CAS 1007882-23-6

Acido 1-pirrolidinocarboxilico, 2,2'-([1,1'-bifenile]-4,4'-diil-di-1H-imidazolo-5,2-diil)bis-, 1,1'-bis(1,1-dimetiletil) estere, (2S,2'S)-

Descrizione:

Acido 1-pirrolidinocarboxilico, 2,2'-([1,1'-bifenile]-4,4'-diil-di-1H-imidazolo-5,2-diil)bis-, 1,1'-bis(1,1-dimetiletil) estere, (2S,2'S)- è un composto organico complesso caratterizzato dalle sue uniche caratteristiche strutturali, tra cui un anello di pirrolidina e un gruppo bifenile-imidazolo. Questo composto probabilmente mostrerà proprietà tipiche degli esteri, come essere meno polare degli acidi corrispondenti, il che può influenzare la sua solubilità nei solventi organici. La presenza di gruppi tert-butilici ingombranti suggerisce che potrebbe avere un'ostruzione sterica, potenzialmente influenzando la sua reattività e le interazioni con i sistemi biologici. La chiralità indicata dalla designazione (2S,2'S) implica che il composto potrebbe mostrare un comportamento stereochimico specifico, che può essere cruciale in contesti biologici, come interazioni enzimatiche o legame ai recettori. Inoltre, la presenza di più gruppi funzionali può consentire una reattività chimica diversificata, rendendolo un candidato per varie applicazioni in chimica medicinale o scienza dei materiali. In generale, la struttura intricata di questo composto suggerisce una potenziale utilità in applicazioni chimiche specializzate.

Formula: C₃₆H₄₄N₆O₄

InChI: InChI=1S/C36H44N6O4/c1-35(2,3)45-33(43)41-19-7-9-29(41)31-37-21-27(39-31)25-15-11-23(12-16-25)24-13-17-26(18-14-24)28-22-38-32(40-28)30-10-8-20-42(30)34(44)46-36(4,5)6/h11-18,21-22,29-30H,7-10,19-20H2,1-6H3,(H,37,39)(H,38,40)/t29-,30-/m0/s1

InChI key: WPMTYMFNINZZHE-KYJUHHDHSA-N

SMILES: CC(C)(C)OC(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)OC(C)(C)C

Sinonimi:

• (2S,2'S)-di-tert-butyl 2,2'-(4,4'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-iMidazole-4,2-diyl))bis(pyrrolidine-1-carboxylate)
• Daclatasvir intermediate-4
• (2S,2'S)-2,2'-[(1,1'-biphenyl)-4,4'-diyldi-1H-imidazole-5,2-diyl]bis-1-pyrrolidinecarboxylic acid 1,1'-bis(1,1-dimethylethyl) ester
• 1-Pyrrolidinecarboxylic acid, 2,2'-([1,1'-biphenyl]-4,4'-diyldi-1H-iMidazole-5,2-diyl)bis-, 1,1'-bis(1,1-diMethylethyl) ester, (2S,2'S)-
• 1-Pyrrolidinecarboxylic acid,2,2'-​ ([1,1'-biphenyl]-4,4'-diyldi-1H-​ imidazole-5,2-diyl)bis-,1,1'-bis(1,1-​ dimethylethyl)ester,(2S,2'S)-
• 1-Pyrrolidinecarboxylic acid,2,2'-([1,1'-biphenyl]-4,4'-diyldi-1H-imidazole-5,2-diyl)bis-
• Daclatasvir Intermediates 4
• di-tert-butyl2,2'-([1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl))(2S,2'S)-bis(pyrrolidine-1-carboxylate)
• 1-Pyrrolidinecarboxylic acid, 2,2'-([1,1'-biphenyl]-4,4'-diyldi-1H-iMidazole-5,2-diyl)bis-, 1,1'-bis(1,1-diMethylethyl) ester, (2S,2'S)-nyl
• (2S,2''S)-Di-tert-butyl 2,2''-(5,5''-([1,1''-biphenyl]-4,4''-diyl)bis(1h-imidazole-5,2-diyl))bis(pyrrolidine-1-carboxylate)
• (2S,2'S)-
• EOS-61352
• HCV-IN-30
• Bis(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate)
• Daclatasvir Intermediates Ⅱ
• Dacaltasvir Intermediate 02
• Methyl-N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
• Daclatasvir Intermediate-2
• Daclatasvir intermediate 02
• Di-tert-butyl2,2'-([1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl))(2S,2'S)-bis(pyridineidine-1-carboxylate)
• di-tert-butyl (2S,2'S)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-pyrrolidinecarboxylate)
• Daclatasvir Intermediates
• 2-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate
• Di-tert-butyl2,2'-([1,1'-biphenyl]-4,4'-diylbis(1H-imidazole-5,2-diyl))(2S,2'S)-bis(pyridineidine-1-

