PCI-24781

CAS : 783355-60-2

Ref. TR-P216400

Informations sur le produit

• Nom: PCI-24781
• Synonymes: CRA 024781, CRA 24781, 2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-, 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide, Abexinostat, Brd K12867552, Cra 024781, Cra 24781, Pci 24781, Thm-I 94
• CAS: 783355-60-2

Description

Applications PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
References Morales, V., et al.: Mol. Cell Biol., 20, 7230 (2000), Th'ng, J., et al.: J. Biol. Chem., 280, 27809 (2005), Esteller, M., et al.: Carcinogenesis, 27, 1121 (2006),

• Marque: TRC

Propriétés chimiques

• Masse moléculaire: 397.4244
• Formule: C₂₁H₂₃N₃O₅
• Couleur/Forme: Neat
• InChI: InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)
• Code InChI: InChIKey=DQUXPVVSVXIQNE-ZOWNYOTGSA-N
• SMILES: CC[C@@]1(c2ccc(N)cc2)CCC(=O)NC1=O.O=C(O)C(O)C(O)C(=O)O