Peptides

Z-Val-Ala-DL-Asp-fluoromethylketone is a drug that is used for the treatment of cancer. It can be used in combination with other chemotherapeutic drugs, such as z-vad-fmk, to induce apoptosis in cancer cells. Z-Val-Ala-DL-Asp-fluoromethylketone also inhibits autophagy and neuronal death by inhibiting caspase activation, which prevents the release of proapoptotic proteins from mitochondria into the cytosol. This drug has been shown to have antiinflammatory effects on IL2 receptor signaling pathways and inhibits the production of proinflammatory cytokines by binding to IL2.

Fmoc-Val-Wang Resin (100-200 mesh) 1% DVB is a resin that is used in the synthesis of peptides. The resin contains Fmoc-protected amino acids, which are cleaved by the use of hydrogen fluoride to release the free acid form. This resin is characterized by its high purity and low viscosity. It has been shown to be an excellent building block for peptide synthesis, as well as a useful tool for biological studies.

Please enquire for more information about 1-Acetyl-5-bromo-6-chloro-1H-indol-3-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

H-Phe-2-ClTrt-Resin (200-400 mesh) 1% DVB is a resin for peptide synthesis. It can be used in the synthesis of thiols, building blocks, alcohols and amines with 1% DVB.

H-Ile-Asn-OH is a chloroplastic amide that is used as a substrate in polymerase chain reactions. It can be used to study the structure of proteins and enzymes by the use of monoclonal antibodies. H-Ile-Asn-OH has been sequenced and assayed, and found to have high binding affinity for carboxylate groups. This chemical has been shown to have multidomain structures as well as an isotype that is specific for triticum aestivum. H-Ile-Asn-OH may also be involved in plant physiology due to its role in photosynthesis.

H-D-Tyr-Val-NH2 is a regulatory group that acts as the prosthetic group for a number of peptidyl and peptide hormones. H-D-Tyr-Val-NH2 is also involved in catalytic mechanism, as it is the amino acid responsible for the formation of peptide bonds in proteins. H-D-Tyr-Val-NH2 is found in high concentrations in the cerebriform tissue and has been shown to be important for the biosynthesis of amides, which are prohormones. H-D-Tyr-Val NH2 also participates in a number of cellular reactions, including those that have a kinetic rate.

H-STQAAIDQINGK^-OHH-STQAAIDQISGK^-OHH-SDAPIGK^-OHH-DEALNNR^-OHH-EFSEVEGR^-OHH-TITNDR^-OHR^ = Arginine (U-13C6,15N4)K^ = Lysine (U-13C6,15N2)Peptide purity: >98%AAA: Concentration – Duplicate100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots

Fluorescent TAT peptide.

Influenza B native 5-peptide mixture of: H-SHFANLK-OHH-SYFANLK-OHH-GVLLPQK-OHH-NLNSLSELEVK-OHH-GILLPQK-OHAAA: Concentration - Duplicate 100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots

Azido-dPEG®4-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

m-dPEG®8-Azide (Azido-m-dPEG®8) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®8-Azide (Azido-m-dPEG®8) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Boc-Val-Leu-Lys-AMC is a research tool that has been shown to activate ion channels and increase the permeability of cell membranes. This compound also binds to receptors on cells, which may be due to its ability to bind with antibodies. Boc-Val-Leu-Lys-AMC has been used as an inhibitor in protein interactions and pharmacology studies, as well as for the study of ion channels in cell biology.

Bz-Arg-His-D-Asp-CH2Cl is a research tool that can be used as an activator or ligand in cell biology and pharmacology. This product is also a receptor, which is a protein that binds to one or more specific substances (ligands) and triggers a change in the activity of cells. Receptors are often located on the surface of cells, such as those in the brain, heart and muscles. Bz-Arg-His-D-Asp-CH2Cl can be used to inhibit ion channels and has been shown to block receptors for acetylcholine, histamine and serotonin. Bz-Arg-His-D-Asp-CH2Cl also blocks calcium channels and potassium channels. This product has been shown to inhibit the activity of phospholipase A2, which helps break down fats into fatty acids. It also inhibits the activity of aminopeptidases, which breaks down proteins into

H-Leu-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin that has been used to synthesize peptides. It can be used as a building block for many other chemical reactions, such as cross-linking and oxidation. This resin is typically used in the synthesis of peptides with an amino acid sequence of H-Leu-2-ClTrt and contains 1% DVB. The resin can be used for the synthesis of small organic molecules, such as antibiotics, with a molecular weight between 500 and 2000 Da.

Peptide Ac-KIFMTK-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

The myelin sheath which is located in both the Central Nervous System (CNS) and the Peripheral Nervous System is crucial for neural insulation and the salutatory conduction of nerve impulses. When this myelin sheath is destroyed neurodegeneration and conduction failure occur. This can be observed in demyelinating diseases in the CNS such as: acute disseminated encephalomyelitis and multiple sclerosis and within the PNS: Guillain–Barré syndrome and Charcot–Marie–Tooth disease. Myelin Basic Protein (MBP) from which this product is derived is the second most abundant protein in myelin. It has been found to be an intrinsically disordered protein and depending on the environmental conditions it can change its conformation. It also folds into ⍺-helical structures which allow MBP to bind tightly to lipid bilayer surfaces. MBP also interacts with other proteins, namely cytoskeletal proteins and calmodulin and may be involved in signalling pathways. Although more research needs to be carried out, it is thought that MBP significantly contributes to the pathogenesis of multiple sclerosis. As MBP is an autoantigen it can be recognized and cleaved by autoantibodies and is a substrate for the immunoproteasome. Additional research has found that post-translational modifications of MBP such as the removal of arginine are increased in and may be involved in the pathogenesis of multiple sclerosis. Therefore this protein derived from MBP can be used to mimic Neurodegenerative disease phenotypes in research and animal models.

Peptide Ac-EQKLISEEDLC-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg is a peptide that is used as an activator and inhibitor of ion channels. This peptide has been shown to be a potent inhibitor of the voltage dependent Na+ channel, which is responsible for the depolarization of nerve and muscle cells. MOCAc has also been shown to bind with high affinity to the NMDAR receptor in a competitive manner. The binding of this peptide to the NMDAR receptor prevents glutamate from binding, which leads to inhibition of downstream signaling pathways such as NMDA receptor activation and intracellular calcium release.

A human truncated analog of Obestatin, a 23 amino acid gastrointestinal peptide, encoded for by the ghrelin gene and is known to reduce food intake through supressing appetite. This peptide has been found to influence the pancreas, cardiovascular system and adipose tissues as well as the gastrointestinal system. One study showed that when high-fat diet fed rats were given chronic administration of obestatin it prevented the development of non-alcoholic fatty liver disease. Consequently Obestatin has the potential to be used in preventing obesity-related diseases.