Peptides
Les peptides sont des chaînes courtes d'acides aminés liées par des liaisons peptidiques, jouant un rôle essentiel en tant que molécules biologiques dans divers processus cellulaires. Ils fonctionnent comme hormones, neurotransmetteurs et molécules de signalisation, et sont largement utilisés dans les applications thérapeutiques et diagnostiques. Les peptides sont également cruciaux dans la recherche pour étudier les interactions protéiques, les activités enzymatiques et les voies de signalisation cellulaire. Chez CymitQuimica, nous proposons une large sélection de peptides de haute qualité pour soutenir vos besoins en recherche et développement en biotechnologie et en pharmacie.
Sous-catégories appartenant à la catégorie "Peptides"
29595 produits trouvés pour "Peptides"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Phytosulfokine-α
CAS :Phytosulfokine (PSK) was introduced in 1996 by Matsubayashi and Sakagami of Nagoya University. It is the world's first peptide phytohormone to be isolated from asparagus culture medium. Tyr undergoes post-translational sulfation modification, which is essential for bioactivity. As an example of oxidative peptides showing bioactivity, in animals, CCK-octapeptide (26-33) (sulfated form), PCK-4100-V, CCK-33 (Human), PCK-4201-S and CCK-33 (Porcine), PCK-4176-S are known, but they were first found in plants. The functions of phytosulfokine are i) plant cell proliferation and differentiation activity acting at nanomolar concentrations ii) chlorophyll synthesis-promoting activityiii) formation of adventitious roots and buds iv) adventitious embryogenesisv) involvement in disease resistance The active expression of these PSKs is accompanied by membrane-bound LRR receptors, which are PSK receptors. Leucine-rich repeat receptor-like kinase is involved.
Formule :C33H46N6O16S2Degré de pureté :Min. 95%Masse moléculaire :846.88 g/molAntipain
CAS :Antipain is a protease inhibitor, which is derived from microbial sources. It inhibits serine and cysteine proteases through the formation of a reversible covalent complex with the active site of the enzyme. This interaction effectively prevents the proteolytic activity of these enzymes, thereby modulating various biological processes.The primary application of Antipain is in biochemical research where it is utilized to study protease function and regulation. By inhibiting specific proteases, researchers can investigate protein degradation pathways and decipher complex signaling mechanisms. Additionally, Antipain is used experimentally to inhibit protease activity in cell lysates, thereby preserving protein integrity during sample preparation. Its specificity for serine and cysteine proteases makes it a valuable tool for differentiating between proteolytic activities in various biological samples.Formule :C27H44N10O6netDegré de pureté :Min. 95%Masse moléculaire :604.7 g/molCyclo(Arg-Gly-Asp-D-Tyr-Glu)
Cyclo(Arg-Gly-Asp-D-Tyr-Glu) is a peptide macrocyclic compound that has been used as a radiolabeling agent for peptides. This compound is an analogue of cyclo(Arg-Gly-Asp), which is a biologically active peptide found in many cell surface receptors. Cyclo(Arg-Gly-Asp) has been shown to have antiangiogenic and antiapoptotic properties.Formule :C26H36N8O10Degré de pureté :Min. 95%Masse moléculaire :620.62 g/molMu-Conotoxin GS
A synthetic cone snail toxin, sourced from the marine snail, Conus geographus. This product has disulfide bonds between Cys2-Cys14, Cys9-Cys19, and Cys13-Cys27 and is available as a 0.5mg vial.Formule :C136H226N52O48S7Degré de pureté :Min. 95%Masse moléculaire :3,618.1 g/molL-Pen(p-Me-Bzl)
