Peptides

<p>Intracellular Sigma peptide is a membrane-permeable peptide mimetic of protein tyrosine phosphatase sigma (PTPσ) wedge. PTPσ is a neural receptor that binds with very high affinity to chondroitin sulfate proteoglycans (CSPGs). Inhibition of this interaction has been shown to promote regeneration of damaged nerves and improve nerve function in animal models. ISP has a protein transduction domain from HIV's trans-activating regulatory protein (Tat). This domain allows facilitates membrane-penetration.</p>

<p>P2-Hp-1935 is an antimicrobial peptide isolated from the skin secretions of the Montevideo tree frog (Hypsiboas pulchellus). P2-Hp-1935 displays activity against Gram positive and negative bacteria.</p>

<p>The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. Also known as the nucleocapsid protein, it is an abundant RNA-binding protein critical for viral genome packaging. These factors make nucleoprotein a good target for developing new antiviral drugs. In addition, the identification of epitopes within the nucleoprotein sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. Nucleoprotein (86-100) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.</p>

<p>Histone 3 (H3) is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.The lysine at position 4 of this peptide has been tri-methylated and it is implicated in studies that this modification may remodel the chromatin so that it is more accessible to transcription factors, which may ultimately increase the level of gene expression. The lysine at position 9 has been acetylated, which neutralizes the positive charge on the amino acid, loosening the chromatin structure. This alteration to the accessibility of chromatin promotes the initiation of transcription. Moreover, the serine at position 10 has been phosphorylated, and studies have suggested that this may induce chromatin condensation, and subsequently repress transcription and gene expression.</p>

The octapeptide cholecystokinin (26-33), known as CCK-8, has the full biological activity of the full-length cholecystokinin (CCK). CCK acts as a hormone and neurotransmitter and is found in the GI and central nervous systems. CCK-8 is a satiety peptide that inhibits food intake.CCK-8 can also inhibit amanitin uptake into hepatocytes.

<p>The Beclin-1 peptide is derived from a region of the Beclin-1 protein, which interacts with a newly identified negative regulator of autophagy, GAPR-1 (also called GLIPR2) to act as a potent inducer of autophagy. Autophagy is an essential process that maintains cellular homeostasis and carries out lysosome-mediated degradation of unwanted proteins in the cytoplasm. It is often examined when looking at disease pathways because of this regulatory function. While the immune system initiates the removal of viruses and pathogens through the autophagic pathway, some viruses (such as HIV) are able to evade this process.</p>

<p>Cellular immunotherapy is an effective treatment option against Epstein-Barr virus (EBV)-driven lymphoproliferation in recipients of hematopoietic stem cells. However, increasing the number of identified epitope targets will help improve the response rate and success. Viral tegument protein BNRF1 is a critical target in EBV inducing specific CD4+ T-cell responses. 18 epitopes within BNRF1 are known, including  (1238-1252). BNRF1-specific CD4+ T cells are cytotoxic and limit EBV-driven B cell transformation. Work with EBV BNRF1 (1238-1252) epitope and others will help improve T cell immunotherapy and our understanding of host-virus interaction.</p>

<p>pVEC is an amphipathic cell-penetrating peptide (CPP). This CPP is derived from murine vascular endothelial cadherin, which is able to cross the blood brain barrier. pVec can permeate cell membrane at low micromolar concentration and mostly localising to the nucleus but is also found throughout the cell. Importantly, pVec shows efficient cellular uptake when carrying large molecular cargo making it a highly potent transporter for drug delivery.pVec is provided here with a N-terminal alkyne attachment. Two of the most regularly encountered functional groups for click chemistry are azides and alkynes, and the azide-alkyne cycloaddition has become the most popular click reaction. The use of click chemistry with alkyne-pVec allows a wide variety of applications particularly for conjugation, modification, and peptide design.</p>

<p>Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (324-338) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.</p>

<p>Binds to the cysteine rich domain of the Frizzled 7 receptor and inhibits Wnt signalling in cultured cells and stem cell function in intestinal organoids.</p>

