Peptides

Amyloid beta (Aβ) is a peptide that is associated with the development of Alzheimer's disease. It is used as a research tool in cell biology, pharmacology and neuroscience. Amyloid beta-protein has been shown to activate certain receptors on the surface of cells, including ion channels. This protein also binds to antibodies that are specific for Aβ and can be used in immunohistochemistry experiments.

TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. particle size: 200 - 250 µmcapacity: 0.2 - 0.3 mmol/g1.5 nmol/bead; 160 000 beads/g.
These resins are designed for single bead synthesis and single bead analysis (mean particle size 200-250 µm: capacity 02-03 meq/g).

Low-density lipoprotein (LDL) is a type of lipoprotein that contains a high proportion of cholesterol and triglycerides. It is called "low-density lipoprotein" because it has less protein and more fat than "high-density lipoproteins", which are the other major group of lipoproteins. LDL is the main carrier of cholesterol in the blood, and carries about 25% of all the body's cholesterol. The LDL receptor is the cellular receptor for LDL, which is located on the surface of liver cells. The binding site for LDL on its receptor is called LDL Receptor Related Protein 1 or LRP1. LRP1 binds to apolipoprotein E on LDL particles and facilitates their uptake into cells by endocytosis.

m-dPEG®23-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, m-dPEG®23-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Anti IL-1beta (Rat) Serum is a peptide used as a research tool in immunology and cell biology. It is an inhibitor of the inflammatory cytokine IL-1β, and binds to its receptor with high affinity. This antibody can be used in pharmacological studies to investigate protein interactions. The use of this antibody has been shown to inhibit the activation of ion channels, which may lead to the treatment of diseases such as Alzheimer's disease and epilepsy.

Amino-dPEG®4-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, amino-dPEG®4-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

DBCO-dPEG®12-Carboxyfluorescein is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.

Ac-Asp-Gln-Thr-Asp-AMC is a synthetic peptide that is used as a research tool for the study of protein interactions and protein function. It can be used to inhibit the activity of ion channels, such as potassium channels, and to activate cell surface receptors. Ac-Asp-Gln-Thr-Asp-AMC has an amino acid sequence that resembles peptides found in naturally occurring proteins. Ac-Asp-Gln-Thr-Asp-AMC also has a molecular weight of 333.6 daltons and a CAS number of 125094–99–0.

The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication.  NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (241-255) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.

Alyerserin-1b is a C-terminally α-amidated 23 residue Cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-1 peptides have limited structural similarity to the ascaphins from the skins of frogs of the Leiopelmatidae family. Alyteserin-1 peptides are selective at inhibiting growth activity of Gram-negative bacteria-such as Escherichia coli and show weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards these peptides compared to conventional antibiotics.

As a member of the tachykinin neuropeptide family, Neurokinin B is involved in the dilation of blood vessels, the contraction of smooth muscles and the excitation of neurons. This product can be applied as a NK3 receptors selective agonist and is available as a 0.5mg vial.

CoV-2 S1 (319-529) is a recombinant peptide that was derived from the CoV-2 S1 protein. It is an activator of ion channels and can be used as a research tool in pharmacology and cell biology. This peptide has been shown to bind to the Na+ channel, which is involved in the generation and propagation of nerve impulses, and to modulate its gating properties. It can also inhibit voltage-gated K+ channels, which are involved in the regulation of neuron excitability. CoV-2 S1 (319-529) is purified at > 98% purity and has a CAS number.

This product is a Fibrinogen Heavy Tryptic Peptide Standard for protein identification and quantitation. Fibrinogen is glycoprotein produced by the liver and is a precursor to fibrin which makes up blood clots.

[Met(O)12]-ANP (Human, 1-28) is a peptide that activates the guanylate cyclase. It has been shown to bind to the receptor for ANP, which is present in many cell types. The binding of [Met(O)12]-ANP (Human, 1-28) to its receptor leads to an increase in intracellular cGMP levels and consequently an increase in intracellular cAMP levels. This product is a research tool for protein interactions and can be used as an inhibitor or activator. The purity of this product is >98%.