L-Penicillamine (L-Pen) is a metabolite of penicillin and is the toxic from of penicillin’s two enantiomers L-Pen and D-Pen. While D-Pen is a clinically useful metal chelator protein with its ability to help treat Wilson’s diseases and possible Alzheimer’s disease, L-Pen can result in neuritis and marrow damage. It is important therefore that methods are developed, particularly in the pharmaceutical industry, to identify and eliminate the presence of L-Pen. One such method is using a chiral molecular imprinting technique.Formule :C13H19NO2SDegré de pureté :Min. 95%Masse moléculaire :253.2 g/molH-Cys(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB
H-Cys(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin for peptide synthesis. It is an acid-labile thiolated polystyrene resin with a low degree of substitution. The resin has been shown to be stable in the presence of strong acid, and can be used for the synthesis of peptides. This product contains 1% DVB as a protective colloid, which resists hydrolysis by acids and bases.Degré de pureté :Min. 95%IL 2 Human
IL-2 is a cytokine that regulates the immune system. It is a protein that is produced by T lymphocytes and natural killer cells, and stimulates the production of other white blood cells. IL-2 has two receptor chains: an alpha chain that binds to IL-2 and a beta chain that binds to IL-2 with high affinity. The receptor chains are encoded by genes in the human major histocompatibility complex (MHC) on chromosome 6. IL-2 has been shown to be an activator of ion channels and ligand for antibody molecules. It also has been used as a research tool in cell biology and as an inhibitor for cancer treatment.br>br> IL 2 Human is a recombinant form of Interleukin 2, which is a type of immunotherapy that is used to treat cancer patients who have not responded well to chemotherapy or radiation therapy. This form of Interleukin 2 is purified from E. coli bacteria, which means it doesDegré de pureté :Min. 95%GpTX-1 Toxin
GpTX-1 is a synthetic 34 amino acid peptide derived from tarantula spider venom. Due to its antagonist activitiy against voltage gated sodium channels such as Na v1.7, it can be used as a possible therapeutic in inflammatory, neuropathic, visceral and nociceptive pain treatment. DpTX-1 has also been found to block voltage-dependent calcium channels.
One-Letter Formula: H-DCLGFMRKCIPDNDKCCRPNLVCSRTHKWCKYVF-NH2Formule :C176H271N53O45S7Degré de pureté :Min. 95%Masse moléculaire :4,073.9 g/molIFN g Mouse
IFN-g Mouse is a recombinant protein that belongs to the group of cytokines. It has been shown to be an activator of cells and is used as a research tool. IFN-g Mouse is also an inhibitor of ion channels and ligands for cell surface receptors, which are important in regulating cellular processes. IFN-g Mouse contains a number of peptides and antibodies that can be used for research purposes.Degré de pureté :>95% By Sds-Page And Rp-Hplc.Fmoc-Pro-Wang Resin (100-200 mesh) 1% DVB
Fmoc-Pro-Wang Resin (100-200 mesh) is a resin that can be used for peptide synthesis. It is a building block for the synthesis of peptides, proteins and other organic compounds. Fmoc-Pro-Wang Resin (100-200 mesh) 1% DVB is an acid labile resin that is polymerized with N,N'-Dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine to form a three dimensional crosslinked network. This resin has 100-200 mesh particle size and 1% DVB content.Degré de pureté :Min. 95%Mob-S-Mercaptoproprionic acid
Mob-S-Mercaptoproprionic acid is a reagent that can be used to synthesize peptides. It is also a Building Block for the synthesis of other molecules. Mob-S-Mercaptoproprionic acid is hydrolyzed to form the corresponding carboxylate and mercaptoacyl amide, which can be used in peptide synthesis by condensation with an amino acid.
Formule :C11H14O3SDegré de pureté :Min. 95%Masse moléculaire :226.3 g/molDnp-Gly-Pro-Leu-Gly-Met-Arg-Gly-Leu-NH2
This peptide is a collagenase, MMP-13 and stromelysin substrate. It can be used as a biochemical in enzyme assays to measure the activity of collagenases and MMPs.
