Modulateurs d'enzymes
Les modulateurs d'enzymes sont des composés qui peuvent augmenter ou inhiber l'activité des enzymes, régulant ainsi la vitesse des réactions biochimiques. Ces modulateurs jouent un rôle essentiel dans le contrôle des voies métaboliques, de la signalisation cellulaire et de divers processus physiologiques. Les modulateurs d'enzymes sont largement utilisés dans la recherche et le développement de médicaments pour étudier les fonctions enzymatiques et développer des agents thérapeutiques. Chez CymitQuimica, nous proposons une gamme complète de modulateurs d'enzymes de haute qualité pour soutenir vos recherches sur la régulation enzymatique et la découverte de médicaments.
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
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AZD 1208
CAS :Inhibits proto-oncogene Pim kinases (Pim-1, Pim-2 and Pim-3); antineoplasticFormule :C21H21N3O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :379.48 g/molODQ
CAS :Inhibitor of guanylyl cyclaseFormule :C9H5N3O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :187.16 g/molOmeprazole - Bio-X ™
CAS :Omeprazole is a proton pump inhibitor (PPI) that inhibits the production of gastric acid in the stomach. This is due to Omeprazole binding through a stable disulphide bond to the H+/K+ ATPase enzyme found on parietal cells, and preventing hydrogen ion transport. Consequently, gastric acid secretion is supressed. As a PPI, Omerprazole can be used to treat disorders where gastric acid is over-secreted. Examples of these disorders are gastroesophageal reflux disease (GERD) and peptic ulcer disease.Formule :C17H19N3O3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :345.42 g/molALW-II-41-27
CAS :LW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor used for cancer treatment.Formule :C32H32F3N5O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :607.69 g/molGKT-137831
CAS :NADPH oxidase inhibitor; anti-inflammatory
Formule :C21H19ClN4O2Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :394.85 g/molA 66
CAS :Specific inhibitor of the phosphoinositide 3-kinase (PI3K) alpha subunit with IC50 of 32 nM. In heart muscle it negatively regulates hypertrophic growth, causes increase in late sodium current and leads to arrhythmias. In tumours it inhibits the p110α subunit of PI3K and blocks growth factor signalling resulting in reduced tumour growth.
Formule :C17H23N5O2S2Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :393.53 g/molOxyphenbutazone hydrate
CAS :Inhibitor of COX-1 and COX-2 cyclooxygenasesFormule :C19H20N2O3•H2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :342.39 g/molLapatinib base - Bio-X ™
CAS :Lapatinib is an antineoplastic agent used to treat breast and lung cancer. This drug is also a tyrosine kinase inhibitor and inhibits human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1). Lapatinib has shown to inhibit ERBB-driven tumor cell growth in vitro and in various animal models.Formule :C29H26ClFN4O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :581.06 g/molIrsogladine maleate - Bio-X ™
CAS :Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formule :C13H11Cl2N5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :372.16 g/molEntinostat
CAS :Inhibits histone deacetylase (HDAC)
Formule :C21H20N4O3Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :376.15354Chymostatin
CAS :Inhibitor of chymotrypsinFormule :C31H41N7O6Couleur et forme :White To Yellowish SolidMasse moléculaire :607.7 g/molPX 866
CAS :Potent and irreversible inhibitor of phosphoinositide-3-kinase (PtdIns-3-kinase) with IC50 of 0.1 nM. PX 866 inhibited cell motility and growth of 3D spheroids of glioblastoma, breast, prostate and colon cancer cell lines at low nanomolar concentrations. PX 866 also exhibited anti-tumoral activity in vivo in xenograft models for ovarian and lung cancer.Formule :C29H35NO8Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :525.59 g/molBAY 607550
CAS :A selective and potent inhibitor of phosphodiesterase 2 (PDE2). Raises cAMP and cGMP levels in neurons, improves social recognition and object memory in murine animals. Reverses anxiolytic effects induced by oxidative stress in mice by blocking cGMP-PKG signaling.
