Flavopiridol

CAS : 146426-40-6

Ref. TM-T6837

Informations sur le produit

• Nom: Flavopiridol
• Synonymes: L868275, Alvocidib, NSC 649890 HCl, HMR-1275, (-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-1-benzopyran-4-one, 2-(2-Chlorophenyl)-5,7-Dihydroxy-8-[(3S,4R)-3-Hydroxy-1-Methyl-4-Piperidyl]Chromen-4-One, 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one, 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, cis-(-)-, 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-, Alvocidib, Dsp 2033, Flavopirodol, Hl 275, Hmr 1275, L 86-8275, L 868275
• CAS: 146426-40-6

Description

Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 401.84
• Formule: C₂₁H₂₀ClNO₅
• Degré de pureté: 99.85%
• Couleur/Forme: Solid