Peptides

<p>The [FITC]-Ahx-(KKEEE)3K carrier peptide contains the fluorescent label fluorescein isothiocyanate (FITC), where the isothiocyanate can generate a stable thiourea linkage through reacting with the amine group present on protein molecules. The Ahx group (1,6-aminohexanoic acid) is used as a spacer to N-terminally link the FITC to the (KKEEE)3K carrier peptide. The (KKEEE)3K peptide sequence has shown significant specific renal targeting, thus giving it kidney-specific drug carrier properties. In particular its ability to target drugs to the proximal tubule cells of the kidney suggests potential to aid in the treatment of renal diseases.</p>

Please enquire for more information about LLPG including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about AF488 Maleimide including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Fmoc-Phe-Rink-Amide MBHA Resin is a peptide resin that has been used as an inhibitor of protein interactions and as a research tool in the study of ion channels. It is a high purity resin that is free of any ligands, activators, or receptors. This product can be used to purify antibodies and other proteins. Fmoc-Phe-Rink-Amide MBHA Resin is also used as an activator of Protein A affinity chromatography and for the purification of antibodies and other proteins.</p>

<p>Cyclorasin 12A is a research tool that can be used to activate or block ligands on their receptors. Cyclorasin 12A is a peptide fragment of cyclosporin A, which is an immunosuppressive agent. Cyclorasin 12A binds to the receptor, which activates the ion channels and inhibits the activity of protein kinases. Cyclorasin 12A has been shown to inhibit ion channels in cells and also has been found to reduce inflammation by inhibiting cytokine production.</p>

H-Asn(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is an alcohol resin that can be used for the synthesis of peptides. The resin has a thiol group on each side, which allows for the attachment of amines or thiols. H-Asn(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is available in different sizes and can be ordered as either powder or pellets.

H-Ala-Phe(para-Fluoro)-Arg-Cha-Cit-Tyr-NH2 is a peptide that has been shown to activate Protease Activated Receptor 1 (PAR1). PAR1 is the receptor for thrombin, which is the enzyme responsible for blood clotting. The peptide was found to be a potent activator of PAR1 in vitro and in vivo. It has also been shown to inhibit the production of angiotensin II, which can lead to hypertension. H-Ala-Phe(para-Fluoro)-Arg-Cha-Cit-Tyr-NH2 is a potential candidate for treating cardiovascular diseases such as hypertension.

Ac-Pro-Arg-Asn-Lys-Acc-NH2 is a peptide that is used to study the catalytic mechanism of enzymes. It has been shown to be an effective substrate for tryptase, which is an enzyme that plays a role in the degradation of proteins. Ac-Pro-Arg-Asn-Lys-Acc-NH2 binds to the active site of tryptase and undergoes a series of reactions that lead to its hydrolysis. The rate constants for these reactions have been measured in order to determine kinetic constants.

Fmoc-D-Glu(OtBu)-Wang resin is a solid support for peptide synthesis. It is used to synthesize peptides with the Fmoc or O-benzyl protecting group. The resin has a 1% DVB content and an average particle size of 100-200 mesh.

<p>Abz-Lys-Lys-Gln-Arg-Ala-Gly-Val-Leu-Tyr(NO2)-NH2 is a peptide that is used as an inhibitor of the Dengue Fever Virus protease. It has been shown to inhibit the activity of the nonstructural protein NS1, which is an enzyme that plays a role in the replication cycle of the virus. This peptide binds to the active site of serine proteases and prevents them from cleaving other proteins. It also inhibits HIV protease, cathepsin L, and trypsin.</p>

<p>This is a peptide fragment of presenilin 1 (349-361) with an amino acid sequence of Ala353,357. It has a molecular weight of 4.1 kDa and a pI of 5.2. The peptide is synthesized by the enzyme glycogen synthase and may be used as a substrate for this enzyme.</p>

<p>H-D-Ala-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for the synthesis of peptides. It is an amino acid resin with D,L-alanyl side chains, which can be cleaved by hydrochloric acid to release the desired amino acid and trityl resin. This resin is used in peptide synthesis reactions to provide a protecting group for the N-terminal amino acid.</p>

A human truncated analog of Obestatin, a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.