HCV-IN-30

CAS: 1007882-23-6

HCV-IN-30

Formula: C₃₆H₄₄N₆O₄

Purezza: 99.5%

Peso molecolare: 624.77

Ref: 54-BUP14081

Bis(2-Methyl-2-Propanyl) (2S,2'S)-2,2'-[4,4'-Biphenyldiylbis(1H-Imidazole-4,2-Diyl)]Di(1-Pyrrolidinecarboxylate)

CAS: 1007882-23-6

Bis(2-Methyl-2-Propanyl) (2S,2'S)-2,2'-[4,4'-Biphenyldiylbis(1H-Imidazole-4,2-Diyl)]Di(1-Pyrrolidinecarboxylate)

Formula: C₃₆H₄₄N₆O₄

Purezza: 95%

Peso molecolare: 624.77

Ref: 54-OR1028309

Daclatasvir Impurity 42

CAS: 1007882-23-6

Formula: C₃₆H₄₄N₆O₄

Peso molecolare: 624.79

Ref: 4Z-D-145041

Bis(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate)

CAS: 1007882-23-6

BIs(2-methyl-2-propanyl) (2S,2'S)-2,2'-[4,4'-biphenyldiylbis(1H-imidazole-4,2-diyl)]di(1-pyrrolidinecarboxylate)

Formula: C₃₆H₄₄N₆O₄

Purezza: 95%

Peso molecolare: 624.77

Ref: IN-DG399001

(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-imidazole-5,2-diyl)bis-1-pyrrolidinecarboxylic Acid 1,1'-Bis(1,1-dimethylethyl) Ester

Prodotto controllato

CAS: 1007882-23-6

Applications (2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-imidazole-5,2-diyl)bis-1-pyrrolidinecarboxylic Acid 1,1'-Bis(1,1-dimethylethyl) Ester is an antiviral agent and Daclatasvir (D101500) intermediate. Daclatasvir inhibits the HCV protein NS5A and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).
References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Formula: C₃₆H₄₄N₆O₄

Colore e forma: Neat

Peso molecolare: 624.772

Ref: TR-B398155

HCV-IN-30

CAS: 1007882-23-6

HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).

Formula: C₃₆H₄₄N₆O₄

Purezza: 99.6%

Colore e forma: White Solid

Peso molecolare: 624.7724

Ref: TM-T11541

Daclatasvir Impurity 4

CAS: 1007882-23-6

Formula: C₃₆H₄₄N₆O₄

Peso molecolare: 624.8

Ref: ST-EA-CP-D71020

1,1'-Bis(1,1-dimethylethyl) (2S,2'S)-2,2'-([1,1'-biphenyl]-4,4'-diyldi-1H-imidazole-5,2-diyl)bis[1-pyrrolidinecarboxylate]

CAS: 1007882-23-6

Formula: C₃₆H₄₄N₆O₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 624.7724

Ref: IN-DA0002VK