<p>Portion of Influenza A</p>

<p>Neurokinin A (NKA) is a member of the classical tachykinins family of peptides which also includes substance P and neurokinin B. These peptides are primarily found in the nervous system where they act as neurotransmitters and neuromodulators. They also play key roles in neuronal inflammation, and high levels of NKA have been linked to poor prognosis of some tumours.The tachykinin peptides are characterised by a common C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X represents either an aromatic (Phe, Tyr) or a branched aliphatic (Val, Ile) amino acid.This C-terminal region is thought to be responsible for activating the receptor. The divergent N-terminal region is thought to play a role in determining the receptor subtype selectivity. NKA binds preferentially to the NK2 receptor.</p>

<p>The identification of T cell epitopes is vital for a range of immunological functions including viral vaccine design. Current influenza vaccines are designed to induce protective humoral immunity by exposure to inactivated influenza leading to an induction of potent CD4+ T cell memory.  However, little is known about how these primed CD4+ T cells effect the response to other viruses that share a common T cell epitope.Sendai Virus nucleoprotein (324-332) has been identified as a T cell epitope and used in T cell assays to stimulate a response. Further use of Sendai virus nucleoprotein (324-332) epitope in vitro could help uncover the effect of immune response to heterologous viruses with common epitopes. It may also help understand the impact of using primed CD4+ T cell as vaccines. This could have consequences for future vaccine design to improve specificity and potency of the immune cells.</p>

<p>Residues 1-10 of the gastrointestinal hormone motilin, secreted from endocrine cells in the small intestines, mainly from the jejunum and duodenum, in response to the fasting, drinking water or the mechanical stimulus of eating.</p>

<p>ID4 is a highly versatile epitope tag. The peptide sequence is highly specific to rhodopsin and related photoreceptor proteins, meaning when used with monoclonal antibodies off-target signals are virtually non-existent. ID4 is also devoid of charged residues therefore reducing nonspecific ionic interactions. Monoclonal antibodies also bind to ID4 with high affinity therefore there is less need for inserting multiple copies of ID4.</p>

<p>Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4 lysine rich tail plays a role in the higher order chromatin folding.The lysine at position 16 has been acetylated, which neutralizes the positive charge on the amino acid, loosening the chromatin structure. This alteration to the accessibility of chromatin promotes the initiation of transcription.Acetyl-Histone H4 (1-23) K16Ac-GG-[Lys(5-FAM)] has a C-terminal GGK linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag. Additionally, this peptide has an uncharged C-terminal amide and is protected from N-terminal modifications by a covalently bonded acetyl group.</p>

<p>Ac-Arg-[Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys]-NH2 is a peptide that has antagonist activity against melanin, the hormone receptor. This peptide can be used to treat skin pigmentation disorders such as vitiligo, which is an autoimmune disorder in which the melanocytes are destroyed. Ac-Arg-[Cys-Met-Ava-Arg-Val-Tyr-Ava-Cys]-NH2 is also an aminovaleric acid derivative, which can inhibit the production of aminovaleric acid and related compounds.</p>

<p>H-His(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin that is used in the synthesis of peptides. It is a building block for synthesizing peptides and proteins. H-His(Trt)-2-ClTrt-Resin (100-200 mesh) 1% DVB is also used as an alcohol for amine coupling. This resin has been shown to be useful in the synthesis of thiols, amines, and building blocks.</p>

Retatrutide is a 39 amino acid single peptide with triple agonist activity at the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). The backbone is conjugated to a C20 fatty diacid moiety at position 17. Retatrutide has a Glucose-dependent insulinotropic polypeptide (GIP) peptide backbone, which then contains three non-coded amino acids. Aib2 (α-amino isobutyric acid) residues at positions 2 and 20 provide stability against Dipeptidyl Peptidase 4 (DPP4) cleavage and contribute to GIP activity. αMeL13 (α-methyl-L-leucine)at position 20 also contributes to GIP and glucagon activity. Retatrutide can be used for the research of obesity obesity, diabetes, and fatty liver disease. It is a works in three ways: stimulating insulin release, suppressing appetite, and promoting fat breakdown.

