmacology. Fmoc-Glu(OtBu)-Rink-Amide MBHA Resin also has been found to inhibit the binding of antibodies to cells and can be used for immunoprecipitation experiments. This product has CAS number 188476-46-4 and is available in 1 g and 5 g sizes.

A synthetic sea anemone toxin peptide, that can be applied as a voltage dependent K+ channel (A Channel) blocker.

Fmoc-Tyr(tBu)-Rink-Amide MBHA Resin is a solid phase peptide synthesis resin that is used for the production of small scale peptides. This resin has high purity and can be used in the synthesis of proteins, antibodies, and other bioactive molecules. Fmoc-Tyr(tBu)-Rink-Amide MBHA Resin is an ion-exchange resin that can be used to purify peptides by binding to their charged side chains. It is also useful as a research tool for cell biology, receptor pharmacology, and as an inhibitor.

Peptide H-SCDKTHTCPPCPAPELLGGPSVFLFPPKPK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-GDELADSALEIFK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-LIETYFSK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-SAPHGVVFL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

KRASᴳ¹²ᴰ peptide is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-FLHVTYVPAQEKNFT-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-EVFNATRFASVYAWN-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-LKPFERDISTEIYQA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Peptide H-EISTNIRQAGVQYSRADEEQ-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide CKIHAREIFDSRGNPTVEC is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>KRAS4A-specific peptide is a RAS protein fragment. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-TPRTPPPSQ-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-ILDTAGHEEY-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-EPVLKGVKL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-QPTESIVRF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-AANMHAQIK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-DLEMLAPYIPMDDDFQL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>K. phaffii binding peptide is used in protein purification. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-WEHR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>PSD95 peptide is a PSD95 fragment. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-DPIYALSWSGMAGGC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-IQNTGDYYDLYGGEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Please enquire for more information about (Des-Gly10,D-His2,D-Trp6,Pro-NHEt 9)-LHRH trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Cyclorasin 9A5 is a small molecule that inhibits the enzyme activity of protein kinase C (PKC). Cyclorasin 9A5 induces apoptosis by activating caspases in cancer cells. This peptide is also a potent inhibitor of PKC, which may be responsible for its anti-cancer effects. Cyclorasin 9A5 has been shown to inhibit the growth of cancer cells in vitro and in vivo. It also activates caspases, which are enzymes that break down proteins and other cellular components during apoptotic cell death. Cyclorasin 9A5 is thought to have potential as an anti-cancer drug due to its ability to inhibit PKC and activate caspases, as well as its low toxicity profile.

Glucagon, human recombinant is a protein that is used to treat low blood sugar levels in people with diabetes. It is a hormone that triggers the release of glucose from the liver and other stored sources of energy. Glucagon, human recombinant can be reconstituted with sterile water for injection and then freeze-dried. This product is calibrated to contain 1 mg of glucagon per milliliter (1 mg/mL) with an n-terminal amino acid sequence that has been determined by Edman degradation to be methionine, valine, threonine, alanine, glutamic acid, proline, lysine and serine. Glucagon, human recombinant is prepared in a chromatographic purification process that utilizes dna replication and biochemical assays for quality control.br> Glucagon, human recombinant is used to treat low blood sugar levels in people with diabetes. It should not be used to treat type 1

Peptide H-YPDAVATWLNPDPSQK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Cyclo[Arg-Gly-Asp-D-Tyr-Lys(PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

Rink-amide is a type of resin that is used in the synthesis of peptides. It is a resin that can be used as a building block for solid phase synthesis. The Rink-amide-AM-resin (200-400 mesh) 1% DVB is available in a variety of sizes and molecular weights.

This resin can be used for preparation of peptide amides (Rink-type) (90 µm) 0.2-0.27 meq/g. TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.

