CAS 59865-13-3

Ciclosporina A

Descrizione:

Ciclosporina A è un polipeptide ciclico composto da 11 aminoacidi, noto principalmente per le sue proprietà immunosoppressive. È prodotto dal fungo Tolypocladium inflatum ed è ampiamente utilizzato in contesti clinici, in particolare nei trapianti d'organo e nelle malattie autoimmuni, per prevenire il rigetto d'organo e gestire condizioni come l'artrite reumatoide. La sostanza agisce inibendo l'attivazione dei linfociti T, riducendo così la risposta immunitaria. Ciclosporina A è lipofilo, il che influisce sulla sua assorbimento e distribuzione nel corpo; viene generalmente somministrato per via orale o endovenosa. La sua farmacocinetica può essere influenzata da vari fattori, inclusi l'assunzione di cibo e farmaci concomitanti, richiedendo un attento monitoraggio dei livelli ematici per evitare tossicità. Gli effetti avversi possono includere nefrotossicità, ipertensione e maggiore suscettibilità alle infezioni. A causa delle sue interazioni complesse e degli effetti collaterali, Ciclosporina A richiede una gestione attenta e aggiustamenti della dose basati sulla risposta individuale del paziente e sul contesto clinico.

Formula: C₆₂H₁₁₁N₁₁O₁₂

InChI: InChI=1/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key: PMATZTZNYRCHOR-CGLBZJNRSA-N

SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Sinonimi:

• Cyclosporina
• Cyclosporine
• Cyclosporin
• Restasis
• cyclosporin A
• Antibiotic S 7481F1
• 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21-bis(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• 1: PN: US6686454 SEQID: 1 claimed protein
• 7: PN: WO0002548 PAGE: 30 claimed protein
• Arpimune ME
• Cicloral
• Cicloral (antibiotic)
• Ciclosporin
• Cipol N
• Consupren
• Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
• Debio088
• Equoral
• Gengraf
• Neoplanta
• Neoral
• Nsc 290193
• Ol 27-400
• Papilock Mini
• Ramihyphin A
• Sandimmun
• Sandimmune
• Sandimmune Neoral
• Sang-35
• SangCyA
• Sdz-Oxl 400
• Sigmasporin Microoral
• S-Neoral
• Zinograf ME

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: >97.0%(HPLC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 1,202.64

Ref: 3B-C2408

Cyclosporin A, 99+%

CAS: 59865-13-3

Cyclosporin A, 59865-13-3, or cyclosporine, is a cyclic polypeptide which acts as a calcineurin inhibitor and immunosuppressive agent. Learn more at Thermo Fisher Scientific.

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 99+%

Colore e forma: White, Powder or crystals or crystalline powder

Peso molecolare: 1202.61

Ref: 02-J63191

CICLOSPORIN CRS

CAS: 59865-13-3

CICLOSPORIN CRS

Colore e forma: Added

Ref: 41-C2163000

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

CAS: 59865-13-3

CICLOSPORIN FOR SYSTEM SUITABILITY A CRS

Colore e forma: Added

Ref: 41-Y0002292

Cyclosporine

CAS: 59865-13-3

Lactams, nesoi

Formula: C₆₂H₁₁₁N₁₁O₁₂

Colore e forma: White Powder

Peso molecolare: 1201.84137

Ref: 45-1158504

Cyclosporine A from Beauveria Nivea

CAS: 59865-13-3

Cyclosporine A from Beauveria Nivea

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 99%

Colore e forma: White Solid

Peso molecolare: 1202.61124

Ref: 54-BITP1533

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A is a Calcineurin Inhibitor Immunosuppressant, and a Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 99.00% - 99.94%

Colore e forma: White Solid

Peso molecolare: 1202.61

Ref: TM-T0945

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 99.5%

Colore e forma: Solid

Peso molecolare: 1202.61

Ref: 54-BUP14762

Cyclosporin A, USP grade

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: ≤ 0.7%

Colore e forma: Colourless crystals, or white to almost white powder

Peso molecolare: 1202.61

Ref: 7W-GA2331

Cyclosporin A

CAS: 59865-13-3

Cyclosporin A

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 97%

Colore e forma: Solid-Powder

Peso molecolare: 1202.62

Ref: 54-BI4559

Cyclosporin A-13C2-d4 (Cyclosporine-13C2-d4)

CAS: 59865-13-3

Formula: C₆₀₁₃C₂H₁₀₇D₄N₁₁O₁₂

Peso molecolare: 1208.64

Ref: 4Z-PC-5441

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 98.5 - 101.5 % (dried basis)

Colore e forma: Colourless crystals, or white to almost white powder

Peso molecolare: 1202.61

Ref: 7W-GA6323

Cyclosporin A (Cyclosporine)

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Colore e forma: White To Off-White Solid

Peso molecolare: 1202.64

Ref: 4Z-PC-541

Cyclosporin A

Prodotto controllato

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1202.61

Ref: 04-C11836300

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 95%~99%

Peso molecolare: 1202.64

Ref: BP-BP0438

Cyclosporin A

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 1202.6112

Ref: IN-DA00IKI7

Ciclosporin

Prodotto controllato

CAS: 59865-13-3

Formula: C₆₂H₁₁₁N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1202.61

Ref: 86-MM0241.00

Cyclosporin A-d4 (Major)

Prodotto controllato

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₀₇D₄N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1206.66

Ref: TR-C988902

Cyclosporin A-13C2,d4 (Major)

Prodotto controllato

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₂C₆₀D₄H₁₀₇N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1208.62

Ref: TR-C988901

Cyclosporin A

CAS: 59865-13-3

Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),

Formula: C₆₂H₁₁₁N₁₁O₁₂

Colore e forma: Neat

Peso molecolare: 1202.61

Ref: TR-C988900