CAS 1239269-52-3

Formula: C29H33FN4O8

InChI: InChI=1S/C25H29FN4O4.C4H4O4/c1-15-22(12-19-18-11-16(26)4-5-20(18)28-24(19)32)27-21-3-2-6-30(25(33)23(15)21)14-17(31)13-29-7-9-34-10-8-29;5-3(6)1-2-4(7)8/h4-5,11-12,17,27,31H,2-3,6-10,13-14H2,1H3,(H,28,32);1-2H,(H,5,6)(H,7,8)/b19-12-;2-1-/t17-;/m1./s1

InChI key: UGVGACHPGHZDMO-LMERLFCISA-N

SMILES: CC1=C(NC2=C1C(=O)N(CCC2)C[C@@H](CN3CCOCC3)O)/C=C\4/C5=C(C=CC(=C5)F)NC4=O.C(=C\C(=O)O)\C(=O)O

Henatinib maleate

CAS: 1239269-52-3

Henatinib maleate is an orally active small-molecule multi-kinase inhibitor. It inhibits the activity of VEGFR-2, c-kit, and PDGFR with IC₅₀ values of 0.6 nM, 3.3 nM, and 41.5 nM, respectively. Henatinib maleate significantly suppresses VEGFR-2 phosphorylation and its downstream signaling pathways, and it possesses extensive antitumor activity.

Formula: C₂₉H₃₃FN₄O₈

Peso molecolare: 584.6

Ref: TM-T214448