Formule :C40H64N14O12SDegré de pureté :Min. 95%Masse moléculaire :965.11 g/molAlpha-Neo-Endorphin (Porcine)
CAS :Alpha-Neo-Endorphin is a peptide that belongs to the group of opioid peptides. It is a potent activator of opioid receptors and has been used as a research tool in cell biology to study the function of opioid receptors. Alpha-Neo-Endorphin activates these receptors by binding to them, and these opioid receptors are involved in the modulation of pain, epidermal nerve fiber regulation and skin homeostasis. It is further demonstrated the ability to in human keratinocytes, stimulate wound healing. alpha-neoendorphin is derived from prodynorphin when it is proteolytically cleaved. This product is available as a 0.5mg vial and is sourced from Porcine.Degré de pureté :Min. 95%Fmoc-Phe-Rink-Amide MBHA Resin
Fmoc-Phe-Rink-Amide MBHA Resin is a peptide resin that has been used as an inhibitor of protein interactions and as a research tool in the study of ion channels. It is a high purity resin that is free of any ligands, activators, or receptors. This product can be used to purify antibodies and other proteins. Fmoc-Phe-Rink-Amide MBHA Resin is also used as an activator of Protein A affinity chromatography and for the purification of antibodies and other proteins.Degré de pureté :Min. 95%Apelin-17 (human, bovine)
Apelin-17 (human, bovine) is derived from the apelin peptide which acts as a ligand for the apelin receptor (APJ) G protein coupled receptor and is a substrate for angiotensin converting enzyme 2. Preprapelin, encoded for by APLN located on Xq25-26.1, is cleaved to form either apelin 36,or apelin 17, 12 and apelin 13. As a member of the adipokine hormone family, which are involved in processes such as vascular homeostasis and angiogenesis, apelin is secreted from adipose tissue.Apelin has been found to be expressed in the spinal cord and the human brain and when performing immunohistochemistry it was observed that apelin-17 is significantly expressed in the human heart, brain, lungs and endothelial cells.Both apelin and the apelin receptor are widely distributed around the body thus apelin has been found to be associated with cardiovascular diseases, obesity, diabetes and cancer. Studies exploring myocardial infarction showed there to be greater apelin mRNA expression during human heart failure compared to in healthy tissue. Apelin protects against heart failure due to, the pyroglutamyl form of apelin, playing a role in decreasing infarct size of myocardial infarctions. Furthermore in rats with hypertension, the expression of apelin and APJ was decreased.
Masse moléculaire :2,137.2 g/molTAT-AKAP79 (326-336) scrambled
The activation of transient receptor potential cation channel subfamily V member 1 (TRPV1) is believed to play a role in hyperalgesia, asthma and hypertension. TRPV1 is important for neuronal pain detection as well as the detection of heat, capsaicin, protons and the neurotransmitter anandamide. -The scaffold protein AKAP79 targets kinases to phosphorylate TRPV1, however it has been shown that inflammatory intermediates prostaglandin-E2 or bradykinin can activate these kinases creating a route for inflammation to cause hyperalgesia.This product is composed of the TRPV1 interacting domain of AKAP79 reordered into a scrambled sequence and conjugated to the cell penetrating TAT domain. This product was shown in vivo to have no effect on TRPV1 algesia and thus is a vital control for research work. This product is a vital tool for research into suitable TRPV1 antagonists.Masse moléculaire :2,878.6 g/molHCV NS3 protease FRET substrate
HCV NS3 protease FRET substrateCouleur et forme :PowderMasse moléculaire :2,112.8 g/molCooP
CooP peptide specifically homes to invasive tumours such as glioblastoma and their blood vessels. Mammary-derived growth inhibitor (MDGI), also known as the fatty-acid binding protein 3 (FABP3) or the heart fatty acid-binding protein (H-FABP) is the binding partner for the CooP peptide. Coop peptide homes to all tumours which express MDGI and their associated vasculature. MDGI is not however expressed in the normal human brain. Therefore the CooP peptide appears to have a highly selective specificity as a homing peptide and the potential to deliver targeted therapy to treat invasive brain tumours.CooP peptide has been successfully used for the targeted delivery of chemotherapy and different nanoparticles.Masse moléculaire :845.4 g/molHIV-1 reverse transcriptase (A2-YI9)
