ALK
Les inhibiteurs d'ALK sont des composés qui ciblent spécifiquement et inhibent la kinase du lymphome anaplasique (ALK), une tyrosine kinase réceptrice impliquée dans le développement et la progression de certains cancers, notamment le cancer du poumon non à petites cellules et le neuroblastome. En inhibant ALK, ces composés bloquent les voies de signalisation qui favorisent la croissance et la survie des cellules tumorales. Chez CymitQuimica, nous proposons des inhibiteurs d'ALK pour soutenir vos recherches en oncologie, thérapies ciblées contre le cancer et transduction du signal.
154 produits trouvés pour "ALK".
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F-1
CAS :F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Formule :C22H27ClN8O3SDegré de pureté :97.66%Couleur et forme :SolidMasse moléculaire :519.02LDN-193189 2HCl
CAS :LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.Formule :C25H24Cl2N6Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :479.404ZX-29
CAS :ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formule :C23H28ClN7O3SDegré de pureté :99.51%Couleur et forme :SolidMasse moléculaire :518.032MS4078
CAS :MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.Formule :C45H52ClN9O8SDegré de pureté :98.74%Couleur et forme :Yellow SolidMasse moléculaire :914.47Ascrinvacumab
CAS :Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.18%Couleur et forme :Transparent LiquidMasse moléculaire :~150 kDaALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :White SolidMasse moléculaire :562.483ALK inhibitor 2
CAS :ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formule :C23H28ClN7O3SDegré de pureté :99.77% - >99.99%Couleur et forme :SolidMasse moléculaire :518.032CEP-28122 mesylate salt
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formule :C29H39ClN6O6SDegré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :635.17ALK-IN-26
CAS :ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.Formule :C24H23NO3SDegré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :405.51Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Degré de pureté :98%Couleur et forme :Odour SolidALK-IN-12
CAS :ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Formule :C24H30ClN6O2PCouleur et forme :SolidMasse moléculaire :500.97ALKBH5-IN-5
CAS :ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Formule :C13H13NO3Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :231.25CPD-1224
CAS :CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formule :C43H47ClN8O7SCouleur et forme :SolidMasse moléculaire :855.4TL13-112
CAS :TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formule :C49H60ClN9O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1002.57SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Formule :C43H49Cl2N10O7PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :919.79ALK-IN-9
CAS :ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Formule :C20H21FN6O3Couleur et forme :SolidMasse moléculaire :412.425Zilurgisertib fumarate
CAS :Zilurgisertib fumarate is a selective ALK2 inhibitor that modulates iron metabolism and improves anemia by inhibiting SMAD phosphorylation and hepcidin production.Formule :C30H38N4O3·xC4H4O4Degré de pureté :99.96%Couleur et forme :Yellow SolidMasse moléculaire :502.66 (free base)ALK2-IN-6
CAS :ALK2-IN-6 is a potent and selective ALK2 inhibitor with an IC50 of 9 nM. ALK2-IN-6 exhibits excellent brain permeability and effectively suppresses bone morphogenetic protein signaling across various preclinical cancer models for the treatment of diffuse intrinsic pontine glioma.Formule :C26H31N3O3Degré de pureté :99.97%Couleur et forme :Gray SolidMasse moléculaire :433.54ALK degrader 2
ALK degrader 2 is an orally active ALK degrader that reduces EML4-ALK protein levels (DC50= 8 nM) and nucleophosmin (NPM)-ALK protein levels (DC50= 102 nM). It facilitates ALK degradation through the Hsp70 chaperone system and the ubiquitin-proteasome pathway. In H3122 cells, ALK degrader 2 causes significant cell cycle arrest at the S phase and induces apoptosis. Additionally, it demonstrates antitumor activity in mice with H3122 xenograft tumors. ALK degrader 2 is a useful compound in researching non-small cell lung cancer (NSCLC).Couleur et forme :Odour SolidFDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Couleur et forme :Liquid