<p>Boc-L-Glutamic Acid bis-Propargyl Amide is a building block for Click Chemistry. It is a white solid that is soluble in DMF, DMSO and other organic solvents. This product can be used as a reagent for peptide synthesis and as an intermediate for the synthesis of amino acids. Boc-L-Glutamic Acid bis-Propargyl Amide reacts with dimethylaminoethanol to form the corresponding amide. It has been shown that this product can be used in click chemistry reactions to form amides and ureas.</p>

<p>[N-Me-Asp1]-Angiotensin II is a peptide that belongs to the peptides and biochemicals group. It is an angiotensin II antagonist, which means that it blocks the action of Angiotensin II on its receptors. This peptide can be used as a vasoconstrictive agent in the treatment of hypertension.</p>

<p>GpTX-1 is a synthetic 34 amino acid peptide derived from tarantula spider venom. Due to its antagonist activitiy against voltage gated sodium channels such as Na v1.7, it can be used as a possible therapeutic in inflammatory, neuropathic, visceral and nociceptive pain treatment. DpTX-1 has also been found to block voltage-dependent calcium channels.<br>One-Letter Formula: H-DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF-NH2</p>

H-Cys(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis. It is an acid-labile thiolated polystyrene resin with a low degree of substitution. The resin has been shown to be stable in the presence of strong acid, and can be used for the synthesis of peptides. This product contains 1% DVB as a protective colloid, which resists hydrolysis by acids and bases.

L-Penicillamine (L-Pen) is a metabolite of penicillin and is the toxic from of penicillin’s two enantiomers L-Pen and D-Pen. While D-Pen is a clinically useful metal chelator protein with its ability to help treat Wilson’s diseases and possible Alzheimer’s disease, L-Pen can result in neuritis and marrow damage. It is important therefore that methods are developed, particularly in the pharmaceutical industry, to identify and eliminate the presence of L-Pen. One such method is using a chiral molecular imprinting technique.

<p>MOCA-Pro-Leu-Gly is a peptide that can bind to the receptor for the neurotransmitter acetylcholine. It is a competitive inhibitor of acetylcholine and has been shown to have an affinity for the nicotinic acetylcholine receptor (nAChR) in vitro. MOCA-Pro-Leu-Gly has been used as a research tool to study protein interactions, as well as to investigate the function of ion channels and receptors. This peptide also has potential therapeutic uses, such as treating Alzheimer's disease by blocking nicotinic acetylcholine receptors in the brain.</p>

Suc-Ala-Pro-Ala-pNA is a synthetic substrate that inhibits serine proteases. It has been shown to inhibit thrombin, trypsin, and chymotrypsin at low concentrations. Suc-Ala-Pro-Ala-pNA is used as an anticoagulant in rat neutrophils and it has also been found to have chemotactic activity for neutrophils at high concentrations. The substrate was also found to be an efficient method of detecting the presence of protease activity in plant physiology experiments. In addition to its use as a proteinase inhibitor, Suc-Ala-Pro-Ala-pNA can also be used as an antiplatelet agent.

Lysostaphin is a bacteriolytic enzyme that is produced by the bacteria Staphylococcus simulans. It cleaves the cross-linked pentaglycine bridges in bacterial cell walls which are essential for their structural integrity. Lysostaphin displays a broad spectrum of activity against Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The recombinant form of lysostaphin has been expressed in E. coli and can be used to produce large quantities of lysostaphin for therapeutic use. Expression of lysostaphin in E. coli has also allowed for the production of other polypeptides with antimicrobial properties, such as the clostridial bacteriocins and staphylokinase.

<p>Antipain is a peptide that inhibits the activity of cathepsins and thiol proteases. It has been shown to have cytotoxic effects on cancer cells and antibacterial effects against Gram-positive bacteria such as Staphylococcus aureus. Antipain is an inhibitor of papain, which is an enzyme that breaks down proteins in the body, and thus may be useful for treating diseases such as cystic fibrosis.</p>

Fmoc-Asp(OtBu)-Wang resin is a 1% DVB resin that can be used as an inhibitor of peptide synthesis. It has been shown to selectively inhibit the binding of the L-type calcium channel, which is a cell membrane protein that affects the transport of calcium ions in and out of cells. Fmoc-Asp(OtBu)-Wang resin binds to the receptor site, preventing the natural ligand from binding. This inhibition prevents the activation of ion channels and reduces calcium ion influx into cells, leading to an anti-inflammatory effect.

MOG (92-106) is a peptide that is derived from myelin basic protein. It has been shown to be immunogenic and can induce the production of antibodies in animals. MOG (92-106) also induces demyelination in mice.

