CAS 118-10-5

Cinchonina

Descrizione:

Cinchonina è un alcaloide derivato dalla corteccia dell'albero della china, noto principalmente per il suo uso nella medicina tradizionale e come precursore nella sintesi di vari farmaci. È una polvere cristallina bianca a gialla pallida con un sapore amaro ed è scarsamente solubile in acqua, ma più solubile in solventi organici come etanolo e cloroformio. La formula molecolare di Cinchonina è C18H21N e presenta una struttura complessa con un sistema ad anello di chinolina. Questo composto mostra stereoisomerismo, con la forma naturale che è l'enantiomero (S). Cinchonina è stato storicamente significativo come agente antimalarico ed è utilizzato anche nella sintesi di altri composti, inclusa la chinina. Inoltre, ha applicazioni in chimica organica come ligando chirale nella sintesi asimmetrica. Le sue proprietà farmacologiche includono effetti antipiretici e analgesici, sebbene oggi sia meno comunemente usato rispetto ai suoi derivati. Le considerazioni di sicurezza includono la potenziale tossicità a dosi elevate, richiedendo un'attenta manipolazione e utilizzo in contesti di laboratorio e medicinali.

Formula: C₁₉H₂₂N₂O

InChI: InChI=1S/C19H22N2O/c1-2-13-12-21-10-8-14(13)11-18(21)19(22)16-7-9-20-17-6-4-3-5-15(16)17/h2-7,9,13-14,18-19,22H,1,8,10-12H2/t13-,14-,18+,19-/m0/s1

InChI key: InChIKey=KMPWYEUPVWOPIM-QAMTZSDWSA-N

SMILES: [C@@H](O)([C@@]1([N@@]2C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(N=CC3)C=CC=C4

Sinonimi:

• (3alpha,9R)-cinchonan-9-ol
• (3alpha,9S)-cinchonan-9-ol
• (4beta,9S)-cinchonan-1-ium-9-ol
• (8R,9S)-Cinchonine
• (8alpha,9S)-cinchonan-9-ol
• (9R)-cinchonan-9-ol
• (9S)-9-hydroxycinchonan-1-ium
• (9S)-cinchonan-9-ol
• Alpha-(5-Vinyl-2-Quinuclidinyl)-4-Quinolinemethanol
• Cinchonan-9-Ol
• Cinchonan-9-ol, (9S)-
• Cinchonin
• Cinconina
• Nsc 6176
• d-Cinchonine
• Cinchonine

Cinchonine

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Purezza: >98.0%(T)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 294.40

Ref: 3B-C0350

(+)-Cinchonine, 98+%, cont. up to 3% quinidine/dihydroquinidine and 3% quinine/dihydroquinine

CAS: 118-10-5

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₉H₂₂N₂O

Purezza: 98+%

Colore e forma: White to pale cream, Crystals or powder or crystalline powder

Peso molecolare: 294.40

Ref: 02-A17523

Cinchonine

CAS: 118-10-5

Cinchonine (LA40221), a potent amide local anesthetic for surface use, is toxic and limited to spinal anesthesia.

Formula: C₁₉H₂₂N₂O

Purezza: 99.45%

Colore e forma: Solid

Peso molecolare: 294.39

Ref: TM-T0012

(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol

CAS: 118-10-5

(5-Ethenyl-1-azabicyclo[2.2.2]oct-2-yl)(quinolin-4-yl)methanol

Formula: C₁₉H₂₂N₂O

Purezza: ≥95%

Colore e forma: White Solid

Peso molecolare: 294.398

Ref: 54-OR28810

Cinchonine

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Purezza: (Titration) ≥ 99.0%

Colore e forma: White to almost white crystalline powder

Peso molecolare: 294.39

Ref: 7W-GK1431

Cinchonine

CAS: 118-10-5

Cinchonine

Formula: C₁₉H₂₂N₂O

Purezza: 99%

Peso molecolare: 294.39

Ref: 54-BUP19783

Cinchonine

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Purezza: 95%~99%

Peso molecolare: 294.398

Ref: BP-BP0362

Cinchonine (Standard)

CAS: 118-10-5

Cinchonine (Standard) is a reference standard for research and analysis in studies involving Cinchonine. Cinchonine (LA40221), a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.

Formula: C₁₉H₂₂N₂O

Peso molecolare: 294.39

Ref: TM-TMSM-2933

(S)-Quinolin-4-yl((1S,2R,4S,5S)-5-vinylquinuclidin-2-yl)methanol

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Purezza: 85%

Colore e forma: Solid

Peso molecolare: 294.3908

Ref: IN-DA0032AT

Cinchonine

CAS: 118-10-5

Stability Light Sensitive
Applications Stereomeric with Cinchonidine (C441925). Antimalarial.
References Litchfield, J., et al.: J. Pharm. Exp. Ther., 96, 99 (1949), Trager, W., et al.: Science, 193, 673 (1976), Panisko, D., et al.: Drugs, 39, 160 (1990), Karle, J., et al.: Antimicrob. Agents Chemother., 36, 1538 (1992),

Formula: C₁₉H₂₂N₂O

Colore e forma: Neat

Peso molecolare: 294.39

Ref: TR-C441935

Cinchonine

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Peso molecolare: 294.40

Ref: 4Z-C-535001

(+)-Cinchonine

CAS: 118-10-5

Cinchona alkaloid

Formula: C₁₉H₂₂N₂O

Purezza: ≥ 95.0 % (HPLC)

Colore e forma: Powder

Peso molecolare: 294.4

Ref: 5G-80963

Cinchonine

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Peso molecolare: 294.4

Ref: BE-RMT17338

(+)-Cinchonine

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Purezza: 85%

Colore e forma: Solid

Peso molecolare: 294.398

Ref: 10-F121600

Quinidine EP Impurity B

CAS: 118-10-5

Formula: C₁₉H₂₂N₂O

Peso molecolare: 294.4

Ref: ST-EA-CP-Q9007

Cinchonine

CAS: 118-10-5

Cinchonine is a naturally occurring alkaloid, which is derived from the bark of the Cinchona tree. This compound is known for its antimalarial properties, functioning primarily through the inhibition of the heme polymerase enzyme in Plasmodium parasites. By interfering with the conversion of toxic heme into the non-toxic hemozoin, cinchonine effectively causes an accumulation of toxic heme within the parasite, ultimately leading to its death.

Formula: C₁₉H₂₂N₂O

Purezza: Min. 95%

Peso molecolare: 294.39 g/mol

Ref: 3D-FC11047