Peptide H-GLPSSIEK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Ac-Pro-Arg-Thr-Lys-Acc-NH2 is a peptide that is used as a substrate for enzymes. This product is a specific substrate of tryptase, which is an enzyme that cleaves proteins in the pancreas. The rate of hydrolysis of Ac-Pro-Arg-Thr-Lys-Acc-NH2 by tryptase is affected by pH and temperature. The kinetic constants at 25°C are Km = 0.096 mM and Vmax = 1.073 μM/min.

IGF1 N15 Human is a desiccated, freeze-dried protein that is stable isotope and suitable for use in metabolic studies. IGF1 N15 Human has the same amino acid sequence as human insulin-like growth factor 1 (IGF1). IGF1 N15 Human can be used to study cell proliferation, sulfation, and sulfate conjugation. This protein is also used in Cytokines research as an alternative to recombinant human IGF1. Reconstitute with water or buffer prior to use.

Synthetic peptide used in treatment of prostrate cancer

H-Leu-Ser-Ile-Gly-Arg-Leu-NH2 is a peptide that has been shown to have coagulation and cardiovascular effects. It also has protease-activated receptor (PAR) and PAR2 activity, which may be the mechanism for its observed antihypertensive effects. H-Leu-Ser-Ile-Gly-Arg-Leu NH2 is a biologically active peptide that belongs to the group of protease activated receptor (PAR) peptides. It has been shown to activate PAR2 in human endothelial cells and stimulate vasodilation and nitric oxide production.

<p>TentaGel; resins are grafted copolymers consisting of a low cross-linked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a "chameleon type" polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of M.W. 3000 Da. The micro spherical shape and the monosized character of this resin allow applications in automated sorters, for creating huge libraries, high speed synthesis etc.<br>Particle size: 20 µm monosized capacity: 0.2 - 0.3 mmol/g.</p>

H-Asp(OtBu)-2-ClTrt-Resin (200-400 mesh) 1% DVB is a tool for peptide synthesis. It contains a set of building blocks including thiols, alcohols, amines, and resin. The resin is used as the solid support for peptide synthesis. The thiols react with the resin to form a covalent bond that anchors the building blocks to the solid support. The alcohols and amines can be reacted with amino acids or other activated carboxylic acids to synthesize peptides on this type of resin.

<p>Cyclo(Arg-Ala-Asp-D-Tyr-Lys) is a peptide macrocycle that has been shown to have potent anti-cancer activity. It binds to the receptor for epidermal growth factor (EGF), which is overexpressed in many cancers, and inhibits its function. Cyclo(Arg-Ala-Asp-D-Tyr-Lys) is also able to inhibit the production of nitric oxide by inhibiting the synthesis of arginase. This peptide has also been shown to induce apoptosis in cancer cells by altering the mitochondrial membrane potential and activating caspases 3 and 9.</p>

CLEAR-Amide Resin (100-200 mesh) (0.3 - 0.5 meq/g) is a high purity resin that can be used as a research tool, pharmacology, and protein interactions.

<p>Fmoc-Cys(Xan)-Wang Resin (100-200 mesh) 1% DVB is a research tool used in the synthesis of peptides. It is an inhibitor that blocks the activity of the protein tyrosine phosphatase, which plays a role in the regulation of cell proliferation and differentiation. This resin can be used to produce peptides with cysteine residues that are important for binding to receptors or ion channels. Fmoc-Cys(Xan)-Wang Resin (100-200 mesh) 1% DVB can also be used as a ligand to activate receptors or ion channels. The resin has a purity of 99% and contains less than 0.1% water, so it is suitable for use in research on proteins and cells.</p>

<p>H-Gly-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that is used as an amine or thiol in peptide synthesis. It is also used as a tool for the synthesis of alcohols and resins.</p>