<p>KKALLALALHHLAHLALHLALALKKA is an amphipathic peptide antibiotic that is able to selectively inhibit the growth of Gram-positive bacteria. It has been shown to be effective against a range of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA), Clostridium perfringens, and Streptococcus pneumoniae. KKALLALALHHLAHLALHLALALKKA has also been shown to have biochemicals and peptides that are active in the treatment of bacterial infections.</p>

<p>RGD Peptide with PEG Spacers for more efficient binding to lipid surfaces with the one letter code sequence: c(RGDfK(PEG-PEG)) where PEG = 8-Amino-3,6-Dioxaoctanoic Acid.<br>This product may requires further derivatization before use.</p>

Fmoc-Phe-Wang Resin is a research tool that is used as an activator, ligand, or receptor for cell biology and protein interactions. It is also used for the synthesis of peptides. Fmoc-Phe-Wang Resin has been used in pharmacology to study ion channels and high purity proteins with high affinity. This resin can be used in antibody production and other life science applications.

Leuprolide is a synthetic hormone that is used for the treatment of prostate cancer. It works by blocking the production of hormones called luteinizing hormone and follicle-stimulating hormone in the body. Leuprolide is also used to treat endometriosis, uterine fibroids, and early puberty. This drug has been shown to have an inhibitory effect on prostate cancer cells in vitro and in vivo.

Amino acids 40-54 derived from the Immunogenic Myelin Oligodendrocyte protein (MOG). Produced by oligodendrocytes, MOG is an integral part of the oligodendrocyte surface membrane, located in the central nervous system (CNS) and plays an important role in the maintenance and disintegration of the myelin sheath. Unique within their immunoglobulin superfamily, MOG is composed of a transmembrane hydrophobic domain, an extracellular immunoglobulin variable (IgV) domain, a short cytoplasmic loop and within the membrane bilayer there is a second hydrophobic region and after this, a cytoplasmic end. In addition to 218 amino acids of the mature MOG protein, it contains a 29 amino acids long signal peptide. MOG has not only been found to be expressed in the CNS but also at low levels in the peripheral nervous system. Generally MOG is expressed during myelination and functions to maintain the myelin sheath’s structurally integrity through mediating interactions between the myelin and the immune system. This is possible due to its adhesion characteristics and its external location which makes it accessible to antibodies and T-cells. Furthermore is has been suggested that MOG is involved in regulating oligodendrocyte microtubule stability and it can be used as a differentiation marker for oligodendrocyte maturation.Myelin forms a lipid layer around neurons which insulates them. MOG has immunodmainant epitopes: 1-22; 35-55 and 92-106 and this is located at the dimer interface which is formed by MOG IgV domains forming a dimer. These MOG epitopes are recognized by encepalitogenic T cells as foreign antigens. As a result demyelination occurs and this happens in the disease state of Multiple Sclerosis (MS). As MOG is associated with inflammatory demyelinating diseases within the CNS such as neuromyelitis optica spectrum disorders and acute disseminated encephalomyelitis, this MOG (40-54) product can be used to induce these disease states in animals models. One-Letter Formula: YRSPFSRVVHLYRNG

Amyloid beta peptide (Aβ) is a neurotrophic factor that is involved in the pathogenic mechanism of Alzheimer's disease. This drug inhibits the production of Aβ by binding to the enzyme, secretase. It has been shown that Aβ binds to a transporter protein and is transported into cells, where it accumulates in the cytoplasm. The physiological levels of Aβ are regulated by proteins called "gene chaperones" which prevent Aβ from aggregating into plaques. Dextran sulfate inhibits this process by binding to amyloid and preventing it from accumulating in the cytoplasm. Amyloid beta peptide trifluoroxalate (ATFX) has been shown to inhibit the production of Aβ with structural analysis, inhibition of cellular uptake and secretion, and inhibition of fibrillization. ATFX also has potential as a biomarker for Alzheimer's disease because it can be detected at low concentrations in urine or serum

Des-n-octanoyl-[Ser3]-ghrelin (DOG) is an analog of ghrelin. It has been shown to reduce food intake in rats and humans. DOG reduces the amount of ghrelin that is released from the stomach, which leads to a reduction in appetite. The mechanism by which this occurs is not clear, but it may be related to its effect on neurons in the hypothalamus or other parts of the brain that regulate feeding behavior. DOG also has effects on cells in the pancreas, liver, and adipose tissue that are involved in regulating blood glucose levels and energy metabolism.

