CAS 1263-89-4

Solfato di paromomicina

Descrizione:

Solfato di paromomicina è un antibiotico aminoglicosidico utilizzato principalmente per trattare infezioni causate da alcuni tipi di batteri, in particolare nei casi di amebiasi intestinale e leishmaniosi. È derivato dal batterio Streptomyces griseus e funziona inibendo la sintesi proteica nei microrganismi suscettibili. Il composto è caratterizzato dalla sua capacità di legarsi alla subunità ribosomiale 30S, portando a una lettura errata dell'mRNA e, in ultima analisi, interrompendo la crescita batterica. La paromomicina viene tipicamente somministrata per via orale o parenterale, a seconda dell'infezione trattata. È nota per la sua tossicità relativamente bassa rispetto ad altri aminoglicosidi, sebbene possa comunque causare effetti collaterali come disturbi gastrointestinali e nefrotossicità in alcuni casi. La forma solfato ne migliora la solubilità in acqua, rendendola adatta per varie formulazioni. La paromomicina è anche oggetto di indagine per il suo potenziale utilizzo nel trattamento di infezioni multiresistenti, evidenziando la sua importanza nel campo della terapia antimicrobica.

Formula: C₂₃H₄₇N₅O₁₈S

InChI: InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23?;/m1./s1

InChI key: InChIKey=LJRDOKAZOAKLDU-UDXJMMFXSA-N

SMILES: S(=O)(=O)(O)O.O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Sinonimi:

• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
• (2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside sulfate (1:1)
• 1600 Antibiotic
• 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Aminosidin sulfate
• Aminosidin sulphate
• Aminosidine Sulphate
• Aminosidine sulfate
• Aminoxidin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (salt)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (1:?)
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-, sulfate (salt)
• Farmiglucin
• Farminosidin
• Fi 5853
• Gabbroral
• Humagel
• Humatin
• Humycin sulfate
• O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptamine sulfate (salt)
• Paramicina
• Pargonyl
• Paricina
• Paromomycin Sulphate
• Paromomycin Sulphates
• Paromomycin sulfate salt
• Paromomycinsulfate
• Sinosid
• Sulfates De Paromomycine
• Sulfatos De Paromomicina
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:?)
• Paromomycin sulfate
• D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI)
• fi5853
• PayoMoMycin Sulfate
• Paromomycin sulphate solution,1000ppm solution
• Barone sulfate kanamycin Solution, 100ppm
• humycinsulfate
• Humatin (tn)
• Paromomycin sulfate (jan/usp)
• O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate
• sulf
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI)
• Paromomycin sulphate solution,100ppm
• aminosidinesulfate
• PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+%
• Paromomycin Sulfate (125 mg)
• paromomycin sulfate cell culture tested
• Paromomycin Sufate
• paromomycin sulfate plant cell*culture tested
• streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof
• NEOMYCIN E
• aminosidinesulphate
• Paramomycinsulfate
• O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate
• aminosidinsulfate
• O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate
• D00868
• PAROMOMYCIN SULFATE USP 97+%
• Paromomycin sulfate ,98%
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1)

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Purezza: >92.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin sulfate

CAS: 1263-89-4

Inhibits initiation and elongation during protein synthesis

Formula: C₂₃H₄₇N₅O₁₈S

Colore e forma: White to pale cream to pale yellow, Powder

Peso molecolare: 713.71

Ref: 02-J61274

PAROMOMYCIN SULFATE RS

CAS: 1263-89-4

PAROMOMYCIN SULFATE RS

Formula: C₂₃H₄₅N₅O₁₄

Peso molecolare: 615.6285

Ref: 41-ICRS0378

Paromomycin Sulfate

CAS: 1263-89-4

Aminoglycoside antibiotics

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Colore e forma: White Off-White Light Yellow Powder

Peso molecolare: 615.2963

Ref: 45-1500003

Paromomycin sulfate

CAS: 1263-89-4

Formula: C₂₃H₄₇N₅O₁₈S

Purezza: 98%

Colore e forma: Solid

Peso molecolare: 713.7070

Ref: IN-DA0072SF

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate, an aminoglycoside antibiotic, binds to 30S ribosomes, disrupting protein synthesis and killing bacteria.

Formula: C₂₃H₄₇N₅O₁₈S

Purezza: 99.73% - 99.86%

Colore e forma: Solid

Peso molecolare: 713.71

Ref: TM-T1104

Paromomycin Sulfate

CAS: 1263-89-4

Paromomycin Sulfate

Purezza: ≥98%

Peso molecolare: 713.71g/mol

Ref: 54-BUP18626

Paromomycin sulfate salt

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Colore e forma: White to off-white powder

Peso molecolare: 713.71

Ref: 7W-GA4947

Paromomycin sulphate

CAS: 1263-89-4

Paromomycin sulphate

Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Purezza: Ph - 6 loss on drying: 3.1% (Typical Value in Batch COA)

Colore e forma: white to faint yellow powder

Peso molecolare: 713.71g/mol

Ref: 54-BIP0141

Paromomycin sulfate

Prodotto controllato

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Colore e forma: Neat

Peso molecolare: 713.71

Ref: 04-C15893500

Paromomycin Sulfate

CAS: 1263-89-4

Stability Hygroscopic
Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Formula: C₂₃H₄₅N₅O₁₄·H₂O₄S

Colore e forma: Neat

Peso molecolare: 713.71

Ref: TR-P205650

Paromomycin sulfate

CAS: 1263-89-4

Paromomycin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis inhibition and is used for treating intestinal infections and leishmaniasis.

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Purezza: ≥675Μg/Mg(On Dried Basis)

Colore e forma: Yellow Powder

Peso molecolare: 615.63 g/mol

Ref: 3D-AP31110

Paromomycin sulfate, Antibiotic for Culture Media Use Only

CAS: 1263-89-4

Paromomycin sulfate is an antibiotic used for culture media to control bacterial contamination of mediums and other laboratory substances. Most Gram-negative bacteria strains are sensitive to paromomycin sulfate, showing a low sensitivity (≀10%) in Enterobacteriaceae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae and Serratia marcescens. Paromomycin sulfate is also used in the treatment of colorectal cancer by blocking DNA synthesis through inhibition of protein synthesis in susceptible cells. This can result in reduced damage in colon tumor cells within the body, although it may have neurotoxic effects on brain tissue. Furthermore, it has anti-inflammatory properties when given orally or intravenously at therapeutic doses. Acridine orange can be used to identify sulfuric acid resistant gram.

Formula: C₂₃H₄₇N₅O₁₈S

Purezza: Min. 95.0 Area-%

Peso molecolare: 713.71 g/mol

Ref: 3D-Q-201537

Paromomycin Sulfate (PRM)

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄·H₂SO₄

Colore e forma: White to off-white, Powder

Peso molecolare: 713.17

Ref: SR-27436

Paromomycin sulfate

CAS: 1263-89-4

Purezza: 95+%

Peso molecolare: 713.710022

Ref: 10-F806731

Neomycin sulfate EP Impurity E

CAS: 1263-89-4

Formula: C₂₃H₄₅N₅O₁₄H₂SO₄

Peso molecolare: 615.63 : 98.07

Ref: ST-EA-CP-N53005