Peptides
Les peptides sont des chaînes courtes d'acides aminés liées par des liaisons peptidiques, jouant un rôle essentiel en tant que molécules biologiques dans divers processus cellulaires. Ils fonctionnent comme hormones, neurotransmetteurs et molécules de signalisation, et sont largement utilisés dans les applications thérapeutiques et diagnostiques. Les peptides sont également cruciaux dans la recherche pour étudier les interactions protéiques, les activités enzymatiques et les voies de signalisation cellulaire. Chez CymitQuimica, nous proposons une large sélection de peptides de haute qualité pour soutenir vos besoins en recherche et développement en biotechnologie et en pharmacie.
Sous-catégories appartenant à la catégorie "Peptides"
29608 produits trouvés pour "Peptides"
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AC253 trifluoroacetate
CAS :AC 253 is an amylin (AMY3) receptor antagonist.
Formule :C122H196N40O39•(C2HF3O)xDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :2,847.1 g/molAnti Galanin (15-29) (Rat) Serum
Anti Galanin (15-29) (Rat) Serum is a recombinant protein that is used as a research tool and has been shown to inhibit the activity of ion channels. It has been used to study the interactions between proteins, peptides, and receptors. This product has not been evaluated by the FDA for use in humans.
Degré de pureté :Min. 95%Anti Pro-LH-RH (1-26), Human Serum
Anti Pro-LH-RH (1-26) is a peptide that binds to the LH/hCG receptor of human cells and inhibits the binding of hCG and LH. This peptide is a cell biology research tool that can be used in antibody production and as an inhibitor in receptor binding studies. Anti Pro-LH-RH (1-26) has been shown to bind to the LH/hCG receptor of human cells and inhibit the binding of hCG and LH, which are necessary for sperm maturation. It also has been shown to inhibit ion channels, such as calcium channels. The high purity of this product makes it ideal for use in antibody production and receptor binding studies.Degré de pureté :Min. 95%BMP 2 Human, Monomer
BMP 2 is a member of the TGF-β superfamily and is a potent activator of bone morphogenetic protein receptors. It is a ligand for type I and II receptor complexes. BMPs play a crucial role in embryonic development, tissue repair, and maintenance of cartilage. BMP 2 has been shown to inhibit ion channels such as calcium-activated potassium channels. It also inhibits protein synthesis by inhibiting the activation of transcription factors like CREB, c-Jun N-terminal kinase (JNK), and p38 mitogen activated protein kinase (MAPK). BMP 2 also binds to antibodies that are specific for phosphorylated receptor tyrosine residues, which can be used as research tools in immunohistochemistry experiments or other applications.Degré de pureté :Min. 95%TentaGel® S SH Resin (90 um)
TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.
Application: (90 µm)
Substitution Functional Group:-CH2-CH2-SHDegré de pureté :Min. 95%Leptin (Mouse)-ELISA Kit (1ea)
Leptin (Mouse)-ELISA Kit is a ready-to-use assay kit for the quantitative determination of mouse leptin in serum, plasma, and cell culture supernatants. The assay is based on a sandwich ELISA using monoclonal antibodies to mouse leptin. This kit provides a simple and accurate method for the detection of mouse leptin in biological samples.Degré de pureté :Min. 95%IGHG1 MS Calibrator-7 (25nmol)
IGHG1 MS Calibrator-7 is a 25nmol peptide that is derived from the C region of Ig gamma-1 chain. It is a tryptic peptide that corresponds to the sequence of IGHG1. The molecular weight of this peptide is 584.6Da and its theoretical pI is 9.26. This calibrator can be used in various proteomics applications, including proteomics tools such as TrypTides and Proteomics Tools from New England Peptide Company.Degré de pureté :Min. 95%FGF4 Human