Formule :C27H32N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :476.24236MGCD 265
CAS :Inhibits MET, VEGFR1-3, Tie and Ron tyrosine kinases; antineoplasticFormule :C26H20FN5O2S2Degré de pureté :Min. 95%Masse moléculaire :517.60 g/molMK 886 - Bio-X ™
CAS :MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.Formule :C27H34ClNO2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :472.08 g/molSCH 772984
CAS :Inhibitor of ERK1 and ERK2 serine/threonine kinasesFormule :C33H33N9O2Degré de pureté :Min. 95%Couleur et forme :Light (Or Pale) Yellow To Yellow SolidMasse moléculaire :587.67 g/molSB 431542
CAS :Inhibitor of activin receptor-like kinases (ALK4, ALK5 and ALK7), members of TGFβ type I receptor family. Blocks activin- and TGFβ-mediated signaling and phosphorylation of Smad2 downstream. Suppresses tumor-promoting and tumor-suppressing effects of TGFβ. Promotes differentiation of human embryonic stem cells (hESCs), whilst sustaining mouse ESCs in the undifferentiated state.Formule :C22H16N4O3Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :384.4 g/moleCF506
CAS :Selective inhibitor of the Src kinase family with subnanomolar IC50 values and good selectivity over c-Abl, PDGFRα and c-Kit kinases. The compound is effective in inhibiting growth in drug resistant cancer cell lines. In a recent study, it inhibited the growth of HER2-positive breast cancer cell lines which were resistant to pan-HER family kinase inhibitors such as lapatinib.Formule :C26H38N8O3Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :510.63 g/molBLU 667
CAS :RET receptor tyroine kinase inhibitorFormule :C27H32FN9O2Degré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :533.6 g/molRigosertib sodium
CAS :Rigosertib sodium is an experimental chemotherapeutic agent that is a derivative of benzyl styryl sulfone. It is synthesized chemically and functions primarily by inhibiting key signaling pathways involved in cancer cell proliferation. Specifically, Rigosertib targets the RAS signaling pathway along with the phosphatidylinositol-3-kinase/AKT and polo-like kinase 1 (Plk1) pathways, impeding the progression of the cell cycle and inducing apoptosis in malignant cells.Formule :C21H24NNaO8SDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :473.47 g/molAbemaciclib
CAS :Inhibitor of cyclin-dependent kinases CDK4 and CDK6Formule :C27H32F2N8Degré de pureté :Min. 95%Masse moléculaire :506.59 g/molGilteritinib
CAS :Inhibitor of FLT3 and AXL tyrosine kinasesFormule :C29H44N8O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :552.71 g/molSulindac - Bio-X ™
CAS :Sulindac is a non-steroidal anti-inflammatory drug that has anti-inflammatory and analgesic properties. It is used to relieve the pain of osteoarthritis and rheumatoid arthritis by reducing inflammation and inhibiting the production of prostaglandins, which are chemicals that cause inflammation.Formule :C20H17FO3SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :356.41 g/mol(-)-Huperzine A
CAS :Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormule :C15H18N2ODegré de pureté :(%) Min. 98%Couleur et forme :PowderMasse moléculaire :242.32 g/molLY 411575
CAS :Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formule :C26H23F2N3O4Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :479.48 g/molMethocarbamol
CAS :Inhibitor of carbonic anhydrase; muscle relaxantFormule :C11H15NO5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :241.24 g/molLovastatin - Bio-X ™
CAS :Lovastatin is an HMG-CoA reductase inhibitor that is used to lower LDL cholesterol levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.Formule :C24H36O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :404.54 g/molFasudil hydrochloride
CAS :Fasudil hydrochloride is a Rho-kinase inhibitor, which is a synthetic compound derived from natural sources, primarily used in scientific research. The mode of action of Fasudil hydrochloride involves the inhibition of Rho-associated protein kinase (ROCK), a crucial player in the regulation of the actin cytoskeleton. By inhibiting ROCK, Fasudil alters various cellular functions, including contraction, motility, proliferation, and apoptosis.Formule :C14H17N3O2S•HClDegré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :327.83 g/molBetrixaban