HIV-1 replication is rapid and error prone which is beneficial to the virus as it allows mutations to arise that aid evasion of the host immune system and resistance to drug treatment. RT is the key target for most anti-HIV drugs and therefore conserved sequences are useful to aid further research into new less toxic antiviral treatments. HIV-1 reverse transcriptase (RT) converts the RNA genome into DNA during retroviral replication. HIV-1 RT is a heterodimer composed of 2 subunits, p66 and p51. HIV-1 RT heterodimer has 2 enzymatic functions, DNA polymerase and Rnase H resulting in nucleic acid translation to a linear DNA duplex. Complete inhibition of viral replication is the only known method of preventing HIV-1 drug resistance and disease progression.HIV RT epitopes have become a useful research tool as an in vitro antigenic challenge to study cytotoxic T lymphocyte (CTL) responses to retroviruses. The HIV-1 RT A2-YI9 sequence has been shown to be an effective epitope for CTL recognition leading to lysis of HIV-infected T cells. The A2-YI9 is also considered a potential for vaccine development due to it being a well conserved sequence.Masse moléculaire :1,012.17 g/molOxytocin (free acid)
Neuropeptide and hormone involved in many processes, including- social bonding--sexual reproduction- childbirth and breastfeeding. Oxytocin is synthesised in the hypothalamus as a prepropeptide consisting of a signal peptide, the oxytocin peptide hormone, a processing signal and the carrier protein- neurophysin. The prohormone then undergoes endoproteolytic cleavage and amidation to form the final oxytocin peptide.Dysregulation of oxytocin has been implicated in the pathophysiology of neuropsychiatric disorders that impact social functioning, such as autism, schizophrenia, and depression as well as anorexia nervosa. Intranasal oxytocin administration may reduce amygdala activity and amygdala-midbrain connectivity in response to fearful situations- reduce cortisol release and anxiety in response to psychosocial stress- increase trust behaviour- increase the ability to interpret mental states, and increase the amount of time spent gazing at the eyes when viewing faces.Masse moléculaire :1,007.4 g/mol(Tos-GFHR)2-[Rh110]
Candidate peptide substrate for kallikrein-related peptidase 5 (KLK5). In its intact state this peptide is not fluorescent, however when this substrate peptide is cleaved, Rhodamine 110 is released and thus fluorescence can then be detected. Contains rhodamine 110 group, a widely used red fluorescent tag. The terminal carboxylic acids in this peptide have been activated by the addition of the p-tosyl moiety, allowing for easy addition of functional groups or further peptide residues.Couleur et forme :PowderMasse moléculaire :1,632.6 g/molMotilin (1-12)
Residues 1-12 of the gastrointestinal hormone motilin, secreted from endocrine cells in the small intestines, mainly from the jejunum and duodenum, in response to the fasting, drinking water or the mechanical stimulus of eating.Masse moléculaire :1,468.8 g/molRAG8
RAG8 is a pepducin- a cell-penetrating palmitoylated peptide with a C-terminal NH2.- Palmitoyl is a 16-carbon aliphatic chain which enhances the hydrophobicity of the peptide, and therefore improves its penetration through lipid structures.The peptide sequence corresponds to a key regulatory sequence at the intracellular C-terminus of PAR4. This motif regulates calcium signalling and PAR4 interactions with the signalling protein-β-arrestin. RAG8 is a PAR4 antagonist that can attenuate calcium signalling and β-arrestin-1 and 2 recruitment to PAR4 which has been activated with the PAR4 agonist AYPGKF-NH2.Disrupting this PAR4/β-arrestin signalling pathway with RAG8 blocks PAR4 dependent platelet activation and reduces stability of blood clots.Couleur et forme :PowderMasse moléculaire :1,170.8 g/molHistone H3 (1-20) K4Me2-GG-[Lys(5-FAM)]
