Modulateurs d'enzymes
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
BMS 777607
CAS :A potent Met kinase inhibitor (IC50 = 3.9 nM). Also inhibits Axl, Ron, and Tyro-3 (IC50 = 1.1, 1.8 and 4.3 nM, respectively). Anti-proliferative in Met-driven tumors in vitro and in vivo. Induces polyploidy in breast cancer cells and thereby chemoresistance.Formule :C25H19ClF2N4O4Degré de pureté :Min. 95%Masse moléculaire :512.10629Dihydrocyclosporin A
CAS :Dihydrocyclosporin A is an immunosuppressant, which is a cyclic undecapeptide derived from fungal metabolites, specifically from the soil fungus Tolypocladium inflatum. This compound functions through the inhibition of calcineurin, which is a crucial phosphatase involved in the activation of T-cells. By binding to the intracellular protein cyclophilin, Dihydrocyclosporin A forms a complex that inhibits calcineurin activity, subsequently blocking the transcription of interleukin-2 and other cytokines essential for T-cell proliferation.
Formule :C62H113N11O12Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :1,204.63 g/molSU11652
CAS :Inhibitor of FLT3 kinase and acid sphingomyelinase
Formule :C22H27ClN4O2Degré de pureté :Min. 95%Masse moléculaire :414.93 g/molPemetrexed - Bio-X ™
CAS :Pemetrexed is a chemotherapy drug that belongs to the class of drugs called folate antimetabolites. It is used for the treatment of various cancers such as non-small cell lung cancer and pleural mesothelioma. Pemetrexed targets the enzymes thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. The drug works by inhibiting those enzymes so that the formation of DNA and RNA is prevented.Formule :C20H21N5O6Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :427.41 g/molAS 2863619
CAS :Cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor
Formule :C16H14Cl2N8ODegré de pureté :Min. 95%Masse moléculaire :405.24 g/molLapatinib ditosylate monohydrate
CAS :Inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptor tyrosine kinases. Used for sensitization of HER2-overexpressing cancer cells to radiation as well as chemotherapy to tamoxifen- and trastuzumab-resistant cell lines. The compound blocks signalling via Akt and mitogen-activated protein kinase (MAPK) pathways leading to reduced cell survival. In trastuzumab resistant cancer cells, it inhibits HER2 phosphorylation, prevents receptor ubiquitination and causes accumulation of inactive HER2 dimers on the cell surface.Formule :C29H26ClFN4O4S•(C7H8O3S)2•H2ODegré de pureté :Min. 95%Masse moléculaire :943.48 g/molGI 254023X
CAS :Inhibitor of ADAM10 metalloproteaseFormule :C21H33N3O4Degré de pureté :Min. 95%Masse moléculaire :391.5 g/molCalpain Inhibitor III
CAS :Inhibitor of calpain and cathepsin BFormule :C22H26N2O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :382.45 g/molSimvastatin Na
CAS :Simvastatin Na is the salt form of Simvastatin. It acts as HMG-CoA reductase inhibitor and suppresses TNF-mediated NF-kappaB activation.Formule :C25H39O6NaDegré de pureté :Min. 95%Couleur et forme :Beige To Brown SolidMasse moléculaire :458.56 g/molLifirafenib
CAS :Lifirafenib is a targeted anticancer therapy, which is a small molecule inhibitor sourced through pharmaceutical development processes. Its mode of action involves the selective inhibition of the RAF kinase family, including B-RAF, which plays a critical role in the MAPK/ERK signaling pathway. By targeting these kinases, Lifirafenib effectively disrupts the aberrant signaling that contributes to tumor growth and survival in certain cancers with mutations such as BRAF V600E.
Formule :C25H17F3N4O3Degré de pureté :Min. 95%Masse moléculaire :478.42 g/molLGX 818
CAS :Inhibitor of B-Raf mutant (V600E); anti-neoplasticFormule :C22H27ClFN7O4SDegré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :540.01 g/molTPPB
CAS :TPPB is a small molecule inhibitor, which is synthetically derived for targeted biochemical studies. It functions by selectively modulating G-protein-coupled receptor (GPCR) signaling pathways through the inhibition of specific protein-protein interactions. This mode of action makes TPPB an insightful tool for dissecting the complex mechanisms by which G-proteins relay extracellular signals to intracellular responses.
Formule :C27H30F3N3O3Degré de pureté :Min. 95 Area-%Couleur et forme :PowderMasse moléculaire :501.54 g/molTegafur - Bio-X ™
CAS :Tegafur is an antineoplastic agent that is used for the treatment of gastric and colorectal cancers in combination with other medications. This drug is a prodrug of 5-fluorouracil and has anticancer properties by inhibiting thymidylate synthase during DNA synthesis. Additionally, Tegafur causes disruptions of RNA functions.
Tegafur is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formule :C8H9FN2O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :200.17 g/molTolcapone - Bio-X ™
CAS :Produit contrôléTolcapone is a catechol-O-methyltransferase (COMT) inhibitor that is used as adjunct therapy to manage symptoms of Parkinson’s disease. Although its precise mechanism is unknown, it is thought to be an inhibitor of COMT and allows for a greater reduction in the symptoms of Parkinson’s.Formule :C14H11NO5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :273.24 g/molOdevixibat
CAS :Odevixibat is a pharmacological agent that functions as an ileal bile acid transport inhibitor, which is synthesized through complex organic chemistry methods to create a specific molecular structure targeting bile acid transport mechanisms. It works by inhibiting the apical sodium-dependent bile acid transporter (ASBT) in the terminal ileum. This action reduces the reabsorption of bile acids from the small intestine back into the liver, thereby reducing overall bile acid levels in the body.Formule :C37H48N4O8S2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :740.93 g/molTizoxanide
CAS :Anti-parasitic; pyruvate ferredoxin oxidoreductase inhibitorFormule :C10H7N3O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :265.25 g/molFlavopiridol hydrochloride
CAS :Inhibitor of CKD1, CDK2, and CDK4 serine/threonine kinases
Formule :C21H21Cl2NO5Degré de pureté :Min. 95%Couleur et forme :Light (Or Pale) Tan SolidMasse moléculaire :438.3 g/molNeostigmine methyl sulfate
CAS :Inhibitor of acetylcholinesteraseFormule :C13H22N2O6SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :334.39 g/molCanertinib dihydrochloride
CAS :Inhibitor of EGFR, HER2 and HER4 tyrosine kinasesFormule :C24H25ClFN5O3·2HClDegré de pureté :Min. 95%Masse moléculaire :558.86TDZD 8
CAS :TDZD 8 is a selective, non-ATP competitive inhibitor of the glycogen synthase kinase GSK3β. TDZD 8 inhibits GSK3β with IC50 of 2 μM and was reported to not significantly affect Cdk-1/cyclin B, casein kinase CK-II, protein kinase A and C (PKA, PKC) activities. TDZD 8 was also identified as an inhibitor of the main protease in coronaviruses. In an in vitro study, TDZD 8 was characterised as an aggregate-based inhibitor as the presence of Triton-X decreased the inhibitory potency to Mpro protease of the SARS-CoV-2 virus (IC50 without Triton-X: 2.15 μM).Formule :C10H10N2O2SDegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :222.26 g/mol