<p>H-Phe-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that is used in peptide synthesis. It has been shown to react with amines and thiols, as well as alcohols, yielding a resin that can be used for the protection of amino acids during peptide synthesis. This product is supplied as a dry powder containing 1% DVB, 100 to 200 mesh.</p>

<p>OD1 toxin is a peptide that belongs to the scorpion family. It is a potent activator of voltage-gated sodium channels and has been shown to be effective in the treatment of pain, inflammation, and other neurological disorders. OD1 toxin also has the ability to regulate the release of neurotransmitters in the central nervous system. The peptides are produced by Odonthobuthus doriae and are structurally rich in disulfide bonds. These molecules have been shown to act as channel activators, which bind to voltage-gated sodium channels at depolarized membrane potentials, increasing neuronal excitability and triggering action potentials.</p>

<p>H-ε-Aca-2-ClTrt-Resin (100-200 mesh) is a resin that can be used for peptide synthesis. It is a building block which contains amines, thiols and alcohols. It also contains DVB (dibenzylideneacetone) which is an additive that stabilizes the resin and prevents it from swelling or dissolving. The resin will be soluble in organic solvents such as chloroform and methanol. H-ε-Aca-2-ClTrt-Resin (100 - 200 mesh) is used for peptide synthesis because it provides good yields of product with low side reactions.</p>

<p>Fmoc-ß-Ala-Rink-Amide MBHA Resin is a peptide synthesis resin that can be used in the production of peptides and proteins. It is an activator for antibody production, as well as an inhibitor of ion channels. Fmoc-ß-Ala-Rink-Amide MBHA Resin also has high purity and excellent solubility. This product is used in life science research to study protein interactions and receptor pharmacology.</p>

<p>Ac-His-D-Phe(p-Iodo)-Arg-Trp-NH2 is a peptide that binds to the melanocortin receptor. It is a potent antagonist of MSH and related peptides and has been shown to be effective in the treatment of cancer, including melanoma.</p>

<p>Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB is a resin that has been synthesized by the Fmoc group. The resin is used to attach peptides, proteins and other organic molecules to a solid support for use in research. The resin is also an activator of ligands and can be used as a receptor for the binding of antibodies. The resin has high purity and is made from methacrylate polymer. It contains no detectable levels of hydroquinone and 4-Vinylpyridine.<br>Fmoc-Met-Wang Resin (100-200 mesh) 1% DVB can be used as a research tool in cell biology, immunology, pharmacology, protein interactions, receptor binding, ion channel activation and more. CAS No.: 58897-27-6</p>

<p>Fmoc-Asp(OtBu)-Rink-Amide MBHA Resin is a building block for peptides. It is an acid labile resin that can be cleaved with TFA to provide amine-protected dipeptides and tripeptides. This product is used as a building block for peptide synthesis.</p>

<p>Abz-Ser-Pro-Tyr(NO2)-OH is a peptide that has been shown to be an angiotensin I converting enzyme II (ACE) substrate and an inhibitor of ACE. It also inhibits the release of renin from the juxtaglomerular apparatus, which is needed for the production of angiotensin II. This peptide is used in biochemical research and as a standard for measuring enzymatic activity.</p>

<p>Purotoxin-1 is a peptide that belongs to the group of activators. It is an inhibitor of potassium channels which are involved in the regulation of excitability and repolarization of cells. Purotoxin-1 has been shown to block the binding of calcium ions to the N-type voltage-gated calcium channels, leading to decreased intracellular calcium levels and reduced neurotransmitter release. Purotoxin-1 has been shown to inhibit tumor growth in vivo, which may be due to its ability to inhibit protein interactions with cell surface receptors.</p>

<p>β-Ala-Lys(AMCA) is a peptide that can inhibit the interactions of proteins. β-Ala-Lys(AMCA) is an inhibitor of protein interactions and can be used as a research tool to study the interactions between proteins. β-Ala-Lys(AMCA) has been shown to activate certain receptors, such as the receptor for angiotensin II, and can be used to increase or decrease the activity of ligands. This drug also has a high purity level, which makes it suitable for use in life science research.</p>

