Modulateurs d'enzymes
Les modulateurs d'enzymes sont des composés qui peuvent augmenter ou inhiber l'activité des enzymes, régulant ainsi la vitesse des réactions biochimiques. Ces modulateurs jouent un rôle essentiel dans le contrôle des voies métaboliques, de la signalisation cellulaire et de divers processus physiologiques. Les modulateurs d'enzymes sont largement utilisés dans la recherche et le développement de médicaments pour étudier les fonctions enzymatiques et développer des agents thérapeutiques. Chez CymitQuimica, nous proposons une gamme complète de modulateurs d'enzymes de haute qualité pour soutenir vos recherches sur la régulation enzymatique et la découverte de médicaments.
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
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Bafilomycin A1
CAS :Inhibitor of vacuolar-type proton pumpFormule :C35H58O9Degré de pureté :Min. 95 Area-%Couleur et forme :White PowderMasse moléculaire :622.83 g/molToceranib phosphate - Bio-X ™
CAS :Produit contrôléToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Formule :C22H25FN4O2·H3O4PDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :494.45 g/molNabumetone - Bio-X ™
CAS :Nabumetone is a non-steroidal anti-inflammatory drug that is used in the treatment of osteoarthritis and rheumatoid arthritis. This drug is also a cyclooxygenase inhibitor and works by inhibiting this enzyme so that pain and inflammation is reduced.Formule :C15H16O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :228.29 g/molCHIR 99021
CAS :Potent and selective inhibitor of the glycogen synthase kinase GSK-3. Promotes cell renewal in embryonic stem cells by modulating Notch, MAPK and TGF-β signalling pathways, which are involved in pluripotency. It also affects the Wnt/β-catenin pathway and alters expression of genes coding for proteins, epigenetic regulatory elements and non-coding RNAs. The combination of CHIR 99021 and basic fibroblast growth factor (bFGF) allows long-term self-renewal in adult mouse retinal progenitor cells.Formule :C22H18Cl2N8Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :465.34 g/mol(Z)-Mycophenolic acid
CAS :(Z)-Mycophenolic acid is an immunosuppressive agent derived from the fermentation of fungi, primarily from the Penicillium species. It functions by inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme crucial for de novo purine synthesis. This selective blockade of IMPDH specifically affects lymphocyte proliferation due to their heavy reliance on this pathway for DNA synthesis, thereby exerting its immunosuppressive effects.Formule :C17H20O6Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :320.34 g/molAfatinib - Bio-X ™
CAS :Afatinib is a small molecule that inhibits the activity of cellular kinases that are involved in the progression of cancer. It is an Irreversible inhibitor of three members of the ErbB family. This molecule binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling which inhibits cellular growth and promotes apoptosis. It has been researched for the treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer and colorectal cancer.Formule :C24H25ClFN5O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :485.94 g/molBIO
CAS :Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.Formule :C16H10BrN3O2Degré de pureté :Min. 95%Couleur et forme :Red To Dark Red SolidMasse moléculaire :356.17 g/molMotesanib
CAS :Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesisFormule :C22H23N5ODegré de pureté :Min. 95%Masse moléculaire :373.45 g/molSB 239063
CAS :Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFormule :C20H21FN4O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :368.4 g/molGDC 0941
CAS :Pan-class I phosphatidylinositide 3-kinase (PI3K) inhibitor (IC50 = 3, 33, 3 and 75 nM at catalytic subunits p110α, p110β, p110δ and p110γ respectively). Inhibits proliferation in several cancer cell lines, such as glioblastoma, breast and prostate cancer cells. Has synergistic anti-cancer effect in combination with MEK/ERK kinase inhibitor GDC-0973 (cobimetinib).
Formule :C23H27N7O3S2Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :513.64 g/molIrsogladine maleate - Bio-X ™
CAS :Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formule :C13H11Cl2N5O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :372.16 g/molBenazepril HCl - Bio-X ™
CAS :Benazepril is a nonsteroidal anti-inflammatory drug that can be used to treat hypertension, heart failure and renal failure. It is an angiotensin-converting enzyme (ACE) inhibitor that blocks the conversion of angiotensin I to angiotensin II. This inhibition prevents the vasoconstrictive effects of this peptide, which are mediated through activation of the renin-angiotensin system.Formule :C24H28N2O5•HClDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :460.95 g/mol(-)-Huperzine A
CAS :Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormule :C15H18N2ODegré de pureté :(%) Min. 98%Couleur et forme :PowderMasse moléculaire :242.32 g/molGNE 6776
CAS :Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formule :C20H20N4O2Degré de pureté :Min. 95%Masse moléculaire :348.4 g/molPD 169316
CAS :Inhibitor of p38 kinase
Formule :C20H13FN4O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :360.34 g/molMethotrexate
CAS :Methotrexate is a chemotherapeutic and immunosuppressive medication, which is a synthetic analog of folic acid. Its source is through chemical synthesis, mimicking the structure of dihydrofolate in order to exert its effects. Methotrexate acts primarily by inhibiting the enzyme dihydrofolate reductase (DHFR), leading to a decrease in tetrahydrofolate production. This disruption in folate metabolism results in the inhibition of DNA, RNA, and protein synthesis, which affects rapidly dividing cells.Methotrexate is employed broadly in clinical oncology as an antineoplastic agent, particularly in the treatment of leukemias, lymphomas, breast cancer, and osteosarcoma. Additionally, it serves as a cornerstone for managing autoimmune diseases such as rheumatoid arthritis and psoriasis, where it helps modulate the aberrant immune response. The dual role of Methotrexate in oncology and immunosuppression underscores its versatility and critical importance in therapeutic regimens. However, its use demands careful monitoring due to potential adverse effects on non-cancerous cells and organ systems, necessitating precise dosage management and patient evaluation.Formule :C20H22N8O5Couleur et forme :Yellow PowderMasse moléculaire :454.44 g/molGC376 sodium
CAS :GC 376 is an inhibitor of the main protease Mpro (3CLpro) in coronaviruses as well as picornaviruses. This broad-spectrum antiviral compound has been used as investigational veterinary drug for treatment of feline infectious peritonitis virus (FIPV) infections. Recent studies also showed that GC 376 inhibits the main protease Mpro (3CLpro) from SARS-CoV-2 with IC50 of 0.03 μM and EC50 of 3.37 μM.
Formule :C21H30N3NaO8SDegré de pureté :Min. 95 Area-%Couleur et forme :White PowderMasse moléculaire :507.53 g/molNilotinib HCl monohydrate - Bio-X ™
CAS :Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Formule :C28H22F3N7O•HCl•H2ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :583.99 g/molPF 06409577
CAS :Potent agonist of a1β1γ1 5′-adenosine monophosphate-activated protein kinase (AMPK). It binds to the allosteric drug and metabolite (ADaM) site at the α- and β- subunit interface of AMPK. It has potential for the treatment of diabetic nephropathy. PF 06409577 reduces infections caused by flaviviruses, mediated by changes in the metabolism of lipids in host cells.
Formule :C19H16ClNO3Degré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :341.79 g/molLOXO-305
CAS :LOXO-305 is a small molecule inhibitor, which is a synthesized chemical compound designed to selectively target specific enzymes or pathways. Its source is rooted in medicinal chemistry and pharmacological research aimed at elucidating pathways involved in oncogenesis.
Formule :C22H21F4N5O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :479.43 g/mol
