Peptides

Derivatizable Cell-Penetrating Peptide (CPP) for Click Chemistry. Can be applied as a Cys- Activated TAT for Cargo Conjunction. This product is available in the salt form: Trifluoroacetate Salt

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

PAR2 plays a particular role in protecting the gastric mucosa mediated by capsaicin-sensitive sensory neurons. PAR2 also serves to aid in gut smooth muscle motility- colon inflammation pathway- hyperalgesia and is also anti-inflammatory in other circumstances.Development of selective agonists for PAR2 are crucial for research. (2-Furoyl)-LIGRL-amide is a far more potent agonist than the native PAR2 activating peptide SLIGRL-NH2. In mice, oral administration conferred cytoprotection from gastrointestinal lesions. However, it was inhibited by capsaicin pre-treatment.

Alpha-synuclein (1-13) is derived from the alpha-synuclein intrinsically disordered protein which is found in the neurons and presynaptic terminals. Encoded by the SNCA1/PARK1 gene alpha-synclein is structurally composed of 140 amino acids, making up the three domains: N-terminal membrane binding domain, a hydrophobic non-amyloid-β component domain and a hydrophilic C-terminal domain. Usually alpha-synuclein plays a role in protecting neurons from apoptotic stimuli and is involved in synaptic vesical trafficking.Accumulation of alpha-synuclein aggregates can lead to neurodegenerative diseases such as Parkinson disease, dementia with Lewy bodies and multiple system atrophy. It is further involved in the fibrilisation of amyloid-b and tau which play a major role in Alzheimer disease. Amyloid fibrils are formed from alpha synuclein monomers within the cytosol and when bound to membranes these monomers can undergo conformational changes to form protofibrils and then ring like oligomers. This can result in the formation of transmembrane pores which disrupts the membrane, calcium homeostasis and signalling.In familial Parkinson disease the SNCA1 gene, can be subjected to point mutations such as A30P, E46K and A53T, or over expression. These can result in the increased aggregation of alpha-synuclein.The methionine at position 5 is oxidised and the oxidation of methionine is common in neurodegenerative diseases and promotes the accumulation of altered α-synuclein. Furthermore when these methionine residues are oxidised, methionine sulfoxides are produced.

Cell permeable peptide where the amyloid forming sequence is homologous to a nucleating sequence from the human Tau protein (306VQIVYK311). Forms long lived oligomers that are taken up by endocytosis and is cytotoxic in multiple cell lines.- Co-localizes with pathological hyperphosphorylated forms of Tau in vitro.

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Src Homology 2 Domain (Biotinylated) is a peptide that binds to the SH2 domain, which is a part of the Src family of kinases. This domain is important for cell signaling. The peptide can be used as a ligand in research or as a probe to detect and map protein-protein interactions. It can also be used to measure the activity of kinases and measure changes in protein-protein interactions. The peptide contains an N-terminal biotin tag, which allows it to be detected using streptavidin conjugated to an enzyme substrate, such as horseradish peroxidase.

Peptide H-EITFHGAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Peptide H-LQEEDTGEYGCV-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.

Fmoc-Pro-OH is a peptide that contains the Fmoc protecting group. It is used in the synthesis of peptides and has been shown to be effective against microbial infections with marine sponges. The synthesis of this compound can be carried out on an on-line automated peptide synthesizer. The Fmoc protecting group is removed by treatment with trifluoroacetic acid (TFA) in dichloromethane, which leaves the side chain unprotected. This compound has a high binding affinity for the receptor site of fibrinogen and can potentially inhibit the growth of bacteria that cause bacterial infection, such as Staphylococcus aureus and Pseudomonas aeruginosa.
Fmoc-Pro-OH can also be used to synthesize other functional groups such as sulfamoyl groups or acetonitrile groups, depending on the desired outcome.