<p>Fmoc-Gly-Arg(Pbf)-OH is a dipeptide building block that can be used in the synthesis of peptides. It is an analogue of Gly-Pro and Arg(Pbf)-OH, which are also dipeptide building blocks. The properties of Fmoc-Gly-Arg(Pbf)-OH make it suitable for peptide synthesis through solid phase chemistry. Dipeptides are important tools for the synthesis of peptides, as they are easy to handle and modify. They are also used as building blocks for constructing more complex molecules such as proteins or nucleic acids.</p>

<p>IL-6 Mouse is a recombinant protein that belongs to the cytokine family. It has been shown to activate IL-6 receptor. This receptor is a member of the GPCR family and possesses seven transmembrane domains with a large extracellular loop between TM2 and TM3. The extracellular domain contains binding sites for two different classes of ligands, including peptides and proteins. IL-6 Mouse is an antibody against IL-6 receptor that can be used as a research tool in pharmacology, protein interactions, cell biology, or immunology.<br>IL-6 Mouse is produced by high purity process and it contains no detectable levels of endotoxin or pyrogens.</p>

<p>H-Asp(2-ClTrt-Resin)-OtBu (α Ester) is a building block that is used in peptide synthesis. It can be resubstituted with the amino acid, aspartic acid, and used in the formation of peptides. This resin is insoluble in water and soluble in dichloromethane and dimethylformamide. The H-Asp(2-ClTrt-Resin)-OtBu (α Ester) can also be used to form disulfides or thioethers.</p>

Ovalbumin (257-264) is an acetate salt of a fragment of the protein ovalbumin.

<p>Fmoc-Phe-Ser(Psi(Me,Me)Pro)-OH is a diastereomer of Fmoc-Phe-Ser. It is used as a substrate for peptide synthesis and can be used to synthesize oxytocin receptor antagonists. It has been shown to have high affinity for the oxytocin receptor and inhibits the binding of oxytocin to the receptor by competing with it for the same site on the receptor. This inhibition leads to decreased levels of oxytocin that are responsible for uterine contractions during labour and milk ejection from the breast during breastfeeding. Fmoc-Phe-Ser(Psi(Me,Me)Pro)-OH also has been shown to be useful in filtration techniques such as chlorides, propargylamines, and divalent cyclopentenones.</p>

<p>Please enquire for more information about rec GM-CSF (murine) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>H-Ile-Asn-OH is a chloroplastic amide that is used as a substrate in polymerase chain reactions. It can be used to study the structure of proteins and enzymes by the use of monoclonal antibodies. H-Ile-Asn-OH has been sequenced and assayed, and found to have high binding affinity for carboxylate groups. This chemical has been shown to have multidomain structures as well as an isotype that is specific for triticum aestivum. H-Ile-Asn-OH may also be involved in plant physiology due to its role in photosynthesis.</p>

<p>H-D-Tyr-Val-NH2 is a regulatory group that acts as the prosthetic group for a number of peptidyl and peptide hormones. H-D-Tyr-Val-NH2 is also involved in catalytic mechanism, as it is the amino acid responsible for the formation of peptide bonds in proteins. H-D-Tyr-Val-NH2 is found in high concentrations in the cerebriform tissue and has been shown to be important for the biosynthesis of amides, which are prohormones. H-D-Tyr-Val NH2 also participates in a number of cellular reactions, including those that have a kinetic rate.</p>

<p>H-STQAAIDQINGK^-OHH-STQAAIDQISGK^-OHH-SDAPIGK^-OHH-DEALNNR^-OHH-EFSEVEGR^-OHH-TITNDR^-OHR^ = Arginine (U-13C6,15N4)K^ = Lysine (U-13C6,15N2)Peptide purity: &gt;98%AAA: Concentration – Duplicate100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots</p>