FGF4 is a protein that is encoded by the FGF4 gene. It belongs to the fibroblast growth factor family and is a potent activator of the receptor tyrosine kinase FGFR1. FGF4 activates cell proliferation and migration, as well as inducing angiogenesis. FGF4 has been shown to inhibit potassium channels in some types of cells, leading to increased neuronal activity in rats. FGF4 also binds to insulin-like growth factor receptor 1 (IGF1R) and IGF2R. It has been shown to regulate the activation of these receptors, which are known for their roles in cell proliferation, differentiation, survival, and metabolism.Degré de pureté :Min. 95%Noggin Human
Noggin is a protein that is involved in the regulation of neuronal growth and development. It acts as a morphogen, binding to a receptor on the surface of cells and initiating signaling cascades that lead to changes in gene expression. Noggin binds to Retinoid-X-receptor (RXR) and the Ligand-binding domain of Notch1. These interactions may be important for the regulation of CNS cells, such as neurons and glial cells. The protein has been shown to have a role in synaptic plasticity, axonal guidance, and synaptogenesis. Noggin has also been shown to be an inhibitor of cell proliferation and an activator of cell differentiation.Degré de pureté :>95% By Sds-Page.FRETS-25Val (1 umol) (1umol)
FRETS-25Val is a research tool that is used to activate, inhibit, or modulate the function of ion channels. FRETS-25Val is an agonist of G protein-coupled receptors (GPCRs) and ligands for receptor tyrosine kinases (RTKs). It has been shown to bind to Ligand Binding Domains (LBDs) on cell surface receptors. FRETS-25Val binds to antibody Fc regions and also inhibits the binding of peptides to proteins by competing with them for binding sites.Degré de pureté :Min. 95%Bromoacetamido-dPEG®3-Azide
Bromoacetamido-dPEG®3-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®3-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Degré de pureté :Min. 95%Masse moléculaire :339.19 g/molCBZ-amido-dPEG®24-amido-dPEG®24-Acid
CBZ-amido-dPEG®24-amido-dPEG®24-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. CBZ-amido-dPEG®24-amido-dPEG®24-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Formule :C110H210N2O53Degré de pureté :Min. 95%Masse moléculaire :2,408.85 g/molGreen Fluorescent Protein Recombinant
The Green Fluorescent Protein Recombinant is a highly versatile product that offers a wide range of applications in the field of proteomics. This PEG-linked peptide is designed to enhance the stability and solubility of proteins, making it an ideal choice for various research purposes. With its unique PEG-protected structure, this recombinant protein ensures optimal performance and long-lasting results. Whether you're conducting protein-protein interaction studies or investigating protein localization, this PEGylated peptide will provide you with accurate and reliable data. Trust in the exceptional quality of this product to advance your research and unlock new insights in the world of proteomics.
Degré de pureté :Min. 95%Anti Gastrin 17 (G17) (Dog) Serum
Anti Gastrin 17 (G17) is a recombinant peptide that is used to study the gastrin receptor. It is an activator of the gastrin receptor, which belongs to the class of G protein-coupled receptors. The binding of G17 to gastrin receptor induces conformational changes in it and stimulates adenylate cyclase activity. This leads to increased levels of cAMP and activation of protein kinase A (PKA). Anti Gastrin 17 has a high purity, with a yield up to 95%. It can be used as a research tool or as an antibody in Western blot analysis.Degré de pureté :Min. 95%Magainin 1
Magainin 1 is a research tool that belongs to the class of activators. It binds to receptor and ligand, which are proteins in cells. Magainin 1 is used as a tool in cell biology to study protein interactions and pharmacology, as well as for the study of ion channels. It has high purity and can be used with other reagents, such as antibodies or peptides, in research.
