CAS 125971-94-0

1,1-Dimetiletil (4R,6R)-6-(cianometil)-2,2-dimetil-1,3-diossano-4-acetato

Descrizione:

1,1-Dimetiletil (4R,6R)-6-(cianometil)-2,2-dimetil-1,3-diossano-4-acetato, con il numero CAS 125971-94-0, è un composto chimico caratterizzato dalla sua struttura complessa, che include un anello di dioxano e vari gruppi funzionali come un gruppo cianometilico e un moiety di acetato. Questo composto è probabile che mostri proprietà tipiche dei derivati del dioxano, inclusa una potenziale solubilità in solventi organici e stabilità in determinate condizioni. La presenza del gruppo cianometilico suggerisce una reattività potenziale, in particolare nelle reazioni di addizione nucleofila. La stereochimica indicata dalla configurazione (4R,6R) può influenzare la sua attività biologica e le interazioni con altre molecole. Come molti composti organici, le sue proprietà fisiche come il punto di ebollizione, il punto di fusione e la densità dipenderebbero dalle interazioni molecolari specifiche e dalla presenza di gruppi funzionali. I dati di sicurezza e le precauzioni di manipolazione devono essere consultati, poiché i composti con funzionalità cianuro possono presentare rischi di tossicità. In generale, questo composto potrebbe avere applicazioni nella sintesi organica o come intermediario nello sviluppo farmaceutico.

Formula: C₁₄H₂₃NO₄

InChI: InChI=1/C14H23NO4/c1-13(2,3)19-12(16)9-11-8-10(6-7-15)17-14(4,5)18-11/h10-11H,6,8-9H2,1-5H3/t10-,11-/m1/s1

InChI key: InChIKey=DPNRMEJBKMQHMC-GHMZBOCLSA-N

SMILES: C(C(OC(C)(C)C)=O)[C@@H]1OC(C)(C)O[C@H](CC#N)C1

Sinonimi:

• ((4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-[1,3]dioxan-4-yl)acetic acid tert-butyl ester
• (4R,3R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R,6R)-Tert-Butyl-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate
• (4R,6R)-t-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate (ATS-8)
• (4R,Cis)-1,1-dimethylethyl-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R-cis)-1,1-Dimethylethyl-6-Cyanomethyl-2,2-dlmethyl-1,3-dioxane-4-acetate
• (6R-Cyanomethyl-2,2-dimethyl-[1,3]dioxan-4R-yl)acetic acid tert-butyl ester
• 1,1-Dimethylethyl (4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
• 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)-
• 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R-cis)-
• ATS-8(for Atorvastatin)
• Ast-8
• Atorvastatin Calcium Intermediate ATS-8
• AtorvastatinCalcium(ATS-8)
• Ats-8
• Tert-Butyl (4R,3R)-6-Cyanomethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetate
• Tert-Butyl 2-((4R,6R)-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl) acetate
• tert-Butyl(3R,5R)-6-cyano-3,5-O-iso-propylidene-3,5-dihydroxyhexanoate
• tert-butyl [(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate
• (4R,CIS)-1,1-DIMETHYLETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE(ATS-8)
• Intermediateofatorvastatinecalcium(CAS#134523-03-8)
• (4R,6R)-Tert-Butyl-6-Cyanometh
• 1,3-Dioxane-4-acetic acid, 6-(cyanomethyl)-2,2-dimethyl-1,1-dimethylethylester
• Ats-8:(4R,Cis)-1,1-Dimethylethyl-Cyanomethyl-2,2-Dimethyl
• ATS-8:(4R-CIS)-T-ETHYL-6-CYANOMETHYL-2,2-DIMETHYL-1,2-DIMETHYL-1,2-DIONMANO 1 ACETATE
• (4R-Cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dio-cxane-4-acetate
• (4R,6R)-t-Butyl-6-AMINOMETHYL-2,2-dimethyl-1,3-dioxane-4-acetate
• (4R,6R)-t-butyl-6-cyanomethyl02,2-dimethyl-1,3-dioxane-4-acetate
• ATS 8 (4R,CIS)-1,1-DIMETHYLETHY-L-CYANOMETHYL-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE
• TERT-BUTYL[(4R,6R)-6-CYANOMETHYL-1,3-DIOXAN-4-YL]ACETATE
• (4R-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dloxane-4-acetate

tert-Butyl (4R,6R)-6-Cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

CAS: 125971-94-0

Formula: C₁₄H₂₃NO₄

Purezza: >98.0%(GC)(N)

Colore e forma: White to Almost white powder to crystal

Peso molecolare: 269.34

Ref: 3B-B3642

Tert-Butyl 2-((4R,6R)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

CAS: 125971-94-0

Formula: C₁₄H₂₃NO₄

Purezza: 95%

Colore e forma: Solid

Peso molecolare: 269.3367

Ref: IN-DA000QLY

Tert-Butyl 2-((4R,6R)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

CAS: 125971-94-0

Tert-Butyl 2-((4R,6R)-6-(Cyanomethyl)-2,2-Dimethyl-1,3-Dioxan-4-yl)Acetate

Formula: C₁₄H₂₃NO₄

Purezza: >99%

Peso molecolare: 269.34

Ref: 54-OR1015132

Atorvastatin Impurity 21

CAS: 125971-94-0

Formula: C₁₄H₂₃NO₄

Colore e forma: White To Off-White Solid

Peso molecolare: 269.34

Ref: 4Z-A-1257

1,1-Dimethylethyl 2-[(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

CAS: 125971-94-0

Colore e forma: Neat

Ref: 86-MM0400.37

tert-butyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

CAS: 125971-94-0

tert-Butyl 2-((4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

Formula: C₁₄H₂₃NO₄

Purezza: 95%

Peso molecolare: 269.34

Ref: IN-DG5737

(4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester

Prodotto controllato

CAS: 125971-94-0

Applications (4R,6R)-6-(Cyanomethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester is an intermediate of Atorvastatin (A791750, Ca salt), a selective, competitive HMG-CoA reductase . Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglyceinhibitorrides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993), Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996), Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000),

Formula: C₁₄H₂₃NO₄

Colore e forma: Neat

Peso molecolare: 269.34

Ref: TR-C982020

Atorvastatin Acetonide t-Butyl Ester Side Chain (4R,6R)-Isomer

CAS: 125971-94-0

Formula: C₁₄H₂₃NO₄

Peso molecolare: 269.34

Ref: ST-EA-CP-A32061