CAS 1005275-19-3

Formula: C22H19ClF3NO3

InChI: InChI=1S/C22H19ClF3NO3/c23-13-8-15-17-10-4-5-11(6-10)18(17)19(27-20(15)16(9-13)21(28)29)12-2-1-3-14(7-12)30-22(24,25)26/h1-3,7-11,17-19,27H,4-6H2,(H,28,29)

InChI key: MDYBVKDISQFLKR-UHFFFAOYSA-N

SMILES: C1CC2CC1C3C2C4=C(C(=CC(=C4)Cl)C(=O)O)NC3C5=CC(=CC=C5)OC(F)(F)F

KLHDC2-IN-1

CAS: 1005275-19-3

KLHDC2-IN-1 (Compound 6) is a ligand that specifically targets the ubiquitin E3 ligase KLHDC2 with a dissociation constant (Kd) of 160 nM. It can be synthesized into a PROTAC capable of effectively degrading BRD4 within cells.

Formula: C₂₂H₁₉ClF₃NO₃

Colore e forma: Solid

Peso molecolare: 437.84

Ref: TM-T211264