Consisting of the disulfide Bonds: Cys6- Cys22, Cys9-Cys12, Cys10- Cys18, and Cys13-Cys21 and of the trifluoroacetate salt form, this product can be used as an internal standard for Hepcidin assays.Hepcidin-24 is a peptide hormone that plays a key role in the regulation of iron metabolism in the body. It is produced by the liver and is secreted into the bloodstream, where it interacts with cells in the intestine and other tissues to control the absorption and distribution of iron. Hepcidin acts as a negative regulator of iron uptake and release by binding to and inhibiting the activity of ferroportin, a protein that facilitates the export of iron from cells into the bloodstream. When hepcidin levels are high, ferroportin activity is reduced, leading to decreased iron absorption from the diet and reduced iron release from cells. When hepcidin-24 levels are low, ferroportin activity is increased, leading to increased iron absorption and release. Imbalances in hepcidin levels can lead to a variety of disorders, including iron-deficiency anemia, hemochromatosis (an iron overload disorder), and anemia of chronic disease. Therefore, hepcidin-24 is a key target for the development of treatments for these and other iron-related disorders. In addition to its role in iron metabolism, hepcidin has been shown to have antimicrobial properties, as it can inhibit the growth of certain bacteria and fungi. It may also be involved in the regulation of immune function and inflammation.

H-Met-Gly-Pro-AMC·HCl is a complex organic compound. It is often used as a reagent in organic synthesis, as well as being a useful intermediate for the production of other fine chemicals. H-Met-Gly-Pro-AMC·HCl is useful for producing speciality chemicals and research chemicals, and can be used as a versatile building block.

Please enquire for more information about H-Met-Pro-OH·HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page

H-Arg-Leu-Leu-Phe-Thr-NH2 is a peptide that has been shown to inhibit the proliferation of cancer cells by interfering with the calcium signaling pathway. It also inhibits the production of pro-inflammatory cytokines and growth factors, which are important in inflammatory diseases. This peptide can be used as a therapeutic agent for ganglia disease, such as human immunodeficiency virus (HIV) infection or diabetes. H-Arg-Leu-Leu-Phe-Thr-NH2 has an inhibitory effect on nociceptors, which are nerve cells that transmit pain signals to the brain. It may also potentiate the effects of other drugs used to treat inflammation.

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC38A1 antibody, catalog no. 70R-1754

A synthetic peptide for use as a blocking control in assays to test for specificity of PEMT antibody, catalog no. 70R-6491

Amyloid beta peptide (Aβ) is a neurotrophic factor that is involved in the pathogenic mechanism of Alzheimer's disease. This drug inhibits the production of Aβ by binding to the enzyme, secretase. It has been shown that Aβ binds to a transporter protein and is transported into cells, where it accumulates in the cytoplasm. The physiological levels of Aβ are regulated by proteins called "gene chaperones" which prevent Aβ from aggregating into plaques. Dextran sulfate inhibits this process by binding to amyloid and preventing it from accumulating in the cytoplasm. Amyloid beta peptide trifluoroxalate (ATFX) has been shown to inhibit the production of Aβ with structural analysis, inhibition of cellular uptake and secretion, and inhibition of fibrillization. ATFX also has potential as a biomarker for Alzheimer's disease because it can be detected at low concentrations in urine or serum

<p>Phytosulfokine (PSK) was introduced in 1996 by Matsubayashi and Sakagami of Nagoya University.  It is the world's first peptide phytohormone to be isolated from asparagus culture medium. Tyr undergoes post-translational sulfation modification, which is essential for bioactivity. As an example of oxidative peptides showing bioactivity, in animals, CCK-octapeptide (26-33) (sulfated form), PCK-4100-V, CCK-33 (Human), PCK-4201-S and CCK-33 (Porcine), PCK-4176-S are known, but they were first found in plants. The functions of phytosulfokine are i) plant cell proliferation and differentiation activity acting at nanomolar concentrations ii) chlorophyll synthesis-promoting activityiii) formation of adventitious roots and buds iv) adventitious embryogenesisv) involvement in disease resistance The active expression of these PSKs is accompanied by membrane-bound LRR receptors, which are PSK receptors. Leucine-rich repeat receptor-like kinase is involved.</p>

