ALK/HDAC-IN-2

Ref. TM-T214972

Informations sur le produit

• Nom: ALK/HDAC-IN-2
• Marque: Targetmol
• Description: ALK/HDAC-IN-2 (Compound 19b) functions as an ALK/HDAC inhibitor, demonstrating IC₅₀ values of 8 nM for ALK WT and 1.18 μM for total HDACs. It is effective against ALK mutants G1202R, F1174L, and L1196M, with IC₅₀ values of 2.74, 9.23, and 34.28 nM, respectively. The compound shows potent and selective inhibition of HDAC1 (IC₅₀= 0.24 μM), while exhibiting weak inhibition against HDAC7, HDAC6, and HDAC11 (IC₅₀> 10 μM). Additionally, ALK/HDAC-IN-2 has broad-spectrum antiproliferative effects on various cancer cell lines, inducing cell cycle arrest and apoptosis. This compound is applicable for neuroblastoma research.