Hepidin-9 (mouse), a trifluoroacetate Salt product, is a variant of the peptide hormone hepcidin-25 that is produced in mice. Hepcidin plays a critical role in regulating iron metabolism in the body by controlling the activity of ferroportin, a protein that facilitates the export of iron from cells into the bloodstream. In mice, hepcidin is primarily produced in the liver, and its expression is regulated by a variety of factors, including iron status, inflammation, and erythropoietic signals. Hepcidin has been found to play a critical role in the development of iron-related disorders in mice, including anemia and iron overload. The study of Hepcidin-9 can provided important insights into the regulation of iron metabolism in mammals and may help to inform the development of treatments for iron-related disorders in humans.

H-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that is used in peptide synthesis. It is a thiol-reactive resin with a pendant amine group. H-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is soluble in common organic solvents and can be used for the synthesis of peptides with amino acids containing aromatic rings.

Cyclo[Arg-Ala-Asp-D-Tyr-Lys(PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

Biotinylated Tat Peptide available in the trifluroacetate salt form. TAT(Transactivated-transcripiton) Peptide Derived from the HIV TAT Protein, is a Cell-Penetrating Peptide which has the ability to transport itself across cell membranes independently. Cell penetrating peptides (CPPs) can be used to carry other molecules into the cell and therefore can be used in many applications. Such applications may include: drug delivery, where small drug peptides or nucleic acids can be delivered into target cells or where CPPs are conjugated to imaging agents such as fluorescent dyes or radiolabeled molecules they can be used for in vivo or in vitro imaging in diagnostics.

<p>H-His(Trt)-2-ClTrt-Resin (200-400 mesh) 1% DVB is a resin for peptide synthesis. It contains thiols, building blocks, alcohols, amines, and other functional groups. The resin is used as a building block in the synthesis of peptides.</p>

Cyclo(Arg-Gly-Glu-D-Phe-Lys) is a cyclic peptide that has been used as an inhibitor of the signaling pathway in cells. Cyclo(Arg-Gly-Glu-D-Phe-Lys) binds to the receptor, which may be associated with an ion channel and the activation of a G protein. This peptide can act as a competitive inhibitor of other ligands for this receptor. Cyclo(Arg-Gly-Glu-D-Phe-Lys) is also known to be an activator for some receptors, including the angiotensin II type 1 receptor (AT1). This peptide has been used as a research tool to study receptor function and cellular signaling pathways. It is also being investigated for use in antibody production.

8-Azido-3,6-Dioxaoctanoic Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. 8-Azido-3,6-Dioxaoctanoic Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Abz-Gly-Phe-Ser-Pro-Tyr(NO2)-OH is a peptide that can be used as an angiotensin I converting enzyme II substrate. It is a synthetic, non-peptide molecule that has been shown to inhibit the activity of the angiotensin I converting enzyme (ACE). This inhibition prevents the conversion of angiotensin I to angiotensin II, which leads to vasodilation and decreased blood pressure.

Fibrinopeptide B is a peptidic, biologically active peptide with the sequence Glu-Lys-Arg-Val. It is an epitope of the fibrinogen protein and has been reported to be involved in various biological processes such as cell proliferation, inflammation, and coagulation. Fibrinopeptide B is also a mass spectrometry standard for calibrating mass spectrometers. Biochemicals such as peptides and proteins can be identified by using this peptide. Fibrinopeptide B may also play a role in cancer metastasis and atherosclerosis.

Amino acids 1-5 of the peptide hormone Ghrelin which exerts its various effects through associating with the growth hormone secretagogue receptor (GHS-R) through its unique N-octanoyl group which is linked to its serine 3 residue covalently. Ghrelin is found in the stomach, brain and other tissues and is involved in stimulating appetite, nutrient sensing and meal initiation. It has also been found to regulate insulin resistance, diabetes and obesity and its key role in glucose homeostasis, energy homeostasis, cardio-protective effects, bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases. This molecule is used as a research tool for studying cell biology and pharmacology.

<p>Peptide H-DCP-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Cyclo[Arg-Ala-Asp-D-Phe-Lys(Biotin-PEG-PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

H-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is a cyclic peptide that contains the sequence of amino acids Arg, Gly, Asp, D, Tyr and Lys. It is a peptide macrocycle that has been shown to be effective against tumor cells. This peptide has been derivatized for targeting purposes and has been shown to be an effective imaging agent for tumor cells in vivo. H-Glu[Cyclo(Arg-Gly-Asp-D-Tyr-Lys)]2 is also biochemically active and can inhibit the growth of cancer cells through multiple mechanisms.