Histone H3 (1-20) K4Me2 is derived from Histone 3 (H3), which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Like the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing many lysine and arginine residues, they have a positive net charge which interacts electrostatically with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone-modifying enzymes which target histone proteins. Both processes change the positioning of the nucleosome, allowing the DNA to be either available to the transcription machinery or inaccessible.Histone tails can undergo multiple modifications, including acetylation, methylation, ubiquitylation and sumoylation. The modification pattern is believed to alter chromatin function/structure. Histone H3 (1-20) K4Me2-GG-[Lys(5-FAM)] lysine 4 has been dimethylated, has a C-terminal GGK linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag. This peptide also has an uncharged C-terminal amide. H3 (1-20) K4Me2 has been investigated to understand its effect on epigenetic regulation through NMR with histone readers such as zinc finger domains. Histone H3 (1-20) K4Me2-GG-[Lys(5-FAM)] can be used to study the function of this pattern on chromatin availability and histone effectors via crystallisation, pull-down assays and protein blots.Masse moléculaire :2,809.5 g/molVP4 (449-454) Nora virus
VP4 is a viral coat protein of Nora virus encoded for by ORF4. The product of these gene is likely cleaved into three capsid proteins, VP4A, B and C. VP4 is also the most conserved gene from Nora virus and related viruses. Nora virus is a non-pathogenic virus found in gut of Drosophila melanogaster. It causes persistent, non-pathological infection, it replicates in the fly gut and is transmitted via the faecal-oral route. Nora virus has a 12333 nucleotides long single-stranded RNA genome of positive polarity.Masse moléculaire :806.4 g/mol[Atto655]-LifeAct (Abp140 1-17)
[Atto655]-LifeAct (Abp140 1-17) contains the 17 amino acid peptide Lifeact derived from amino acids 1-17 of the Saccharomyces cerevisiae actin binding protein, Abp140. These first 17 amino acids of Abp140 are crucial in allowing Lifeact to localise to actin filaments (F-actin) and therefore it can be used as a cytoskeletal marker. One application of lifeact is in the study of plant development and pathogen defence as filamentous actin within the plant's actin cytoskeleton is important in key processes such as cell division, membrane trafficking and stomatal movements. The addition of the oxazine fluorophore Atto655 which has single molecule (SM) imaging properties allows the location of the LifeAct (Abp140 1-17) to be detected.
Couleur et forme :PowderMasse moléculaire :2,432.2 g/molV5 epitope tag
The V5 tag is derived from a small epitope (Pk) found on the P and V proteins of the paramyxovirus (of the simian virus 5 (SV5) family) and is extensively used as a general epitope tag in expression vectors.Couleur et forme :PowderMasse moléculaire :1,420.6 g/molAngiotensin III
Aspartyl aminopeptidase A (APA) and glutamyl APA, produce angiotensin III (Ang-III) by removing an aspartic acid from the N-terminal of angiotensin-II (Ang-II). Ang-III has many similar biological properties to Ang-II including aldosterone secretion and vasoconstriction, however some of its functions oppose those of Ang-II, such as sodium excretion and secretion of atrial natriuretic peptide (ANP). Due to its ability to promote ANP secretion Ang-III has some cardio protective effects.Ang-III likely binds to both G-protein-coupled Ang-II type 1 (AT1) and Ang-II type 2 (AT2) receptors with a similar affinity to that of Ang-II. Ang-III appears to be cleared from the plasma at a faster rate than Ang-II, therefore the physiological effects of Ang-III are likely to limited to the site at which it is produced.Couleur et forme :PowderMasse moléculaire :931.09 g/molHistone H3 (1-20) K4Me3-GG-[Cys(Aurora™ Fluor 647)]
Histone H3 (1 - 20) K4Me3 is derived from Histone 3 (H3), which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Like the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing many lysine and arginine residues, they have a positive net charge which interacts electrostatically with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone-modifying enzymes which target histone proteins. Both processes alter the positioning of the nucleosome, allowing the DNA to be either available or inaccessible to the transcription machinery.Histone tails can undergo multiple modifications, including acetylation, methylation, ubiquitylation and sumoylation. The modification pattern is believed to alter chromatin function/structure. Lysine 4 of histone H3 (1 - 20) K4Me3 has been tri-methylated. This is a common cis-tail histone methylation pattern, read by histone effectors such as Spindlin1. H3 (1 - 20) K4Me3 has been used to understand interactions with histone effectors in co-crystallisation. H3 (1 - 20) K4Me3 is labelled with the Aurora Fluor 647 fluorescent tag.Masse moléculaire :3,435.7 g/molCodesane
