Peptides

Adrenomedullin (Human, 1-25) is a vasopressor fragment of the human peptide hormone adrenomedulin. This product has a disulfide bond between Cys16-Cys21 and is available as a 0.5mg vial.

NHS-dPEG®4-( m-dPEG®12)3-Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-dPEG®4-( m-dPEG®12)3-Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Big Endothelin-2 (Human, 22-38) Antiserum is an antibody that binds to the endothelin receptor and blocks the binding of endothelin. It is a research tool that can be used in cell biology and pharmacology to study the effects of endothelin on ion channels, ligands, and receptor activation. Big Endothelin-2 (Human, 22-38) Antiserum has high purity and is suitable for use in immunohistochemistry or Western blotting techniques. It is also used as an inhibitor for other antibodies, such as anti-endothelin antibody.

Methoxytrityl-S-dPEG®4 Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Methoxytrityl-S-dPEG®4 Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

FGF13 is a protein that belongs to the FGF family of growth factors. It is a ligand for FGFR1 and FGFR2, two receptors that are involved in bone and cartilage formation. FGF13 also has been shown to be an activator of the receptor tyrosine kinase MET, which is important for cell proliferation and differentiation. This protein shows no activity against FGFR3 or FGFR4.
FGF13 can be used as a research tool for studying protein interactions and as an antibody for immunoprecipitation or Western blotting. It can also be used to block certain cellular pathways by inhibiting the activation of different receptors, such as the EGFR receptor.

Leptin is a hormone that regulates energy metabolism by modulating appetite and body weight. Leptin is produced by fat cells and signals to the hypothalamus of the brain about how much fat tissue there is. It also helps regulate other metabolic processes, such as insulin resistance and glucose tolerance. Leptin has been shown to have an anorectic effect in rodents, which may be due to its ability to reduce food intake or increase energy expenditure. In humans, leptin levels are higher in obese individuals than in those with normal weight, which indicates that this hormone may play a role in obesity.

Peroxiredoxin-2 is a protein that belongs to the peroxidase family of enzymes. It has been shown to be an activator of ion channels, which suggests that it may play a role in cell regulation. Peroxiredoxin-2 has also been shown to bind to peptides and antibodies, with potential therapeutic applications.

An inhibitor of β-Glucuronidase

Ac-Lys-Val-Pro-Leu-ACC is a peptide used as a research tool to study protein interactions. Ac-Lys-Val-Pro-Leu-ACC binds to the extracellular domain of the human epidermal growth factor receptor (EGFR) and inhibits EGFR signaling. It blocks ligand binding and receptor activation, which prevents the phosphorylation of downstream signaling proteins. Ac-Lys-Val-Pro-Leu-ACC can be used in pharmacology to identify new drugs that inhibit EGFR signaling pathways.

Glutathione synthetase is an enzyme that catalyzes the synthesis of glutathione from gamma-glutamylcysteine and glycine. It is a homodimeric protein composed of two identical subunits with a molecular weight of about 30 kDa. Each subunit contains one active site for the catalysis. The recombinant human glutathione synthetase has been shown to be stable in different pH buffers and can be used as a research tool or an inhibitor in cell biology experiments.

TentaGel based resin for protected peptide amides; particle size: 90 µmcapacity: 0.18 - 0.25 mmol/g

HMGB1 is a protein that belongs to the family of high-mobility group box proteins. It is involved in regulating the release of inflammatory mediators and cytokines, such as IL-1β, IL-6, TNF-α and MCP-1. HMGB1 also plays a role in activation of neutrophils and macrophages. The recombinant form of HMGB1 has been shown to be an excellent research tool for studying protein interactions and receptor ligand interactions. High purity HMGB1 can be used as a pharmacological inhibitor or activator.

IL 13 Mouse is a recombinant mouse IL-13 protein that binds to the IL-4 receptor. This recombinant protein is used as a research tool in pharmacology and cell biology. It can be used in the study of protein interactions and the activation of cells by cytokines.

AMY1A is a tryptic peptide derived from the alpha-amylase 1 from the salivary gland of the fruit fly, Drosophila melanogaster. Alpha-amylase 1 is a member of the amylase family and has been shown to be biologically active in vitro. AMY1A is used as a calibrator for mass spectrometry and proteomics applications. It is also used in conjunction with other peptides to identify proteins in proteomic experiments.

MonoFITC RLN2 is a peptide inhibitor of the human receptor for insulin-like growth factor 1. It has been shown to inhibit protein interactions with the insulin-like growth factor 1 receptor, which may lead to a reduction in its activation. MonoFITC RLN2 is also an activator of the G protein-coupled receptors, including adrenergic and muscarinic receptors. This peptide contains a fluorophore for easy detection.

Ac-Asp-Met-Gln-Asp-H aldehyde is a synthetic peptide that has been shown to inhibit protein interactions with the extracellular domain of the human insulin receptor. It also has been shown to activate the receptor, which leads to increased intracellular calcium levels and increased insulin secretion. Ac-Asp-Met-Gln-Asp-H aldehyde may be used as a research tool for studying protein interactions or as an antibody labeling agent. It is highly pure and can be used in cell biology and life science laboratories.

A Ceruloplasmin Heavy Tryptic Peptide Standard for use in protein identification and quantitation studies. Ceruloplasmin is a serum ferroxidase key to transporting copper in the blood. It also plays a role in iron metabolism regulation and the pathogenesis of Wilson disease. Furthermore it has been found in elevated levels during inflammation.

