CAS 120685-11-2

4'-N-benzoilestaurosporina

Descrizione:

4'-N-benzoilestaurosporina, con il numero CAS 120685-11-2, è un composto sintetico derivato dalla staurosporina, un alcaloide naturale noto per i suoi potenti effetti inibitori sulle chinasi proteiche. Questo composto presenta un gruppo benzilico attaccato all'atomo di azoto nella posizione 4' della struttura della staurosporina, il che ne migliora l'attività biologica e la selettività. È caratterizzato dalla sua complessa struttura policiclica, che contribuisce alla sua capacità di interagire con vari bersagli biologici. 4'-N-benzoilestaurosporina mostra significative proprietà antitumorali, rendendolo un argomento di interesse nella ricerca farmacologica. Il suo meccanismo d'azione coinvolge principalmente l'inibizione di chinasi specifiche, che svolgono ruoli cruciali nelle vie di segnalazione cellulare relative alla crescita e alla proliferazione. Inoltre, questo composto è spesso studiato per il suo potenziale nel trattamento di varie malattie, incluso il cancro, grazie alla sua capacità di indurre apoptosi nelle cellule maligne. Come per molte sostanze chimiche, le precauzioni di sicurezza e di manipolazione sono essenziali a causa della sua natura bioattiva.

Formula: C₃₅H₃₀N₄O₄

InChI: InChI=1/C35H30N4O4/c1-34(42-4)30(37(3)32(41)19-12-6-5-7-13-19)33-38-23-16-10-8-14-20(23)26-27-22(18-36-31(27)40)25-21-15-9-11-17-24(21)39(29(25)28(26)38)35(34,2)43-33/h5-17,30,33H,18H2,1-4H3,(H,36,40)/t30-,33-,34-,35+/m1/s1

InChI key: InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N

SMILES: C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@@H](N(C(=O)C9=CC=CC=C9)C)[C@H]2OC)[H])=CC=CC8

Sinonimi:

• 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonine, benzamide deriv.
• Benzamide, N-(2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-, [9S-(9α,10β,11β,13α)]-
• Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
• Benzoylstaurosporine
• Cgp 41231
• Cgp 41251
• Midostaurin
• N-Benzoylstaurosporine
• N-[(5R,6S,7R,8S)-7-methoxy-7,8-dimethyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacen-6-yl]-N-methylbenzamide
• N-[(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide
• Pkc 412
• Rydapt
• PKC412
• Midostaurin(PKC412)
• PKC412 from Staurosporine
• Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7B,12A-triazadibenzo(A,G)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)-
• CS-730
• Midostaurin, Benzoylstaurosporine, 4'-N-Benzoylstaurosporine, CGP 41251
• (Midostaurin) Benzoylstaurosporine
• [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
• PKC412 (Midostaurin)
• Midostaurin USP/EP/BP
• Cgp 41 251
• Midostaurin [inn]
• MIDOSTAURIN; CGP-41251; PKC-412; PKC412;PKC 412
• PKC412(Midostaurin,CGP41231,CGP41251)
• Staurosporine, N-Benzoyl
• QTH113
• PKC412 CGP 41231 CGP 41251 Midostaurin Benzoylstaurosporine
• Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-
• Midaustorin
• midostaruin
• N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide
• Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-J)(1,7)benzodiazonin-11-yl)-N-methyl-
• PKC-412, CGP-41251
• CGP 41251MIDOSTAURIN(PKC412)
• MIDOSTAURIN (PKC412; CGP 41251)

Midostaurin

CAS: 120685-11-2

Midostaurin

Purezza: 99.95%

Peso molecolare: 570.649

Ref: 10-F979299

PKC412

CAS: 120685-11-2

PKC412

Formula: C₃₅H₃₀N₄O₄

Colore e forma: Off-white Solid-Powder

Peso molecolare: 570.6371

Ref: 54-BIP1007

Midostaurin-d5

CAS: 120685-11-2

Formula: C₃₅H₂₅D₅N₄O₄

Colore e forma: Off-White Solid

Peso molecolare: 575.68

Ref: 4Z-M-160004

Midostaurin

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Colore e forma: White To Off-White Solid

Peso molecolare: 570.65

Ref: 4Z-M-160001

Midostaurin

CAS: 120685-11-2

Midostaurin

Formula: C₃₅H₃₀N₄O₄

Purezza: 99.5%

Peso molecolare: 570.649

Ref: 54-BUP12418

N-Benzoylstaurosporine

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Purezza: 99%

Colore e forma: Solid

Peso molecolare: 570.6371

Ref: IN-DA00386D

Midostaurin-13C6

Prodotto controllato

CAS: 120685-11-2

Stability Hygroscopic
Applications Midostaurin-13C6 is the labelled analogue of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₂₉C₆H₃₀N₄O₄

Colore e forma: Neat

Peso molecolare: 576.59

Ref: TR-M343762

Midostaurin

CAS: 120685-11-2

Stability Hygroscopic
Applications Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012);

Formula: C₃₅H₃₀N₄O₄

Colore e forma: Neat

Peso molecolare: 570.64

Ref: TR-M343760

Midostaurin-D5

Prodotto controllato

CAS: 120685-11-2

Formula: C₃₅D₅H₂₅N₄O₄

Colore e forma: Neat

Peso molecolare: 575.668

Ref: TR-M343764

N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

CAS: 120685-11-2

N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

Formula: C₃₅H₃₀N₄O₄

Purezza: 99%

Peso molecolare: 570.64

Ref: IN-DG305504

Midostaurin

CAS: 120685-11-2

PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.

Formula: C₃₅H₃₀N₄O₄

Purezza: 97.61% - >99.99%

Colore e forma: Solid

Peso molecolare: 570.64

Ref: TM-T3211

Midostaurin

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Peso molecolare: 570.65

Ref: ST-EA-CP-M107000

PKC 412

CAS: 120685-11-2

Inhibits multiple protein kinases, such as PKC and FLT3

Formula: C₃₅H₃₀N₄O₄

Purezza: Min. 95%

Colore e forma: Powder

Peso molecolare: 570.64 g/mol

Ref: 3D-FP43194

Midaustorin-[13C6]

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Peso molecolare: 570.6

Ref: BE-MC-7592

Midostaurin

CAS: 120685-11-2

Formula: C₃₅H₃₀N₄O₄

Peso molecolare: 570.6

Ref: BE-RMCM189000

N-Benzoyloxy Midostaurin

Prodotto controllato

CAS: 120685-11-2

Formula: C₃₅H₃₀O₅N₄

Colore e forma: Neat

Peso molecolare: 586.65

Ref: TR-B208086