<p>Custom research peptide; min purity 95%.</p>

Myelin oligodendrocyte glycoprotein (MOG) is a type I integral membrane glycoprotein of the immunoglobulin superfamily (Ig) found exclusively in mammals. The 26-28 kDa protein is located on the external surface of the oligodendrocyte membrane, mostly on the peripheral lamellae of myelin sheaths of the Central nervous system (CNS). The immunodominant 35-55 epitope of MOG (MOG 35-55) is a primary target for both cellular and humoral immune responses1. Anti-MOG antibodies and the abnormal activation of encepalitogenic T cells upon recognition of MOG (35-55) peptide cause the destruction of myelin sheath during Multiple sclerosis (MS), a common inflammatory autoimmune disorder of the CNS. Although MOG is a minor component of the CNS, the 35-55 epitope of MOG (MOG 35-55) is strongly immunogenic and therefore is widely used for in vivo biological evaluation and immunological studies of the Experimental Autoimmune Encephalomyelitis (EAE), a mouse animal model for T-cell-mediated inflammatory demyelinating autoimmune diseases of the CNS. Administration of MOG (35-55) peptide in mice produces anti-MOG antibodies that cause demyelination and a chronic Experimental Autoimmune Encephalomyelitis. Anti-MOG antibodies are observed in cerebrospinal fluid (CFS) and the serum of MS pateints. There is a direct correlation between the severity of the MS symptomes and anti-MOG titers. The progression of Multiple sclerosis is rapid and relapses occur more frequently in presence of anti-MOG antibodies. Therefore, anti-MOG antibodies are an indicator for the prognosis and progression of Multiple sclerosis. They can be detected by MOG (35-55) epitope-coated ELISA for quantification. MOG (35-55)-induced EAE models can help elucidating the immunopathological mechanism of Multiple sclerosis and promote the developement of novel therapeutics. One therapeutic approach consists on the administration of a mixture of peptides, representing immunodominant epitopes of different myelin proteins including MOG peptide at a proper dose to modulate the immune response and induce tolerance.

H-Asn-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block for the synthesis of peptides. It is a resin that contains amines, thiols, and alcohols. The resin has a particle size of 100 to 200 mesh and contains 1% DVB.

Tachyplesin is a type of cationic β-hairpin antimicrobial peptide (AMP) discovered from horseshoe crab hemocytes. This product has disulfide bonds between Cys3-Cys16, Cys7-Cys12 and is available as a trifluoroacetate salt. One letter code: H-KWCFRVCYRGICYRKCR-NH2

<p>Peptide H-DCL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Antimicrobial peptide consisting of disulfide bonds between Cys2-Cys30, Cys4-Cys19, and Cys9-Cys29. Alpha-defensin-4 is a small, cationic peptide that is part of the alpha-defensin family of antimicrobial peptides in humans. It is primarily produced by neutrophils, which are a type of white blood cell that plays a critical role in the immune response to bacterial infections.<br>Alpha-defensin-4 is known to have broad-spectrum antimicrobial activity against a wide range of bacterial pathogens, including both Gram-positive and Gram-negative bacteria. Like other alpha-defensins, alpha-defensin-4 achieves its antimicrobial activity by disrupting the cell membranes of the pathogens, leading to cell lysis and death.<br>In addition to its antimicrobial activity, alpha-defensin-4 has been found to have other functions in the body, including modulating the immune response and promoting tissue repair. It has also been implicated in the pathogenesis of certain inflammatory and autoimmune diseases, including rheumatoid arthritis and psoriasis.<br>Alpha-defensin-4 is typically found in various bodily fluids, including blood, urine, and semen, and its levels can be used as a diagnostic marker for certain conditions. For example, elevated levels of alpha-defensin-4 in joint fluid can be indicative of a bacterial infection in the joint, which can help to guide treatment decisions.</p>

Serum Amyloid A protein is a custom research peptide; min purity 95%, TFA salt. For different specs please use the Peptide Quote Tool

<p>H-Pro-Ile-OH is an amino acid that is found in the mitochondria of cells. It is a prodrug that binds to angiotensin and blocks its conversion to angiotensin II, which has been shown to have blood pressure lowering effects. H-Pro-Ile-OH has been shown to be a competitive inhibitor of oligopeptidase, with a half maximal inhibitory concentration (IC50) of 0.5 mM, and has also been shown to have antihypertensive properties.</p>

Nesfatin-1 is a peptide hormone that is synthesized in the brain, pancreas, and gut. It can be found in human plasma and cerebrospinal fluid. Nesfatin-1 has been shown to decrease food intake through its effects on the hypothalamus. This peptide hormone also stimulates insulin secretion from pancreatic beta cells, which may be due to its ability to inhibit the release of glucagon. Nesfatin-1 has been shown to have a strong effect on glucose homeostasis and may be used as an adjunct therapy for diabetes mellitus type 2 patients who are resistant to metformin treatment.

