CAS 110078-46-1

Plerixafor

Descrizione:

Plerixafor, con il numero CAS 110078-46-1, è una piccola molecola che funge da antagonista del recettore delle chemiochine, specificamente mirata al recettore CXCR4. È utilizzata principalmente nel contesto della mobilizzazione delle cellule staminali ematopoietiche per i pazienti sottoposti a trapianto di cellule staminali. Plerixafor agisce bloccando l'interazione tra il recettore CXCR4 e il suo ligando, il fattore-1 derivato dallo stroma (SDF-1), che è cruciale per la ritenzione delle cellule staminali nel midollo osseo. Questa azione facilita la mobilizzazione delle cellule staminali nel flusso sanguigno, rendendole più accessibili per la raccolta. La sostanza viene tipicamente somministrata tramite iniezione sottocutanea e ha una emivita relativamente breve, richiedendo un attento tempismo in relazione alle procedure di raccolta delle cellule staminali. Plerixafor è generalmente ben tollerato, sebbene possa causare effetti collaterali come reazioni nel sito di iniezione, nausea e diarrea. Il suo sviluppo ha migliorato significativamente l'efficienza della raccolta delle cellule staminali, in particolare nei pazienti con alcune neoplasie ematologiche.

Formula: C₂₈H₅₄N₈

InChI: InChI=1/C28H54N8.8BrH.2H2O/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;;;/h5-8,29-34H,1-4,9-26H2;8*1H;2*1H2

InChI key: InChIKey=YIQPUIGJQJDJOS-UHFFFAOYSA-N

SMILES: C(C1=CC=C(CN2CCCNCCNCCCNCC2)C=C1)N3CCCNCCNCCCNCC3

Sinonimi:

• 1,1'-(Benzene-1,4-Diyldimethanediyl)Bis(1,4,8,11-Tetraazacyclotetradecane)
• 1,1'-(Benzene-1,4-Diyldimethanediyl)Bis-1,4,8,11-Tetraazacyclotetradecane Octahydrobromide Dihydrate
• 1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
• 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]Octahydrobromide Dihydrate
• 1,1′-Xylyl bis-1.4,8,11 tetraaza cyclotetradecane
• 1,4,8,11-Tetraazacyclotetradecane, 1,1′-[1,4-phenylenebis(methylene)]bis-
• 1,4-Bis((1,4,8,11-Tetraazacyclotetradecan-1-Yl)Methyl)Benzene
• 1-[[4-(1,4,8,11-Tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
• Amd 3100
• Jkl 169
• Jm 3100
• Mozobil
• Sdz Sid 791
• Plerixafor
• Plerixafor(AMD3100)
• Plerixafor/JM3100/AMD3100
• plerixafor, AMD 3100, AMD-3100, AMD3100, JLK 169, Mozobil, 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylMethyl)phenyl] Methyl]-1,4,8,11-tetrazacyclotetradecane
• AMD310
• 1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylMethyl)phenyl]Methyl}-1,4,8,11-tetraazacyclotetradecane
• AMD3100 (Plerixafor)
• Unii-S915p5499n

Plerixafor

CAS: 110078-46-1

Drugs with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Formula: C₂₈H₅₄N₈

Colore e forma: White Off-White Powder

Peso molecolare: 502.44714

Ref: 45-1545135

1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)phenyl]methyl}-1,4,8,11-tetraazacyclotetradecane

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 502.7820

Ref: IN-DA007VXT

Plerixafor

CAS: 110078-46-1

Plerixafor

Formula: C₂₈H₅₄N₈

Purezza: >98%

Peso molecolare: 502.78

Ref: 54-OR1025718

Plerixafor

CAS: 110078-46-1

Plerixafor

Formula: C₂₈H₅₄N₈

Purezza: ≥95%

Peso molecolare: 502.78

Ref: 54-BUP13173

Plerixafor

CAS: 110078-46-1

Colore e forma: Neat

Ref: 86-MM3938.00

Plerixafor

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purezza: >98.0%(GC)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 502.80

Ref: 3B-P2678

Plerixafor

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purezza: ≥ 98.0%

Colore e forma: White powder

Peso molecolare: 502.78

Ref: 7W-GP0472

Plerixafor-d4

CAS: 110078-46-1

Formula: C₂₈H₅₀N₈D₄

Peso molecolare: 506.82

Ref: 4Z-P-552

Plerixafor

CAS: 110078-46-1

1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene

Formula: C₂₈H₅₄N₈

Purezza: 99%

Peso molecolare: 502.78

Ref: IN-DG208340

Plerixafor

CAS: 110078-46-1

Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.

Formula: C₂₈H₅₄N₈

Purezza: 99.17% - >99.99%

Colore e forma: Solid

Peso molecolare: 502.78

Ref: TM-T1776

Plerixafor Impurity 24

CAS: 110078-46-1

Formula: C₁₈H₃₀N₄O₂

Peso molecolare: 334.46

Ref: 4Z-P-5528

Plerixafor

CAS: 110078-46-1

Stability Hygroscopic
Applications Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM). Selective CXCR4 antagonist.
References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),

Formula: C₂₈H₅₄N₈

Colore e forma: Neat

Peso molecolare: 502.78

Ref: TR-P580500

Plerixafor

CAS: 110078-46-1

Initially identified as a selective inhibitor of HIV-1 and HIV-2 replication. This activity was ascribed to the specific binding to chemokine receptor CXCR4 and inhibition of its signaling downstream, mediated by SDF-1. Antagonizes binding of CXCL12 to CXCR4, inducing mobilization of hematopoietic progenitor cells that is enhanced in synergy with G-CSF.

Formula: C₂₈H₅₄N₈

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 502.78 g/mol

Ref: 3D-FP36846

1,4-Bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Purezza: 95+%

Colore e forma: Solid

Peso molecolare: 502.796

Ref: 10-F362020

Plerixafor

CAS: 110078-46-1

Formula: C₂₈H₅₄N₈

Peso molecolare: 502.8

Ref: ST-EA-CP-P68000