CAS 104987-11-3

Tacrolimus

Descrizione:

Tacrolimus, con il numero CAS 104987-11-3, è un farmaco immunosoppressore utilizzato principalmente per prevenire il rigetto degli organi nei pazienti trapiantati e per trattare alcune condizioni autoimmuni. È una lactone macrolide derivata dal batterio Streptomyces tsukubaensis. Tacrolimus agisce inibendo l'attivazione e la proliferazione dei linfociti T, principalmente attraverso l'inibizione della calcineurina, un enzima critica nella segnalazione delle cellule T. Questo meccanismo aiuta a sopprimere la risposta immunitaria. La sostanza viene tipicamente somministrata nella sua forma topica per condizioni della pelle come la dermatite atopica o come formulazione orale per uso sistemico. Tacrolimus è lipofilo, il che influisce sulla sua assorbimento e distribuzione nel corpo. Ha una vita media relativamente lunga, richiedendo un attento monitoraggio dei livelli ematici per evitare tossicità. Gli effetti collaterali comuni includono un aumento del rischio di infezioni, nefrotossicità e neurotossicità. A causa dei suoi potenti effetti immunosoppressori, Tacrolimus è spesso usato in combinazione con altri immunosoppressori per aumentare l'efficacia riducendo al minimo gli effetti avversi.

Formula: C₄₄H₆₉NO₁₂

InChI: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

InChI key: InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N

SMILES: O(C)[C@@H]1[C@@]2(O[C@](O)([C@H](C)C1)C(=O)C(=O)N3[C@](C(=O)O[C@H](\C(=C\[C@H]4C[C@@H](OC)[C@H](O)CC4)\C)[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(\C)/C[C@H](C)C[C@@H]2OC)(CCCC3)[H])[H]

Sinonimi:

• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
• FR 900506
• 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-
• (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

CAS: 104987-11-3

Formula: C₄₄H₆₉NO₁₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 804.0182

Ref: IN-DA0039L0

Tacrolimus

CAS: 104987-11-3

Formula: C₄₄H₆₉NO₁₂

Colore e forma: White To Off-White Solid

Peso molecolare: 804.03

Ref: 4Z-T-391

Tacrolimus

CAS: 104987-11-3

Tacrolimus

Purezza: ≥98%

Peso molecolare: 804.02g/mol

Ref: 54-BUP15701

FK-506

CAS: 104987-11-3

FK-506

Formula: C₄₄H₆₉NO₁₂

Purezza: By hplc: 99.91% (Typical Value in Batch COA)

Colore e forma: white powder

Peso molecolare: 804.01816g/mol

Ref: 54-BIF1003

Tacrolimus Monohydrate

CAS: 104987-11-3, 109581-93-3

Formula: C₄₄H₆₉NO₁₂·H₂O

Purezza: >80.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 822.05

Ref: 3B-M2258

Tacrolimus

CAS: 104987-11-3

Formula: C₄₄H₆₉NO₁₂

Purezza: 95%~99%

Peso molecolare: 804.031

Ref: BP-BP1358

Tacrolimus

CAS: 104987-11-3

Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein

Formula: C₄₄H₆₉NO₁₂

Purezza: 98% - 99.94%

Colore e forma: White Or Off-White Crystalline Powder

Peso molecolare: 804.02

Ref: TM-T2144

Tacrolimus

CAS: 104987-11-3

Formula: C₄₄H₆₉NO₁₂

Peso molecolare: 804.03

Ref: ST-EA-CP-T39000

Tacrolimus (FK506)

CAS: 104987-11-3

Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)

Formula: C₄₄H₆₉NO₁₂

Colore e forma: Neat

Peso molecolare: 804.02

Ref: TR-F370000

Tacrolimus - Bio-X ™

CAS: 104987-11-3

Tacrolimus is a calcineurin inhibitor drug that is used for the prevention of rejection after an organ transplant. This drug can also be used in the treatment of severe atopic dermatitis. Tacrolimus’ mechanism of action is not well known however it is understood that this drug inhibits T-lymphocyte activation by binding to an intracellular protein called FKBP-12. This drug also has anti-inflammatory properties.

Formula: C₄₄H₆₉NO₁₂

Purezza: Min. 95%

Colore e forma: White Off-White Powder

Peso molecolare: 804.02 g/mol

Ref: 3D-BT164430

Tacrolimus

CAS: 104987-11-3

Antirheumatic; immunosuppressant; neuroprotective; neuroregenerative

Formula: C₄₄H₆₉NO₁₂

Purezza: Min. 98 Area-%

Colore e forma: White Powder

Peso molecolare: 804.02 g/mol

Ref: 3D-AT23293

Everolimus, Cyclosporine and Tacrolimus Mix Standard

Prodotto controllato

CAS: 104987-11-3, 159351-69-6, 59865-13-3

Formula: MixtureVisitourWebsite

Colore e forma: Mixture

Peso molecolare: Mixture - Visit our Website

Ref: TR-E608165

FK-506 (Tacrolimus)

CAS: 104987-11-3

FK-506 is an immunosuppressant that is produced by fermentation. It is used to prevent the rejection of transplanted organs and to treat a number of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. FK-506 binds to the IL-2 receptor on T-cells and inhibits their proliferation, thereby preventing activation of other immune cells. FK-506 has been shown to be effective in treating a number of diseases, including myocardial infarcts, coronary heart disease, and oral hypoglycaemic. The optimum concentration for this drug is not known, but it appears that higher concentrations are more beneficial in treating some conditions.

Formula: C₄₄H₆₉NO₁₂

Purezza: Min. 95%

Peso molecolare: 804 g/mol

Ref: 3D-INT-3098-PI