<p>H-Glu(Met-OH)-OH is an enzyme that catalyzes the conversion of stachyose to sucrose. It is also a synthetase that catalyzes the formation of fatty acids. H-Glu(Met-OH)-OH has been shown to be active in cancer cells and may be used as a potential therapeutic target for cancer treatment. This enzyme is inhibited by sodium hydroxide solution, hydrochloric acid, and urea nitrogen. The activity of H-Glu(Met-OH)-OH is measured by its ability to synthesize fatty acids from glucose in the presence of ATP and NADPH. Hydroxide solution can also be used to measure the activity of H-Glu(Met-OH)-OH as it converts stachyose to sucrose in the presence of ATP, NADP+, and sodium hydroxide solution. The rate at which this reaction occurs can be measured using a spectrophotometer with a carboxylate absorb</p>

<p>H-Asp(OtBu)-2-ClTrt-Resin is a resin that is used for peptide synthesis. It can be used in the synthesis of building blocks, such as thiols, alcohols, amines, and so on. H-Asp(OtBu)-2-ClTrt-Resin can be found in the Tools for Peptide Synthesis category.</p>

CLEAR-Acid Resin (100-200 mesh) is a high purity resin that is used for peptide synthesis. It has been used in research as an activator and inhibitor of protein interactions, such as receptor-ligand and antibody-antigen. CLEAR-Acid Resin (100-200 mesh) is often used in antibody production, where it binds to the antigen and activates the immune response against it. CLEAR-Acid Resin (100-200 mesh) has also been used for ion channel research due to its ability to inhibit potassium channels in neuronal cells. The CAS Number for CLEAR-Acid Resin (100-200 mesh) is

A synthetic peptide for use as a blocking control in assays to test for specificity of PTPRN antibody, catalog no. 70R-6312

Fmoc-Asp(OtBu)-Wang resin is a 1% DVB resin that can be used as an inhibitor of peptide synthesis. It has been shown to selectively inhibit the binding of the L-type calcium channel, which is a cell membrane protein that affects the transport of calcium ions in and out of cells. Fmoc-Asp(OtBu)-Wang resin binds to the receptor site, preventing the natural ligand from binding. This inhibition prevents the activation of ion channels and reduces calcium ion influx into cells, leading to an anti-inflammatory effect.

Cyclo[Arg-Ala-Asp-D-Phe-Lys(Ac-SCH2CO)] is a peptide that is derived by the sequential removal of amino acids from the C-terminal end of the RGD sequence. This peptide has been shown to interact with integrin αvβ3 and inhibit tumor cell proliferation and migration. Cyclo[Arg-Ala-Asp-D-Phe-Lys(Ac-SCH2CO)] also inhibits production of inflammatory cytokines by inhibiting NFκB signaling pathways.

A synthetic peptide for use as a blocking control in assays to test for specificity of TREM2 antibody, catalog no. 70R-4485

Lysostaphin is a bacteriolytic enzyme that is produced by the bacteria Staphylococcus simulans. It cleaves the cross-linked pentaglycine bridges in bacterial cell walls which are essential for their structural integrity. Lysostaphin displays a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The recombinant form of lysostaphin has been expressed in E. coli and can be used to produce large quantities of lysostaphin for therapeutic use. Expression of lysostaphin in E. coli has also allowed for the production of other polypeptides with antimicrobial properties, such as the clostridial bacteriocins and staphylokinase.

H-Gly-Asp-Gly-Val-D-Ile-Thr-Arg-Ile-Arg-OH is a peptide that is used in biochemical research. It is a synthetic peptide that has been shown to inhibit the enzyme phospholipase A2 in vitro and has been demonstrated to be a potent inhibitor of the growth of cancer cells.

