CAS 102601-58-1

N-cbz-gly-gly-arg 7-amido-4-*metilcumarina idro

Descrizione:

N-Cbz-gly-gly-arg 7-amido-4-metilcoumarina idro, identificato dal numero CAS 102601-58-1, è un composto sintetico spesso utilizzato nella ricerca biochimica, in particolare nello studio delle enzimi proteolitiche. Questo composto presenta un moiety di cumarina, noto per le sue proprietà fluorescenti, rendendolo prezioso in vari saggi e tecniche di imaging. La presenza del gruppo N-Cbz (carbobenzyloxy) indica che è un derivato di amminoacido protetto, comunemente usato per facilitare la sintesi di peptidi. La sequenza gly-gly-arg suggerisce che sia un substrato peptidico, potenzialmente utile per studiare la specificità e l'attività delle proteasi. La sua designazione idro implica che possa esistere in una forma idratata o essere coinvolto in reazioni idrolitiche. In generale, le caratteristiche strutturali uniche e i gruppi funzionali di questo composto lo rendono uno strumento significativo nel campo della biochimica, in particolare per applicazioni che coinvolgono cinetica enzimatica e specificità del substrato.

Formula: C₂₈H₃₄ClN₇O₇

InChI: InChI=1/C28H33N7O7.ClH/c1-17-12-25(38)42-22-13-19(9-10-20(17)22)34-26(39)21(8-5-11-31-27(29)30)35-24(37)15-32-23(36)14-33-28(40)41-16-18-6-3-2-4-7-18;/h2-4,6-7,9-10,12-13,21H,5,8,11,14-16H2,1H3,(H,32,36)(H,33,40)(H,34,39)(H,35,37)(H4,29,30,31);1H

SMILES: Cc1cc(=O)oc2cc(ccc12)N=C(C(CCCNC(=N)N)N=C(CN=C(CN=C(O)OCc1ccccc1)O)O)O.Cl

Sinonimi:

• Z-Gly-Gly-Arg-AMC . HCl
• N-[(benzyloxy)carbonyl]glycylglycyl-N5-(diaminomethylidene)-N-(4-methyl-2-oxo-2H-chromen-7-yl)ornithinamide hydrochloride
• Z-Gly-Gly-Arg-7-Amino-4-Methylcoumarin

Z-Gly-Gly-Arg-AMC · HCl

CAS: 102601-58-1

Z-GGR-AMC has been used as substrate in a direct fluorometric assay of urokinase and tissue-type plasminogen activator as well as for assaying trypsin and thrombin.The substrate is used as thrombin substrate in the calibrated automated thrombogram (CAT), an automated test developed by Hemker et al., for determining hyper- and hypocoagulability. Z-GGR-AMC can also be used for determining the tryptic activity of proteasomes.

Formula: C₂₈H₃₃N₇O₇·HCl

Purezza: > 99%

Colore e forma: White

Peso molecolare: 616.07

Ref: 01-4002155

L-Argininamide, N-[(phenylmethoxy)carbonyl]glycylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, hydrochloride (1:1)

CAS: 102601-58-1

Formula: C₉H₁₀ClNO₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 215.6336

Ref: IN-DA0007VN

Z-Gly-Gly-Arg-AMC HCl

CAS: 102601-58-1

Z-Gly-Gly-Arg-AMC HCl

Formula: C₂₈H₃₃N₇O₇·ClH

Colore e forma: Solid

Peso molecolare: 616.06526

Ref: 54-BIBA1003

N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride

CAS: 102601-58-1

Applications N-CBZ-Glycyl-glycyl-L-arginine 7-Amido-4-methylcoumarin Hydrochloride is a fluorogenic substrate for uPA (urokinase).
References Zimmerman, M., et al. Proc. Natl. Acad. Sci. USA 75, 750 (1978);

Formula: C₂₈H₃₃N₇O₇·HCl

Colore e forma: Neat

Peso molecolare: 579.6

Ref: TR-C227058

Z-Gly-Gly-Arg-AMC·HCl

CAS: 102601-58-1

Z-Gly-Gly-Arg-AMC·HCl is a proteolytic enzyme that cleaves proteins at the carboxyl side of the amino acid arginine. It has been shown to have potential as a drug target and has been found to be active against carcinoma cell lines, but not normal cells. Z-Gly-Gly-Arg-AMC·HCl is activated by light and can be inhibited by natural compounds such as 2-aminoethoxydiphenyl borate. In addition, it specifically cleaves proteins at the carboxyl side of arginine residues, which makes it useful for studying protein degradation mechanisms in living cells and tissues.

Formula: C₂₈H₃₃N₇O₇·HCl

Purezza: Min. 98%

Colore e forma: White Powder

Peso molecolare: 616.07 g/mol

Ref: 3D-FG110492

Z-Glycyl-Glycyl-L-Arginine 7-Amido-4-Methylcoumarin Hydrochloride Salt extrapure, 95%

CAS: 102601-58-1

Formula: C₂₈H₃₃N₇O₇·HCl

Peso molecolare: 616.07

Ref: SR-72998