Modulateurs d'enzymes
Sous-catégories appartenant à la catégorie "Modulateurs d'enzymes"
693 produits trouvés pour "Modulateurs d'enzymes"
WM 1119
CAS :Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values in low nanomolar range. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and was shown to arrest lymphoma progression in mice models. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.
Formule :C18H13F2N3O3SDegré de pureté :Min. 95%Couleur et forme :White/Off-White SolidMasse moléculaire :389.38 g/molMethotrexate disodium
CAS :Methotrexate is a drug that suppresses the immune system by inhibiting the production of white blood cells. It is used in the treatment of a number of diseases, including some cancers and autoimmune diseases such as rheumatoid arthritis and psoriasis. Methotrexate is metabolized to its active form, methotrexate, by an enzyme called dihydrofolate reductase (DHFR). The DHFR inhibitor activity of methotrexate blocks the synthesis of folate-dependent enzymes and prevents DNA synthesis in rapidly dividing cells. Methotrexate has been used in combination with other drugs to treat cancer. Methotrexate has also been shown to have antifungal properties against opportunistic fungal infections.Formule :C20H20N8Na2O5Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :498.4 g/molDoramapimod
CAS :p38α MAP kinase inhibitor; JNK2α2 protein kinase inhibitorFormule :C31H37N5O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :527.66 g/molGKA 50
CAS :Glucokinase activatorFormule :C26H28N2O6Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :464.51 g/molMLN 8237
CAS :Antagonist of Aurora A serine/threonine protein kinase; antineoplastic
Formule :C27H20ClFN4O4Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :518.92 g/molSildenafil
CAS :Sildenafil is a pharmaceutical compound, which is a synthetic product derived from chemical processes. It functions as a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). By inhibiting PDE5, sildenafil increases cyclic guanosine monophosphate (cGMP) levels within the smooth muscle cells of the corpus cavernosum. This leads to smooth muscle relaxation and vasodilation, allowing increased blood flow and facilitating penile erection in the presence of sexual stimulation.Formule :C22H30N6O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :474.58 g/molRosuvastatin
CAS :Rosuvastatin is a synthetic lipid-lowering agent, which is a product of pharmaceutical manufacturing derived from extensive research in cardiovascular pharmacology. It functions as an HMG-CoA reductase inhibitor, effectively blocking the enzyme responsible for cholesterol biosynthesis in the liver. By inhibiting this enzyme, Rosuvastatin reduces the production of cholesterol, especially low-density lipoprotein (LDL) cholesterol, which is known to contribute to atherosclerosis.Formule :C22H28FN3O6SDegré de pureté :Min. 95%Masse moléculaire :481.54 g/molL 690330
CAS :Inositol monophosphatase (IMPase) inhibitorFormule :C8H12O8P2Degré de pureté :Min. 95%Masse moléculaire :298.12 g/molCyclosporine U
CAS :Cyclosporine U is a cyclic polypeptide immunosuppressant, which is a derivative of the natural product Cyclosporine A, produced by the fermentation process involving the filamentous fungus *Tolypocladium inflatum*. It primarily acts by inhibiting the activity of calcineurin, a phosphatase enzyme, which in turn blocks the transcription of interleukin-2 and other cytokines. This mechanism suppresses the activation of T-lymphocytes, a crucial component in the immune response.
Formule :C61H109N11O12Degré de pureté :Min. 95%Masse moléculaire :1,188.58 g/molN-alpha-Benzoyl-L-argininamide
CAS :N-alpha-Benzoyl-L-argininamide is a synthetic compound that is used as an enzyme inhibitor. It binds to the active site of proteases, thereby inhibiting their activity. This drug has been shown to inhibit the activities of phosphodiesterase and phosphatase enzymes in vitro. N-alpha-Benzoyl-L-argininamide also inhibits the proteolytic degradation of hippuric acid and casein in vitro. The binding affinity for this drug is due to its structural similarity with substrates such as glutamate and rhizosphere exudates.
Formule :C13H19N5O2Degré de pureté :Min 98%Couleur et forme :White PowderMasse moléculaire :277.32 g/molCyclosporin G
CAS :Cyclosporin G is an immunosuppressive agent, which is derived from fungal sources with a specific mode of action that involves inhibiting calcineurin. The source of Cyclosporin G is primarily from the fermentation of the fungus *Tolypocladium inflatum*. Its mode of action involves binding to the cytosolic protein cyclophilin in T-lymphocytes, which subsequently inhibits the phosphatase activity of calcineurin. This inhibition prevents the dephosphorylation and nuclear translocation of the nuclear factor of activated T-cells (NFAT), thereby reducing the transcription of interleukin-2 and other cytokines critical for T-cell activation.Formule :C63H113N11O12Degré de pureté :Min. 95%Masse moléculaire :1,216.64 g/mol(+/-)-Blebbistatin
CAS :Inactive enantiomer of the inhibitor of myosin II-ATPaseFormule :C18H16N2O2Degré de pureté :Min. 95%Masse moléculaire :292.33 g/molABT 494
CAS :Inhibitor of Janus kinase JAK-1Formule :C17H19F3N6ODegré de pureté :Min. 95%Masse moléculaire :380.37 g/molLY 294002
CAS :First generation PI 3-kinase inhibitor
Formule :C19H17O3NDegré de pureté :Min. 95%Couleur et forme :White To Off-White SolidMasse moléculaire :307.12084AR-AO 14418
CAS :Inhibitor of GSK3β kinaseFormule :C12H12N4O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :308.31 g/molN-(5-Aminopentyl) methotrexate amide-LC-biotin
N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.Formule :C41H59N13O7SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :878.06 g/molCAY10727
CAS :CAY10727 is a potent biochemical inhibitor, which is derived from synthetic sources with specific action targeting cyclooxygenase-2 (COX-2) enzymes. It functions by selectively blocking the enzymatic activity of COX-2, which plays a critical role in the biosynthesis of prostaglandins involved in inflammatory responses. This targeted inhibition allows the study of COX-2-related pathways without interference from COX-1, which is significant for maintaining gastrointestinal integrity.The use and applications of CAY10727 are primarily in research settings where understanding the pathways involved in inflammation, pain, and cancer progression are critical. This compound is utilized in various in vitro experiments to delineate the role of COX-2 in cellular and molecular contexts, enabling scientists to dissect complex signaling networks. Given its specificity, CAY10727 is instrumental in the development of new therapeutic approaches where selective COX-2 inhibition might offer benefits over non-selective inhibitors.Formule :C21H22Cl2N4O2Degré de pureté :Min. 95%Masse moléculaire :433.3 g/molUNC 0379
CAS :Inhibitor of the histone methyltransferase SETD8 that supresses methylation of the K20 residue in histone 4. UNC 0379 treatment of human glioma reduced recruitment of 53BP1 protein to double strand breaks and sensitised cells to radiotherapy without altering cell cycle kinetics.
Formule :C23H35N5O2Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :413.56 g/molAnagrelide HCl - Bio-X ™
CAS :Anagrelide is a thrombocytopenic drug that is used to treat thrombocythemia and related conditions. This drug works by decreasing the platelet count by suppressing transcription factors that are necessary for the maturation of platelets. This drug is also a phosphodiesterase III inhibitor.Formule :C10H7Cl2N3O•HClDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :292.55 g/molGSK 583
CAS :A potent and selective inhibitor of cell death-inducing kinase RIP2 (IC50 = 5 nM). Reduces release of pro-inflammatory cytokines. Inhibits production of TNF-α and IL-6 in intestinal explants from patients with Crohn's disease and ulcerative colitis.
Formule :C20H19FN4O2SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :398.46 g/mol