Codesane (COD), is a cationic α-helical amphipathic-anti-microbial-peptide isolated from the venom of the wild bee Colletes daviesanus (Hymenoptera Colletidae). COD exhibits-anti-microbial-activity against Gram-positive and Gram-negative bacteria and Candida albicans but also noticeable haemolytic activity.COD peptide works by permeating both the outer and inner cytoplasmic membranes of Escherichia coli.Masse moléculaire :1,915.2 g/molPseudin-2
Pseudin-2 (Ps) is one of the four pseudin peptides isolated from the skin of the paradoxical frog Pseudis-paradoxa. Pseudins are structurally related, cationic, amphipathic, a-helical anti-microbial peptides (AMP) that share sequence homology with an apoptosis regulating protein. Pseudin-2 is the most abundant and potent of the four pseudins.Pseudin-2 is active against Escherichia coli (with minimum inhibitory concentrations (MIC) of 2.5 mM), Staphylococcus aureus (MIC: 80 mM), and Candida albicans (MIC: 130 mM). Pseudin-2 also has low haemolytic activity against human erythrocytes (the concentration of Pseudin-2 producing 50% haemolysis: >300 mM).In addition to its anti-microbial properties, pseudin-2 has also been shown to stimulate insulin release and may be useful as a therapy for type 2 diabetes. This peptides has a non-amidated C-terminal end, as per the naturally occurring pseudin-2.
Couleur et forme :PowderMasse moléculaire :2,684 g/molCyclo(-RGDyK)
The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys-) is a highly potent and selective inhibitor for the alphavβ3 integrin receptor. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val), is a promising anti-cancer drug candidate- it inhibits angiogenesis and induces apoptosis in vascular cells.Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.
Masse moléculaire :619.3 g/molFSY tripeptide
Angiotensin I-converting enzyme (ACE) plays a critical role in blood pressure regulation. There is a rise in conditions linked to hypertension such as heart attacks, strokes, and dementia. This has led to search for novel inhibitors of ACE to regulate blood pressure. Food-derived bioactive peptides have been identified and utilised for their health-promoting abilities. The tripeptide FSY (Phe-Ser-Tyr) was identified from shrimp (Pandalus borealis) protein hydrolysate as a highly potent inhibitor of ACE activity. FSY is capable of being absorbed in the digestive tract to be transported in the blood to the receptors which is a useful feature for clinical application. Further study can provide deeper understanding of FSY potency on ACE function and may lead to drug development.Masse moléculaire :415.2 g/molPepstatin A Biotin
Pepstatin A was originally purified from Actinomycetes species. The peptide is unusual in containing the amino acid statine (4-amino-hydroxy-6-methylheptanoic acid also known as AMHA). Pepstatin A competitively binds with acid proteases in a highly selective reversible manner to inhibit protease activity. Pepstatin A is ineffective on thiol, neutral and serine proteases. The functions of proteases have been investigated by the application of pepstatin A such as renin, pepsin, bovine chymosin and retroviral proteases from HIV. Characterisation of HIV protease using pepstatin A has been vital in development of HIV treatment to block viral replication. Pepstatin A is also a reagent to disrupt autophagy- this helps characterise the function of proteosome degradation in research such as during influenza A replication and improving drug delivery of therapeutic cancer treatments. Biotin is C-terminally linked to this peptide for convenient detection and purification. The polyethylene glycol (PEG) linker improves the water solubility of biotin labelled proteins.Masse moléculaire :1,041.7 g/mol(Arg)9
(Arg)9 is a cationic cell-penetrating peptide (CPP)consisting of 9 arginines. Arginine rich CPPs enter cells in a passive manner through membrane multilamellarity and fusion. Evidently as a CPP, (Arg)9 can function to deliver specific molecules to target cells and can be used for drug delivery purposes.Masse moléculaire :1,423.69 g/molalpha-gliadin (58-73)