<p>Influenza B native 5-peptide mixture of:<br>H-SHFANLK-OHH-SYFANLK-OHH-GVLLPQK-OHH-NLNSLSELEVK-OHH-GILLPQK-OHAAA: Concentration - Duplicate<br>100 aliquots/pack total to equal 1nmol/peptide/vial dry aliquots</p>

<p>supplied as the TFA salt</p>

Endogenous calcitonin gene-related peptide receptor (CGRP) agonist which is secreted in both peripheral and central neurons. It is a potent vasodilator and can function in the transmission of nociception as well as acting as an appetite suppressant and contributing to gastric acid secretion.  It also has a function in temperature homeostasis, increases heart rate, and can play a role in the release of the pituitary hormone.

<p>H-Glu[Cyclo(Arg-Ala-Asp-D-Phe-Lys)]2 is a peptide macrocycle with a cyclic structure. It belongs to the group of biologically active peptides and biochemicals. The peptide macrocycle has an RGD sequence that binds to integrin receptors on cells, which are involved in cell adhesion, migration, and proliferation. This peptide can be used as an agent for cancer research or as a drug to treat cardiovascular diseases.</p>

PLP (139-151) is derived from Proteolipid Protein (PLP), an epitope of immunodominant encephalitogenic PLP and is involved in promoting encephalomyelitis.

<p>Z-His-Glu-Lys-AMC is an activator of ion channels. It is a ligand that binds to the receptor and stimulates the opening of ion channels in cells. Z-His-Glu-Lys-AMC has been used as a research tool to study protein interactions, pharmacology, and cell biology. It has also been used to study ion channel function and its role in diseases such as epilepsy or schizophrenia.</p>

Ac-Asp-Glu-Val-Asp-pNA is a peptide that is derived from the human tumor necrosis factor (TNF) precursor protein. It has been shown to inhibit the growth of tumor cells in vitro by inducing apoptosis. Ac-Asp-Glu-Val-Asp-pNA binds to and activates caspase 3, which leads to cleavage of the proapoptotic protein Bid into Bax and Bak, leading to mitochondrial membrane potential collapse and cell death. The peptide also inhibits DNA synthesis in HL60 cells and hemocytes. Ac-Asp-Glu-Val-Asp-pNA also inhibits proliferation of K562 cells through proteolytic degradation of the antiapoptotic protein Bcl2L11.

H-Val-AMC is a scleral depressant that has been shown to lower intraocular pressure (IOP) in humans and animals. It is a non-penetrating agent that has been show to be well tolerated in humans with no significant side effects. H-Val-AMC can be used as an alternative to medications such as timolol, which are not well tolerated by many patients. The effectiveness of H-Val-AMC is statistically significant when compared to timolol and other agents, but it does not produce a substantial reduction in IOP. This drug should be administered in conjunction with other glaucoma treatment methods including positioning, suturing, perimetry, pachymetry and sclerectomy.

Calcitonin (salmon) acetate is a peptide hormone that is naturally produced by the parafollicular cells of salmon. It contains a disulphide bridge between two cysteine residues, which is crucial for its biological activity. This hormone plays an important role in regulating calcium levels in the body and is commonly used in life sciences research. Calcitonin (salmon) acetate has been shown to have potent effects on bone metabolism, making it a valuable tool for studying osteoporosis and other bone disorders. Its unique structure and function make it an essential component of biochemical studies and research in the field of endocrinology.

<p>H-Gln-2-ClTrt-Resin (100-200 mesh) 1% DVB is a resin that is used in peptide synthesis. It is an amine-thiol resin with a DVB backbone and HCl groups on the secondary amines. This resin can be used as a building block for peptide synthesis, and it has been used to synthesize peptides containing an N-terminal thiol group.</p>

<p>Myelin PLP (180-199) is a peptide that has been shown to be immunogenic and biochemically active. It belongs to the group of peptides and biochemicals, which are organic compounds of high molecular weight. Myelin PLP (180-199) is an immunogenic compound that can be used as a vaccine adjuvant. It also has been shown to have anti-inflammatory activities, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of BTN2A1 antibody, catalog no. 70R-7238</p>