MAL-dPEG®6-NHS Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®6-NHS Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

This is a Biologically Active Peptides, Short=PN-II, Proteomics, Amyloid Precursor Protein, New England Peptide calibrated to 25nmol. This peptide has been shown to be a major component of amyloid plaques in Alzheimer's Disease. It is one of the most abundant proteins in the brain and is found in association with beta-amyloid protein (A4). The precursor protein for APP is encoded by the gene on chromosome 21. APP and its products are involved in many cellular processes such as signal transduction, cell proliferation, apoptosis and inflammation. APP can be cleaved by Beta-secretase or Gamma secretase to release A4 and N-APP.

D-Amino Acid Oxidase is an enzyme that catalyzes the conversion of D-amino acid to alpha keto acid and ammonia. It is also known as DAAO or DAO.

DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Portion of EBV RTA

Bromoacetamido-dPEG®23-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®23-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Carboxyfluorescein-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.

Atosiban is a drug that is used to prevent preterm labor in pregnant women. It works by inhibiting the release of oxytocin from the hypothalamus, which decreases contractions and relaxes the uterus. Atosiban has been shown to be effective in decreasing the incidence of preterm birth in women with bacterial vaginosis who are at high risk for preterm delivery (e.g., those with a history of preterm labor). Clinical trials have shown that it may also be useful as an adjunct therapy in treating women with unexplained infertility and recurrent pregnancy loss. The drug binds to receptors on cells, which inhibits the release of intracellular calcium, thus preventing contraction of uterine muscle cells. This effect can be reversed by administration of estradiol benzoate or other drugs that affect receptor activity. It is not known whether atosiban affects fetal development during pregnancy or if it causes any effects on the mother's heart rate or body mass index after childbirth.

IL-1 beta is a cytokine, which belongs to the IL-1 family of cytokines. It is a proinflammatory cytokine that induces fever and pain, and stimulates the immune system. IL-1 beta binds to the IL-1 receptor, which is a member of the class 1 cytokine receptor family. The binding activates phospholipase A2 and protein kinase C, which leads to an increase in prostaglandin production by cyclooxygenase 2. IL-1 beta also has been shown to inhibit ion channel activity and calcium uptake in cells.

Antithrombin III heavy tryptic peptide standard for protein identification and quantitation studies. Antithrombin III is a glycoprotein found in blood plasma and is involved in the regulation of the coagulation process.

This is a vivitide catalogue product. Please send your vivitide product enquiry to sales@vivitide.com for an up-to-date price and availability.

Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) is a research tool that can be used to study the effects of neuromedin U on the activation of receptors. This peptide is a ligand for the receptor and has been shown to inhibit ion channels. Neuromedin U Precursor-Related Peptide 33 (Rat, Mouse) may also be used as an antibody or in protein interactions studies. This product is made from high purity materials and can be used in pharmacology and life science experiments.

Schizophrenia Related Peptide is a research tool that can be used to study ion channels and receptors. It is an artificial peptide that has the same amino acid sequence as the part of the human brain that is believed to be responsible for schizophrenia. The Schizophrenia Related Peptide can bind to cell membranes and inhibit protein interactions, which may lead to new pharmacological treatments for schizophrenia.

A synthetic peptide for use as a blocking control in assays to test for specificity of C17orf48 antibody, catalog no. 70R-4091

A synthetic peptide for use as a blocking control in assays to test for specificity of NTF5 antibody, catalog no. 70R-6217

A synthetic peptide for use as a blocking control in assays to test for specificity of IDH2 antibody, catalog no. 70R-2523

A synthetic peptide for use as a blocking control in assays to test for specificity of ASPHD2 antibody, catalog no. 70R-3531

A synthetic peptide for use as a blocking control in assays to test for specificity of PSMB2 antibody, catalog no. 70R-2347

A synthetic peptide for use as a blocking control in assays to test for specificity of PDE8A antibody, catalog no. 70R-9537

A synthetic peptide for use as a blocking control in assays to test for specificity of RDH11 antibody, catalog no. 70R-5410

A synthetic peptide for use as a blocking control in assays to test for specificity of GALR2 antibody, catalog no. 70R-10309

A synthetic peptide for use as a blocking control in assays to test for specificity of CALD1 antibody, catalog no. 70R-3868

A synthetic peptide for use as a blocking control in assays to test for specificity of MRGPRX2 antibody, catalog no. 70R-9930