Degré de pureté :Min. 95%Scyllatoxin
CAS :This Scyllatoxin product is a synthetic scorpion (Leiurus quinquestriatus hebraeus) toxin with disulfide bonds between Cys3-Cys21, Cys8-Cys26, and Cys12-Cys28. It can be used as a small conductance Ca2+-activated K+ channel blocker and may assist in pharmacology receptor studies. This product is available as a 0.1mg vial.Formule :C142H237N45O39S7Degré de pureté :Min. 95%Masse moléculaire :3,423.1 g/molPLGF 2 Human
PLGF-2 is a cytokine that is secreted by activated platelets. It has been shown to inhibit the proliferation of various human cancer cells, including breast and prostate cancer cells. PLGF-2 is also a potent stimulator of endothelial cell growth and angiogenesis.Degré de pureté :Min. 95%Apelin-36 (Human, 1-16 Amide)
Apelin-36 is a peptide hormone that is derived from a larger precursor protein. It is a member of the apelin peptide family, which is involved in regulating cardiovascular and metabolic functions. Apelin-36 binds to a G protein-coupled receptor called APJ (apelin receptor), which is widely expressed in various tissues. The interaction between apelin-36 and APJ receptor leads to a range of physiological effects, such as cardiac contractility stimulation and blood pressure suppression as well as lowering body weight and improving glucose homeostasis. Research has shown that apelin-36 may have therapeutic potential in the treatment of cardiovascular diseases, such as hypertension and heart failure, as well as metabolic disorders, such as obesity and diabetes. Apelin-36 has also been implicated in other physiological processes, including inflammation, angiogenesis, and cancer progression. This product is available as a 0.1 mg vial.Formule :C74H117N27O20Degré de pureté :Min. 95%Masse moléculaire :1,704.9 g/molParathyroid Hormone (Human, 69-84)
CAS :Parathyroid Hormone (Human, 69-84) is a peptide hormone that regulates the levels of calcium and phosphate in the blood. It regulates bone formation and remodeling by targeting bone mineralization. Parathyroid hormone binds to to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available has a 0.5mg vial.Formule :C72H125N21O27Degré de pureté :Min. 95%Masse moléculaire :1,716.9 g/molAzido-dPEG®8-OH
Azido-dPEG®8-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, Aazido-dPEG®8-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.
Formule :C64H108F4N2O29Degré de pureté :Min. 95%Masse moléculaire :1,445.53 g/molNH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-NH-m-dPEG®24
NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.Formule :C97H185N7O48Degré de pureté :Min. 95%Masse moléculaire :2,217.52 g/molMAL-dPEG®24-Tris (-dPEG®24-Tris (m-dPEG®24)3)3
MAL-dPEG®24-Tris (-dPEG®24-Tris (m-dPEG®24)3)3 is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®24-Tris (-dPEG®24-Tris (m-dPEG®24)3)3 is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Formule :C704H1386N18O343Degré de pureté :Min. 95%Masse moléculaire :15,592.45 g/molBis-Bromoacetamido-dPEG®11
Bis-Bromoacetamido-dPEG®11 is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-bromoacetamido-dPEG®11 is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.Degré de pureté :Min. 95%Masse moléculaire :786.54 g/mol(Des-Asp1-Ile5)angiotensin I trifluoroacetate
CAS :(Des-Asp1-Ile5)angiotensin I trifluoroacetate is an analog of angiotensin I that acts as an inhibitor of kinases. It has been shown to induce apoptosis in human cancer cells and may have potential as an anticancer agent. This compound is derived from Chinese urine and has been found to be effective against a variety of tumors, including those resistant to chloroquine or artesunate treatment. The mechanism by which (Des-Asp1-Ile5)angiotensin I trifluoroacetate exerts its anticancer effects is not fully understood, but it is believed to involve the inhibition of kinase activity and the induction of apoptosis in cancer cells. This compound may hold promise as a novel inhibitor for the treatment of various cancers.Formule :C58H84N16O11•(C2HF3O2)xDegré de pureté :Min. 95%T4 DNA Ligase (recombinant)
T4 DNA Ligase is a recombinant protein that catalyzes the formation of DNA molecules from complementary single-stranded DNA. T4 DNA Ligase is used as a research tool in cell biology and biochemistry to study the interactions between proteins and peptides. It is also used to produce recombinant proteins, such as antibodies. T4 DNA Ligase binds to its substrate by an ionic interaction with adenosine triphosphate (ATP) and to the complementary strand by hydrogen bonding. The enzyme cleaves the phosphate backbone of both strands at the junction point, forming two new phosphodiester bonds. This enzyme has been shown to bind to other proteins and peptides, such as receptor tyrosine kinases, which are involved in signal transduction pathways that regulate cell growth and differentiation.Degré de pureté :Min. 95%Peptide YY (Human)-EIA Kit (1ea)
Peptide YY (Human)-EIA Kit (1ea) is an EIA kit for the quantitative analysis of human peptide YY. Peptide YY is a neuropeptide with a role in the regulation of food intake and energy expenditure. The kit contains one vial each of peptide YY antiserum, peptide YY antibody, and standard reference material. The assay can be used to detect the level of peptide YY in tissue samples or cell culture supernatants.
