CAS 128625-52-5
:PyBOP
Descrizione:
PyBOP, o benzotriazolo-1-ossido-tris(dimetilamino)fosfonio esafluorofosfato, è un reagente di accoppiamento comunemente utilizzato nella sintesi di peptidi. Facilita la formazione di legami peptidici attivando gli acidi carbossilici, rendendoli più reattivi nei confronti delle ammine. PyBOP è caratterizzato dalla sua alta efficienza e condizioni di reazione delicate, che aiutano a minimizzare le reazioni secondarie e a proteggere i gruppi funzionali sensibili. Viene tipicamente utilizzato nella sintesi di peptidi in fase solida e in reazioni in fase soluzione. Il reagente è noto per la sua stabilità e facilità di manipolazione, spesso preferito rispetto ad altri agenti di accoppiamento grazie alla sua capacità di fornire alti rendimenti dei prodotti peptidici desiderati. Inoltre, PyBOP è solubile in comuni solventi organici, il che ne aumenta la versatilità in vari protocolli sintetici. Tuttavia, è importante maneggiare PyBOP con cautela, poiché può essere pericoloso, e devono essere adottate le opportune misure di sicurezza durante il suo utilizzo. In generale, PyBOP è uno strumento prezioso nel campo della chimica organica e medicinale, in particolare nella sintesi di peptidi complessi.
Formula:C18H28N6OP·F6P
InChI:InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
InChI key:InChIKey=VIAFLMPQBHAMLI-UHFFFAOYSA-N
SMILES:[P+](ON1C=2C(N=N1)=CC=CC2)(N3CCCC3)(N4CCCC4)N5CCCC5.[P+5]([F-])([F-])([F-])([F-])([F-])[F-]
Sinonimi:- (1-Hydroxy-1H-benzotriazolato-O)tri-1-pyrrolidinylphosphorus(1+) hexafluorophosphate(1-)
- 1-Benzotriazolyloxytripyrrolidinylphosphonium hexafluorophosphate
- 1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate
- 1H-Benzotriazole, 1-hydroxy-, phosphorus complex
- Benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
- Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate
- Benzotriazole-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate
- Phosphorus(1+), [1-(hydroxy-κO)-1H-benzotriazolato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1)
- PyBOP
- Pyrrolidine, phosphorus complex
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Reagents for Condensation Reactions (1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate) (HPMC encapsulated)
CAS:Formula:C18H28F6N6OP2Peso molecolare:520.401H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate [Coupling Reagent for Peptide]
CAS:Formula:C18H28F6N6OP2Purezza:>98.0%(HPLC)Colore e forma:White to Light yellow powder to crystalPeso molecolare:520.401H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 98%
CAS:1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl) phosphonium hexafluorophosphate is a peptide coupling reagent utilized in solid phase peptide synthesis. It is also used as a substitute for the (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent. This Thermo Scientific CFormula:C18H28N6OPPurezza:98%Colore e forma:White to pale cream, Crystals or powder or crystalline powderPeso molecolare:375.441H-Benzotriazol-1-yloxytripyrrolidinophosphonium hexafluorophosphate
CAS:Formula:C18H28F6N6OP2Purezza:98.0%Colore e forma:SolidPeso molecolare:520.401Benzotriazol-1-yloxytripyrrolidino phosphonium hexafluorophosphate, min. 99% [CalBOP]
CAS:Formula:C18H28F6N6OP2Purezza:min. 99%Colore e forma:WhitePeso molecolare:520.39PyBOP
CAS:A trademark of Merck KGaA, Darmstadt, Germany PyBOP is a well-established, effective coupling reagent. It has been developed to replace BOP which generates the carcinogenic HMPT as a by-product during coupling. Contrary to activation with uronium/aminium-type coupling reagents, by-products resulting from guanidinylation of the amino group cannot be formed. PyBOP has been used as well for obtaining peptide thioesters.Formula:C18H28N6OP·PF6Colore e forma:WhitePeso molecolare:520.4[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphate
CAS:[(1H-Benzotriazol-1-yl)oxy][tri(pyrrolidin-1-yl)]phosphonium hexafluorophosphateFormula:C18H28N6OP·PF6Purezza:≥95%Colore e forma:SolidPeso molecolare:520.39246Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
CAS:Formula:C18H28N6OP·PF6Purezza:≥ 97.5%Colore e forma:White to off-white or slightly yellow crystalline powderPeso molecolare:520.40(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
CAS:Formula:C18H28F6N6OP2Purezza:98%Colore e forma:SolidPeso molecolare:520.3925Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate
CAS:Prodotto controllatoApplications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.
Formula:C18H28N6OP·F6PColore e forma:NeatPeso molecolare:520.39(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
CAS:PyBOP is a phosphonium salt used as a coupling reagent for peptide synthesis. PyBOP is very efficient: high yields, low epimerisation and high conversion rates can be achieved. PyBOP generates an activated HOBt ester in situ, in the presence of a base such as triethylamine or Hünig’s base. PyBOP is the pyrrolidino derivative of the phosphonium coupling reagent BOP, which is equally efficient, but generates the extremely toxic and carcinogenic HMPA as a by-product in situ. PyBOP is generally preferred over BOP because it gives comparable performances but generates a less toxic by-product.Formula:C18H28N6OP·PF6Purezza:Min. 98 Area-%Colore e forma:White PowderPeso molecolare:520.39 g/molPyBOP
CAS:((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)Formula:C18H28F6N6OP2Purezza:98%Peso molecolare:520.39PyBOP
CAS:PyBOP is an acyclic nucleoside phosphonate that is structurally similar to cyclic peptides and coumarin derivatives. It has been shown to be active against infectious diseases such as malaria and hepatitis C, as well as metabolic disorders such as obesity. PyBOP also has a number of physiological effects, including thermal expansion and immunomodulation. PyBOP binds to the 3'-hydroxyl group of RNA by hydrogen bonding interactions in vivo and inhibits rRNA synthesis, leading to the inhibition of protein synthesis. This drug also disrupts the disulfide bond between cysteine residues in proteins, which may lead to autoimmune diseases. PyBOP is water-soluble and highly soluble in organic solvents, but not soluble in water or polar solvents such as DMSO or acetone. br>br> The thermal expansion coefficient for PyBOP is about 10^6 K^-1mol^
Formula:C18H28N6OP2F6Purezza:Min. 95%Peso molecolare:520.39 g/molRef: 3D-KPC-1068-PI
Prodotto fuori produzione
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