<p>H-Ile-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin that is used in peptide synthesis. It can be used to synthesize peptides with one or more C terminal amine groups. This resin has been shown to be useful for the synthesis of N-terminal thiol building blocks such as H-Val(OMe)-2,4,6-ClTrt and H-Val(OSiMe3)-2,4,6-ClTrt. The resin has also been shown to be effective for the synthesis of C terminal alcohols such as H-(CH2)4OH.</p>

<p>A dimeric RGD peptide for click chemistry (PEG3 = 11-amino-3,6,9-Trioxaundecanoic acid). This product is available as a trifluoracetate salt.</p>

<p>A 27 amino acid peptide toxin from the venom of the Chinese red-headed centipede and a potent activator of TRPV1 capsaicin receptor, inducing intense pain. This product is available in the salt form: trifluoroacetate and has the following disulfide Bonds: Cys1-Cys3, Cys2-Cys4.</p>

L-Penicillamine (L-Pen) is a metabolite of penicillin and is the toxic from of penicillin’s two enantiomers L-Pen and D-Pen. While D-Pen is a clinically useful metal chelator protein with its ability to help treat Wilson’s diseases and possible Alzheimer’s disease, L-Pen can result in neuritis and marrow damage. It is important therefore that methods are developed, particularly in the pharmaceutical industry, to identify and eliminate the presence of L-Pen. One such method is using a chiral molecular imprinting technique.

H-Cys(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis. It is an acid-labile thiolated polystyrene resin with a low degree of substitution. The resin has been shown to be stable in the presence of strong acid, and can be used for the synthesis of peptides. This product contains 1% DVB as a protective colloid, which resists hydrolysis by acids and bases.

IL-2 is a cytokine that regulates the immune system. It is a protein that is produced by T lymphocytes and natural killer cells, and stimulates the production of other white blood cells. IL-2 has two receptor chains: an alpha chain that binds to IL-2 and a beta chain that binds to IL-2 with high affinity. The receptor chains are encoded by genes in the human major histocompatibility complex (MHC) on chromosome 6. IL-2 has been shown to be an activator of ion channels and ligand for antibody molecules. It also has been used as a research tool in cell biology and as an inhibitor for cancer treatment.br>br> IL 2 Human is a recombinant form of Interleukin 2, which is a type of immunotherapy that is used to treat cancer patients who have not responded well to chemotherapy or radiation therapy. This form of Interleukin 2 is purified from E. coli bacteria, which means it does

Cys- Activated and FAM-labeled TAT for Cargo Conjunction. This product is available as a trifluoroacetate salt

Fmoc-Pro-Wang Resin (100-200 mesh) is a resin that can be used for peptide synthesis. It is a building block for the synthesis of peptides, proteins and other organic compounds. Fmoc-Pro-Wang Resin (100-200 mesh) 1% DVB is an acid labile resin that is polymerized with N,N'-Dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine to form a three dimensional crosslinked network. This resin has 100-200 mesh particle size and 1% DVB content.

<p>This peptide is a collagenase, MMP-13 and stromelysin substrate. It can be used as a biochemical in enzyme assays to measure the activity of collagenases and MMPs.</p>

<p>BNP Human, recombinant is a research tool that is an activator of the BNP receptor. It has been used to study the interactions and functions of ion channels, cell biology, and pharmacology. The purified protein is a ligand for the BNP receptor. BNP Human, recombinant has been shown to inhibit peptide bonds in proteins by specific binding to the carboxyl terminus of peptides with a sequence of C-terminal arginine residues.</p>

Fmoc-Ala-Rink-Amide MBHA Resin is a resin used in peptide synthesis. It is mainly used as an inhibitor of peptidase A or B, and can also be used to inhibit the proteolytic activity of other enzymes. This product has CAS No. 68945-59-6, and is available in a high purity 99% form. Fmoc-Ala-Rink-Amide MBHA Resin is mainly used as a research tool for the study of protein interactions, activator ligands, and receptor ligands. It can also be used for biochemistry experiments involving ion channels and antibodies.

Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA). It mimics the GLP-1 hormone, released in the gut in response to eating.  Semaglutide can enhance insulin secretion and suppress glucagon section in a glucose-dependent manner. It also increases gastric emptying time and reduces intestinal motility. This combination leads to a decrease in appetite. Semaglutide has a long half-life allowing weekly subcutaneous application. Semaglutide also has positive effects on heart, liver, and lung function. Semalgutide also slows the progression of the effects of Alzheimer’s disease. This is a heavy isotype-labelled version of semaglutide that is suited to peptide quantification by mass spectrometry. This allows it to be used as an internal standard for quantification of semaglutide. There are two phenylalanine residues isotopically labelled with carbon-13 (9) and nitrogen-15 (1); one valine is labelled with carbon-13 (5) and nitrogen-15 (1); two leucine residues labelled with carbon-13 (6) and nitrogen-15 (1). This semaglutide peptide has a mass increase of 40 compared to the unlabelled peptide.25nmol = 0.1mg

<p>Prolactin-releasing peptide (PrRP20) was originally identified for being able to stimulate lactin release. However, that is not considered its function anymore, it is reclassified as a neuropeptide with a role in energy balance, and an inhibitor of appetite. PrRP20 is considered a central neuromodulator found within the A1 and A2 noradrenergic neurons and neurons of the dorsomedial nucleus of the hypothalamus. PrRP20 binds with high affinity to the G protein coupled receptor GPR10. Binding can lead to activation of numerous signalling pathways including activation of mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK1/2) and cAMP response element-binding protein (CREB).  Not much is known about the binding mechanism and activation of GPR10. Use of PrRP20 and its analogs have aimed to provide greater insight to the binding and activation of GRP10 to better understand how this effects energy balance. With new links being made between diabetes and obesity with Alzheimer's disease it raises the question of whether PrRP20 and GP10 may be a factor in the disease development due to the colocalization in the same brain regions. Further study may lead to novel therapies for obesity, diabetes, and Alzheimer's disease in the future.</p>

<p>Penetratin is a cell-penetrating peptide (CPP), also known as a protein transduction domain (PTD), of which the first 16 amino acids are derived from the third helix of the Antennapedia protein homeodomain. Penetratin linked to a phosphodiester oligonucleotide is capable of permeating through neuronal cell membranes and down-regulating genes.</p>

<p>Ghrelin is involved in several physiological processes, including feeding and lipid accumulation, stress response, anxiety, cardiac performance, immunity and inflammation, taste sensation, reward-seeking behaviour, regulation of glucose metabolism and thermogenesis, memory, motivation and learning.Ghrelin is a peptide hormone that typically has a serine at the third residue and relies on modification with a fatty acid to give ghrelin its functional activity. In its modified form, ghrelin is an endogenous ligand for the pituitary gland's growth hormone receptor (GHS-R) and stimulates growth hormone release.Ghrelin acts on the hypothalamic arcuate nucleus as an orexigenic agent to stimulate appetite. Ghrelin is produced in the stomach as a precursor peptide preproghrelin, cleaved to ghrelin. Ghrelin circulates in the blood and can cross the blood-brain barrier. Levels of ghrelin respond to fasting conditions and allow signals about the energy status to be transmitted from the peripheral organs to the central nervous system to maintain energy homeostasis.Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.</p>

CPPs can transport molecules such as nucleic acids, proteins and imaging agents into cells of inter-est. PR9, Pas non-arginine, is an arginine rich CPP. It is composed of the nona-arginine: R9 and Pas which is a peptide penetrating accelerating sequence and it functions to export molecules out of endocytic vesicles. During a study in which PR9 was in complex with a Quantum dot probe (QD) it was evident that the PR9/QD complex was transported into the cell through endocytosis where it co-localises with actins, lysosomes, early endosomes and the nucleus. Due to the non-toxicity of the PR9/QD complex it can be used as a safe vector for biomedical purposes.It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

<p>Portion of EBV</p>