The H-KL-D-Leu-RLL-D-Lys-D-Lys-L-D-Leu-RL-D-Leu peptide is a peptide that has been shown to inhibit the growth of tumor cells. It binds to the tumor cell surface and inhibits cell proliferation. The H-KL peptide may also be useful as an antiinflammatory agent, as it has been shown to inhibit the production of prostaglandins in mice with arthritis.

Ac-Asp-pNA is a carboxy, serine protease that is used as an antigen in bactericidal and antibacterial assays. It also has been shown to be effective against neutral ph organisms such as E. coli and Pseudomonas aeruginosa. Ac-Asp-pNA elutes from the column when it is inactivated under neutral ph conditions, which can be seen by the presence of reactive peaks. The protonation of Ac-Asp-pNA at high pH results in a loss of reactivity, which can be detected by the diminazene peak at low pH. This protein is activated by potassium ions and cellular proteins, which can be seen by the presence of peaks at m/z 816 and 806 respectively.

This peptide is a PAR1-specific agonist that has been shown to produce cardioprotective effects in experimental models of myocardial infarction. It is a potent inhibitor of platelet aggregation and coagulation, and was found to be an effective antithrombotic agent in animal models. The peptide is also a potent vasodilator with potential for the treatment of hypertension.

This product is an antiserum targeting amino acids 37-43 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms. This product may also be used to detect amyloid beta protein in cell cultures, tissues, or fluids by immunohistochemistry or ELISA. It is suitable for use in life sciences, cell biology, and pharmacology studies.

Beta-2 Microglobulin Human is a research tool that can be used to study the activation of receptors, ion channels, and protein interactions. It is a ligand that binds to cell surface receptors. It is also an inhibitor that blocks the formation of antibodies by binding to human immunoglobulin G (IgG) and prevents it from binding to antigens. Beta-2 Microglobulin Human is a high purity protein with a CAS number of 1768-01-7.

<p>Amino acids 1-10 of the peptide hormone Ghrelin which is found in the stomach, brain and other tissues and plays a key role in regulating energy balance. Ghrelin associates with growth hormone secretagogue receptors (GHS-R) through its unique N-octanoyl group which is linked to its serine 3 residue covalently. As a result it is able to influence the body in various ways such as stimulating appetite, nutrient sensing, meal initiation and the regulation of insulin resistance, diabetes and obesity. Its wider functions are also associated with glucose homeostasis, energy homeostasis, cardio-protective effects, bone metabolism and its potential to be a target for cancer means that it can be used to develop therapies for a whole spectrum of diseases. This molecule is used as a research tool for studying cell biology and pharmacology.</p>

Fmoc4-Lys2-Lys-ß-Ala-Wang resin is a resin that is used as an activator for the synthesis of peptides. It has been used in research to study the interactions between proteins, as well as other cell biology and pharmacology studies. The resin is also used to prepare antibodies with high purity. Fmoc4-Lys2-Lys-ß-Ala-Wang resin can be used to purify ligands and receptors, including those that are difficult to purify by conventional methods.

H-Thr-Phe-Arg-Gly-Ala-Pro-NH2 is a peptide that activates coagulation. It is a biologically active peptide and has been shown to activate protease activated receptor (PAR) peptides, PAR2, and PAR3. H-Thr-Phe-Arg-Gly-Ala-Pro-NH2 regulates hypertension by inhibiting the activity of angiotensin II type 1 receptors.

This resin can be used for preparation of peptide amides (Rink-type) (90 µm) 0.2-0.27 meq/g. TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.

Rink-amide is a type of resin that is used in the synthesis of peptides. It is a resin that can be used as a building block for solid phase synthesis. The Rink-amide-AM-resin (200-400 mesh) 1% DVB is available in a variety of sizes and molecular weights.

