CAS 1217247-62-5

Formula: C20H23FN4O2

InChI: InChI=1S/C20H23FN4O2/c1-4-22-7-8-23-20(27)18-11(2)17(24-12(18)3)10-15-14-9-13(21)5-6-16(14)25-19(15)26/h5-6,9-10,22,24H,4,7-8H2,1-3H3,(H,23,27)(H,25,26)/b15-10-/i1D3,4D2

InChI key: LIZNIAKSBJKPQC-WTRGBYKBSA-N

SMILES: [2H]C([2H])([2H])C([2H])([2H])NCCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C

N-Desethyl Sunitinib-d5

CAS: 1217247-62-5

N-Desethyl Sunitinib-d5

Formula: C₂₀H₁₈D₅FN₄O₂

Peso molecolare: 375.45

Ref: 54-DE2687

N-Desethyl Sunitinib-D5

CAS: 1217247-62-5

N-Desethyl Sunitinib D5 is a deuterated compound of N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU012662) is the primary active metabolite of Sunitinib produced by the metabolism of cytochrome P450 enzyme 3A4 (CYP3A4).Sunitinib is an orally available inhibitor of a number of tyrosine kinases involved in tumor proliferation and angiogenesis, including VEGFR, PDGFR, KIT, and FLT3, and was approved for the treatment of advanced/metastatic renal cell carcinoma (RCC)

Formula: C₂₀H₁₈D₅FN₄O₂

Peso molecolare: 375.45

Ref: TM-TMIG-0015

N-Desethyl Sunitinib-d5

Prodotto controllato

CAS: 1217247-62-5

Applications A labelled metabolite of Sunitinib (S820000).
References Sun, L., et al.: J. Med. Chem., 46, 1116 (2003), Mendel, D.B., et al.: Clin. Cancer Res., 9, 327 (2003), Sistla, A., et al.: Drug Dev. Ind. Pharm., 30, 19 (2004), Sakamoto, K.M., et al.: Curr. Opin. Invest. Drugs, 5. 1329 (2004),

Formula: C₂₀H₁₈D₅FN₄O₂

Colore e forma: Neat

Peso molecolare: 375.45

Ref: TR-D289652

N-Desethyl sunitinib-d5

CAS: 1217247-62-5

Sunitinib is a drug that is used to treat renal cell cancer. It is a tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme, which prevents the activation of the protein. Sunitinib has been shown to be effective against metastatic renal cell cancer and can be used with other drugs such as docetaxel or paclitaxel. Sunitinib's active metabolite, N-desethyl sunitinib, has also been shown to have similar effects on kidney cancer cells as its parent compound. Monitoring blood levels of sunitinib and its metabolites may help determine an individualized dose for each patient.

Formula: C₂₀H₂₃FN₄O₂

Purezza: Min. 95%

Peso molecolare: 375.5 g/mol

Ref: 3D-SYB24762