Degré de pureté :Min. 95%Methoxytrityl-S-dPEG®12-Acid
CAS :Please enquire for more information about Methoxytrityl-S-dPEG®12-Acid including the price, delivery time and more detailed product information at the technical inquiry form on this pageFormule :C47H70O15SDegré de pureté :Min. 95%Masse moléculaire :907.11 g/molNH2-dPEG®4-Glu(OH)-NH-m-dPEG®24
NH2-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.Formule :C65H129N3O32Degré de pureté :Min. 95%Masse moléculaire :1,464.72 g/molm-dPEG®48-CO(CH2)3-Acid
m-dPEG®48-CO(CH2)3-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®48-CO(CH2)3-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Formule :C102H203NO51Degré de pureté :Min. 95%Masse moléculaire :2,259.7 g/molTentaGel® R NH2 Resin (90 um)
This resin is specially designed for difficult and long sequences. TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. Particle size 90 µm; capacity: 0.18-0.22 meq/g. Substiution Functional Group: -O-CH2-CH2-NH2Degré de pureté :Min. 95%Pyr-Pro-Val-pNA
CAS :Pyr-Pro-Val-pNA is a research tool that can be used to study protein interactions. It is an activator ligand that binds to the receptor and can activate ion channels. Pyr-Pro-Val-pNA has been shown to inhibit the binding of antibodies to their antigen. This ligand can be used as a pharmacological agent for the treatment of various diseases, including cancer.Formule :C21H27N5O6Degré de pureté :Min. 95%Masse moléculaire :445.47 g/molEndokinin C, human
Endokinin C is a peptide that is an inhibitor of protein interactions. It has a CAS number of 52783-30-4. Endokinin C has been shown to have the ability to inhibit the activity of ion channels, such as potassium channels, sodium channels, and calcium channels. This peptide also activates ligands and receptors in the body, including epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGF1R), and nerve growth factor receptor (NGFR). Endokinin C is purified from human urine. It has high purity with a protein content of less than 5%.Formule :C78H123N21O20Degré de pureté :Min. 95%Masse moléculaire :1,674.9 g/molEGF Mouse
Epidermal Growth Factor, Mouse sequence. Produced recombinantly in E.Coli. 53 amino acids (6 kDa) including 3 intramolecular disulfide-bonds.Degré de pureté :Min. 95%Anti G-Protein: Galpha olf (23-38), Human Serum
Anti G-Protein: Galpha olf (23-38), humanSerum is a research tool that is used to study protein interactions. It can be used for the investigation of ion channels, cell biology, and pharmacology. The antibody reacts with the specific antigen for which it was raised. The antibody may be used in immunohistochemistry on tissue sections or in ELISA as a detection tool.
Degré de pureté :Min. 95%[Sar1,Ala8]-Angiotensin II
Sar1,Ala8]-Angiotensin II is a peptide that has been shown to bind to the angiotensin receptor and activate it. This peptide is a research tool for studying ion channels, ligand-receptor interactions, and protein interactions. The peptide can be used to study the pharmacology of the angiotensin receptor, as well as its role in cell biology and other biological processes. Sar1,Ala8]-Angiotensin II binds to the angiotensin receptor with high affinity, making it an excellent candidate for use in antibody production against this receptor.Formule :C43H67N13O10Degré de pureté :Min. 95%Masse moléculaire :926.07 g/molFGF 8 Human
FGF 8 is a protein that is involved in the regulation of cell growth, differentiation and survival. It can bind to FGF receptors on cells, which triggers a signal transduction pathway. The activation of this pathway leads to the inhibition of GSK3β activity and the activation of Akt. FGF 8 also binds to FGFR4, which activates phospholipase C (PLC) and increases intracellular Ca2+. This leads to the activation of PKC and calpain, which then activate nitric oxide synthases (NOS). Activation of NOS leads to increased production of nitric oxide, which causes vasodilation.Degré de pureté :Min. 95%m-dPEG®12-Acid
m-dPEG®12-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®12-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.Degré de pureté :Min. 95%Insulin I (Rat, Mouse)