<p>Z-Val-Met-OH is a high purity synthetic compound that can be used as a research tool in cell biology, ion channels and peptides. This compound is an activator of the receptor for bradykinin and has been shown to inhibit the activity of protein kinase C. Z-Val-Met-OH is also a ligand for the acetylcholine receptor and has been shown to inhibit acetylcholinesterase, leading to an increase in acetylcholine levels. Z-Val-Met-OH binds to the receptor for insulin and can be used as an inhibitor of insulin release from pancreatic beta cells.</p>

Cyclo[Arg-Ala-Asp-D-Phe-Lys(PEG-PEG)] is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

<p>Body Protecting Compound (BPC) 157 is a pentadecapeptide gut peptide with free radical scavenging activity.  As a gastric juice pentadecapeptide fragment, BPC 157 stimulates nitric oxide synthase generation, offering significant gastric cytoprotection. It has been shown to heal lesions in experimental models of bowel disease, Unlike many other peptides, BPC 157 effectively acts without a carrier, notably aiding in muscle healing, such as in the treatment of gastrocnemius muscle complex injuries.  BPC 157 is also an anti-inflammatory agent that has been shown to have clinical relevance in patients with congestive heart failure. BPC 157 has been shown to inhibit inflammation by blocking the production of proinflammatory mediators such as prostaglandins and leukotrienes. It also suppresses the production of proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). BPC 157 also downregulates genes that are involved in liver fibrosis, which may account for its efficacy in patients with liver cirrhosis. BPC 157 increases the production of hepatocyte growth factors (HGFs), which stimulate cell proliferation and promote tissue repair. It also upregulates genes involved in wound healing. Additionally, BPC 157 displays antianxiety and antidepressant effects. At the cellular level, it fosters proliferation, migration, and tube formation in human umbilical vein endothelial cells by activating ERK1/2 phosphorylation.</p>

<p>H-Phe-Ile-Arg-Gly-Gly-Met-Tyr-Glu-Gly-Lys-Lys is a peptide that has biological activity. It is a member of the class of Biologically Active Peptides, which are biochemicals that have been shown to have cardioprotective effects. This peptide was found to reduce cardiac injury and dysfunction in animal models of myocardial infarction.</p>

Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh) is a research tool that is used in the study of protein interactions. It has been shown to be an effective inhibitor for ion channels and cell biology. This resin can also be used to identify ligands and receptors, as well as their binding affinities. Fmoc-Lys(Alloc)-Wang Resin (100-200 mesh) is a high purity product that can be used in pharmacology and peptide synthesis.

Glucagon, human recombinant is a protein that is used to treat low blood sugar levels in people with diabetes. It is a hormone that triggers the release of glucose from the liver and other stored sources of energy. Glucagon, human recombinant can be reconstituted with sterile water for injection and then freeze-dried. This product is calibrated to contain 1 mg of glucagon per milliliter (1 mg/mL) with an n-terminal amino acid sequence that has been determined by Edman degradation to be methionine, valine, threonine, alanine, glutamic acid, proline, lysine and serine. Glucagon, human recombinant is prepared in a chromatographic purification process that utilizes dna replication and biochemical assays for quality control.br> Glucagon, human recombinant is used to treat low blood sugar levels in people with diabetes. It should not be used to treat type 1

Cyclo(Arg-Ala-Asp-D-Tyr-Cys) is a peptide that has been shown to activate ion channels, which may lead to an increase in the permeability of the membrane. Cyclo(Arg-Ala-Asp-D-Tyr-Cys) has also been shown to inhibit ligand binding to receptors and antibody production. Cyclo(Arg-Ala-Asp-D-Tyr-Cys) is not intended for use as a research tool or in cell biology.

Fmoc8-Lys4-Lys2-Lys-ß-Ala-Wang resin is an inhibitor of protein interactions. It is a peptide that contains a sequence of amino acids that binds to other proteins and prevents them from forming. Fmoc8-Lys4-Lys2-Lys-ß-Ala-Wang resin can be used in the study of protein interactions and receptor binding, as well as for the production of antibodies.

Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2 is a peptide that has shown to be a potent inhibitor of MMP-1. It may also inhibit other proteases such as collagenase, stromelysin and cathepsins. Dnp-Pro-Cha-Abu-Cys(Me)-His-Ala-Lys(N-Me)-NH2 has a fluorogenic property, which makes it useful for high throughput screening of protease inhibitors. This peptide can be used in the development of new drugs for the treatment and prevention of various diseases such as cancer, cardiovascular disease and arthritis.

