CAS 1208222-39-2

Formula: C22H14F3NO3

InChI: InChI=1S/C22H14F3NO3/c23-22(24,25)29-17-10-11-19-18(12-17)20(27)21(28)26(19)13-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-12H,13H2

InChI key: SPBGRXOPAXZSER-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)CN3C4=C(C=C(C=C4)OC(F)(F)F)C(=O)C3=O

VU 0365114

CAS: 1208222-39-2

VU 0365114 is a positive allosteric modulator of mAChR M5 and increases ACh-induced calcium mobilization(EC50: 2.7 μM).

Formula: C₂₂H₁₄F₃NO₃

Purezza: 99.86%

Colore e forma: Red Solid

Peso molecolare: 397.35

Ref: TM-T13325

VU 0365114

CAS: 1208222-39-2

VU 0365114

Formula: C₂₂H₁₄F₃NO₃

Purezza: 99.5%

Peso molecolare: 397.35

Ref: 54-BUP12940

1-([1,1'-Biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione

CAS: 1208222-39-2

Formula: C₂₂H₁₄F₃NO₃

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 397.3467

Ref: IN-DA008VNP

VU 0365114

CAS: 1208222-39-2

1-([1,1'-Biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione

Formula: C₂₂H₁₄F₃NO₃

Purezza: 98%

Peso molecolare: 397.35

Ref: IN-DG00802581

VU 0365114

Prodotto controllato

CAS: 1208222-39-2

Applications VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).
References Bridges, T.M., et al.: Bioorg. Med. Chem. Lett., 20, 5617 (2010);

Formula: C₂₂H₁₄F₃NO₃

Colore e forma: Neat

Peso molecolare: 397.347

Ref: TR-V787560

VU 0365114

CAS: 1208222-39-2

VU 0365114 is a novel compound that is synthesized to act as an allosteric modulator of the acetylcholine receptor. It has been shown to have antagonistic properties at the receptor subtype. VU 0365114 has been found to be active in knockout mice, and it was able to produce effects in the ventral tegmental area and substantia nigra. The drug was also able to increase phosphatidyl fumarate levels, which may be due to its ability to inhibit fumarate reductase activity.

Formula: C₂₂H₁₄F₃NO₃

Purezza: Min. 95%

Peso molecolare: 397.35 g/mol

Ref: 3D-IYB22239