CAS :Insulin is a peptide hormone that regulates blood glucose levels and promotes the uptake of glucose by cells. Insulin is produced in the pancreas and consists of 51 amino acids. It has a molecular weight of 5808 Da and consists of two chains, A (21-amino acid) and B (30-amino acid). The A chain is primarily responsible for insulin's activity, while the B chain improves its stability. Insulin binds to receptors on the cell surface, which activates an intracellular signaling cascade that subsequently leads to changes in gene expression. Insulin has been widely used as a research tool to study protein interactions, ligand binding, receptor activation, ion channel modulation, antibody production, and other cellular processes. Insulin I (Rat) is isolated from rat pancreas using a purification process that yields high purity insulin with minimal contaminating proteins or peptides. This product can be used in life science research applications such as pharmacology studies and antibody production. This product has the three letter code: A-chain: Gly-Ile-Val-Asp-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn ; B-chain: Phe-Val-Lys-Gln-His-Leu-Cys-Gly-Pro-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ser has the disulfide Bonds: CysA6-CysA11, CysA7-CysB7, and CysA20-CysB19 and is available as a 50µg vial.Formule :C259H387N65O75S6Degré de pureté :Min. 95%Masse moléculaire :5,803.6 g/molI-TAC, human, recombinant (CXCL11)
I-TAC is a chemokine that is expressed in high amounts in the human blood and leukocytes. It also has been shown to be an inducible chemoattractant for leukocytes. I-TAC is a member of the CXC family of chemokines, which are small proteins that act as chemoattractants for cells of the immune system. I-TAC has been shown to attract neutrophils, monocytes, and T cells by binding to their receptors.Degré de pureté :Min. 95%Bis-dPEG®4-TFP Ester
Bis-dPEG®4-TFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®4-TFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.
Formule :C24H22F8O8Degré de pureté :Min. 95%Masse moléculaire :590.41 g/molAnti NO Synthase I (998-1024), Human Serum
Anti NO Synthase I (998-1024), human Serum is a peptide that is an activator. It has been shown to inhibit the activity of a protein called Nitric oxide synthase I, which catalyzes the production of nitric oxide from L-arginine and oxygen. The antibody for this product can be used for research and cell biology applications, such as investigating protein interactions in living cells or studying ion channels in isolated cells. This product is also useful for pharmacological studies, such as identifying receptor ligands or evaluating inhibitors of protein interactions.Degré de pureté :Min. 95%MAGE-3 Antigen (271-279) (human) trifluoroacetate salt
CAS :ALPHA FACTOR SIGNALING PEPTIDEFormule :C53H79N13O10Degré de pureté :Min. 95%Masse moléculaire :1,058.28 g/molBiotin Substance P
Substance P (SP) is a peptide that is highly conserved across the animal kingdom and is involved in a number of inflammatory and growth promoting processes. SP has a net positive charge at physiological pH, it is an amphiphilic peptide with positively charged residues at the N-terminus and hydrophobic residues at the C-terminus, this controls how it interacts with cell membranes. SP is stable in plasma (several hours) but has a short half-life in tissues (seconds/minutes).SP is encoded by the TAC1 gene and is a member of the tachykinin peptide hormone family. SP is expressed by many cell types including: neurons, astrocytes, microglia, epithelial cells, endothelial cells, immune cells such as T cells and macrophages- dendritic cells and eosinophils and some stem cells and progenitor cells. The huge variety of cell types expressing SP suggest it is involved in a wide variety of physiological and pathophysiological functions.SP mediates its functions by interacting with members of the neurokinin (NK) family of G protein-coupled receptors with high selectivity. Among these, SP binds to NK1R with the highest affinity, this receptor is expressed in a wide range of tissue types.Biotin (B7) has been added to the N-terminus.Masse moléculaire :1,572.8 g/molHistone H3-GG-[Cys(5-FAM)]-amide
Histone H3 peptide with a C-terminal GGC linker labelled with fluorescein.Masse moléculaire :2,825.4 g/molSer3-n-octanoyl Ghrelin-[Cys(AF647)] Human
