CAS 7542-37-2

Paromomicina

Descrizione:

Paromomicina è un antibiotico aminoglicosidico utilizzato principalmente per trattare infezioni causate da alcuni parassiti e batteri. È derivato dal batterio Streptomyces griseus ed è particolarmente efficace contro le infezioni protozoarie come la leishmaniosi e l'amebiasi. Paromomicina agisce legandosi alla subunità ribosomiale 30S dei batteri, inibendo la sintesi proteica, il che porta infine alla morte cellulare batterica. Il composto è caratterizzato dalla sua tossicità relativamente bassa rispetto ad altri aminoglicosidi, rendendolo adatto per l'uso in popolazioni specifiche, comprese le donne in gravidanza per alcune infezioni. Paromomicina viene tipicamente somministrato per via orale o intramuscolare, a seconda della condizione da trattare. La sua solubilità in acqua consente una facile formulazione in varie preparazioni farmaceutiche. Tuttavia, è importante monitorare i potenziali effetti collaterali, inclusi disturbi gastrointestinali e nefrotossicità, specialmente nei pazienti con condizioni renali preesistenti. In generale, Paromomicina rimane un agente terapeutico prezioso nel trattamento di specifiche malattie infettive.

Formula: C₂₃H₄₅N₅O₁₄

InChI: InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

InChI key: InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N

SMILES: O([C@H]1[C@H](O[C@H]2[C@H](O)[C@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@@H](CO)O2)[C@@H](O)[C@H](N)C[C@@H]1N)[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N

Sinonimi:

• (1R,2R,3S,4R,6S)-4,6-Diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
• 231-423-0
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-<smallcap>L</smallcap>-idopyranosyl-(1→3)-β-<smallcap>D</span>-ribofuranosyl-(1→5)]-2-deoxy-
• Aminosidin
• Aminosidine
• Aminosidine I
• Amminosidin
• Antibiotic 2230D
• Antibiotic 503-3
• Antibiotic SF 767B
• Catenulin
• Crestomycin
• D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• D-Streptamine, O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-
• Gabbromicina
• Gabbromycin
• Gabromycin
• Humycin
• Hydroxymycin
• Monomycin A
• Neomycin E
• O-2,6-Diamino-2,6-dideoxy-β-<span class="text-smallcaps">L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• Paromomicina
• Paromomycin I
• Paromomycine
• Paucimycin
• Quintomycin C
• R 400
• Streptamine, O-2,6-diamino-2,6-dideoxy-β-<span class="text-smallcaps">L</smallcap>-idopyranosyl-(1→3)-O-β-<smallcap>D</smallcap>-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-2-deoxy-
• Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-
• Zygomycin A1
• Zygomycin A₁

Paromomycin Sulfate

CAS: 1263-89-4, 7542-37-2, 84420-34-8

Formula: C₂₃H₄₅N₅O₁₄·xH₂SO₄

Purezza: >92.0%(HPLC)

Colore e forma: White to Almost white powder to crystal

Ref: 3B-P2092

Paromomycin Deuterated Acetic Acid Salt

Prodotto controllato

CAS: 7542-37-2

Applications Paromomycin Deuterated Acetic Acid Salt is the isotope labelled analog of Paromomycin Sulfate. Paromomycin Sulfate is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Formula: C₂₃H₄₅N₅O₁₄•5(CH₃COOH)forundeuterated

Colore e forma: Neat

Peso molecolare: 615.63

Ref: TR-P205653

Paromomycin

CAS: 7542-37-2

Formula: C₂₃H₄₅N₅O₁₄

Peso molecolare: 615.63

Ref: ST-EA-CP-P156000

Neomycin EP Impurity E

CAS: 7542-37-2

Formula: C₂₃H₄₅N₅O₁₄

Peso molecolare: 615.63

Ref: ST-EA-CP-N53012