α-Gliadin (58-73) is derived from Gliadin peptides, the component of wheat involved in the gastrointestinal symptoms of wheat allergy and Celiac Disease (CD). During wheat allergies histamines and leukotrienes are secreted due to gliadin peptide sequences cross-linking two IgE molecules on mast cells and basophils.The glutamine and proline rich peptides of which Gliadin is composed of are resistant to proteolysis during digestion, leaving them active in the gastrointestinal tract. Subsequently these are deamidated by tissue transglutaminase and can bind to HLA-DQ2 or DQ8. As a result in patients with the autoimmune disease CD, there is a Th1-mediated inflammatory immune response against these gliadin peptides.Gliadin can exert additional effects on the intestinal microbiota and ileal barrier function. It has been found that gut microbiota members such as Bifidobacterium and lactobacillus have the ability to digest and inactivate gliadin peptides hence reducing their inflammatory effects in the gastrointestinal system.Couleur et forme :PowderMasse moléculaire :1,906 g/molPro-BNP (47-76)
Pro B-type natriuretic peptide (Pro-BNP) is secreted from cardiac myocytes and cleaved into BNP and the remaining part of the prohormone N-terminal proBNP (NT-proBNP). When the heart fibres become stretched more BNP and NT-proBNP are released to try and compensate for the increased pressure. During heart failure the walls of the atria become over stretched and thus increase the levels of NT-proBNP detectable. NT-proBNP has a longer half-life than BNP and therefore is detectable at higher levels in blood plasma than BNP. NT-pro-BNP is believed to be cleared by renal excretion, but this is not confirmed. As a diagnostic tool, NT-proBNP (47-76) has become very useful in helping diagnose heart failure and provide a prognosis. The measurement of NT-proBNP (47-76) has been incorporated into management and guidelines of clinical settings. As a research tool it still provides valuable data such as symptoms onset in relation to NT-proBNP levels and how inflammation effects the level of BNP as well as the BNP/ NT-proBNP ratio.Masse moléculaire :3,463.9 g/molCyclo(RGDfK)
The cyclic pentapeptide cyclo(Arg-Gly-Asp-[D-Phe]-Lys) is a highly potent and selective inhibitor for the alphavβ3 integrin receptor. A related compound, cyclo(Arg-Gly-Asp-[D-Phe]-Val), is a promising anticancer drug candidate- it inhibits angiogenesis and induces apoptosis in vascular cells.Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.Couleur et forme :PowderMasse moléculaire :603.3 g/molHistone H3 (1-22)
Histone H3 (1-22) is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into a structure known as the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.
Couleur et forme :PowderMasse moléculaire :2,354.4 g/molACTH (1-17) Human
Amino acids 1-17 of human adrenocorticotropic hormone (ACTH). ACTH, also known as corticotropin, is a tropic hormone produced and secreted by the anterior pituitary gland and member of the melanocortins peptide family. ACTH is cleaved from the precursor proopiomelanocortin (POMC). ACTH is an important component of the hypothalamic-pituitary-adrenal (HPA) axis and is often produced in response to biological stress. ACTH acts to increase the production and release of cortisol via its interaction with the ACTH receptor- ACTHR, also known as melanocortin type 2 receptor (MC2R). Receptor activation increases the intracellular concentration of cAMP via adenylyl cyclase.Abnormal ACTH levels in the body has been linked to primary adrenal insufficiency/Addison's disease, Cushing's disease and secondary adrenal insufficiency.Masse moléculaire :2,093.42 g/molHistone H4 (1-21) R3Me1
Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are fundamental in compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4's lysine rich tail plays a role in the higher order chromatin folding.Modifications allow histones to contribute to gene regulation, chromosome condensation and DNA repair. In yeast, methylation of R3 of Histone 4 results in the recruitment of histone acetyl transferase to the chromatin and the acetylation of Histone 4 K5.Masse moléculaire :2,105.3 g/molMHV EP™
