TRK-IN-24

CAS : 2937544-01-7

Ref. TM-T79706

Informations sur le produit

• Nom: TRK-IN-24

Description

TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM, respectively. It demonstrates antitumor activity in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models and inhibits the proliferation of Ba/F3 cells expressing single mutants SF, GK, and xDFG, with an IC50 range of 1.43-47.56 nM [1].

• Marque: Targetmol

Propriétés chimiques

• Masse moléculaire: 659.82
• Formule: C₃₉H₄₅N₇O₃
• Degré de pureté: 98%