Please enquire for more information about Angiotensin including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Dansyl-Gly-Cys-Val-Leu-Ser-OH is an α subunit of the enzyme farnesyl diphosphate synthase. Dansyl-Gly-Cys-Val-Leu-Ser-OH is a substrate for this enzyme, which catalyzes the conversion of prenyl pyrophosphates to farnesyl pyrophosphate. The biological function of this peptide is not well understood, but it may be involved in cholesterol synthesis or cellular signaling. This peptide binds to cell membranes and has been shown to have a fluorescent property. Dansyl-Gly-Cys-Val-Leu-Ser OH can also bind to peptides and proteins, including the protein receptor for the HIV virus (CD4).</p>

<p>Extensin peptide fragment is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LLPRELFPPL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-LQEEDAGEYGCMVDGAR-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Β-sheet amyloid aggregate peptide is a short peptide that has been shown to form β-sheet amyloid aggregates in vitro. Proteins that contain such sequences are likely to be problematic for a cell, due to their potential to aggregate into toxic structures. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-SCDTPPPCPR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LPPLLTDEM-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Peptide H-DPIYALSWSGMAGGC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>PSD95 peptide is a PSD95 fragment. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-LFDLVDGFAESTK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is an activator that has been shown to be able to inhibit ion channels. This peptide can also be used as a research tool for studying protein interactions, receptors, and ligands.

Peptide H-HLIPAANTGESK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-RVDPVNF-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-KLAELFTSW-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Please enquire for more information about Cyclin-D2 Human Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Cyclin-B1 Human Recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>Z-Tyr-Ser-OH is a fine chemical that is used as a versatile building block in the synthesis of complex compounds. It is also a useful intermediate for the production of many other chemicals, including pharmaceuticals, agrochemicals and research chemicals. The CAS number for Z-Tyr-Ser-OH is 20448-71-9. This compound has been shown to be a high quality reagent with many applications in research and commercial manufacturing.</p>

<p>Please enquire for more information about rec IL-10 (human) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

Cyclo(-Leu-Trp) is a sweetener that has been used in the food industry for many years. Cyclo(-Leu-Trp) is able to bind with quinine and form a complex that can be detected using analytical methods. Cyclo(-Leu-Trp) has been investigated as a ligand that may be able to bind to receptors on cancer cells, which could lead to new treatments for cancer. Cyclo(-Leu-Trp) also has amphipathic properties and can form liposomes at high concentrations. This molecule has also been studied for its ability to induce transduction of DNA into bacterial cells and cellular thermogenesis.

<p>H-Trp-Trp-Trp-OH is a protonated tripeptide that has hydrophobic properties. It is highly soluble in water, but not in organic solvents. The protonation of the amino acid residues in H-Trp-Trp-Trp-OH has been shown to be pH dependent. This compound is synthesized by reacting an amino acid with a carboxylic acid, which gives the product a bitter taste. The synthesis of this compound also yields reaction products that are acidic and exhibit anti tumor effects. This product can be used as a prebiotic to promote the growth of beneficial bacteria in the gastrointestinal tract.</p>

Peptide H-NSLYLQMNSLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

<p>Please enquire for more information about Peptide M trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

3-O-Hexadecyl-sn glycerol (3OHG) is a neutral, high molecular weight glycol ether that is used for the preparation of zirconium oxide. 3OHG has been shown to be a substrate for carbohydrate chemistry and as an inhibitor of enzymes, such as hexokinase and phosphoglycerate kinase. 3OHG has minimal toxicity when administered orally to rats and does not cause any hemolysis in human erythrocytes. This compound is also a monoclonal antibody that binds to the surface glycoprotein on the HL-60 cell line and inhibits its growth. 3OHG is not cytotoxic at concentrations up to 10 mM in cultured cells, but it can induce Ca2+ release from the cytosol in HL-60 cells with minimal toxicity. The structure of 3OHG appears closely related to benzalkonium chloride (BAC).

Hippuryl-arginine is a peptide hormone that is released by the hypothalamus and stimulates the pituitary gland to release other hormones. It has been shown to increase chemotactic activity in human serum, although it has no effect on carboxypeptidase or soybean trypsin activity. Hippuryl-arginine binds with basic proteins, such as albumin and immunoglobulins, and increases their enzymatic activities. This hormone also inhibits enzymes such as carboxy terminal phosphatases and aminopeptidases that are responsible for degrading amino acids. Activation of hippuryl-arginine may be due to its carboxy terminal group, which is susceptible to cleavage by proteolytic enzymes.

<p>This substrate contains the nsp4/nsp5 cleavage sequence, GVLQ↓SG19, and works as a generic peptide substrate for several coronavirus. The main protease (Mpro­), also called endopeptidase C30 or 3C-like proteinase (3CLpro), controls viral replication activities, and is a prime therapeutical target. It also contains SARS-CoV2 Replicase pp1ab (3235-3246). It can be used as a Fluorogenic Substrate for SARS-CoV/SARS-CoV-2 Main Protease (Mpro) and is avaiable in as a Trifluoroacetate Salt.</p>

<p>Peptide H-YLTQETNK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-RLTDQSRWSW-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>