Post-transmembrane region (PTM) from the envelope protein (E) of the coronavirus- Mouse Hepatitis Virus (MHV). This protein region is involved in direct membrane binding, with the C-terminal hydrophobic residues of this peptide, thought to be most relevant for membrane binding. After replication, coronaviruses (CoVs) assemble on intracellular membranes, the coronavirus envelope protein (E) is involved in virus assembly and release. E proteins have been located in the endoplasmic reticulum Golgi intermediate compartment (ERGIC) and Golgi of infected cells but are not thought to traffic to the cell surface of infected cells. CoV E is a small hydrophobic protein which is conserved between coronaviruses. E consist of a short hydrophilic amino terminal region, a hydrophobic transmembrane region and a carboxy-terminal region. CoV E protein is an integral membrane protein.E has been considered a therapeutic target for SARS-CoV-2.Masse moléculaire :1,781 g/molLL-13-37
LL-13-37 is an active fragment of the LL-37 peptide which has been shown to have anti-fungal properties against Candida albicans.LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37- this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also has anti-cancer properties and regulates many aspects of the innate immune system- overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis.Masse moléculaire :3,043.57 g/molClick R9F2
R9F2 is a specifically designed arginine-rich cell penetrating peptide (CPP) for delivery of antisense molecules (AMOs). Synthetic AMOs are used to interfere with translation and RNA synthesis however their delivery into leukocytes has been an issue. The creation of CPPs such as R9F2 has allowed a new more effective method of delivering AMOs for altering gene expression. The design of the arginine rich peptide with two phenylalanine to the C-terminus allowed better interaction with cell membrane and improved uptake of the cargo. R9F2 has been effectively tested on murine leukocytes to evaluate its efficacy at altering pre-mRNA splicing.R9F2 is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-R9F2 allows a wide variety of applications particularly for conjugation, modification, and peptide design.Couleur et forme :PowderMasse moléculaire :1,796.1 g/molSARS-CoV-2 Nucleoprotein (61-75)
The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. The nucleoprotein has a critical role in virus assembly and RNA transcription. The nucleoprotein is essential in the formation of helical ribonucleoproteins and in regulating viral RNA synthesis. The nucleoprotein can also regulate infected host cellular mechanisms. It is highly expressed during infection and may induce protective immune responses against SARS-CoV and SARS-CoV-2.The nucleoprotein residues KEDLKFPRGQGVPIN (61-75) from SARS-CoV-2 have been identified as a T-cell epitope with a predicted HLA restriction. Immune targeting of confirmed epitopes may potentially offer protection against SARS-CoV-2 and help the development of vaccines for long-lasting immunity.
Masse moléculaire :1,696.9 g/molELA Elabela/Toddler-32
Elabela/Toddler-32 (ELA-32) has been identified as a new endogenous ligand for the apelin G protein coupled receptor (GPCR). Apelin levels have been shown to be reduced in heart failure and pulmonary arterial hypertension (PAH). ELA-32 delivery could be used to supplement the deficit of apelin. It can be cleaved to shorter forms Elabela/Toddler-21, and Elabela/Toddler-11. Apelin and ELA-32 share almost no sequence homology which is unusual for receptor ligands, it suggests a future for apelin receptor biased agonist design.Exogenous administration of ELA-32 to rats has been shown to compensate for the downregulation of apelin seen in PAH. Further research into the potential of this peptide as an endogenous agonist reducing the severity of PAH could provide vital therapeutics in the future for cardiovascular disease.Couleur et forme :PowderMasse moléculaire :3,965.1 g/mol
![(Tos-GFHR)2-[Rh110]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1100667.webp&w=3840&q=75)
![Histone H3 (1-20) K4Me2-GG-[Lys(5-FAM)]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101683.webp&w=3840&q=75)
![[Atto655]-LifeAct (Abp140 1-17)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101303.webp&w=3840&q=75)
![Histone H3 (1-20) K4Me3-GG-[Cys(Aurora™ Fluor 647)]](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FCRB1101679.webp&w=3840&q=75)