CAS :Inhibitor of factor XaFormule :C23H22ClN5O3Degré de pureté :Min. 95%Couleur et forme :Off-White PowderMasse moléculaire :451.91 g/molMRK 560
CAS :γ-secretase inhibitor; reduces amyloid-β in brainÂ
Formule :C19H17ClF5NO4S2Degré de pureté :Min. 95%Masse moléculaire :517.92 g/molLarotrectinib sulphate
CAS :A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.Formule :C21H22F2N6O2H2SO4Degré de pureté :Min. 95%Masse moléculaire :526.51 g/molTacrolimus
CAS :Antirheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormule :C44H69NO12Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :804.02 g/molGNE 6776
CAS :Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formule :C20H20N4O2Degré de pureté :Min. 95%Masse moléculaire :348.4 g/mol5-Fluorouracil - Bio-X ™
CAS :5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death.Formule :C4H3FN2O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :130.08 g/molGRL 0617
CAS :A novel non-covalent inhibitor of the PLpro protease from SARS-CoV-2 and SARS-CoV viruses. GRL 0617 inhibits the proteolytic processing of the viral polypeptide. As PLpro also acts as a protease in pathways involved in innate immunity, there are indications that it can promote immunity against the virus.Formule :C20H20N2ODegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :304.39 g/molOdiparcil
CAS :Dipeptidyl peptidase 4 (DPP4) inhibitor
Formule :C15H16O6SDegré de pureté :Min. 99%Couleur et forme :PowderMasse moléculaire :324.35 g/molIdelalisib
CAS :Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Formule :C22H18FN7ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :415.42 g/molTemsirolimus
CAS :mTOR serine/threonine kinase inhibitorFormule :C56H87NO16Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :1,030.29 g/molBKM 120
CAS :Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Formule :C18H21O2N6F3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :410.39 g/molN-Butyldeoxynojirimycin
CAS :Competitive inhibitor of ceramide-glycosyltransferase used for substrate reduction therapy in lysosomal storage disorders. It inhibits glucosylceramide synthase, which catalyses the initial step in glycosphingolipid biosynthetic pathway. This compound delays the onset of symptoms in type 1 Gaucher disease, Sandhoff disease and Tay-Sachs disease. It also reduces brain abnormalities in mucolipidosis type IV.Formule :C10H21NO4Degré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :219.28 g/molPKC 412
CAS :Inhibits multiple protein kinases, such as PKC and FLT3Formule :C35H30N4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :570.64 g/molTivozanib
CAS :Inhibitor of VEGF receptorsFormule :C22H19ClN4O5Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :454.86 g/molPimasertib
CAS :A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formule :C15H15FIN3O3Degré de pureté :Min. 95%Couleur et forme :White To Yellow SolidMasse moléculaire :431.2 g/molDabigatran etexilate - Bio-X ™
CAS :Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.
Formule :C34H41N7O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :627.73 g/molTacrolimus monohydrate
CAS :Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormule :C44H69NO12·H2ODegré de pureté :Min. 98 Area-%Couleur et forme :White PowderMasse moléculaire :822.03 g/molJNJ 10198409
CAS :Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Formule :C18H16FN3O2Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :325.34 g/molApatinib mesylate
CAS :Inhibitor of VEGFR; antineoplasticFormule :C24H23N5O·CH4O3SDegré de pureté :Min. 95%Masse moléculaire :493.58 g/molA 939572
CAS :Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes. A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.Formule :C20H22ClN3O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :387.86 g/molKU-0063794
CAS :Inhibits mTORC1 and mTORC2 serine/threonine kinasesFormule :C25H31N5O4Degré de pureté :Min. 95%Couleur et forme :White To Beige To Yellow SolidMasse moléculaire :465.54 g/molNiacinamide
CAS :Vitamin B3; antioxidant; favours cell repairFormule :C6H6N2ODegré de pureté :98.5 To 101.5 Area-%Couleur et forme :White PowderMasse moléculaire :122.12 g/mol