LISA-101 is a peptide that can be used as a research tool for the study of receptor activation and ligand binding. LISA-101 is an inhibitor of ion channels, which are proteins that allow electrically charged particles to move in and out of cells. LISA-101 binds to receptors on the surface of cells and blocks ion channels from opening. This prevents the flow of ions across the membrane, which blocks nerve impulses, leading to a decrease in pain sensation. LISA-101 has been shown to inhibit voltage-gated sodium channels and calcium channels, both which are involved in pain perception.

Argininosuccinate lyase is an enzyme that catalyzes the reaction of arginine and fumarate to form urea and ornithine. It is a homodimer with each subunit containing four domains. The active site of argininosuccinate lyase is located in domain 1, which contains a zinc ion coordinated by two histidine residues, a glutamate residue, and a water molecule. The enzyme is composed of one polypeptide chain that has three domains: the N-terminal domain (domain 1), the middle domain (domain 2), and the C-terminal domain (domain 3). Argininosuccinate lyase has been shown to be present in Escherichia coli as well as in human tissues.

This ELISA kit is designed for the quantitative measurement of human GIP (total) in serum, plasma and cell culture supernatant. It is a colorimetric competitive immunoassay with a sensitivity of 0.1 ng/mL. This assay has been designed to measure human GIP (total) from mouse, rat, monkey and human samples. The kit contains all the necessary reagents required for the complete assay, including calibrators and controls, along with detailed instructions and protocols.

MOCA is a small peptide with anti-inflammatory properties that binds to the receptor IL-1R. It has been shown to inhibit sodium currents in neurons by binding to the Na+ channel and preventing the influx of sodium ions, which leads to an inhibition of action potentials. MOCA has also been shown to bind with high affinity to the IL-1R and blocks its activity. This inhibition of IL-1R leads to decreased production of proinflammatory cytokines.
MOCA has not been shown to have any affinity for other receptors or ligands.

A potent vasoconstrictor (Source rat, 110-123) containing disulfide bonds between Cys8-Cys13 and available as a 0.5mg vial.  
Urotensin II is a peptide involved in biological systems such as the nervous, endocrine, cardiovascular and renal and in rats it is primarily found in brainstem and spinal cord motor neurons. Like that of urotensin II-related peptide, urotensin II contains the hexapeptide -CYS-TYR-LYS-TRP-PHE-CYS- known as the core and this is crucial to its biological function.
Urotensin II can also increase the concentration of intercellular calcium through binding to its G protein coupled receptor: urotensin-II receptor which causes the activation of Protein kinase C followed by the activation of Phospholipase C.
UT-II has been shown to have a wide range of physiological effects in rats, including vasoconstriction, modulation of blood pressure, and stimulation of the release of aldosterone and vasopressin.
In addition to its physiological effects, UT-II has also been implicated in the pathogenesis of various cardiovascular and metabolic disorders, including hypertension, heart failure, and diabetes. Inhibition of UT-II signaling has been suggested as a potential therapeutic target for these conditions.

IL 17A/F Human is a recombinant protein that activates the IL-17 receptor, which is a member of the IL-1 family. It can be used as a research tool in pharmacology and cell biology to study protein interactions. IL 17A/F Human is also an inhibitor of IL-17 and can be used for the treatment of autoimmune diseases.

Anti Galanin (1-15) (Rat) Serum is a peptide that is expressed in the rat brain and has an inhibitory effect on the release of galanin from neurons. The peptide interacts with high affinity to receptors for galanin, which are present in many tissues, including the central nervous system. Anti Galanin (1-15) (Rat) Serum is used as a research tool for the study of ion channels and ligands. This product can be used as an inhibitor for various activities such as receptor binding, enzyme inhibition, and cell signaling.

NHS-m-dPEG®(MW = 1214) is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. NHS-m-dPEG®(MW = 1214) is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

DBCO-dPEG®12-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DBCO-dPEG®12-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A soluble transferrin receptor (sTfR) light tryptic peptide standard for protein identification and quantitation studies. sTfR is a cleaved extracellular segments of the transferrin receptor 1 and it can be used to measure the status of iron in the blood and thus help in studies into anemia, where iron is deficient.

Antiproliferative factor Sialoglycopeptide is a research tool that has been shown to activate the immune system. It has been used as a vaccine carrier and in immunotherapy. Antiproliferative factor Sialoglycopeptide binds to the C-type lectin receptor on erythrocytes, triggering an antibody response. This protein also interacts with ion channels, such as Ca2+ channels, and inhibits protein synthesis by inhibiting the tyrosine kinase activity of protein kinase A (PKA). Antiproliferative factor Sialoglycopeptide is a peptide that is active against many types of cancer cells and has been shown to inhibit tumor growth in mice. The CAS number for Antiproliferative Factor Sialoglycopeptide is 12074-48-2.

BD 3 Human is a recombinant cytokine that has been shown to have a spectrum of activity against gram-positive and gram-negative bacteria, as well as yeast. BD 3 Human is produced by recombinant DNA technology and encodes the amino acid sequence of human interleukin-1 beta (IL-1β). It is a member of the IL-1 family, which includes IL-1α, IL-1β, IL-18, and IL-33. The molecular mass of BD 3 Human is 18 kDa. Cytokines are proteins that regulate cellular activities in response to stimuli from other cells or from the extracellular environment. Recombinant cytokines are produced by microorganisms or cells into which recombinant DNA has been introduced. They are used for research purposes, but not for diagnostic purposes or other therapeutic applications. Reconstitute with sterile water for injection before use. Reconstituted solutions may be stored at 2°C to 8°C