Peptides

<p>Applications L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.<br>References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);<br></p>

<p>Applications Boc-L-Valine is used in amino acid conjugates as proteasome inhibitors.<br>References Wan, S. et al.: Int. J. Mol. Med., 26, 447 (2010);<br></p>

<p>Applications Phenylalanine derivative used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.<br>References Tomisaka, K. et al.: Chem. Comm., 1, 133 (2001); Magours, R., et al.: Biochim. Biophys. Acta, Mol. Cell Res., 858, 158 (1985)<br></p>

<p>Applications 2-NBDG is a fluorescent glucose uptake indicator, used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry.<br>References Zou, Chenhui., et al.: J Biochem Biophys Methods., 64, 207 (2005); Yamada, Katsuya., et al.: J. Biol. Chem., 275, 22278 (2000)<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 30,000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);<br></p>

<p>Applications Spaglumic Acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.<br>References Taylor, M.J., et al.: Int. J. Neuropharmacol., 15, 1541 (2012); Shi, D.X., et al.: J. Neurochem., 123, 971 (2012); Sun,W., et al.: Science., 339, 197 (2013);<br></p>

<p>Applications 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol (cas# 106984-09-2) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Boc-ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon., et al.: J. Pharmacol., 58, 53 (1936), Boissier, J., et al.: Eur. J. Pharmacol., 22, 141 (1973), Nillne, E., et al.: J. Biol. Chem., 277, 48587 (2002),<br></p>

<p>Applications Fmoc-d-asn(trt)-oh, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.<br></p>

<p>Applications N-tert-Boc-D-alanine is an N-Boc-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.<br>References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. &amp; Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)<br></p>

<p>Stability Light Sensitive<br>Applications A PEG derivative, which contains a free amine that can be conjugated to biological molecules directly by an amide linkage (or via the corresponding isothiocyanate) and an azide that can be reduced to an amine for conjugation to other molecules. PEG derivatives are water soluble. Bifunctional water soluble compounds with flexible dimensions allow for conjugation of small molecules to proteins or molecular probes. 1-amino-11-azido-3,6,9-trioxaundecane can be reacted with small organic molecules for the synthesis of heterobifunctional compounds. It has been used to synthesize a mannose-fluorescein conjugate for the study of cell-surface mannose-specific lectins.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aslan, K., et al.: J. Fluoresc., 14, 391 (2004), Gole, A., et al.: Langmuir, 20, 7117 (2004), Cavalcante, A., et al.: Biochem. Eng. J., 29, 258 (2006),<br></p>

<p>Applications N-CBZ-Glycyl-L-proline 7-Amido-4-methylcoumarin is a fluorogenic substrate used for post-proline cleaving enzyme prolyl endopeptidase.<br>References J. Momand, S. Clarke Biochemistry 26, 7798, (1987)<br></p>

<p>Applications Linaclotide is a guanylate cyclase-C agonist currently being studied in Phase 3 trials for the treatment of irritable bowel syndrome with constipation.<br>References Chey, W.D., et al.: Am. J. Gastroenterol., 107, 1702 (2012); Rao, S., et al.: Am. J. Gastroentrol., 107, 1714 (2012); Brierley, S.M., et al.: Curr. Opinion. Pharmacol., 12, 632 (2012);<br></p>

<p>Applications N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate is used as an efficient coupling agent in phosphonamidation reactions; used as coupling reagent in the synthesis of solid phase peptide<br>References Fredriksen, K., et al.: Eur. J. Org. Chem., 3, 474 (2016); Achyuthan, K., et al.: J. Pept. Sci., 21, 751 (2015);<br></p>

<p>Applications FMOC-ALA-GLY-OH (cas# 116747-54-7) is a useful research chemical.<br></p>

<p>Applications Mal-amido-peg6-NHS can be used as a crosslinking agent and modifier of DNA.<br>References Vogel, Katrin, et al.: Small, 9(2), 255-262 (2013);Talvitie, Elina, et al.: Carbohydrate Polymers, 89(3), 948-954 (2012)<br></p>

<p>Applications A Wittig reagent.<br>References Laine, D., et al.: J. Med. Chem., 52, 5241 (2009), Nakao, A., et al.: Bioorg. Med. Chem. Lett., 19, 4607 (2009), Arakawa, Y., et al.: Chem. Pharm. Bull., 57, 167 (2009),<br></p>

<p>Applications N-Fmoc-L-isoleucine is a N-Fmoc-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications Bis(NHS)PEG5 (CAS# 756526-03-1) is a useful research chemical compound.<br></p>

<p>Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.<br>References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);<br></p>

<p>Applications L-valyl-L-histidyl-L-leucyl-L-threonyl-L-prolyl-L-glutamic Acid, is used as an analyte for the determination of ionization efficiency of glycated and non-glycated peptides from N-terminal of Hb β-chain by electrospray ionization mass spectrometry.<br>References Nakanishi, T., et al., J. Chromatogr. B. Biomed. Sci. Appl., 746, 83 (2000)<br></p>

<p>Applications Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.<br>References Verlackt, C., et al.: J Phys Chem C, 121, 5787 (2017)<br></p>

<p>Applications 1-Amino-3,6,9-trioxaundecanyl-11-ol (cas# 86770-74-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Boc-L-isoleucine is the N-Boc-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.<br>References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)<br></p>

<p>Applications Fmoc-L-Tyr(tBu)-OH is tyrosine derivative used in soiid phase peptide synthesis.<br>References Atherton, E., et al.: J. Chem. Soc. Chem. Comm., 20, 970 (1980);<br></p>

<p>Applications 23-Azido-3,6,9,12,15,18,21-Heptaoxatricosan-1-ol is used in the synthesis of heterobifunctionalized oligo(ethylene glycol) linkers for use in drug delivery.<br>References Goswami, L. et al.: Org. Biomol. Chem., 11, 1116 (2013);<br></p>

<p>Applications Nα-Fmoc-Nε-biotinyl-L-lysine is used in the synthesis of site-specific biotinylated probes.<br>References Macielag, M., et al.: Int. J. Pep. Protein Res., 44, 582 (1994)<br></p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of 2610034B18Rik antibody, catalog no. 70R-9356</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of C2orf29 antibody, catalog no. 70R-3470</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of EXOC1 antibody, catalog no. 70R-9538</p>