Ghrelin is involved in several physiological processes, including feeding and lipid accumulation, stress response- anxiety- cardiac performance- immunity and inflammation- taste sensation, reward-seeking behaviour, regulation of glucose metabolism and thermogenesis, memory, motivation and learning.Ghrelin is a peptide hormone that typically has a serine at the third residue and relies on modification with a fatty acid to give ghrelin its functional activity. In its modified form, ghrelin is an endogenous ligand for the pituitary gland's growth hormone receptor (GHS-R) and stimulates growth hormone release.Ghrelin acts on the hypothalamic arcuate nucleus as an orexigenic agent to stimulate appetite. Ghrelin is produced in the stomach as a precursor peptide preproghrelin, cleaved to ghrelin. Ghrelin circulates in the blood and can cross the blood-brain barrier. Levels of ghrelin respond to fasting conditions and allow signals about the energy status to be transmitted from the peripheral organs to the central nervous system to maintain energy homeostasis.Ghrelin is a valuable target for treating conditions such as anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal disorders, inflammatory disorders and metabolic syndrome.Ser3-n-octanoyl ghrelin has a C-terminal AF647, a structural analog to Alexa Fluor 647, a widely used far-red fluorescent dye. Its excitation is ideally suited to 594nm or 633nm. This dye is suited for low abundance targets as it has high initial brightness and a high photostability allowing detection of low abundance peptides.Masse moléculaire :4,450.9 g/molHistone H3-GGC-amide
Histone protein H3 is a core component of the nucleosome, functioning in DNA compaction and availability to transcription machinery. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodelling. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, &-ldquo-histone tail&-rdquo- which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. There is a wealth of data recording these modifications but understanding their significance is not as clear. The first 20 residues (1-20) of H3 N terminal domain are provided here. This sequence has already been used to investigate H3 phosphorylation and methylation events in the cell cycle.A glycine linker is C-terminally attached as a highly flexibly linker to allow the best pharmacokinetic profiling of the fused domain such as expression, localisation, or activity data. Provision of this H3 sequence with a glycine linker may allow further understanding of histone regulation.
Masse moléculaire :2,398.3 g/mol[5-FAM]-Collagen alpha-1(I)-(5-TAMRA)
Collagens are the most abundant family of extra cellular matrix (ECM) proteins, accounting for two-thirds of the dry mass of adult articular cartilage. Several subtypes have been identified including types II, IX, X, XI, VI, XII, and XIV collagen, however 80 to 90% of the collagen in the body consists of types I, II, and III. Collagen is a long thin protein which consists of three coiled subunits: two α1(I) chains and one α2(I). Type 1 collagen forms part of the major structure of the bone, and mutations in the α1(I) or α2(I) genes lead to-osteogenesis imperfecta, or brittle-bone disease.Collagen is cleaved by mammalian tolloid (mTld) and its splice variant- bone morphogenetic protein 1 (BMP1), a metalloprotease and member of the peptidase M12A family enzymes.This peptide contains a FRET (fluorescence or Fö-rster resonance energy transfer) pair. N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag which excites at 495 nm and emits at 517 nm, and a 5-Carboxytetramethylrhodamine-(5-TAMRA), present on the side chain of a C-terminal lysine which has been added to the peptide. 5-TAMRA is a widely used fluorescent dye which excites at 546 nm and emits at 579 nm. In the intact peptide TAMRA quenches the fluorescence of 5-FAM, however upon cleavage of the peptide by a protease such as BMP1, the fluorescence of 5-FAM is recovered and can be monitored.Masse moléculaire :2,738.1 g/molSARS-CoV-2 Nucleoprotein 1 (56-70)
The coronavirus (CoV) nucleoprotein is the major component of CoV structural proteins. Also known as the nucleocapsid protein, it is an abundant RNA-binding protein critical for viral genome packaging. These factors make nucleoprotein a good target for developing new antiviral drugs. In addition, the identification of epitopes within the nucleoprotein sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. Nucleoprotein (56-70) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Masse moléculaire :1,752.9 g/molLiraglutide
Liraglutide is sold under the brand name €˜Victoza' and is a medication used to treat diabetes mellitus type 2 and obesity.Liraglutide binds to and activates the GLP-1 (glucagon-like peptide-1) receptor to bring about an increase in insulin secretion and a decrease in glucagon secretion and gastric emptying.Masse moléculaire :3,748.9 g/molAF647 RGD peptide
The RGD peptide is an adhesive peptide present in extracellular matrix proteins allowing them to attach to a range of biological materials. It is labelled with Alexa Fluor 647.Masse moléculaire :1,432.2 g/mol
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